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1. 发明公开

EP2233157A1 A BIOCOMPATIBLE DENATURED STARCH SPONGE MATERIAL 审中-公开
标题翻译： BIOKOMPATIBLES SCHWAMMMATERIAL MIT DENATURIERTERSTÄRKE
公开(公告)号：EP2233157A1
公开(公告)日：2010-09-29
申请号：EP08862032.3
申请日：2008-12-08
申请人： Ji, Xin
发明人： Ji, Xin
IPC分类号： A61L15/28 , A61K31/715
CPC分类号： A61L15/28 , A61L15/58 , A61L26/0023 , A61L26/0085 , C08L3/04
摘要： The present invention relates to a biocompatible modified starch hemostatic sponge/foam and its new use as any of the hemostat, anti-adhesion material, promoting tissue healing material, surgical sealant and tissue adhesive glue. The said modified starch includes any or a composite of more than one of the pregelatinized starch, acid modified starch, oxidized starch, esterified starch, etherized starch, cross-linked starch, and grafted starch, composite modified starch.
The said hemostatic sponge/foam in this patent is made from modified starch, or a combination of modified starch with other biocompatible hemostat, blood coagulants, plasticizer etc. via vacuum freeze drying process. The advantages of the modified starch hemostatic foam/sponge include 1) multimodality - it can be applied directly to bleeding wound site; 2) having super biocompatibility which can minimize the risks of anaphylaxis, wound infection and wound healing retardation resulting from applying other animal/human components derived hemostats; 3) having super adhesive properties following water absorption which can create the adhesive matrix of clot to adhere and seal the bleeding vessels and wound tissue in particular when profuse bleeding.
摘要翻译：本发明涉及一种生物相容性改性淀粉止血海绵/泡沫及其作为任何止血剂，抗粘连材料，促进组织愈合材料，手术密封剂和组织粘合剂胶的新用途。所述改性淀粉包括预胶化淀粉，酸改性淀粉，氧化淀粉，酯化淀粉，醚化淀粉，交联淀粉和接枝淀粉，复合改性淀粉中的多于一种的任何或复合物。该专利中所述的止血海绵/泡沫由改性淀粉，或经由真空冷冻干燥法与改性淀粉与其它生物相容性止血剂，凝血剂，增塑剂等组合而成。改性淀粉止血泡沫/海绵的优点包括1）多模态 - 可直接应用于出血部位; 2）具有超级生物相容性，可以最大限度地减少因施用其他动物/人类成分而产生的止血剂引起的过敏反应，伤口感染和伤口愈合延迟的风险; 3）在吸水后具有超级粘合性能，其可以产生凝块的粘合剂基质，以粘附并密封出血血管和伤口组织，特别是当大量出血时。

2. 发明公开

EP2233157A4 A BIOCOMPATIBLE DENATURED STARCH SPONGE MATERIAL 审中-公开
标题翻译：用工业强度的生物相容性海绵材料
公开(公告)号：EP2233157A4
公开(公告)日：2011-11-30
申请号：EP08862032
申请日：2008-12-08
申请人： JI XIN
发明人： JI XIN
IPC分类号： A61L15/28 , A61K31/715
CPC分类号： A61L15/28 , A61L15/58 , A61L26/0023 , A61L26/0085 , C08L3/04

3. 发明授权

EP2203053B1 MODIFIED STARCH MATERIAL OF BIOCOMPATIBLE HEMOSTASIS 有权转让
标题翻译：生物相容性血液肿瘤的改性淀粉材料
公开(公告)号：EP2203053B1
公开(公告)日：2017-09-20
申请号：EP09701521.8
申请日：2009-01-13
申请人： Ji, Xin
发明人： JI, Xin , XING, Cheng , SHI, Xueshen , CHEN, Jianping
IPC分类号： A01N43/04 , A61K31/715 , A61L26/00
CPC分类号： A61K31/715 , A61L24/08 , A61L26/0023 , A61L26/0052 , A61L26/0076 , A61L31/041 , A61L31/042 , A61L2400/04 , C08L3/04

