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1. 发明专利

GB8918214D0 PRESSURE MONITORING APPARATUS 未知
公开(公告)号：GB8918214D0
公开(公告)日：1989-09-20
申请号：GB8918214
申请日：1989-08-09
申请人： JONES BRIAN A

2. 发明专利

GB8918210D0 A PRESSURE TRANSDUCER 未知
公开(公告)号：GB8918210D0
公开(公告)日：1989-09-20
申请号：GB8918210
申请日：1989-08-09
申请人： JONES BRIAN A

3. 发明申请

WO2010096200A3 GAS CHROMATOGRAPHY INLET LINER HAVING AT LEAST ONE INDICATOR 审中-公开
标题翻译：气体色谱入口衬里具有至少一个指示器
公开(公告)号：WO2010096200A3
公开(公告)日：2014-03-27
申请号：PCT/US2010000522
申请日：2010-02-23
申请人： RESTEK CORP , JONES BRIAN A , KANE THOMAS E
发明人： JONES BRIAN A , KANE THOMAS E
IPC分类号： B01D53/02
CPC分类号： G01N30/12
摘要： A gas chromatography inlet liner comprises a glass tube formed by a glass wall, the glass wall having pore channels formed therein, and an indicator present in the pore channels in at least part of the inlet liner. The indicator may be any element, compound, dopant, or mixture additive that modifies color or transparency of the inlet liner.
摘要翻译：气相色谱入口衬套包括由玻璃壁形成的玻璃管，其中形成有孔通道的玻璃壁和存在于入口衬里的至少一部分中的孔通道中的指示器。指示剂可以是改变入口衬里的颜色或透明度的任何元素，化合物，掺杂剂或混合物添加剂。

