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1. 发明申请

WO1995013739A1 METHOD AND DEVICE FOR THE NON-INVASIVE TRANSCUTANEAN DETERMINATION OF THE CONCENTRATIONS OF SUBSTANCES IN HUMAN BODY FLUIDS OR TISSUES 审中-公开
标题翻译：方法和设备，用于体液或人的组织燃料浓度变化无创，经皮测定
公开(公告)号：WO1995013739A1
公开(公告)日：1995-05-26
申请号：PCT/EP1994003316
申请日：1994-10-07
申请人： JENOPTIK GMBH , FISCHBACHER, Christoph , JAGEMANN, Kay-Uwe , DANZER, Klaus , MÜLLER, Ulrich, Alfons , PAPENKORDT, Lutz , SCHÜLER, Jost
发明人： JENOPTIK GMBH
IPC分类号： A61B05/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/7264 , G01N21/359
摘要： The aim of the invention is to provide a method and device for the non-invasive transcutaneous determination of the concentrations of substances in the human body, the method being unaffected by person-dependent interference variables, and the dominance of water absorption, as well as the effect of blood circulation through the tissues, being reduced. This aim is achieved by irradiating (1, 2) a suitable area of the skin with broad-band radiation, by recording the transmission or reflection spectrum (3, 4, 6), by making a series of intensity measurements at suitably spaced intervals (12) over this spectrum and by processing the series of intensity measurements using an artificial neuronal network (13). The neuronal network (13) is taught, in a teaching phase, with a multiplicity of intensity-measurement series and simultaneously invasively obtained concentration values in order to generate weight matrices. The invention is suitable for use in the non-invasive determination of the concentrations of substances in human blood, e.g. haemoglobin, bilirubin, glucose, albumin, urea, cholesterol and other metabolic products.
摘要翻译：本发明涉及一种方法和用于体液或人的组织的非侵入性经皮确定物质浓度的布置。找到抑制在两个人依赖性干扰变量在人体内提供的非侵入性经皮确定物质浓度的可能性的目的和吸水率的主导地位和组织血流量的影响减少，根据本发明通过皮肤的合适的部分来实现被照射的宽带（1 ，2），一个传输或反射光谱（3,4，6）中的溶液，（从适当安排光谱间隔12）的该频谱确定了一系列强度测量值和通过人工神经网络（13），其中，所述的装置评估的系列强度测量值的与多个强度测量值的序列的学习阶段的神经网络（13），并在同一时间进行加权矩阵的生成创测量浓度值被训练。本发明是用于非侵入性测定物质浓度的人血中，例如，血红蛋白，胆红素，葡萄糖，白蛋白，尿素，胆固醇和其他代谢产物。

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