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1. 发明专利

JP2017513524A 細胞の集団を拡大する方法、キット、及び装置审中-公开
公开(公告)号：JP2017513524A
公开(公告)日：2017-06-01
申请号：JP2017505717
申请日：2015-04-16
申请人：ユノ・セラピューティクス・ゲーエムベーハーJuno Therapeutics Gmbh , ユノ・セラピューティクス・ゲーエムベーハーJuno Therapeutics Gmbh
发明人：ゲルメロート，ロタール , シュテンベルガー，クリスティアン
IPC分类号： C12N5/0783 , C07K1/04 , C07K1/16 , C07K1/22 , C12M3/00 , C12N5/0781 , C12N15/115 , G01N33/48
CPC分类号： C12N5/0636 , C12M47/02 , C12M47/12
摘要：本発明は、リンパ球等の細胞の集団を拡大するインビトロ方法であって、細胞の集団を含むサンプルを多量体化試薬と接触させることを含む方法に関する。前記細胞に一次活性化シグナルを提供する第1の剤、そして、任意で、共刺激シグナルを提供する第2の剤が、前記多量体化試薬上に可逆的に固定化されている(結合している)。また、本発明は、細胞を拡大するための多量体化試薬、キット、配置、及び装置を提供する。

2. 发明专利

JP2020124210A 細胞の集団を拡大する方法、キット、及び装置审中-公开
公开(公告)号：JP2020124210A
公开(公告)日：2020-08-20
申请号：JP2020076705
申请日：2020-04-23
申请人：ユノ・セラピューティクス・ゲーエムベーハー , JUNO THERAPEUTICS GMBH
发明人：ゲルメロート,ロタール , シュテンベルガー,クリスティアン
IPC分类号： C12M1/00 , C12N5/078
摘要：【課題】リンパ球等の細胞の集団を拡大するインビトロ方法の提供。【解決手段】細胞の集団を含むサンプルを多量体化試薬と接触させることを含む方法。前記細胞に一次活性化シグナルを提供する第1の剤、そして、任意で、共刺激シグナルを提供する第2の剤が、前記多量体化試薬上に可逆的に固定化されている。また、本発明は、細胞を拡大するための多量体化試薬、キット、配置、及び装置を提供する。【選択図】なし

4. 发明专利

TW201842335A 寡聚粒子試劑及其使用方法审中-公开
简体标题：寡聚粒子试剂及其使用方法
公开(公告)号：TW201842335A
公开(公告)日：2018-12-01
申请号：TW107114567
申请日：2018-04-27
申请人：德商朱諾醫療公司 , JUNO THERAPEUTICS GMBH
发明人：史庫米特湯瑪仕 , SCHMIDT, THOMAS , 史坦伯格克里斯蒂安 , STEMBERGER, CHRISTIAN , 柯斯奇湯姆 , KOWSKI, TOM , 普瑞提斯肯 , PRENTICE, KEN
IPC分类号： G01N33/68 , G01N33/53 , C07K14/315 , C07K16/12 , C07K16/24 , C12P21/00 , C12N5/07
摘要：本文提供寡聚試劑，包括抗生蛋白鏈菌素或抗生蛋白鏈菌素突變蛋白之寡聚試劑、及其組合物、及製造寡聚試劑之方法，包括可靠地製造具有所需尺寸之寡聚粒子試劑之方法。在一些情況下，該等試劑為含有複數個針對試劑之結合位點的寡聚粒子試劑，且因此一或多種試劑係藉由可逆地結合至該寡聚粒子試劑而多聚化，例如藉此產生多聚化寡聚粒子試劑，讓刺激劑在其上面多聚化。亦提供使用該等寡聚試劑進行培育或培養之方法，以誘導刺激細胞，諸如淋巴細胞群體之組合物擴增(增殖)、活化、共刺激及/或存活。在一些態樣中，本發明提供刺激例如細胞群體之擴增(增殖)、存活或續存、活化、共刺激或其他效應的方法及試劑，其包含將試劑結合至細胞表面上之分子，藉此向該等細胞提供一或多個信號。
简体摘要：本文提供寡聚试剂，包括抗生蛋白链菌素或抗生蛋白链菌素突变蛋白之寡聚试剂、及其组合物、及制造寡聚试剂之方法，包括可靠地制造具有所需尺寸之寡聚粒子试剂之方法。在一些情况下，该等试剂为含有复数个针对试剂之结合位点的寡聚粒子试剂，且因此一或多种试剂系借由可逆地结合至该寡聚粒子试剂而多聚化，例如借此产生多聚化寡聚粒子试剂，让刺激剂在其上面多聚化。亦提供使用该等寡聚试剂进行培育或培养之方法，以诱导刺激细胞，诸如淋巴细胞群体之组合物扩增(增殖)、活化、共刺激及/或存活。在一些态样中，本发明提供刺激例如细胞群体之扩增(增殖)、存活或续存、活化、共刺激或其他效应的方法及试剂，其包含将试剂结合至细胞表面上之分子，借此向该等细胞提供一或多个信号。

