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1. 发明授权

US07956063B2 Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 有权
标题翻译： 4 - [[4 - [[4-（2-氰基乙烯基）-2,6-二甲基苯基]氨基] -2-嘧啶基]氨基]苄腈
公开(公告)号：US07956063B2
公开(公告)日：2011-06-07
申请号：US12168540
申请日：2008-07-07
申请人： Jérôme Emile Georges Guillemont , Paul Theodoor Agnes Stevens , Alex Herman Copmans , Jozef Peeters , Alfred Elisabeth Stappers , Roger Petrus Gerebern Vandecruys , Paul Stoffels
发明人： Jérôme Emile Georges Guillemont , Paul Theodoor Agnes Stevens , Alex Herman Copmans , Jozef Peeters , Alfred Elisabeth Stappers , Roger Petrus Gerebern Vandecruys , Paul Stoffels
IPC分类号： A61K31/505 , A61P31/18 , C07D239/48
CPC分类号： A61K31/505 , C07D239/48
摘要： The present invention relates to a pharmaceutical composition comprising as active ingredient the hydrochloric acid salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethyl-phenyl]amino]-2-pyrimidinyl]amino]benzonitrile and to processes for their preparation.
摘要翻译：本发明涉及药物组合物，其包含4 - [[4 - [[4-（2-氰基乙烯基）-2,6-二甲基 - 苯基]氨基] -2-嘧啶基]氨基] 苄腈和其制备方法。

2. 发明申请

US20110124870A1 NOVEL MYCOBACTERIAL INHIBITORS 审中-公开
标题翻译：新型MYCOBACTERIAL INHIBITORS
公开(公告)号：US20110124870A1
公开(公告)日：2011-05-26
申请号：US13020079
申请日：2011-02-03
申请人： Jérôme Emile Georges GUILLEMONT , Elisabeth Therese Jeanne Pasquier , David Francis Alain Lancois
发明人： Jérôme Emile Georges GUILLEMONT , Elisabeth Therese Jeanne Pasquier , David Francis Alain Lancois
IPC分类号： C07D405/04 , C07D409/04 , C07D215/14
CPC分类号： C07D215/14 , C07D215/227 , C07D215/38 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/14
摘要： The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or the general Formula (Ib) the pharmaceutically acceptable acid or base addition salts thereof, the quaternary amines thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof. The claimed compounds are useful for the treatment of mycobacterial diseases. In particular, compounds are claimed in which, independently from each other, R1 is halo; p=1; R2 is optionally substituted alkyloxy, alkyl, Ar, Het, or a radical of formula R3 is optionally substituted Ar or Het; q=1, R4 and R5 each independently are alkyl; R6 is hydrogen or a radical of formula r is equal to 0 or 1 and R7 is hydrogen or Ar. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of mycobacterial diseases and a process for preparing the claimed compounds.
摘要翻译：本发明涉及根据通式（Ia）或通式（Ib）的新的取代喹啉衍生物，其药学上可接受的酸或碱加成盐，其季胺，其立体化学异构形式，其互变异构形式和其N-氧化物形式。所要求保护的化合物可用于治疗分枝杆菌病。特别地，要求保护的化合物，其中R1彼此独立地为卤素; p = 1; R 2是任选取代的烷氧基，烷基，Ar，Het或式R3的基团是任选取代的Ar或Het; q = 1，R4和R5各自独立地为烷基; R6是氢或式r的基团等于0或1，而R7是氢或Ar。还要求保护的是包含药学上可接受的载体和作为活性成分的治疗有效量的要求保护的化合物的组合物，所要求保护的化合物或组合物在制备用于治疗分枝杆菌疾病的药物中的用途以及制备方法要求保护的化合物。

3. 发明授权

US07879857B2 6-substituted 2-quinolinones and 2-quinoxalinones as poly (adp-ribose) polymerase inhibitors 有权
标题翻译： 6-取代的2-喹啉酮和2-喹喔啉酮作为聚（adp-核糖）聚合酶抑制剂
公开(公告)号：US07879857B2
公开(公告)日：2011-02-01
申请号：US10596086
申请日：2004-11-18
申请人： Dominique Jean-Pierre Mabire , Jérôme Emile Georges Guillemont , Jacobus Alphonsus Josephus Van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
发明人： Dominique Jean-Pierre Mabire , Jérôme Emile Georges Guillemont , Jacobus Alphonsus Josephus Van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
IPC分类号： C07D241/44 , C07D215/227 , A61K31/498 , A61K31/4704 , A61P25/28
CPC分类号： C04B35/632 , C07D241/44 , C07D401/12 , C07D407/06 , C07D409/14
摘要： The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, R1, R2, R3, R4 and X have defined meanings.
摘要翻译：本发明提供式（I）化合物，它们作为PARP抑制剂的用途以及包含所述式（I）化合物的药物组合物，其中n，R1，R2，R3，R4和X具有定义的含义。

