专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP2776822A4 QUANTIFICATION OF AN ANALYTE IN SERUM AND OTHER BIOLOGICAL MATRICES 有权转让
标题翻译：数量化分析物血清等生物矩阵的
公开(公告)号：EP2776822A4
公开(公告)日：2015-05-27
申请号：EP12843906
申请日：2012-10-26
申请人： DH TECHNOLOGIES DEV PTE LTD , PHYTRONIX TECHNOLOGIES INC , AUGER SERGE , BLACHON GREGORY , GHOBARAH HESHAM , JARVIS MICHAEL , PICARD PIERRE
发明人： AUGER SERGE , BLACHON GREGORY , GHOBARAH HESHAM , JARVIS MICHAEL , PICARD PIERRE
IPC分类号： G01N27/62 , H01J49/26
CPC分类号： H01J49/0031 , G01N27/624 , G01N33/82 , H01J49/0431 , H01J49/0445 , H01J49/0463 , H01J49/168

2. 发明公开

EP2776822A1 QUANTIFICATION OF AN ANALYTE IN SERUM AND OTHER BIOLOGICAL MATRICES 有权转让
标题翻译：数量化分析物血清等生物矩阵的
公开(公告)号：EP2776822A1
公开(公告)日：2014-09-17
申请号：EP12843906.4
申请日：2012-10-26
申请人： DH Technologies Development Pte. Ltd. , Phytronix Technologies Inc. , Auger, Serge , Blachon, Gregory , Ghobarah, Hesham , Jarvis, Michael , Picard, Pierre
发明人： AUGER, Serge , BLACHON, Gregory , GHOBARAH, Hesham , JARVIS, Michael , PICARD, Pierre
IPC分类号： G01N27/62 , H01J49/26
CPC分类号： H01J49/0031 , G01N27/624 , G01N33/82 , H01J49/0431 , H01J49/0445 , H01J49/0463 , H01J49/168
摘要： Methods and systems for quantifying analytes in a biological sample are provided comprising preparing a biological sample for mass spectrometric analysis, utilizing an ionization source to ionize at least a portion of the prepared biological sample to generate an ionized analyte flow, introducing the ionized analyte flow into a differential mobility spectrometer set at a compensation voltage selected to extract ionized analyte molecules from the ionized analyte flow, introducing an output analyte flow of the differential mobility spectrometer into a mass spectrometer to detect and quantify analyte ions in the output analyte flow.

3. 发明专利

GB9410803D0 Liquid applications 未知
公开(公告)号：GB9410803D0
公开(公告)日：1994-07-20
申请号：GB9410803
申请日：1994-05-28
申请人： INGRAM LESLIE W , JARVIS MICHAEL L , INGRAM STEPHEN L

4. 发明申请

WO2007115192A2 P2X7 ANTAGONISTS TO TREAT AFFECTIVE DISORDERS 审中-公开
标题翻译： P2X7治疗有害疾病的拮抗剂
公开(公告)号：WO2007115192A2
公开(公告)日：2007-10-11
申请号：PCT/US2007/065669
申请日：2007-03-30
申请人： ABBOTT LABORATORIES , BRATCHER, Natalie , RUETER, Lynne, E. , DECKER, Michael, W. , HARRIS, Richard, R. , JARVIS, Michael, F. , CARROLL, William, A. , BASSO, Ana, M.
发明人： BRATCHER, Natalie , RUETER, Lynne, E. , DECKER, Michael, W. , HARRIS, Richard, R. , JARVIS, Michael, F. , CARROLL, William, A. , BASSO, Ana, M.
IPC分类号： C07C231/10
CPC分类号： A61K31/381 , A61K31/47 , A61K45/06
摘要： The present invention provides methods to treat mood disorders and anxiety disorders using antagonists of the P2X 7 receptor and pharmaceutical compositions thereof, or combinations.
摘要翻译：本发明提供使用P2X 7受体及其药物组合物或组合的拮抗剂治疗情绪障碍和焦虑症的方法。