4. 发明公开

EP3199025A1 MODIFIED STARCH MATERIAL OF BIOCOMPATIBLE HEMOSTASIS 审中-公开
公开(公告)号：EP3199025A1
公开(公告)日：2017-08-02
申请号：EP17160575.1
申请日：2009-01-13
申请人： Ji, Xin
发明人： JI, Xin , XING, Cheng , SHI, Xueshen , CHEN, Jianping
IPC分类号： A01N43/04 , A61K31/715 , A61L26/00
CPC分类号： A61K31/715 , A61L24/08 , A61L26/0023 , A61L26/0052 , A61L26/0076 , A61L31/041 , A61L31/042 , A61L2400/04 , C08L3/04
摘要： A modified starch material for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a biocompatible modified starch to the tissue of animals. The modified starch material produces hemostasis, reduces bleeding of the wound, extravasation of blood and tissue exudation, preserves the wound surface or the wound in relative wetness or dryness, inhibits the growth of bacteria and inflammatory response, minimizes tissue inflammation, and relieves patient pain. Any excess modified starch not involved in hemostatic activity is readily dissolved and rinsed away through saline irrigation during operation. After treatment of surgical wounds, combat wounds, trauma and emergency wounds, the modified starch hemostatic material is rapidly absorbed by the body without the complications associated with gauze and bandage removal.

5. 发明公开

EP2680912A4 INTERNAL DRY POWDER DELIVERY SYSTEM AND METHOD THEREOF 审中-公开
标题翻译： VERFAHRENDAFÜR的INTERNES TROCKENPULVERFREISETZUNGSSYSTEM
公开(公告)号：EP2680912A4
公开(公告)日：2015-08-19
申请号：EP11859709
申请日：2011-03-21
申请人： JI XIN
发明人： JI XIN
IPC分类号： A61M11/00 , A61B17/12 , A61M13/00 , A61M15/00 , A61M31/00
CPC分类号： A61M13/00 , A61B17/00491 , A61B2017/00893 , A61M11/007 , A61M11/008 , A61M15/0016 , A61M2202/064 , B05B11/062
摘要： An internal dry powder delivery system through a working channel of an endoscopic cannula for directly applying the powder form medication to an internal tissue/organ site, includes an elongated tubular delivery channel and a powder supply device for producing pressurized gas mixing with the dry powder for feeding to form a mixture of dry powder and pressurized gas delivering to an internal tissue/organ site through the delivery channel via endoscopic cannula. It ensures a smooth powder release by preventing liquid from accumulation at the tip of the delivery channel and offers physicians a new powder form drug delivery method via endoscope. Also, it offers new minimal invasive application by directly and precisely applying the powder format drug to the internal sites of human gastrointestinal organ via endoscope to achieve hemostasis, anti-inflammation, anti-ulcer and anti-tumor treatment, etc.
摘要翻译：通过内窥镜套管的工作通道的内部干粉递送系统，用于将粉末形式的药物直接施加到内部组织/器官部位，包括细长的管状递送通道和用于产生与干粉混合的加压气体的粉末供应装置，进料以形成通过内窥镜插管通过输送通道输送到内部组织/器官部位的干粉和加压气体的混合物。通过防止液体在输送通道的尖端积聚，确保粉末释放光滑，并通过内窥镜向医生提供新的粉末形式的药物输送方法。此外，通过内窥镜直接精确地将粉末形式药物直接应用于人体胃肠器官的内部位置，实现止血，抗炎，抗溃疡，抗肿瘤治疗等功能，提供了最新的微创应用。

6. 发明公开

EP2680912A1 INTERNAL DRY POWDER DELIVERY SYSTEM AND METHOD THEREOF 审中-公开
标题翻译：内部干粉发布系统及其方法
公开(公告)号：EP2680912A1
公开(公告)日：2014-01-08
申请号：EP11859709.5
申请日：2011-03-21
申请人： Ji, Xin , Starch Medical Inc.
发明人： JI, Xin
IPC分类号： A61M11/00
CPC分类号： A61M13/00 , A61B17/00491 , A61B2017/00893 , A61M11/007 , A61M11/008 , A61M15/0016 , A61M2202/064 , B05B11/062
摘要： An internal dry powder delivery system through a working channel of an endoscopic cannula for directly applying the powder form medication to an internal tissue/organ site, includes an elongated tubular delivery channel and a powder supply device for producing pressurized gas mixing with the dry powder for feeding to form a mixture of dry powder and pressurized gas delivering to an internal tissue/organ site through the delivery channel via endoscopic cannula. It ensures a smooth powder release by preventing liquid from accumulation at the tip of the delivery channel and offers physicians a new powder form drug delivery method via endoscope. Also, it offers new minimal invasive application by directly and precisely applying the powder format drug to the internal sites of human gastrointestinal organ via endoscope to achieve hemostasis, anti-inflammation, anti-ulcer and anti-tumor treatment, etc.