4. 发明申请

WO2004074290A1 SUBSTITUTED AMINO HETEROCYCLES AS VR-1 ANTAGONISTS FOR TREATING PAIN 审中-公开
标题翻译：作为VR-1拮抗剂治疗疼痛的替代氨基酸异种
公开(公告)号：WO2004074290A1
公开(公告)日：2004-09-02
申请号：PCT/GB2004/000702
申请日：2004-02-20
申请人： MERCK SHARP & DOHME LIMITED , BROWN, Rebecca, Elizabeth , BURKAMP, Frank , DOUGHTY, Victoria, Alexandra , FLETCHER, Stephen, Robert , HOLLINGWORTH, Gregory, John , JONES, Brian, A. , SPAREY, Timothy, Jason
发明人： BROWN, Rebecca, Elizabeth , BURKAMP, Frank , DOUGHTY, Victoria, Alexandra , FLETCHER, Stephen, Robert , HOLLINGWORTH, Gregory, John , JONES, Brian, A. , SPAREY, Timothy, Jason
IPC分类号： C07D487/04
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention provides compounds of formula I: in which: one of T 1 and T 4 is N and the other is C; T 2 and T 3 are independently N or C(CH 2 ) n R 2 ; X, Y and Z are independently N or C(CH 2 ) n R 3 ; R 1 is Ar 1 or R 1 is C 1-6 alkyl optionally substituted with one or two groups Ar1; Ar1 is an optionally substituted cyclohexyl, piperidinyl, piperazinyl, morpholinyl, adamantyl, phenyl, naphthyl, a six - membered heteroaromatic ring containing one, two or three nitrogen atoms, a five-membered heteroaromatic ring containing one, two, three or four heteroatoms chosen from O, N and S, at most one O or S atom being present, or a nine - or ten - membered bicyclic heteroaromatic ring in which phenyl or a six - membered heteroaromatic ring as defined above is fused to a six - or five - membered heteroaromatic ring as defined above; Ar is an optionally substituted phenyl, a six - membered heteroaromatic ring containing one, two or three nitrogen atoms or a five - membered heteroaromatic ring containing one, two, three or four heteroatoms chosen from O, N and S, at most one heteroatom being O or S, Ar being optionally substituted by one, two or three groups chosen from halogen, CF 3 , OCF 3 , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, nitro, cyano, isonitrile, hydroxy, C 1-6 alkoxy, C 1-6 alkylthio, -NR 6 R 7 , -CONR 6 R 7 , -COH, CO 2 H, C 1-6 alkoxycarbonyl, haloC 1-6 alkyl, hydroxyC 1-6 alkyl, aminoC 1-6 alkyl, C 1-6 alkylcarbonyl and a five - membered heteroaromatic ring containing one, two, three or four heteroatoms chosen from O, N and S, at most one heteroatom being O or S, optionally substituted by C 1-6 alkyl, halogen, amino, hydroxy or cyano; or a pharmaceutically acceptable salt thereof as a VR-1 ligand; pharmaceutical compositions comprising it; its use in therapy; use of it in the manufacture of a medicament to treat pain; and methods of treating subjects suffering from pain.
摘要翻译：本发明提供了式I化合物：其中：T 1和T 4中的一个是N，另一个是C; T 2和T 3独立地是N或C（CH 2）n R 2; X，Y和Z独立地为N或C（CH 2）n R 3; R 1是Ar 1或R 1是任选被一个或两个Ar 1基团取代的C 1-6烷基; Ar1是任选取代的环己基，哌啶基，哌嗪基，吗啉基，金刚烷基，苯基，萘基，含有一个，两个或三个氮原子的六元杂芳环，含有一个，两个，三个或四个的五元杂芳环选自O，N和S，至多存在一个O或S原子的杂原子，或其中如上所定义的苯基或六元杂芳环的九个或十元二环杂芳环是与如上定义的六个或五元杂芳族杂环稠合; Ar是任选取代的苯基，含有一个，两个或三个氮原子的六元杂芳族环或含有一个，两个，三个或四个选自O，N和S的杂原子的五元杂芳环，在大多数一个杂原子是O或S，Ar任选被一个，两个或三个选自卤素，CF 3，OCF 3，C 1-6烷基，C 2-6烯基，C 2-6炔基，硝基，氰基，异氰酸酯，羟基，C 1-6烷氧基，C 1-6烷硫基，-NR 6 R 7，-CONR 6 R 7，-COH，CO 2 H，C 1-6烷氧基羰基，卤代C 1-6烷基，羟基C 1-6烷基，氨基C 1-6烷基，C 1-6烷基羰基和含有一个，两个，三个或四个选自O，N和S的杂原子的五元杂芳环，最多一个杂原子是O或S，任选被C 1-6烷基，卤素，氨基，羟基或氰基取代; 或其药学上可接受的盐作为VR-1配体; 包含它的药物组合物; 其用于治疗; 在制造治疗疼痛的药物中的用途; 以及治疗痛苦患者的方法。

5. 发明申请

WO2003045382A1 THERAPEUTIC COMPOUNDS FOR TREATING DYSLIPIDEMIC CONDITIONS 审中-公开
标题翻译：用于治疗多发性疾病的治疗化合物
公开(公告)号：WO2003045382A1
公开(公告)日：2003-06-05
申请号：PCT/US2002/036911
申请日：2002-11-18
申请人： MERCK & CO., INC. , ADAMS, Alan, D. , TSE, Bruno , HUANG, Shaei, Y. , JONES, Brian, A.
发明人： ADAMS, Alan, D. , TSE, Bruno , HUANG, Shaei, Y. , JONES, Brian, A.
IPC分类号： A61K31/423
CPC分类号： C07D413/12 , A61K31/423 , A61K31/4439 , A61K31/454 , C07D261/20 , C07D401/12
摘要： Compounds of Formula I and the pharmaceutically acceptable salts and esters thereof, are novel LXR ligands and are useful in the treatment of dyslipidemic conditions, particularly depressed levels of HDL cholesterol.
摘要翻译：式I化合物及其药学上可接受的盐和酯是新型LXR配体，可用于治疗血脂异常，特别是低密度脂蛋白胆固醇水平降低。

