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1. 发明授权

US07615378B2 Pipetting needle 有权
标题翻译：移液针
公开(公告)号：US07615378B2
公开(公告)日：2009-11-10
申请号：US11128677
申请日：2005-05-13
申请人： Jürg Dual , Olivier Elsenhans , Frank May
发明人： Jürg Dual , Olivier Elsenhans , Frank May
IPC分类号： B01L3/02 , G01N1/10
CPC分类号： B01L3/0268 , B01L2400/0439 , G01N2035/1039 , Y10T436/2575
摘要： A method and a micropipetting apparatus is described for dispensing a liquid volume into a vessel via pipetting needle without any contact between the needle and a liquid contained in the vessel. The method comprises forming a drop at the delivery tip of the pipetting needle, the drop being retained at the tip by adhesion forces, and ejecting the drop from the tip of the pipetting needle by focusing at the tip of the pipetting needle a mechanical excitation wave applied at an excitation point at some distance from the tip of the pipetting needle. The apparatus comprises a pipetting needle, an electromechanical transducer mechanically connected with said pipetting needle for mechanically exciting the pipetting needle with a pulse of mechanical waves that propagate through the needle, and an electrical signal generator for generating an excitation pulse signal and for applying this signal to the electromechanical transducer.
摘要翻译：描述了一种方法和微量移液装置，用于通过移液针将液体体积分配到容器中，而不会在针与包含在容器中的液体之间发生任何接触。该方法包括在移液针的输送末端形成液滴，液滴通过粘附力保持在末端，并通过在吸液针的尖端聚焦机械激发波而从吸液针的顶端喷出液滴在距离移液针的尖端一定距离处的激发点施加。该装置包括一个移液针，一个与所述移液针机械连接的机电换能器，用于通过穿过该针传播的机械波脉冲来机械地激励移液针;以及电信号发生器，用于产生激励脉冲信号并施加该信号到机电换能器。

2. 发明授权

US07416706B2 Level sensor apparatus for detecting contact of a pipetting needle with a liquid in a vessel 有权
标题翻译：液位传感器装置，用于检测移液针与容器中液体的接触
公开(公告)号：US07416706B2
公开(公告)日：2008-08-26
申请号：US11128542
申请日：2005-05-13
申请人： Markus Brunner , Jürg Dual , Olivier Elsenhans , Frank May , Vuk Siljegovic
发明人： Markus Brunner , Jürg Dual , Olivier Elsenhans , Frank May , Vuk Siljegovic
IPC分类号： G05D9/12 , B01L3/02
CPC分类号： G01N35/1011 , B01L3/021 , G01F23/2965 , G01F23/2966 , G01N2035/1025
摘要： A level sensor apparatus is disclosed for detecting contact of a pipetting needle with a liquid contained in a vessel. The apparatus includes a sensor head made up of a pipetting needle, a needle holder, and an electromechanical transducer. The sensor head also has an associated mechanical resonance frequency. An electrical signal generator is used to generate a driving signal which when applied to the electromechanical transducer causes vibration of the pipetting needle at the resonance frequency. A measurement device is used to measure a parameter of a vibration signal indicative of the mechanical vibration of the pipetting needle when it is driven by the driving signal. An electronic circuit and associated computer software is provided to evaluate variation of the vibration signal with time and thus detect contact of the pipetting needle with a liquid contained in the vessel.
摘要翻译：公开了一种液位传感器装置，用于检测移液针与容纳在容器中的液体的接触。该装置包括由移液针，针保持器和机电换能器构成的传感器头。传感器头还具有相关的机械共振频率。电信号发生器用于产生一个驱动信号，当驱动信号被施加到机电换能器时，会使谐振频率下的移液针振动。测量装置用于测量当由驱动信号驱动时指示移液针的机械振动的振动信号的参数。提供电子电路和相关联的计算机软件以评估振动信号随时间的变化，从而检测移液针与容纳在容器中的液体的接触。