7. 发明申请

WO2017079253A1 METHOD AND DEVICE FOR IN SITU CANCER MARGIN DETECTION 审中-公开
标题翻译：用于原位癌检测的方法和装置
公开(公告)号：WO2017079253A1
公开(公告)日：2017-05-11
申请号：PCT/US2016/060062
申请日：2016-11-02
申请人： CHENG, Ji-xin , WANG, Pu , LAN, Lu , LI, Rui
发明人： CHENG, Ji-xin , WANG, Pu , LAN, Lu , LI, Rui
IPC分类号： G01H9/00
CPC分类号： A61B8/5223 , A61B5/0095 , A61B8/0825 , A61B8/085 , A61B8/4281 , A61B8/4416
摘要： A multimodal ultrasound/photoacoustic tumor margin detection system. The system can be comprised of an imaging and system control console, which can include an ultrasound and data acquisition subsystem including an ultrasound transmitter and receiver configured to transmit and receive ultrasonic energy. A host-control computer configured to provide a function generator function and a delay generation function can also be a part of the imaging and system control console.
摘要翻译：多峰超声/光声肿瘤边缘检测系统。该系统可以包括成像和系统控制台，其可以包括超声波和数据采集子系统，该超声波和数据采集子系统包括被配置为发送和接收超声能量的超声发射器和接收器。配置成提供函数发生器功能和延迟生成功能的主机控制计算机也可以是成像和系统控制台的一部分。

8. 发明申请

WO2009091549A1 MODIFIED STARCH MATERIAL OF BIOCOMPATIBLE HEMOSTASIS 审中-公开
标题翻译：生物化学性质的改良淀粉材料
公开(公告)号：WO2009091549A1
公开(公告)日：2009-07-23
申请号：PCT/US2009/000227
申请日：2009-01-13
申请人： STARCH MEDICAL INC. , JI, Xin , XING, Cheng , SHI, Xueshen , CHEN, Jianping
发明人： JI, Xin , XING, Cheng , SHI, Xueshen , CHEN, Jianping
IPC分类号： A01N43/04 , A61K31/715
CPC分类号： A61K31/715 , A61L24/08 , A61L26/0023 , A61L26/0052 , A61L26/0076 , A61L31/041 , A61L31/042 , A61L2400/04 , C08L3/04
摘要： A modified starch material for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a biocompatible modified starch to the tissue of animals. The modified starch material produces hemostasis, reduces bleeding of the wound, extravasation of blood and tissue exudation, preserves the wound surface or the wound in relative wetness or dryness, inhibits the growth of bacteria and inflammatory response, minimizes tissue inflammation, and relieves patient pain. Any excess modified starch not involved in hemostatic activity is readily dissolved and rinsed away through saline irrigation during operation. After treatment of surgical wounds, combat wounds, trauma and emergency wounds, the modified starch hemostatic material is rapidly absorbed by the body without the complications associated with gauze and bandage removal.
摘要翻译：当作为生物相容性改性淀粉应用于动物组织时，用于生物相容性止血，生物相容性粘附预防，组织愈合促进，可吸收外科伤口密封和组织粘合的改性淀粉材料。改性淀粉材料产生止血，减少伤口出血，外渗和组织渗出，保持伤口表面或伤口相对湿润或干燥，抑制细菌生长和炎症反应，减少组织炎症，缓解患者疼痛。不参与止血活性的任何多余的改性淀粉容易溶解，并在操作期间通过盐水冲洗冲洗掉。手术伤口治疗后，对伤口，创伤和紧急伤口进行治疗，改性淀粉止血材料被身体快速吸收，无与纱布和绷带去除有关的并发症。

