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1. 发明公开

EP0839356A2 ELECTRONIC BOOK WITH MULTIPLE PAGE DISPLAYS 失效
标题翻译：具有多侧面展示电子书
公开(公告)号：EP0839356A2
公开(公告)日：1998-05-06
申请号：EP96924641.0
申请日：1996-07-19
申请人： Jacobson, Joseph M.
发明人： Jacobson, Joseph M.
IPC分类号： G02F1 , B41J3 , G02B26 , G04G1 , G06F1 , G06F3 , G06F15 , G09F9 , G09G3 , H01L27 , H01L51
CPC分类号： H01L27/28 , B41J3/407 , B41J3/4076 , G02B26/026 , G02F1/167 , G06F15/0283 , G09G3/20 , G09G3/30 , G09G3/344 , G09G3/3611 , G09G3/3674 , G09G3/3685 , G09G3/38 , G09G2310/0267 , G09G2310/0275 , H01L27/3281 , H01L51/005 , H01L51/0077 , H01L51/0512 , H01L2251/5338 , Y10S345/901
摘要： An electronic book comprising multiple, electronically addressable, page displays is described. Said page displays may be formed on flexible, thin substrates. Said book may additionnally encompass memory, power, control functions and communications.

2. 发明申请

WO2008127283A2 ENGINEERED METABOLIC PATHWAYS 审中-公开
标题翻译：工程代表途径
公开(公告)号：WO2008127283A2
公开(公告)日：2008-10-23
申请号：PCT/US2007021473
申请日：2007-10-06
申请人： CODON DEVICES INC , JACOBSON JOSEPH M , CHURCH GEORGE , BAYNES BRIAN M
发明人： JACOBSON JOSEPH M , CHURCH GEORGE , BAYNES BRIAN M
CPC分类号： C12N15/10 , C12N15/1093 , C12N15/52
摘要： Certain aspects of the present invention provide methods for designing and engineering metabolic pathways. Aspects of the invention also provide metabolic pathway components and cells containing engineered metabolic pathways. Certain aspects of the invention provide medical, pharmaceutical, industrial, agricultural, environmental, and other Nuses for engineered metabolic pathways of the invention.
摘要翻译：本发明的某些方面提供了用于设计和工程化代谢途径的方法。本发明的方面还提供含有工程化代谢途径的代谢途径成分和细胞。本发明的某些方面为本发明的工程代谢途径提供医学，制药，工业，农业，环境和其它用途。

3. 发明申请

WO2007087377A3 PHOTOELECTROCHEMICAL SYNTHESIS OF HIGH DENSITY COMBINATORIAL POLYMER ARRAYS 审中-公开
标题翻译：高密度组合聚合物阵列的光电化学合成
公开(公告)号：WO2007087377A3
公开(公告)日：2008-01-03
申请号：PCT/US2007001976
申请日：2007-01-25
申请人： MASSACHUSETTS INST TECHNOLOGY , EMIG CHRISTOPHER J , CHOW BRIAN Y , JACOBSON JOSEPH M
发明人： EMIG CHRISTOPHER J , CHOW BRIAN Y , JACOBSON JOSEPH M
IPC分类号： H01L27/148
CPC分类号： C25B3/00 , B01J19/0046 , B01J2219/00317 , B01J2219/00432 , B01J2219/00439 , B01J2219/00441 , B01J2219/00448 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00641 , B01J2219/00653 , B01J2219/00659 , B01J2219/00675 , B01J2219/00711 , B01J2219/00713 , B01J2219/00722 , B82Y30/00 , C12Q1/6837 , C40B50/14 , C40B60/14 , H01L27/148
摘要： In a method for creating polymer arrays through photoelectrochemically modulated acid/base/radical generation for combinatorial synthesis, electrochemical synthesis is guided by a spatially modulated light source striking a semiconductor in an electrolyte solution. A substrate having at its surface at least one photoelectrode that is proximate to at least one molecule bearing at least one chemical functional group is provided, along with a reagent-generating chemistry co-localized with the chemical functional group and capable of generating reagents when subjected to a potential above a threshold. An input potential is then applied to the photoelectrode that exceeds the threshold in the presence of light and that does not exceed the threshold in the absence of light, causing the transfer of electrons to or from the substrate, and creating a patterned substrate. The process is repeated until a polymer array of desired size is created.
摘要翻译：在通过光电化学调制的酸/碱/自由基产生用于组合合成的聚合物阵列的制备方法中，电化学合成由在电解质溶液中冲击半导体的空间调制光源引导。提供了在其表面上具有至少一个接近至少一个具有至少一个化学官能团的分子的光电极，以及与化学官能团共定位的试剂产生化学物质，并且当经受达到高于阈值的潜力。然后在存在光的情况下将输入电位施加到超过阈值的光电极，并且在不存在光的情况下不超过阈值，导致电子传递到衬底或从衬底转移，并产生图案化衬底。重复该过程，直到产生所需尺寸的聚合物阵列。