6. 发明申请

WO2011081653A1 GAS CHROMATOGRAPHY INLET LINERS AND SAMPLE PATH CONTAINERS 审中-公开
标题翻译：气体色谱入口和样品路径容器
公开(公告)号：WO2011081653A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/003175
申请日：2010-12-15
申请人： RESTEK CORPORATION , JONES, Brian, A. , GROSSMAN, Scott, L. , STROHM, Valerie, S. , KANE, Thomas, E.
发明人： JONES, Brian, A. , GROSSMAN, Scott, L. , STROHM, Valerie, S. , KANE, Thomas, E.
IPC分类号： B01D53/02
CPC分类号： G01N33/00 , B01L3/50 , B01L2200/143 , B01L2200/147 , B01L2300/0832 , B05D1/18 , G01K13/00 , G01N30/04 , G01N2030/126 , G01N2030/167
摘要： A container used for chromatographic sample analysis has (a) at least one silica uppermost layer, which is deposited onto the container using a liquid phase deposition process, and, optionally, (b) at least one indicator present in at least part of the at least one silica uppermost layer for visually distinguishing the container from other containers, and/or determining the "use status" of the container, and/or identifying the proper orientation of the container when it is to be put in use, and/or providing a means of decoration, identification, or counterfeit detection. In one preferred embodiment, the indicator is thermochromic. In another preferred embodiment, the indicator is photochromic.
摘要翻译：用于色谱样品分析的容器具有（a）至少一个二氧化硅最上层，其使用液相沉积工艺沉积到容器上，并且任选地（b）至少一个指示剂存在于至少一部分至少一个二氧化硅最上层，用于将容器与其他容器视觉区分，和/或确定容器的“使用状态”，和/或在容器投入使用时识别容器的正确取向，和/或提供一种装饰，鉴定或假冒检测的手段。在一个优选实施方案中，指示剂是热变色的。在另一个优选实施方案中，指示剂是光致变色的。

7. 发明申请

WO2010096200A2 GAS CHROMATOGRAPHY INLET LINER HAVING AT LEAST ONE INDICATOR 审中-公开
标题翻译：气体色谱入口衬里具有至少一个指示器
公开(公告)号：WO2010096200A2
公开(公告)日：2010-08-26
申请号：PCT/US2010/000522
申请日：2010-02-23
申请人： RESTEK CORPORATION , JONES, Brian, A. , KANE, Thomas, E.
发明人： JONES, Brian, A. , KANE, Thomas, E.
IPC分类号： G01N30/16
CPC分类号： G01N30/12
摘要： A gas chromatography inlet liner comprises a glass tube formed by a glass wall, the glass wall having pore channels formed therein, and an indicator present in the pore channels in at least part of the inlet liner. The indicator may be any element, compound, dopant, or mixture additive that modifies color or transparency of the inlet liner.
摘要翻译：气相色谱入口衬套包括由玻璃壁形成的玻璃管，其中形成有孔隙通道的玻璃壁和存在于入口衬里的至少一部分中的孔通道中的指示器。指示剂可以是改变入口衬里的颜色或透明度的任何元素，化合物，掺杂剂或混合物添加剂。