9. 发明申请

WO2010071682A3 A MULTIMODAL PLATFORM FOR NONLINEAR OPTICAL MICROSCOPY AND MICROSPECTROSCOPY 审中-公开
标题翻译：非线性光学显微镜和显微电镜的多平台
公开(公告)号：WO2010071682A3
公开(公告)日：2010-08-26
申请号：PCT/US2009006691
申请日：2009-12-18
申请人： PURDUE RESEARCH FOUNDATION , CHENG JI-XIN , CHEN HONGTAO , SLIPCHENKO MIKHAIL , WANG HAIFENG
发明人： CHENG JI-XIN , CHEN HONGTAO , SLIPCHENKO MIKHAIL , WANG HAIFENG
IPC分类号： G01N21/65 , G01B9/04 , G01J3/44 , G01N13/00 , G01N21/64 , G02B21/00 , G02B21/06
CPC分类号： G01N21/6486 , G01J3/44 , G01N21/636 , G01N21/6458 , G01N21/65 , G01N2021/653 , G02B21/16
摘要： A method for providing images using a multimodal nonlinear optical microscope is disclosed. The method includes providing a foundation femtosecond laser beam, generating a first femtosecond laser beam and a second femtosecond laser beam corresponding to the foundation femtosecond laser beam, combining the first femtosecond laser beam and the foundation femtosecond laser beam to generate a first combination femtosecond laser beam, and generating a coherent anti-Stokes Raman scattering (CARS) signal based on the first combination femtosecond laser beam. A multimodal nonlinear optical microscopy platform is also disclosed.
摘要翻译：公开了一种使用多模式非线性光学显微镜提供图像的方法。该方法包括提供基础飞秒激光束，产生对应于基础飞秒激光束的第一飞秒激光束和第二飞秒激光束，将第一飞秒激光束和基础飞秒激光束组合以产生第一组合飞秒激光束并基于第一组合飞秒激光束产生相干反斯托克斯拉曼散射（CARS）信号。还公开了多模态非线性光学显微镜平台。

10. 发明申请

WO2010071682A2 A MULTIMODAL PLATFORM FOR NONLINEAR OPTICAL MICROSCOPY AND MICROSPECTROSCOPY 审中-公开
标题翻译：用于非线性光学显微镜和微结构的多模式平台
公开(公告)号：WO2010071682A2
公开(公告)日：2010-06-24
申请号：PCT/US2009/006691
申请日：2009-12-18
申请人： PURDUE RESEARCH FOUNDATION , CHENG, Ji-xin , CHEN, Hongtao , SLIPCHENKO, Mikhail , WANG, Haifeng
发明人： CHENG, Ji-xin , CHEN, Hongtao , SLIPCHENKO, Mikhail , WANG, Haifeng
IPC分类号： G01N21/65 , G01N21/64 , G01N13/00 , G01J3/44 , G01B9/04 , G02B21/06 , G02B21/00
CPC分类号： G01N21/6486 , G01J3/44 , G01N21/636 , G01N21/6458 , G01N21/65 , G01N2021/653 , G02B21/16
摘要： A method for providing images using a multimodal nonlinear optical microscope is disclosed. The method includes providing a foundation femtosecond laser beam, generating a first femtosecond laser beam and a second femtosecond laser beam corresponding to the foundation femtosecond laser beam, combining the first femtosecond laser beam and the foundation femtosecond laser beam to generate a first combination femtosecond laser beam, and generating a coherent anti-Stokes Raman scattering (CARS) signal based on the first combination femtosecond laser beam. A multimodal nonlinear optical microscopy platform is also disclosed.
摘要翻译：公开了一种使用多模式非线性光学显微镜提供图像的方法。该方法包括提供基础飞秒激光束，产生对应于基础飞秒激光束的第一飞秒激光束和第二飞秒激光束，组合第一飞秒激光束和基础飞秒激光束以产生第一组合飞秒激光束并且基于第一组合飞秒激光束产生相干的反斯托克斯拉曼散射（CARS）信号。还公开了一种多模式非线性光学显微镜平台。

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