4. 发明申请

WO2007136833A2 METHODS AND COMPOSITIONS FOR APTAMER PRODUCTION AND USES THEREOF 审中-公开
标题翻译： APTAMER生产的方法和组合及其用途
公开(公告)号：WO2007136833A2
公开(公告)日：2007-11-29
申请号：PCT/US2007012075
申请日：2007-05-19
申请人： CODON DEVICES INC , CHURCH GEORGE , JACOBSON JOSEPH M , BAYNES BRIAN M
发明人： CHURCH GEORGE , JACOBSON JOSEPH M , BAYNES BRIAN M
IPC分类号： C12Q1/68 , C12N15/11 , C12N15/115
CPC分类号： C12N15/115 , C12N15/1048 , C12N15/111 , C12N2310/16 , C12N2320/10 , C12N2330/31
摘要： Certain aspects of the present invention provide methods for assembling nucleic acid libraries that represent large numbers of sequence variants. Some embodiments involve generating libraries of RNA molecules that can be subjected to in vivo screens or selections to identify one or more aptamers. Certain aspects of the invention provide cells that transcribe one or more different aptamers (e.g., 10) that each bind to a different ligand and are each fused to a different reporter RNA.
摘要翻译：本发明的某些方面提供组装代表大量序列变体的核酸文库的方法。一些实施方案涉及产生可以经受体内筛选或选择以鉴定一种或多种适体的RNA分子的文库。本发明的某些方面提供转录一种或多种不同适配体（例如，10）的细胞，其各自结合不同的配体并且各自与不同的报道RNA融合。

5. 发明申请

WO2005059097A3 METHODS FOR HIGH FIDELITY PRODUCTION OF LONG NUCLEIC ACID MOLECULES 审中-公开
标题翻译：高浓度生产长核酸分子的方法
公开(公告)号：WO2005059097A3
公开(公告)日：2005-11-17
申请号：PCT/US2004041478
申请日：2004-12-10
申请人： MASSACHUSETTS INST TECHNOLOGY , CARR PETER A , CHOW BRIAN Y , JACOBSON JOSEPH M
发明人： CARR PETER A , CHOW BRIAN Y , JACOBSON JOSEPH M
IPC分类号： C07H19/00 , C12N20060101 , C12P19/34 , C12Q1/68
CPC分类号： C12P19/34 , C12Q1/6825 , C12Q1/6834 , C12Q1/6848 , C12Q2565/518 , C12Q2565/513 , C12Q2521/514
摘要： This invention generally relates to nucleic acid synthesis, in particular DNA synthesis. More particularly, the invention relates to the production of long nucleic acid molecules with precise user control over sequence content. This invention also relates to the prevention and/or removal of erros within nucleic acid molecules.
摘要翻译：本发明一般涉及核酸合成，特别是DNA合成。更具体地，本发明涉及具有对序列内容的精确用户控制的长核酸分子的生产。本发明还涉及预防和/或去除核酸分子内的错误。