8. 发明申请

WO2009091604A1 GAS CHROMATOGRAPHIC DEVICE 审中-公开
标题翻译：气体色谱装置
公开(公告)号：WO2009091604A1
公开(公告)日：2009-07-23
申请号：PCT/US2009/000323
申请日：2009-01-16
申请人： RESTEK CORPORATION , JONES, Brian, A. , DE ZEEUW, Jaap , COCHRAN, Jack , GROSSMAN, Scott, L.
发明人： JONES, Brian, A. , DE ZEEUW, Jaap , COCHRAN, Jack , GROSSMAN, Scott, L.
IPC分类号： G01N30/00 , G01N30/74 , B01D15/10
CPC分类号： G01N30/16 , B01D53/0415 , G01N30/32 , G01N2030/025 , G01N2030/167 , G01N2030/6008 , G01N2030/621
摘要： A gas chromatographic device comprises an inlet system and a chromatography column. The inlet system includes a liner having pressure reducing means contained therein for reducing pressure between an inlet of the pressure reducing means and an outlet of the pressure reducing means. When the devise is in use, the chromatography column is positioned in the liner of the inlet system downstream from the pressure reducing means, and the chromatography column is under vacuum at its outlet.
摘要翻译：气相色谱装置包括入口系统和色谱柱。入口系统包括其中包含减压装置的衬套，用于减小减压装置的入口与减压装置的出口之间的压力。当设备使用时，色谱柱位于进口系统的衬垫中，位于减压装置的下游，色谱柱在其出口处处于真空状态。

9. 发明申请

WO2010120371A1 SOLID ALIQUOTS OF MULTIRESIDUE METHOD SALTS FOR SOLID PHASE EXTRACTION APPLICATIONS 审中-公开
标题翻译：用于固相萃取应用的多种方法的固体浓度
公开(公告)号：WO2010120371A1
公开(公告)日：2010-10-21
申请号：PCT/US2010/001131
申请日：2010-04-16
申请人： RESTEK CORPORATION , MOSESMAN, Neil, H. , JONES, Brian, A. , COCHRAN, Jack, W.
发明人： MOSESMAN, Neil, H. , JONES, Brian, A. , COCHRAN, Jack, W.
IPC分类号： B01D11/02
CPC分类号： G01N1/34 , G01N1/405
摘要： It is an object of the invention to improve the current QuEChERS technology. In one aspect of the invention, the buffer-salt powder mixture of the first stage of the QuEChERS process is compressed into a solid dosage form before it is used in the first stage of the QuEChERS process. Replacing the QuEChERS powders (the buffer-salt powder mixture of the first stage of the QuEChERS process) with solid aliquots eliminates the need for using centrifuge tubes for packaging the product.
摘要翻译：本发明的目的是改进目前的QuEChERS技术。在本发明的一个方面，QuEChERS过程的第一阶段的缓冲盐混合物在QuEChERS过程的第一阶段被用于固体剂型之前。用固体等分试样替代QuEChERS粉末（QuEChERS工艺第一阶段的缓冲盐粉末混合物），无需使用离心管来包装产品。

10. 发明申请

WO2005086652A2 POLYCARBOSILANE TREATMENT OF SUBSTRATES 审中-公开
标题翻译：基质的多硫化物处理
公开(公告)号：WO2005086652A2
公开(公告)日：2005-09-22
申请号：PCT/US2005/005731
申请日：2005-02-24
申请人： SELERITY TECHNOLOGIES, INCORPORATED , JONES, Brian, A.
发明人： JONES, Brian, A.
IPC分类号： B32B25/20 , C08K9/06 , C09D183/14 , C09D183/16
CPC分类号： C09D183/14 , C08K9/06 , C09D183/16 , Y10T428/31663
摘要： A polycarbosilane functionalized substrate can comprise a substrate having a surface including surface oxide or surface hydroxyl groups, and a polycarbosilane layer covalently bonded thereto. The polycarbosilane layer can include a web of interconnected polycarbosilane groups wherein the carbon bonded silane portions of the polycarbosilane groups are alkylene moieties. Optionally, an additional polycarbosilane layer(s) can be applied to the polycarbosilane layer.
摘要翻译：聚碳硅烷官能化基材可以包括具有包括表面氧化物或表面羟基的表面的基材和与其共价键合的聚碳硅烷层。聚碳硅烷层可以包括互连的聚碳硅烷基的网，其中聚碳硅烷基的碳键合硅烷部分是亚烷基部分。任选地，可以向聚碳硅烷层施加另外的聚碳硅烷层。

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