5. 发明授权

US12066365B2 Chromatographic isolation of cells and other complex biological materials 有权
公开(公告)号：US12066365B2
公开(公告)日：2024-08-20
申请号：US16231188
申请日：2018-12-21
申请人： Juno Therapeutics GmbH
发明人： Herbert Stadler
IPC分类号： G01N33/53 , B01D15/38 , G01N1/40 , G01N33/543 , G01N33/569
CPC分类号： G01N1/405 , B01D15/3809 , B01D15/3823 , G01N33/54306 , G01N33/56966 , G01N33/56972 , G01N2333/7051 , G01N2333/70517
摘要： The present invention relates to the chromatographic isolation of a target cell or another complex biological material, in particular by column chromatography such as affinity chromatography or gel permeation chromatography. The invention employs a receptor binding reagent that binds to a receptor molecule that is located on the surface of a target cell. The invention in general provides novel methods for the traceless isolation of biologic materials such as cells, cell organelles, viruses and the like. The invention also relates to an apparatus for the isolation of cells and other complex biological materials.

6. 发明公开

US20240216508A1 ENGINEERED T CELLS CONDITIONALLY EXPRESSING A RECOMBINANT RECEPTOR, RELATED POLYNUCLEOTIDES AND METHODS 审中-公开
公开(公告)号：US20240216508A1
公开(公告)日：2024-07-04
申请号：US18011780
申请日：2021-06-25
申请人： Juno Therapeutics GmbH
发明人： Mateusz Pawel POLTORAK , Christian STEMBERGER , Lothar GERMEROTH
IPC分类号： A61K39/00 , A61P35/00 , C07K14/725 , C12N9/22 , C12N15/11 , C12N15/90
CPC分类号： A61K39/4611 , A61K39/4631 , A61P35/00 , C07K14/7051 , C12N9/22 , C12N15/11 , C12N15/907 , A61K2239/22 , C07K2319/02 , C12N2310/20
摘要： Provided are engineered T cells that contain a modified T cell stimulation-associated locus encoding a recombinant receptor or a portion thereof. In some aspects, the nucleic acid sequence encoding the recombinant receptor or a portion thereof is operably linked to an endogenous transcriptional regulatory element of the T cell stimulation-associated locus, in some cases, engineered by targeted integration. In some aspects, the engineered cells conditionally express the recombinant receptor, such as upon stimulation or activation signal in the T cell. Also disclosed are cell compositions, nucleic acids for engineering cells, and methods and articles of manufacture for producing the engineered cells. In some embodiments, the engineered cells can be used in connection with cell therapy, including in connection with cancer immunotherapy comprising adoptive transfer of the engineered cells.