4. 发明申请

US20100204270A1 Quinoline Derivatives as Antibacterial Agents 审中-公开
标题翻译：喹啉衍生物作为抗菌剂
公开(公告)号：US20100204270A1
公开(公告)日：2010-08-12
申请号：US11917923
申请日：2006-06-26
申请人： Koenraad Jozef Lodewijk Marcel Andries , Anil Koul , Jérôme Emile Georges Guillemont , Magali Madeleine Simone Motte
发明人： Koenraad Jozef Lodewijk Marcel Andries , Anil Koul , Jérôme Emile Georges Guillemont , Magali Madeleine Simone Motte
IPC分类号： A61K31/47 , C07D215/16 , A61P31/04
CPC分类号： C07D215/227 , A61K31/4353 , A61K45/06 , C07D215/36 , A61K2300/00
摘要： Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of formula (Ia) or (Ib) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or a N-oxide form thereof. Several of these compounds are also claimed as such. Further the combination of the above compounds with other antibacterial agents is described
摘要翻译：使用化合物制造用于治疗细菌感染的药物，只要细菌感染不是分枝杆菌感染，所述化合物是式（Ia）或（Ib）的化合物，其药学上可接受的酸或碱加成其盐，其立体化学异构形式，其互变异构形式或其N-氧化物形式。这些化合物中的几种也是这样声称的。此外，还描述了上述化合物与其它抗菌剂的组合

5. 发明授权

US07709498B2 Quinoline derivatives as antibacterial agents 有权
标题翻译：喹啉衍生物作为抗菌剂
公开(公告)号：US07709498B2
公开(公告)日：2010-05-04
申请号：US11296918
申请日：2005-12-08
申请人： Koenraad Jozef Lodewijk Marcel Andries , Anil Koul , Jérôme Emile Georges Guillemont , Elisabeth Therese Jeanne Pasquier
发明人： Koenraad Jozef Lodewijk Marcel Andries , Anil Koul , Jérôme Emile Georges Guillemont , Elisabeth Therese Jeanne Pasquier
IPC分类号： C07D215/38
CPC分类号： C07D215/227 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K31/541 , C07D215/36 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D409/06 , Y02A50/473
摘要： The present invention relates to a method for the treatment of a bacterial infection comprising administering a therapeutically effective amount of a compound of formula or a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof or a N-oxide form thereof, wherein R1 is hydrogen, halo, polyhaloC1-6alkyl, C1-6alkyl, Ar or Het; p is an integer equal to 1 or 2; R2 is C1-6alkyloxy, C1-6alkyloxyC1-6alkyloxy or C1-6alkylthio; R3 is Ar, Het or Het1; R4 and R5 each independently are hydrogen, C1-6alkyl or benzyl; or R4 and R5 together and including the N to which they are attached may form a radical selected from the group of pyrrolidinyl, 2-pyrrolinyl, 3-pyrrolinyl, pyrrolyl, imidazolidinyl, pyrazolidinyl, 2-imidazolinyl, 2-pyrazolinyl, imidazolyl, pyrazolyl, triazolyl, piperidinyl, pyridinyl, piperazinyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, morpholinyl and thiomorpholinyl, each of said rings may optionally be substituted with C1-6alkyl, halo, polyhaloC1-6alkyl, hydroxy, hydroxyC1-6alkyl, C1-6alkyloxy, amino, mono- or di(C1-6alkyl)amino, C1-6alkylthio, C1-6alkyloxyC1-6alkyl, C1-6alkylthioC1-6alkyl or pyrimidinyl; R6 is hydrogen, halo, polyhaloC1-6alkyl, C1-6alkyl, C1-6alkyloxy, C1-6alkylthio; or two vicinal R6 radicals may be taken together to form a bivalent radical of formula —CH═CH—CH═CH—; r is an integer equal to 1 or 2; R7 is hydrogen, C1-6alkyl, Ar, Het or Het1; provided that to bacterial infection is other than a Mycobacterial infection.
摘要翻译：本发明涉及一种治疗细菌感染的方法，包括给予治疗有效量的式的化合物或其药学上可接受的酸或碱加成盐，其立体化学异构形式或其N-氧化物形式，其中 R 1是氢，卤素，多卤代C 1-6烷基，C 1-6烷基，Ar或Het; p是等于1或2的整数; R2是C1-6烷氧基，C1-6烷氧基C1-6烷氧基或C1-6烷硫基; R3是Ar，Het或Het1; R 4和R 5各自独立地为氢，C 1-6烷基或苄基; 或R4和R5一起并且包括它们所连接的N可以形成选自吡咯烷基，2-吡咯啉基，3-吡咯啉基，吡咯基，咪唑烷基，吡唑烷基，2-咪唑啉基，2-吡唑啉基，咪唑基，吡唑基三唑基，哌啶基，吡啶基，哌嗪基，哒嗪基，嘧啶基，吡嗪基，三嗪基，吗啉基和硫代吗啉基，每个所述环可任选被C 1-6烷基，卤素，多卤代C 1-6烷基，羟基，羟基C 1-6烷基，C 1-6烷氧基，氨基，单或二（C 1-6烷基）氨基，C 1-6烷硫基，C 1-6烷氧基C 1-6烷基，C 1-6烷硫基C 1-6烷基或嘧啶基; R 6是氢，卤素，多卤代C 1-6烷基，C 1-6烷基，C 1-6烷氧基，C 1-6烷硫基; 或两个连位的R6基团可以一起形成式-CH = CH-CH = CH-的二价基团; r是等于1或2的整数; R7是氢，C1-6烷基，Ar，Het或Het1; 只要细菌感染不是分枝杆菌感染。