6. 发明申请

WO9704398A3 ELECTRONIC BOOK WITH MULTIPLE PAGE DISPLAYS 审中-公开
标题翻译：具有多页显示的电子书
公开(公告)号：WO9704398A3
公开(公告)日：1997-03-06
申请号：PCT/US9612000
申请日：1996-07-19
申请人： JACOBSON JOSEPH M
发明人： JACOBSON JOSEPH M
IPC分类号： G02F1/167 , B41J3/407 , G02B26/02 , G04G21/04 , G06F1/16 , G06F3/048 , G06F15/02 , G09F9/00 , G09F9/30 , G09F9/35 , G09F9/37 , G09F9/40 , G09G3/20 , G09G3/30 , G09G3/34 , G09G3/36 , G09G3/38 , H01L27/28 , H01L27/32 , H01L51/00 , H01L51/05 , H01L51/30
CPC分类号： H01L27/28 , B41J3/407 , B41J3/4076 , G02B26/026 , G02F1/167 , G06F15/0283 , G09G3/20 , G09G3/30 , G09G3/344 , G09G3/3611 , G09G3/3674 , G09G3/3685 , G09G3/38 , G09G2310/0267 , G09G2310/0275 , H01L27/3281 , H01L51/005 , H01L51/0077 , H01L51/0512 , H01L2251/5338 , Y10S345/901
摘要： An electronic book comprising multiple, electronically addressable, page displays is described. Said page displays may be formed on flexible, thin substrates. Said book may additionnally encompass memory, power, control functions and communications.
摘要翻译：描述了包括多个可电子寻址的页面显示的电子书。所述页面显示可以形成在柔性的薄基板上。所述书可以另外包括存储器，功率，控制功能和通信。

7. 发明申请

WO2007087347A2 METHODS, SYSTEMS, AND APPARATUS FOR FACILITATING THE DESIGN OF MOLECULAR CONSTRUCTS 审中-公开
标题翻译：用于促进分子构建体设计的方法，系统和装置
公开(公告)号：WO2007087347A2
公开(公告)日：2007-08-02
申请号：PCT/US2007/001888
申请日：2007-01-24
申请人： CODON DEVICES, INC. , JACOBSON, Joseph, M. , ENDY, Drew , PITCHER, Edmund, R.
发明人： JACOBSON, Joseph, M. , ENDY, Drew , PITCHER, Edmund, R.
CPC分类号： G06Q50/22 , G06F19/18 , G06F19/28
摘要： A system and method for aiding in the design of molecular constructs is provided. A feature set associated with a molecular building block in a construct may be determined, wherein the feature set may comprise data indicative of third party rights that restrict use of the molecular segment or the lack of such rights. The method may include steps of defining a molecular structure for use in the construct; searching a database including a plurality of molecular structures and a plurality of rights, each right of the plurality of rights associated with each of the plurality of molecular structures; and displaying rights associated with the defined molecular structures in response to the search of said database. The system may include a library aggregating a plurality of intellectual property rights relating to fabricating biological constructs; a licensing module licensing the intellectual property rights required to make the specific construct for a fee; an accounts receivable module receiving the fee from a potential maker of the specific construct; and an accounts payable module distributing remuneration to the holders of the intellectual property rights required to make the specific construct.
摘要翻译：提供了用于帮助设计分子构建体的系统和方法。可以确定与构建体中的分子构建块相关联的特征集，其中该特征集可以包括指示限制分子段的使用或缺乏这种权利的第三方权利的数据。该方法可以包括定义用于构建体中的分子结构的步骤; 搜索包括多个分子结构和多个权利的数据库，与所述多个分子结构中的每一个相关的所述多个权利中的每一个权利; 以及响应于对所述数据库的搜索而显示与所定义的分子结构相关联的权利。该系统可以包括集合涉及制造生物构建体的多个知识产权的库; 一个授权模块，授权收取特定结构所需的知识产权; 应收账款模块，从特定建筑的潜在制造商处收取费用; 以及向制作特定结构所需的知识产权持有人分配报酬的应付账款模块。