7. 发明申请

US20220243223A1 METHODS, KITS, AGENTS AND APPARATUSES FOR TRANSDUCTION 有权
公开(公告)号：US20220243223A1
公开(公告)日：2022-08-04
申请号：US17578425
申请日：2022-01-18
申请人： Juno Therapeutics GmbH
发明人： Keenan BASHOUR , Semih U. TAREEN
IPC分类号： C12N15/86 , C07K14/315 , C07K14/725 , C07K16/28 , C12N5/0783
摘要： Provided herein are methods for transducing a plurality of cells in a composition of cells, such as a population of lymphocytes, containing viral particles. In some aspects, provided methods and reagents for the transduction of cell populations involve binding of agents to a molecule on the surface of the cells. In some cases, the reagents are multimerization reagents and the one or more agents are multimerized by reversibly binding to the reagent. In some aspects, the multimerized agent can provide for transduction and/or expansion or proliferation or other stimulation of a population of cells, and then such agents can be removed by disruption of the reversible bond. Also provided are compositions, apparatus and methods of use thereof.

8. 发明授权

US11320431B2 Combination of reversible and irreversible cell labeling for analizing receptor-ligand koff rate 有权
公开(公告)号：US11320431B2
公开(公告)日：2022-05-03
申请号：US16314126
申请日：2017-06-27
申请人： TECHNISCHE UNIVERSITAET MUENCHEN , JUNO THERAPEUTICS GMBH
发明人： Magdalena Nauerth , Dirk Busch , Lothar Germeroth
IPC分类号： G01N33/557 , G01N33/566 , G01N33/543 , G01N33/50 , C07K14/74 , C12Q1/04 , C12N5/0783
摘要： The invention relates to a method of determining the dissociation rate constant (koff) of a receptor molecule R on a target cell using a combination of reversible and irreversible cell labeling. The invention further relates to a cell comprising such a receptor molecule R, wherein the cell has bound to it such a combination of cell labeling. The invention further relates to a kit and an apparatus useful in performing the methods of the invention. The invention further relates to a method of isolation a high-avidity T cell.

9. 发明授权

US11248238B2 Methods, kits, agents and apparatuses for transduction 有权
公开(公告)号：US11248238B2
公开(公告)日：2022-02-15
申请号：US15770177
申请日：2016-10-20
申请人： Juno Therapeutics GmbH
发明人： Keenan Bashour , Semih U. Tareen
IPC分类号： C12N5/0783 , C12N15/86 , C07K14/315 , C07K14/725 , C07K16/28
摘要： Provided herein are methods for transducing a plurality of cells in a composition of cells, such as a population of lymphocytes, containing viral particles. In some aspects, provided methods and reagents for the transduction of cell populations involve binding of agents to a molecule on the surface of the cells. In some cases, the reagents are multimerization reagents and the one or more agents are multimerized by reversibly binding to the reagent. In some aspects, the multimerized agent can provide for transduction and/or expansion or proliferation or other stimulation of a population of cells, and then such agents can be removed by disruption of the reversible bond. Also provided are compositions, apparatus and methods of use thereof.

10. 发明申请

US20190234844A1 CHROMATOGRAPHIC ISOLATION OF CELLS AND OTHER COMPLEX BIOLOGICAL MATERIALS 审中-公开
公开(公告)号：US20190234844A1
公开(公告)日：2019-08-01
申请号：US16231193
申请日：2018-12-21
申请人： Juno Therapeutics GmbH
发明人： Herbert STADLER
IPC分类号： G01N1/40 , G01N33/543 , G01N33/569
CPC分类号： G01N1/405 , G01N33/54306 , G01N33/56966 , G01N33/56972 , G01N2333/7051 , G01N2333/70517
摘要： The present invention relates to the chromatographic isolation of a target cell or another complex biological material, in particular by column chromatography such as affinity chromatography or gel permeation chromatography. The invention employs a receptor binding reagent that binds to a receptor molecule that is located on the surface of a target cell. The invention in general provides novel methods for the traceless isolation of biologic materials such as cells, cell organelles, viruses and the like. The invention also relates to an apparatus for the isolation of cells and other complex biological materials.

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