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1. 发明专利

JPH09155226A CHARGING APPARATUS 失效
公开(公告)号：JPH09155226A
公开(公告)日：1997-06-17
申请号：JP20460396
申请日：1996-08-02
申请人： JENSEN PETER MASCHF GMBH & CO
发明人： BOELLE PETER
IPC分类号： B02C23/02 , B02C18/14 , B02C18/22 , B27L11/00
摘要： PROBLEM TO BE SOLVED: To make it possible to improve working efficiency and to pulverize materials, such as timber in a larger amt. in a specified period of time with a charging device for machines for pulverizing the materials described above by providing the device with two chain conveyor belts in a supply hopper and making the upper belt displaceable toward the lower belt. SOLUTION: A rotary shredding assembly driven by a V-belt drive device 12 is disposed with the supply hopper 4 in front thereof. The upper steel conveyor belt 2 is so mounted in the hopper 4 as to be vibrate in the hopper 4. One 15 of chain wheels around which this belt 2 is wound is mounted rotatably at the free end of a projecting member 5 for holding extending below from above the hopper 4 and the other wheel 16 is born by a horizontal bearing guiding means 6. The lower belt 1 is wound around wheels 17, 18 in the hopper 4 and is provided with a teethed supply roller 3 near the wheel 18. As a result, the supply of the materials to the shredding assembly is executed.

2. 发明授权

EP1081287B1 Noise abatement means 有权
标题翻译：设备的降噪
公开(公告)号：EP1081287B1
公开(公告)日：2005-02-02
申请号：EP00610090.3
申请日：2000-09-04
申请人： Jensen, Peter B.
发明人： Jensen, Peter B.
IPC分类号： E01F8/00
CPC分类号： E01F8/0058 , E01F8/0011 , E01F8/0029

3. 发明公开

EP1081287A1 Noise abatement means 有权
标题翻译： Vorrichtung zurLärmminderung
公开(公告)号：EP1081287A1
公开(公告)日：2001-03-07
申请号：EP00610090.3
申请日：2000-09-04
申请人： Jensen, Peter B.
发明人： Jensen, Peter B.
IPC分类号： E01F8/00
CPC分类号： E01F8/0058 , E01F8/0011 , E01F8/0029
摘要： Noise abatement shields (2) of light construction and of the kind which consists of spaced outer sides (14) extending upwards from a surface (12), where in the spaces between the outer sides there is provided a core (4) of sound-absorbing material, consisting of elements (6) of solid wood, which comprises an aired outer cladding having elements (14) consisting of spaced, edge-joined boards, and also where the rear sides of which are covered with sound-absorbing material.
摘要翻译：具有轻型结构的噪声消除屏蔽（2）和由表面（12）向上延伸的间隔开的外侧（14）组成的类型的噪声消除屏蔽件（2），其中在其外侧之间的空间中设置有声 - 吸收材料由实心木材的元件（6）组成，其包括具有由间隔开的边缘连接板组成的元件（14）的被覆盖的外包层，并且其背面被吸音材料覆盖。

4. 发明公开

EP0934406A2 ARTIFICIAL PROMOTER LIBRARIES FOR SELECTED ORGANISMS AND PROMOTERS DERIVED FROM SUCH LIBRARIES 失效
标题翻译：人工启动子库中选择的生物和文章ENTSTAMMENDE发起人
公开(公告)号：EP0934406A2
公开(公告)日：1999-08-11
申请号：EP97936613.0
申请日：1997-08-25
申请人： Jensen, Peter Ruhdal
发明人： JENSEN, Peter Ruhdal , HAMMER, Karin
IPC分类号： C12N15
CPC分类号： C12N15/63 , C12N15/1051
摘要： An artificial promoter library for a selected organism or group of organisms is constructed as a mixture of double stranded DNA fragments, the sense strands of which comprise at least two consensus sequences of efficient promoters from said organism or group of organisms, or parts thereof comprising at least half of each, and surrounding or intermediate nucleotide sequences (spacers) of variable length in which at least 7 nucleotides are selected randomly among the nucleobases A, T, C and G. The sense strands of the double stranded DNA fragments may also include a regulatory DNA sequence imparting a specific regulatory feature, such as activation by a change in the growth conditions, to the promoters of the library. Further, they may have a sequence comprising one or more recognition sites for restriction endonucleases added to one of or both their ends. The selected organism or group or organisms may be selected from prokaryotes and from eukaryotes; and in prokaryotes the consensus sequences to be retained most often will comprise the -35 signal (-35 to -30): TTGACA and the -10 signal (-12 to -7): TATAAT or parts of both comprising at least 3 conserved nucleotides of each, while in eukaryotes said consensus sequences should comprise a TATA box and at least one upstream activation sequence (UAS). Such artificial promoter libraries can be used i.a. for optimizing the expression of specific genes in various selected organisms.

