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    • 2. 发明申请
    • TOPICAL COMPOSITION FLUORESCENCE DETECTION
    • 主题成分荧光检测
    • WO2006118835A3
    • 2007-04-12
    • PCT/US2006015314
    • 2006-04-21
    • JOHNSON & JOHNSON CONSUMERS COCOLE CURTISNIKIFOROS KOLLIAS
    • COLE CURTISNIKIFOROS KOLLIAS
    • A61Q17/04A61K8/49G01N21/64
    • A61Q17/04A61K8/02A61K2800/434A61K2800/438A61K2800/88G01N21/64
    • Compositions, devices, methods, and kits are provided for determining the presence of topical compositions on surfaces, such as skin. Disclosed is in a first embodiment a composition comprising one or more oil or water soluble ultraviolet sunscreen agents and a fluorescent chromophore, wherein the fluorescent chromophore is oil soluble or water-soluble and has a wavelength of excitation greater than about 400nm (so-called daylight fluorescent compound). Also disclosed is a method of manufacturing a topical composition, comprising mixing a fluorescent chromophore and a sunscreen sufficiently to form a single phase composition. Further, a device for use with the fluorescent composition is described, for determining the presence of the composition on a surface, which device comprises a light emitter, a light detector, an electronic evaluation system to determine the level of fluorescence of the fluorescent chromophore, and a display system.
    • 提供组合物,装置,方法和试剂盒以确定表面如皮肤上局部组合物的存在。 在第一个实施方案中公开了包含一种或多种油或水溶性紫外线防晒剂和荧光发色团的组合物,其中所述荧光发色团是油溶性或水溶性的并且具有大于约400nm的激发波长(所谓的日光 荧光化合物)。 还公开了一种制备局部组合物的方法,其包括充分混合荧光发色团和防晒剂以形成单相组合物。 此外,描述了用于确定荧光组合物在表面上的组合物的存在的装置,该装置包括光发射器,光检测器,用于确定荧光发色团的荧光水平的电子评估系统, 和显示系统。