5. 发明申请

WO2006086229A1 THE USE OF SELECTIVE P2X7 RECEPTOR ANTAGONISTS 审中-公开
标题翻译：选择性P2X7受体拮抗剂的使用
公开(公告)号：WO2006086229A1
公开(公告)日：2006-08-17
申请号：PCT/US2006/003865
申请日：2006-02-03
申请人： ABBOTT LABORATORIES , PEREZ-MEDRANO, Arturo , NELSON, Derek, W. , CARROLL, William, A. , KORT, Michael, E. , GREGG, Robert, J. , VOIGHT, Eric, A. , JARVIS, Michael, F. , KOWALUK, Elizabeth, A.
发明人： PEREZ-MEDRANO, Arturo , NELSON, Derek, W. , CARROLL, William, A. , KORT, Michael, E. , GREGG, Robert, J. , VOIGHT, Eric, A. , JARVIS, Michael, F. , KOWALUK, Elizabeth, A.
IPC分类号： A61K31/381 , A61P25/00 , A61P29/00
CPC分类号： A61K31/381 , A61K31/41 , A61K31/4439
摘要： The present invention relates to the use of selective P2X 7 receptor antagonists of formula (I), or a pharmaceutically acceptable salt or prodrug thereof wherein D, R 1 and R 2 are as defined in claim 1, for the treatment of neuropathic pain, chronic inflammatory pain, inflammation, neurodegeneration and for promoting neuroregeneration.
摘要翻译：本发明涉及式（I）的选择性P2X 7受体拮抗剂或其药学上可接受的盐或前药，其中D，R 1和R 2 > 2 如权利要求1中所定义，用于治疗神经性疼痛，慢性炎性疼痛，炎症，神经变性和促进神经再生。

6. 发明申请

WO2005067911A1 (2S)-AMINO(PHENYL)ACETIC ACID AND DERIVATIVES AS α2δ VOLTAGE-GATED CALCIUM CHANNEL LIGANDS 审中-公开
标题翻译：（2S）-AMINO（苯乙烯）乙酸和衍生物作为α2delta电压通道钙通道配体
公开(公告)号：WO2005067911A1
公开(公告)日：2005-07-28
申请号：PCT/US2004/040965
申请日：2004-12-08
申请人： ABBOTT LABORATORIES , LEE, Chih-Hung , JARVIS, Michael, F.
发明人： LEE, Chih-Hung , JARVIS, Michael, F.
IPC分类号： A61K31/198
CPC分类号： A61K31/198 , A61K31/485
摘要： The present invention relates to a method of treating disorders associated with the α 2 δ voltage-gated calcium channel ligand, comprising the administration of compounds of formula (I), or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof.
摘要翻译：本发明涉及一种治疗与α2δ电压门控钙通道配体相关的疾病的方法，包括施用式（I）化合物或其药学上可接受的盐，酰胺，酯或前药。

7. 发明申请

WO2013061146A1 QUANTIFICATION OF AN ANALYTE IN SERUM AND OTHER BIOLOGICAL MATRICES 审中-公开
标题翻译：分析血清和其他生物学基础的分析数据
公开(公告)号：WO2013061146A1
公开(公告)日：2013-05-02
申请号：PCT/IB2012/002158
申请日：2012-10-26
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD. , PHYTRONIX TECHNOLOGIES INC. , AUGER, Serge , BLACHON, Gregory , GHOBARAH, Hesham , JARVIS, Michael , PICARD, Pierre
发明人： AUGER, Serge , BLACHON, Gregory , GHOBARAH, Hesham , JARVIS, Michael , PICARD, Pierre
IPC分类号： G01N27/62 , H01J49/26
CPC分类号： H01J49/0031 , G01N27/624 , G01N33/82 , H01J49/0431 , H01J49/0445 , H01J49/0463 , H01J49/168
摘要： Methods and systems for quantifying analytes in a biological sample are provided comprising preparing a biological sample for mass spectrometric analysis, utilizing an ionization source to ionize at least a portion of the prepared biological sample to generate an ionized analyte flow, introducing the ionized analyte flow into a differential mobility spectrometer set at a compensation voltage selected to extract ionized analyte molecules from the ionized analyte flow, introducing an output analyte flow of the differential mobility spectrometer into a mass spectrometer to detect and quantify analyte ions in the output analyte flow.
摘要翻译：提供了用于量化生物样品中分析物的方法和系统，包括制备用于质谱分析的生物样品，利用电离源将至少一部分制备的生物样品电离以产生电离的分析物流，将电离的分析物流引入差示迁移率光谱仪设置在选择的电压分析物流中的离子化分析物分子的选择补偿电压，将差分迁移率光谱仪的输出分析物流引入质谱仪中，以检测和量化输出分析物流中的分析物离子。

