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2. 发明申请

WO2004112746A1 CONTROLLED RELEASE-DRUG DELIVERY SYSTEM FOR ORAL ADMINISTRATION 审中-公开
标题翻译：用于口腔管理的控制释放药物递送系统
公开(公告)号：WO2004112746A1
公开(公告)日：2004-12-29
申请号：PCT/KR2004/001437
申请日：2004-06-16
申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY , LEE, Hai Bang , CHO, Sun Hang , KHANG, Gilson , JEONG, Sang Young , KANG, Bok Ki , SEO, Kwang Su , KIM, Moon Suk , CHON, Se Kang
发明人： LEE, Hai Bang , CHO, Sun Hang , KHANG, Gilson , JEONG, Sang Young , KANG, Bok Ki , SEO, Kwang Su , KIM, Moon Suk , CHON, Se Kang
IPC分类号： A61K9/00
CPC分类号： A61K9/5042 , A61K9/5026 , A61K9/5047 , A61K9/5078
摘要： The present invention relates to a controlled-release drug delivery system for oral administration and a composition for forming a controlled-release porous membrane employed in the system. The controlled-release drug delivery system for oral administration of the present invention comprises a core containing a pharmaceutically active ingredient; and a controlled-release porous membrane coated on the outer surface of the core comprising at least one film formation material selected from the group consisting of a cellulose based compound, polymethacrylate, an acetate based compound, polyamide, polyurethane and sulfonated polystyrene. The controlled-release drug delivery system for oral administration according to the present invention can provide an effective and consistent drug release in gastrointestinal tracts because the release rate of the drugs can be controlled. Also, the timing of drug release can be controlled by varying the thickness of the porous membrane, composition of the membrane material, amount of the plasticizer and amount of the vehicles. And, preparation of the controlled-release formulation becomes simple and cost-effective because a small amount of the porous membrane is coated on a conventional tablet or granule. In addition, since the membrane is highly stable, a controlled-release formulation for oral administration not affected by temperature or humidity can be produced in large quantities.
摘要翻译：本发明涉及用于口服给药的控释药物递送系统和用于形成用于该系统的控释多孔膜的组合物。用于口服本发明的控释药物递送系统包含含有药物活性成分的核心; 以及涂布在所述芯的外表面上的控释多孔膜，其包含选自纤维素基化合物，聚甲基丙烯酸酯，乙酸酯基化合物，聚酰胺，聚氨酯和磺化聚苯乙烯的至少一种成膜材料。根据本发明的用于口服给药的控释药物递送系统可以在胃肠道中提供有效且一致的药物释放，因为可以控制药物的释放速率。此外，可以通过改变多孔膜的厚度，膜材料的组成，增塑剂的量和车辆的量来控制药物释放的时间。并且，由于少量的多孔膜被涂覆在常规的片剂或颗粒上，所以控制释放制剂的制备变得简单且成本有效。此外，由于膜是高度稳定的，因此可以大量生产不受温度或湿度影响的用于口服的控释制剂。

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