3. 发明授权

US07691570B2 Chemical analysis using dynamic viscometry 失效
标题翻译：化学分析采用动态粘度计
公开(公告)号：US07691570B2
公开(公告)日：2010-04-06
申请号：US10578942
申请日：2004-11-05
申请人： Jürg Dual , Lukas Bestmann , Klaus Häusler
发明人： Jürg Dual , Lukas Bestmann , Klaus Häusler
IPC分类号： C12Q1/68
CPC分类号： G01N11/162 , C12Q1/6816 , Y10T436/145555 , C12Q2527/137
摘要： The invention relates to a method for determining the reactive state of a chemical reaction process in a reaction mixture (110), in particular an amplification reaction for nucleic acids. The method comprises a viscosity determination, which preferably uses a dynamic viscometer (1). The invention also relates to an improved dynamic viscometer (1) for carrying out said method. The viscometer is characterised by an appropriate choice of material for the resonator (101) and optimised geometric ratios.
摘要翻译：本发明涉及一种用于测定反应混合物（110）中化学反应过程的反应状态，特别是核酸扩增反应的方法。该方法包括粘度测定，其优选使用动态粘度计（1）。本发明还涉及用于实施所述方法的改进的动态粘度计（1）。粘度计的特征在于适当选择谐振器（101）的材料和优化的几何比。

4. 发明申请

US20080026369A1 Chemical Analysis Using Dynamic Viscometry 失效
标题翻译：使用动态粘度计的化学分析
公开(公告)号：US20080026369A1
公开(公告)日：2008-01-31
申请号：US10578942
申请日：2004-11-05
申请人： Jürg Dual , Lukas Bestmann , Klaus Häusler
发明人： Jürg Dual , Lukas Bestmann , Klaus Häusler
IPC分类号： C12Q1/68 , B01J19/00 , G01N33/00 , C12M1/34
CPC分类号： G01N11/162 , C12Q1/6816 , Y10T436/145555 , C12Q2527/137
摘要： The invention relates to a method for determining the reactive state of a chemical reaction process in a reaction mixture (110), in particular an amplification reaction for nucleic acids. Said method comprises a viscosity determination, which preferably uses a dynamic viscometer (1). The invention also relates to an improved dynamic viscometer (1) for carrying out said method. Said viscometer is characterised by an appropriate choice of material for the resonator (101) and optimised geometric ratios.
摘要翻译：本发明涉及一种用于测定反应混合物（110）中化学反应过程的反应状态，特别是核酸扩增反应的方法。所述方法包括粘度测定，其优选使用动态粘度计（1）。本发明还涉及用于实施所述方法的改进的动态粘度计（1）。所述粘度计的特征在于适当选择谐振器（101）的材料和优化的几何比。

5. 发明授权

US07601267B2 Method for positioning small particles in a fluid 失效
标题翻译：将小颗粒定位在流体中的方法
公开(公告)号：US07601267B2
公开(公告)日：2009-10-13
申请号：US10548116
申请日：2003-09-25
申请人： Albrecht Haake , Jürg Dual
发明人： Albrecht Haake , Jürg Dual
IPC分类号： C02F1/32 , G01N33/00
CPC分类号： G10K15/00 , B01D21/283
摘要： The invention covers the field of positioning of small particles (58, 59) in a fluid (55). Disclosed is a method by which small particles (58, 59) are positioned by a sound field. For generating the sound field an apparatus contains a plate (51) excited to vibrations by a transducer (52) and a reflecting body with a rigid surface (54). A mounting (53) holds the vibrating plate (51) and the transducer (52). The particles will be concentrated at predetermined positions either at the rigid surface of the reflecting body (58) or levitating in the fluid (59). Due to the fact that the sound waves are emitted by the vibrating plate particles can be positioned in entire area between the vibrating plate and the reflecting body.
摘要翻译：本发明涵盖了在流体（55）中定位小颗粒（58,59）的领域。公开了一种通过声场定位小颗粒（58,59）的方法。为了产生声场，装置包含由换能器（52）和具有刚性表面（54）的反射体激发的振动板（51）。安装件（53）固定振动板（51）和换能器（52）。颗粒将集中在反射体（58）的刚性表面处的预定位置或在流体（59）中悬浮。由于声波由振动板发射，因此可以将振动板和反射体之间的整个区域定位。

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