8. 发明申请

WO2009027392A1 4-(4-PYRIDINYL)-BENZAMIDES AND THEIR USE AS ROCK ACTIVITY MODULATORS 审中-公开
标题翻译： 4-（4-吡啶基） - 苯甲酸酯及其作为岩石活性调节剂的用途
公开(公告)号：WO2009027392A1
公开(公告)日：2009-03-05
申请号：PCT/EP2008/061135
申请日：2008-08-26
申请人： ABBOTT GMBH & CO. KG , MACK, Helmut , TEUSCH, Nicole , MÜLLER, Bernhard K. , HORNBERGER, Wilfried , JARVIS, Michael F. , SAUER, Daryl
发明人： MACK, Helmut , TEUSCH, Nicole , MÜLLER, Bernhard K. , HORNBERGER, Wilfried , JARVIS, Michael F. , SAUER, Daryl
IPC分类号： C07D213/56 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , A61K31/44 , A61K31/4427 , A61P9/00 , A61P25/00 , A61P35/00 , A61P29/00
CPC分类号： C07D401/12 , C07D213/56 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention relates to novel 4-(4-pyridyl)-benzamides of the formula (I). The compounds I possess valuable therapeutic properties and are suitable, in particular, for treating diseases that respond to modulation of Rho kinases (ROCKs). R 1 and R 2 are, independently of each other, hydrogen, hydroxy, cyano, C 1 -C 8 -alkyl, C 1 - C 8 -haloalkyl, C 1 -C 8 -alkoxy or C 1 -C 8 -haloalkoxy; R 3 , R 4 , R 5 and R 6 are, independently of each other, hydrogen, hydroxy, halogen, cyano, C 1 -C 8 -alkyl, C 1 -C 8 -haloalkyl, C 1 -C 8 -alkoxy, C 1 -C 8 -haloalkoxy, amino, C 1 -C 8 -alkylamino or di-(C 1 -C 8 -alkyl)-amino; R 7 is hydrogen, C 1 -C 8 -alkyl, C 1 -C 8 -haloalkyl, aryl or aryl-C 1 -C 8 -alkyl; R 8 is a group of the formula -X-W, where X is a single bond, C 1 -C 4 -alkylene or C 1 -C 4 -alkylene-O-, where the alkylene group in the three last-mentioned radicals may be linear or branched and may be partly or fully halogenated and/or may be substituted by a hydroxyl group and/or may be interrupted by an oxygen atom; and W is a cyclic radical selected from phenyl and a 5- or 6-membered saturated, partly unsaturated or aromatic heterocyclic ring which contains as ring members 1, 2 or 3 heteroatoms selected from O, S and N and optionally 1 or 2 carbonyl groups; R 9 is a group of the formula -Y-Z, where Z is hydrogen, halogen, OR 11 , NR 12 R 13 , S(O) m -R 14 , phenyl which may carry 1, 2, 3 or 4 substituents R 15 or a 5- or 6-membered saturated, partly unsaturated or aromatic heterocyclic ring; and Y is linear or branched C 1 C 4 -alkylene which may be partly or fully halogenated and/or may be substituted by a hydroxyl group and/or a phenyl ring; or, in case Z is phenyl or the 5- or 6-membered heterocyclic ring as defined above, Y can also be a single bond.
摘要翻译：本发明涉及式（I）的新型4-（4-吡啶基） - 苯甲酰胺。化合物I具有有价值的治疗特性，特别适用于治疗对Rho激酶（ROCK）的调节作用的疾病。 R 1和R 2彼此独立地为氢，羟基，氰基，C 1 -C 8 - 烷基，C 1 -C 8 - 卤代烷基，C 1 -C 8 - 烷氧基或C 1 -C 8 - 卤代烷氧基; R3，R4，R5和R6彼此独立地为氢，羟基，卤素，氰基，C1-C8-烷基，C1-C8-卤代烷基，C1-C8-烷氧基，C1-C8-卤代烷氧基，氨基，C1- C 8 - 烷基氨基或二 - （C 1 -C 8 - 烷基） - 氨基; R 7是氢，C 1 -C 8 - 烷基，C 1 -C 8 - 卤代烷基，芳基或芳基-C 1 -C 8 - 烷基; R8是式-XW的基团，其中X是单键，C1-C4-亚烷基或C1-C4-亚烷基-O-，其中三个最后提及的基团中的亚烷基可以是直链或支链的，并且可以部分或完全卤化和/或可以被羟基取代和/或可被氧原子中断; 并且W是选自苯基和5-或6-元饱和，部分不饱和或芳族杂环的环状基团，其含有作为环成员1,2或3的选自O，S和N的杂原子和任选的1或2个羰基 ; R9是式-YZ的基团，其中Z是氢，卤素，OR11，NR12R13，S（O）m -R14，可以携带1,2,3或4个取代基R15或5-或6-元的苯基饱和，部分不饱和或芳族杂环; Y是可部分或完全卤化和/或可被羟基和/或苯环取代的直链或支链C 1 -C 4亚烷基; 或者Z为苯基或上述5-或6-元杂环的情况下，Y也可以是单键。