6. 发明授权

US07071192B1 Respiratory syncytial virus replication inhibitors 失效
公开(公告)号：US07071192B1
公开(公告)日：2006-07-04
申请号：US10019376
申请日：2000-06-20
申请人： Frans Eduard Janssens , Jean Fernand Armand Lacrampe , Jérôme Emile Georges Guillemont , Marc Gaston Venet , Koenraad Jozef Lodewijk Marcel Andries
发明人： Frans Eduard Janssens , Jean Fernand Armand Lacrampe , Jérôme Emile Georges Guillemont , Marc Gaston Venet , Koenraad Jozef Lodewijk Marcel Andries
IPC分类号： A61P31/00 , A61K31/495 , A61K31/445 , C07D239/00 , C07D215/00
CPC分类号： C07D401/14 , C07D409/14 , C07D471/04 , Y02P20/55
摘要： The present invention concerns compounds of formula (I), prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof wherein -a1=a2-a3=a4-represents a radical of formula —CH═CH—CH═CH—; —N—CH—CH═CH—; —CH═N—CH═CH—; —CH═CH—N═CH—; —CH═CH—CH═N—; wherein each hydrogen atom may optionally be substituted; Q is a radical of formulae (b-1), (b-2), (b-3), (b-4), (b-5), (b-6), (b-7) and (b-8), wherein Alk is C1-6alkanediyl; Y1 is a bivalent radical of formula —NR2— or —CH(NR2R4)—; X1 is NR4, S, S(═O), S(═O)2, O, CH2, C(═O), CH(═CH2), CH(OH), CH(CH3), CH(OCH3), CH(SCH3), CH(NR5aR5b), CH2—NR4 or NR4—CH2; X2 is a direct bond, CH2, C(═O), NR4, C1-4alkyl-NR4, NR4—C1-4alkyl, t is 2 to 5; u is 1 to 5; v is 2 or 3; and whereby each hydrogen in Alk and in (b-3), (b-4), (b-5), (b-6), (b-7) and (b-8), may optionally be replaced by R3: provided that when R3 is hydroxy or C1-6alkyloxy, then R3 cannot replace a hydrogen atom in the a position relative to a nitrogen atom; G is a direct bond or optionally substituted C1-10alkanediyl; R1 is an optionally substituted bicyclic heterocycle; R2 is hydrogen, formyl, C1-6alkylcarbonyl, Hetcarbonyl, pyrrolidinyl, piperidinyl, homopiperidinyl, C3-7cycloalkyl or C1-10alkyl substituted with N(R6)2 and optionally with another substituent; R3 is hydrogen, hydroxy, C1-6alkyl, C1-6alkyloxy, aryl C1-6alkyl or aryl C1-6alkyloxy, R4 is hydrogen, C1-6alkyl or aryl C1-6alkyl; R5a, R5b, R5c and R5d are hydrogen or C1-6alkyl; or R5a and R5b, or R5c and R5d taken together from a bivalent radical of formula —(CH2)5- wherein S is 4 or 5; R6 is hydrogen, C1-4alkyl, formyl, hydroxy C1-6alkyl, C1-6alkylcarbonyl or C1-6alkyloxycarbonyl; aryl is optionally substituted phenyl; Het is pyridyl, pyrimidinyl, pyridazinyl, pyridazinyl; as respiratory syncytial virus replication inhibitors; their preparation, compositions containing them and their use as a medicine.