5. 发明公开

EP0939830A1 A METHOD OF IMPROVING THE PRODUCTION OF BIOMASS OR A DESIRED PRODUCT FROM A CELL 失效
标题翻译：方法提高所需产物的制备从细胞的
公开(公告)号：EP0939830A1
公开(公告)日：1999-09-08
申请号：EP97938813.0
申请日：1997-09-08
申请人： Jensen, Peter Ruhdal
发明人： JENSEN, Peter, Ruhdal , SNOEP, Jacky, Leendert , WESTERHOFF, Hans, Victor
IPC分类号： C12N15 , C12N1 , C12N9 , C12P1 , C12Q1
CPC分类号： C12N1/16 , C12N1/20 , C12N9/14 , C12P1/00
摘要： The production of biomass or a desired product from a cell can be improved by inducing conversion of ATP to ADP without primary effects on other cellular metabolites or functions which is achieved by expressing an uncoupled ATPase activity in said cell and incubating the cell with a suitable substrate to produce said biomass or product. This is conveniently done by expressing in said cell the soluble part (F1) of the membrane bound (F0F1 type) H+-ATPase or a portion of F¿1? exhibiting ATPase activity. The organism from which the F1 ATPase or portions thereof is derived, or in which the F1 ATPase or portions thereof is expressed, may be selected from prokaryotes and eukaryotes. In particular the DNA encoding F1 or a portion thereof may be derived from bacteria and eukaryotic microorganisms such as yeasts, other fungi and cell lines of higher organisms and be selected from the group consisting of the gene encoding the F1 subunit β or a portion thereof and various combinations of said gene or portion with the genes encoding the other F1 subunits or portions thereof. The method can be used i.a. for optimizing the formation of biomass or a desired product by a cell by expressing different levels of uncoupled ATPase activity in the cell, incubating the cell on a suitable substrate, measuring the conversion rate of substrate into biomass or the desired product at each level of ATPase expression, and choosing a level of ATPase expression at which the conversion rate is optimized.

6. 发明授权

EP2229589B1 DISEASE PATHWAY-BASED METHOD TO GENERATE BIOMARKER PANELS TAILORED TO SPECIFIC THERAPEUTICS FOR INDIVIDUALIZED TREATMENTS 有权
标题翻译：作为制作具体的治疗学的生物标志物量身打造的面板个性化的治疗KRANKEITSSTOFFWECHSELWEGEN化进程
公开(公告)号：EP2229589B1
公开(公告)日：2015-06-10
申请号：EP08860005.1
申请日：2008-12-10
申请人： Blume-Jensen, Peter
发明人： Blume-Jensen, Peter
IPC分类号： G01N33/48 , G01N33/53
CPC分类号： C12Q1/6883

7. 发明公开

EP2034021A1 Artificial promoter libraries for selected organisms and promoters derived from such libraries 失效
标题翻译： Künstliche促进剂bibliothekenfürausgewählteorganismen sowie daraus entstammende promotoren
公开(公告)号：EP2034021A1
公开(公告)日：2009-03-11
申请号：EP08169178.4
申请日：1997-08-25
申请人： Jensen, Peter Ruhdal
发明人： Jensen, Peter Ruhdal , Hammer, Karin
IPC分类号： C12N15/10
CPC分类号： C12N15/63 , C12N15/1051
摘要： An artificial promoter library for a selected organism or group of organisms is constructed as a mixture of double stranded DNA fragments, the sense strands of which comprise at least two consensus sequences of efficient promoters from said organism or group of organism, or parts thereof comprising at least half of each, and surrounding or intermediate nucleotide sequences (spacers) of variable length in which at least 7 nucleotides are selected randomly among the nucleobases A, T, C and G. The sense strands of the double stranded DNA fragments may also include a regulatory DNA sequence imparting a specific regulatory feature, such as activation by a change in the growth conditions, to the promoters of the library. Further, they may have a sequence comprising one or more recognition sites for restriction endonucleases added to one of or both their ends. The selected organism or group or organisms may be selected from prokaryotes and from eukaryotes; and in prokaryotes the consensus sequences to be retained most often will comprise the -35 signal (-35 to -30): TTGACA and the -10 signal (-12 to -7): TATAAT or parts of both comprising at least 3 conserved nucleotides of each, while in eukaryotes said consensus sequences should comprise a TATA box and at least one upstream activation sequence (UAS). Such artificial promoter libraries can be used i.e. for optimizing the expression of specific genes in various selected organism.
摘要翻译：构建所选生物体或生物体组的人造启动子文库，其为双链DNA片段的混合物，其有义链包含来自所述生物体或生物体组的至少两个有效启动子的共有序列或其部分，其包含每个的至少一半，以及在核碱基A，T，C和G中随机选择至少7个核苷酸的可变长度的周围或中间核苷酸序列（间隔区）。双链DNA片段的有义链还可以包括调节性DNA序列赋予特异性调节特征，例如通过生长条件变化的激活，向文库的启动子。此外，它们可以具有包含一个或多个加入其末端中的一个或两个的限制性内切核酸酶的识别位点的序列。所选生物体或组或生物体可以选自原核生物和真核生物; 并且在原核生物中，最常保留的共有序列将包含-35信号（-35至-30）：TTGACA和-10信号（-12至-7）：TATAAT或两者的部分包含至少3个保守核苷酸而在真核生物中，共有序列应包含TATA盒和至少一个上游激活序列（UAS）。可以使用这样的人工启动子文库，即用于优化各种选择的生物体中的特定基因的表达。