9. 发明申请

WO2008040124A1 A SELF CLEANING PILL COUNTING DEVICE, AND CLEANING METHOD 审中-公开
标题翻译：自清洁药丸计数装置和清洁方法
公开(公告)号：WO2008040124A1
公开(公告)日：2008-04-10
申请号：PCT/CA2007/001760
申请日：2007-10-02
申请人： TRAMAR PRODUCTS , FAY, Brent , JARVIS, Michael
发明人： FAY, Brent , JARVIS, Michael
IPC分类号： A61J7/02
CPC分类号： A61J7/02 , B08B5/02 , B08B5/04 , B08B9/00 , B24C1/003
摘要： A pills counting device provided with cleaning means and comprising in combination, a tray comprising: a base member having an upper surface for receiving a bulk quantity of pills; a trough member alongside the base member and provided with a depression having opposite ends and at least one surface for receiving a load of a counted quantity of pills from said bulk quantity, one of said opposite ends further defining a spout for the unloading said counted quantity of pills in a pills container, a lid member having a lower surface, said lid member being mounted on the base member and being movable between two extreme positions, that is: a first position where the lower surface of the lid member is away from the upper surface of the base member and the surface of the depression of the trough member; a second position where the lower surface of the lid member is close and above the upper surface of the base member and the surface of the depression of the trough member to thereby create a cavity; at least one port provided in the tray and/or in the lid member and adapted to be connected in fluid communication with the cavity and with an air intake of a vacuum device that can be remotely controlled; being understood that when the lid is in the second position and a vacuum is applied to said at least one port, an air stream is established between said surfaces to entrain toward the vacuum device particles that may be present on said surfaces to clean said surfaces. A cleaning method using aforesaid pills counting device.
摘要翻译：一种具有清洁装置并且包括组合的药丸计数装置，其包括：基部构件，具有用于接收大量药丸的上表面; 槽底部件，与底座部件一起设置，并设置有具有相对端部的凹部和至少一个表面，用于从所述批量接收计数量的药丸的载荷，所述相对端部中的一个还限定用于卸载所述计数量的喷口在药丸容器中的药丸，具有下表面的盖构件，所述盖构件安装在基座构件上并且可在两个极限位置之间移动，即，第一位置，其中盖构件的下表面远离基部构件的上表面和槽构件的凹部的表面; 第二位置，其中盖构件的下表面靠近并且在基部构件的上表面和槽构件的凹部的表面之上，从而形成空腔; 设置在所述托盘和/或所述盖构件中的至少一个端口，并且适于与所述空腔流体连通并与可远程控制的真空装置的进气口连接; 应当理解，当盖处于第二位置并且对所述至少一个端口施加真空时，在所述表面之间建立空气流以夹带可能存在于所述表面上的真空装置颗粒以清洁所述表面。使用上述药丸计数装置的清洁方法。