7. 发明授权

US08841321B2 Quinoline derivatives as antibacterial agents 有权
标题翻译：喹啉衍生物作为抗菌剂
公开(公告)号：US08841321B2
公开(公告)日：2014-09-23
申请号：US11993145
申请日：2006-06-26
申请人： Koenraad Jozef Lodewijk Marcel Andries , Anil Koul , Jérôme Emile Georges Guillemont , David Francis Alain Lançois , Magali Madeleine Simone Motte , Ismet Dorange , Leo Jacobus Jozef Backx , Lieven Meerpoel
发明人： Koenraad Jozef Lodewijk Marcel Andries , Anil Koul , Jérôme Emile Georges Guillemont , David Francis Alain Lançois , Magali Madeleine Simone Motte , Ismet Dorange , Leo Jacobus Jozef Backx , Lieven Meerpoel
IPC分类号： A01N43/42 , A61K31/47 , A01N43/40 , A61K31/445 , A61K31/44 , C07D215/227
CPC分类号： A61K31/47 , C07D215/227
摘要： Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of formula (Ia) or (Ib) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or a N-oxide form thereof, wherein R1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is 1, 2, 3 or 4; R2 is hydrogen, hydroxy, mercapto, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formula; R3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; q is 1, 2 or 3; R4 and R5 are hydrogen, alkyl or benzyl; or R4 and R5 together and including the N to which they are attached may form a ring; R6 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkythioalkyl, Ar-alkyl or di(Ar)alkyl; or two vicinal R6 radicals may be taken together to form a bivalent radical of formula —CH═CH—CH═CH—; r is 1, 2, 3, 4 or 5; R7 is hydrogen, alkyl, Ar or Het; R8 is hydrogen or alkyl; R9 is oxo; or R8 and R9 together form the radical —CH═CH—N═.
摘要翻译：使用化合物制造用于治疗细菌感染的药物，只要细菌感染不是分枝杆菌感染，所述化合物是式（Ia）或（Ib）的化合物，其药学上可接受的酸或碱加成其盐，其立体化学异构形式，其互变异构形式或其N-氧化物形式，其中R 1是氢，卤素，卤代烷基，氰基，羟基，Ar，Het，烷基，烷氧基，烷硫基，烷氧基烷基，烷硫基烷基，烷基或二（Ar）烷基; p为1,2,3或4; R2是氢，羟基，巯基，烷氧基，烷氧基烷氧基，烷硫基，一或二（烷基）氨基或式的基团; R3是烷基，Ar，Ar-烷基，Het或Het-烷基; q为1,2或3; R4和R5是氢，烷基或苄基; 或R 4和R 5一起并包括它们所连接的N可以形成环; R 6是氢，卤素，卤代烷基，羟基，Ar，烷基，烷氧基，烷硫基，烷氧基烷基，链仲烷基，芳烷基或二（Ar）或两个连位的R6基团可以一起形成式-CH = CH-CH = CH-的二价基团; r为1,2,3,4或5; R7是氢，烷基，Ar或Het; R8是氢或烷基; R9是氧代; 或R8和R9一起形成基团-CH = CH-N =。

