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2. 发明申请

WO1994014422A1 IMPROVED RAPIDLY DISINTEGRATING TABLET 审中-公开
标题翻译：改进的快速消毒片
公开(公告)号：WO1994014422A1
公开(公告)日：1994-07-07
申请号：PCT/US1993012566
申请日：1993-12-23
申请人： OREGON FREEZE DRY , PEBLEY, Walter, S. , JAGER, Norman, E. , THOMPSON, Sally, J.
发明人： OREGON FREEZE DRY
IPC分类号： A61K09/20
CPC分类号： A61K9/2095 , A61K9/0056
摘要： A tablet that rapidly disintegrates in aqueous solution includes a partially collapsed matrix network that has been vacuum-dried above the collapse temperature of the matrix. The matrix is preferably at least partially dried below the equilibrium freezing point of the matrix. Vacuum drying the tablet above its collapse temperature instead of freeze drying it below its collapse temperature provides a process for producing tablets with commercially-acceptable structural strength and resistance to damage which rapidly disintegrates in normal amounts of saliva. The tablet preferably carries a drug, such as acetaminophen. The matrix network of the tablet preferably includes a gum, a carbohydrate and the drug. Especially preferred embodiments also include a flavoring, a sweetener and surfactant. The gum is preferably acacia, guar, xanthan, carrageenan or tragacanth gum. The carbohydrate is preferably mannitol, dextrose, sucrose, lactose, maltose, maltodextrin or corn syrup solids.
摘要翻译：在水溶液中快速崩解的片剂包括在基质的塌陷温度以上真空干燥的部分收缩的基质网络。基质优选在基质的平衡凝固点以下至少部分干燥。将片剂真空干燥超过其塌陷温度而不是将其冷冻干燥至低于其塌陷温度，提供了具有商业上可接受的结构强度和耐受正常量唾液快速崩解的抗损伤性片剂的方法。片剂优选携带药物，例如对乙酰氨基酚。片剂的基质网络优选包括口香糖，碳水化合物和药物。特别优选的实施方案还包括调味剂，甜味剂和表面活性剂。口香糖优选是阿拉伯胶，瓜尔胶，黄原胶，角叉菜胶或黄蓍胶。碳水化合物优选为甘露醇，葡萄糖，蔗糖，乳糖，麦芽糖，麦芽糖糊精或玉米糖浆固体。

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