8. 发明授权

EP0939830B1 A METHOD OF IMPROVING THE PRODUCTION OF A DESIRED PRODUCT FROM A CELL 失效
标题翻译：方法提高所需产物的制备从细胞的
公开(公告)号：EP0939830B1
公开(公告)日：2008-12-31
申请号：EP97938813.9
申请日：1997-09-08
申请人： Jensen, Peter Ruhdal
发明人： JENSEN, Peter, Ruhdal , SNOEP, Jacky, Leendert , WESTERHOFF, Hans, Victor
IPC分类号： C12P1/00 , C12N15/67
CPC分类号： C12N1/16 , C12N1/20 , C12N9/14 , C12P1/00
摘要： The production of biomass or a desired product from a cell can be improved by inducing conversion of ATP to ADP without primary effects on other cellular metabolites or functions which is achieved by expressing an uncoupled ATPase activity in said cell and incubating the cell with a suitable substrate to produce said biomass or product. This is conveniently done by expressing in said cell the soluble part (F1) of the membrane bound (F0F1 type) H -ATPase or a portion of F1 exhibiting ATPase activity. The organism from which the F1 ATPase or portions thereof is derived, or in which the F1 ATPase or portions thereof is expressed, may be selected from prokaryotes and eukaryotes. In particular the DNA encoding F1 or a portion thereof may be derived from bacteria and eukaryotic microorganisms such as yeasts, other fungi and cell lines of higher organisms and be selected from the group consisting of the gene encoding the F1 subunit beta or a portion thereof and various combinations of said gene or portion with the genes encoding the other F1 subunits or portions thereof. The method can be used i.a. for optimizing the formation of biomass or a desired product by a cell by expressing different levels of uncoupled ATPase activity in the cell, incubating the cell on a suitable substrate, measuring the conversion rate of substrate into biomass or the desired product at each level of ATPase expression, and choosing a level of ATPase expression at which the conversion rate is optimized.

9. 发明公开

EP1839154A4 SYSTEM AND METHOD OF ERASING NON-VOLATILE RECORDING MEDIA 审中-公开
标题翻译：系统和方法拆卸的非易失性记录介质
公开(公告)号：EP1839154A4
公开(公告)日：2008-07-09
申请号：EP04813277
申请日：2004-12-06
申请人： TEAC AEROSPACE TECHNOLOGIES IN , JENSEN PETER
发明人： JENSEN PETER
IPC分类号： G06F3/06 , G06F12/00 , G06F21/62 , G11B5/024 , G11C16/16
CPC分类号： G06F3/0652 , G06F3/0623 , G06F3/0676 , G06F21/6209 , G06F2221/2143 , G11C16/16
摘要： A method and system for the erasing of data from a non-volatile recording medium includes a non-volatile recording medium controller, a non-volatile recording medium, and a CPU. A data pattern used in an erasure command is sent to the non-volatile recording medium a single time. Consequently, the amount of data transferred to the non-volatile recording medium controller is reduced to a minimum. After receiving the erasure command, the non-volatile recording medium controller overwrites an erasure area with the data pattern.

10. 发明公开

EP0874630A1 TOPOISOMERASE II POISON AND BIS-DIOXYPIPERAZINE DERIVATIVE COMBINATION THERAPY 失效
标题翻译：拓扑异构酶II毒素和BIS DIOXYPIPERAZINDERIVATEN的联合治疗
公开(公告)号：EP0874630A1
公开(公告)日：1998-11-04
申请号：EP97900205.0
申请日：1997-01-10
申请人： Jensen, Peter Buhl , Sehested, Maxwell
发明人： Jensen, Peter Buhl , Sehested, Maxwell
IPC分类号： A61K31 , A61K45
CPC分类号： A61K31/704 , A61K31/495 , A61K31/70 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a method for selectively killing tumour or metastatic cells within a defined compartment of the organism of a large mammal, in particular a human, said method comprising administering to a mammal an effective tumour- or metastasis-killing amount of a topoisomerase II poison except doxorubicin, and protecting non-tumourous tissue of the mammal against the toxic action of the topoisomerase II poison by administration of a bis-dioxypiperazine compound. In particular, the invention relates to a pharmaceutical kit for selectively killing tumour or metastatic cells within the central nervous system of a large mammal, in particular a human, said kit comprising: a) a dosage unit of a bis-dioxypiperazine and a pharmaceutically acceptable carrier, and b) a dosage unit of topoisomerase II poisons except doxorubicin and a pharmaceutically acceptable carrier.

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