8. 发明申请

US20140147386A1 1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES 审中-公开
标题翻译： 1-芳基-4-甲基 - [1,2,4]三唑并[4,3-a]喹啉衍生物
公开(公告)号：US20140147386A1
公开(公告)日：2014-05-29
申请号：US14128835
申请日：2012-06-26
申请人： José Ignacio Andrés-Gil , Peter Jacobus Johannes Antonius Buijnsters , Andrés Avelino Trabanco-Suárez , Meri De Angelis , Greta Constantia Peter Vanhoof , Jérôme Emile Georges Guillemont , Frederik Jan Rita Rombouts , Maarten Vliegen , Guy Maurits R. Bormans , SofleJeanne Leopoldine Celens
发明人： José Ignacio Andrés-Gil , Peter Jacobus Johannes Antonius Buijnsters , Andrés Avelino Trabanco-Suárez , Meri De Angelis , Greta Constantia Peter Vanhoof , Jérôme Emile Georges Guillemont , Frederik Jan Rita Rombouts , Maarten Vliegen , Guy Maurits R. Bormans , SofleJeanne Leopoldine Celens
IPC分类号： C07D487/04 , G01N33/60 , A61K45/06 , A61K31/4985 , A61K51/04
CPC分类号： C07D487/04 , A61K31/4985 , A61K45/06 , A61K51/0463 , G01N33/60
摘要： The present invention relates to novel 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]-quinoxaline derivatives as inhibitors of phosphodiesterase 2 (PDE2) and to a lesser extent of phosphodiesterase 10 (PDE10) or as inhibitors of both, phosphodiesterases 2 and 10. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which PDE2 is involved, or disorders in which both PDE2 and PDE 10 are involved, such as neurological and psychiatric disorders, and endocrinological or metabolic diseases. The present invention also relates to radiolabelled compounds which may be useful for imaging and quantifying the PDE2 enzyme in tissues, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and compositions, to the use of such compounds and compositions for imaging a tissue, cells or a host, in vitro or in vivo and to precursors of said compounds.
摘要翻译：本发明涉及作为磷酸二酯酶2（PDE2）抑制剂的新型1-芳基-4-甲基 - [1,2,4]三唑并[4,3-a] - 喹喔啉衍生物和较少程度的磷酸二酯酶10（PDE10 ）或作为磷酸二酯酶2和10两者的抑制剂。本发明还涉及包含这些化合物的药物组合物，制备此类化合物和组合物的方法，以及用于预防和治疗疾病的化合物和组合物涉及PDE2或PDE2和PDE10两者涉及的疾病，如神经和精神疾病，以及内分泌或代谢疾病。本发明还涉及放射性标记的化合物，其可用于使用正电子发射断层摄影（PET）在组织中成像和定量PDE2酶。本发明还涉及包含这些化合物的组合物，用于制备此类化合物和组合物的方法，以使用这些化合物和组合物用于在体外或体内成像组织，细胞或宿主以及所述化合物的前体。

9. 发明授权

US08450486B2 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors 有权
公开(公告)号：US08450486B2
公开(公告)日：2013-05-28
申请号：US13284110
申请日：2011-10-28
申请人： Dominique Jean-Pierre Mabire , Jérôme Emile Georges Guillemont , Jacobus Alphonsus Josephus Van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
发明人： Dominique Jean-Pierre Mabire , Jérôme Emile Georges Guillemont , Jacobus Alphonsus Josephus Van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
IPC分类号： A61K31/498
CPC分类号： C07D215/227 , C07D241/44 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/12
摘要： The present invention provides compounds of formula (I) and compounds of formula (VII-a) as well as pharmaceutical compositions comprising said compounds and their use as PARP inhibitors wherein n, R1, R2, R3, R4, R5, R6, R7, Re, Rd and X have defined meanings.

10. 发明授权

US08101629B2 Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 有权
标题翻译： 4 - [[4 - [[4-（2-氰基乙烯基）-2,6-二甲基苯基]氨基] -2-嘧啶基]氨基]苄腈
公开(公告)号：US08101629B2
公开(公告)日：2012-01-24
申请号：US12845463
申请日：2010-07-28
申请人： Jérôme Emile Georges Guillemont , Paul Theodoor Agnes Stevens , Alex Herman Copmans , Jozef Peeters , Alfred Elisabeth Stappers , Roger Petrus Gerebern Vandecruys , Paul Stoffels
发明人： Jérôme Emile Georges Guillemont , Paul Theodoor Agnes Stevens , Alex Herman Copmans , Jozef Peeters , Alfred Elisabeth Stappers , Roger Petrus Gerebern Vandecruys , Paul Stoffels
IPC分类号： A61K31/505 , C07D239/48 , A61P31/18
CPC分类号： A61K31/505 , A61K9/2018 , A61K9/2866 , C07D239/48
摘要： The present invention relates to a pharmaceutical composition comprising as active ingredient the hydrochloric acid salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethyl-phenyl]amino]-2-pyrimidinyl]amino]benzonitrile and to processes for their preparation.
摘要翻译：本发明涉及药物组合物，其包含4 - [[4 - [[4-（2-氰基乙烯基）-2,6-二甲基 - 苯基]氨基] -2-嘧啶基]氨基] 苄腈和其制备方法。

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