8. 发明申请

WO2005059097A2 METHODS FOR HIGH FIDELITY PRODUCTION OF LONG NUCLEIC ACID MOLECULES 审中-公开
标题翻译：高保真度生产长核酸分子的方法
公开(公告)号：WO2005059097A2
公开(公告)日：2005-06-30
申请号：PCT/US2004/041478
申请日：2004-12-10
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , CARR, Peter, A. , CHOW, Brian, Y. , JACOBSON, Joseph, M.
发明人： CARR, Peter, A. , CHOW, Brian, Y. , JACOBSON, Joseph, M.
IPC分类号： C12N
CPC分类号： C12P19/34 , C12Q1/6825 , C12Q1/6834 , C12Q1/6848 , C12Q2565/518 , C12Q2565/513 , C12Q2521/514
摘要： This invention generally relates to nucleic acid synthesis, in particular DNA synthesis. More particularly, the invention relates to the production of long nucleic acid molecules with precise user control over sequence content. This invention also relates to the prevention and/or removal of erros within nucleic acid molecules.
摘要翻译：本发明一般涉及核酸合成，特别是DNA合成。更具体地说，本发明涉及具有精确的用户控制序列含量的长核酸分子的生产。本发明还涉及预防和/或除去核酸分子内的错误。

9. 发明申请

WO2005059096A2 METHODS FOR HIGH FIDELITY PRODUCTION OF LONG NUCLEIC ACID MOLECULES WITH ERROR CONTROL 审中-公开
标题翻译：用于高错误生产具有错误控制的长核酸分子的方法
公开(公告)号：WO2005059096A2
公开(公告)日：2005-06-30
申请号：PCT/US2004/041268
申请日：2004-12-10
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , CARR, Peter, A. , CHOW, Brian, Y. , JACOBSON, Joseph, M.
发明人： CARR, Peter, A. , CHOW, Brian, Y. , JACOBSON, Joseph, M.
IPC分类号： C12N
CPC分类号： B01J19/0046 , B01J2219/00608 , B01J2219/00659 , B01J2219/00722 , C12Q1/6827 , C12Q1/6837 , C12Q1/6846 , C12Q1/6848 , C12Q2565/518 , C12Q2537/149 , C12Q2521/514 , C12Q2537/113 , C12Q2565/537 , C12Q2565/513
摘要： This invention generally relates to nucleic acid synthesis, in particular DNA synthesis. More particularly, the invention relates to the production of long nucleic acid molecules with precise user control over sequence content. This invention also relates to the prevention and/or removal of errors within nucleic acid molecules.
摘要翻译：本发明一般涉及核酸合成，特别是DNA合成。更具体地，本发明涉及具有对序列内容的精确用户控制的长核酸分子的生产。本发明还涉及预防和/或去除核酸分子中的错误。

10. 发明申请

WO1998003896A1 ELECTRONICALLY ADDRESSABLE MICROENCAPSULATED INK AND DISPLAY THEREOF 审中-公开
标题翻译：电子式可寻址微型墨水和显示器
公开(公告)号：WO1998003896A1
公开(公告)日：1998-01-29
申请号：PCT/US1996013469
申请日：1996-08-20
申请人： JACOBSON, Joseph, M.
IPC分类号： G02F01/133
CPC分类号： B82Y20/00 , B41J2/01 , B41J2/02 , B41J3/4076 , C09D11/30 , C09D11/50 , G02B26/026 , G02F1/1334 , G02F1/13439 , G02F1/167 , G02F1/19 , G04B47/00 , G09F9/372 , G09G3/344 , G09G2380/04 , H01L51/0508 , H05K1/097 , H05K3/105 , H05K3/1241
摘要： We describe a system of electronically active inks which may include electronically addressable contrast media, conductors, insulators, resistors, semiconductive materials, magnetic materials or spin materials. We further describe a printing system capable of laying down said materials in a definite pattern. Such a system may be used for instance to print a flat panel display complete with onboard drive logic or to print a working logic ciruit onto any of a large class of substrates.
摘要翻译：我们描述了一种电子活性油墨系统，其可以包括电子可寻址造影剂，导体，绝缘体，电阻器，半导体材料，磁性材料或旋转材料。我们进一步描述能够以确定的模式放置所述材料的打印系统。这样的系统可以用于例如打印具有车载驱动逻辑的平板显示器或者将工作逻辑电路打印到任何大类基板上。

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