10. 发明申请

WO2011143653A3 RECOMBINANT HCMV AND RHCMV VECTORS AND USES THEREOF 审中-公开
标题翻译：重组HCMV和RHCMV矢量及其用途
公开(公告)号：WO2011143653A3
公开(公告)日：2012-05-31
申请号：PCT/US2011036657
申请日：2011-05-16
申请人： UNIV OREGON HEALTH & SCIENCE , PICKER LOUIS , NELSON JAY A , FRUEH KLAUS , JARVIS MICHAEL A , HANSEN SCOTT G
发明人： PICKER LOUIS , NELSON JAY A , FRUEH KLAUS , JARVIS MICHAEL A , HANSEN SCOTT G
IPC分类号： C12N15/869 , A61K39/12 , A61P31/12 , A61P35/00 , C12N15/33
CPC分类号： C12N7/00 , A61K39/0011 , A61K39/08 , A61K39/12 , A61K39/13 , A61K39/145 , A61K39/275 , A61K2039/5254 , A61K2039/5256 , A61K2039/552 , A61K2039/572 , A61K2039/58 , C07K14/005 , C07K14/045 , C07K14/16 , C07K14/161 , C07K14/162 , C07K14/163 , C12N15/86 , C12N15/869 , C12N2710/16111 , C12N2710/16134 , C12N2710/16141 , C12N2710/16143 , C12N2710/16162 , C12N2710/16171 , C12N2710/24134 , C12N2740/15022 , C12N2740/15034 , C12N2760/14134 , C12N2760/16134 , C12N2770/32634
摘要： Described herein are recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors encoding heterologous antigens, such as pathogen-specific antigens or tumor antigens. The recombinant vectors elicit and maintain high level cellular and humoral immune responses specific for the heterologous antigen. The recombinant RhCMV and HCMV vectors may be used, for example, for the treatment or prevention of infectious disease or cancer. In some examples, the recombinant RhCMV or HCMV vectors may include deletions in genes encoding immunomodulatory proteins. In some examples, the recombinant RhCMV or HCMV vectors may be deficient or impaired in their ability to replicate within a cell, disseminate within the host or spread among hosts by including a deletion in one or more genes essential or augmenting for CMV replication, dissemination or spread.
摘要翻译：本文描述了编码异源抗原如病原体特异性抗原或肿瘤抗原的重组恒河猴巨细胞病毒（RhCMV）和人巨细胞病毒（HCMV）载体。重组载体引发和维持对异源抗原特异的高水平细胞和体液免疫应答。重组RhCMV和HCMV载体可用于例如治疗或预防感染性疾病或癌症。在一些实例中，重组RhCMV或HCMV载体可以包括编码免疫调节蛋白的基因中的缺失。在一些实例中，重组RhCMV或HCMV载体在细胞内复制的能力可能是缺陷或受损的，在宿主内扩散或通过在一个或多个基因或增加CMV复制，扩散或扩增的基因中包含缺失而在宿主间扩散传播。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式