专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2004029053A1 NOVEL 1,4-DIAZABICYCLOALKANE DERIVATIVES, THEIR PREPARATION AND USE 审中-公开
标题翻译：新型1,4-二氮杂环戊烷衍生物，其制备和使用
公开(公告)号：WO2004029053A1
公开(公告)日：2004-04-08
申请号：PCT/DK2003/000639
申请日：2003-09-29
申请人： NEUROSEARCH A/S , PETERS, Dan , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , JØRGENSEN, Tino, Dyhring , AHRING, Philip, K.
发明人： PETERS, Dan , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , JØRGENSEN, Tino, Dyhring , AHRING, Philip, K.
IPC分类号： C07D471/08
CPC分类号： C07D471/08 , C07D487/04
摘要： This invention relates to novel 1,4-diazabicycloalkane derivatives of formula (I): any of its enantiomers or any mixture of its enantiomers, or a pharmaceutically-acceptable addition salt thereof, or an N-oxide thereof, and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
摘要翻译：本发明涉及式（I）的新型1,4-二氮杂双环烷烃衍生物：其任何对映异构体或其对映异构体的任何混合物或其药学上可接受的加成盐或其N-氧化物及其在制备中的用途的药物组合物。发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状有关的疾病或病症。

2. 发明申请

WO2004016608A1 NOVEL QUINUCLIDINE DERIVATIVES AND THEIR USE 审中-公开
标题翻译：新型喹啉衍生物及其用途
公开(公告)号：WO2004016608A1
公开(公告)日：2004-02-26
申请号：PCT/DK2003/000538
申请日：2003-08-13
申请人： NEUROSEARCH A/S , PETERS, Dan , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , AHRING, Philip, K. , JØRGENSEN, Tino, Dyhring
发明人： PETERS, Dan , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , AHRING, Philip, K. , JØRGENSEN, Tino, Dyhring
IPC分类号： C07D453/02
CPC分类号： C07D453/02
摘要： This invention relates to novel quinuclidine derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
摘要翻译：本发明涉及新的奎宁环衍生物及其作为药物的用途。由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状有关的疾病或病症。

3. 发明申请

WO2005111033A2 NOVEL AZABICYCLIC ARYL DERIVATIVES 审中-公开
标题翻译：新型亚硫酸衍生物衍生物
公开(公告)号：WO2005111033A2
公开(公告)日：2005-11-24
申请号：PCT/EP2005/052107
申请日：2005-05-10
申请人： NEUROSEARCH A/S , PETERS, Dan , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , JØRGENSEN, Tino, Dyhring , TIMMERMANN, Daniel, B.
发明人： PETERS, Dan , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , JØRGENSEN, Tino, Dyhring , TIMMERMANN, Daniel, B.
IPC分类号： C07D453/02
CPC分类号： C07D453/02
摘要： This invention relates to novel azabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
摘要翻译：本发明涉及在尼古丁乙酰胆碱受体中被发现是胆碱能配体的新的氮杂双环芳基衍生物。由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状有关的疾病或病症。

4. 发明申请

WO2003094831A3 NOVEL DIAZABICYCLIC BIARYL DERIVATIVES 审中-公开
公开(公告)号：WO2003094831A3
公开(公告)日：2003-11-20
申请号：PCT/DK2003/000295
申请日：2003-05-06
申请人： NEUROSEARCH A/S , PETERS, Dan , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , JØRGENSEN, Tino, Dyhring , AHRING, Philip, K.
发明人： PETERS, Dan , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , JØRGENSEN, Tino, Dyhring , AHRING, Philip, K.
IPC分类号： C07D487/08
摘要： This invention relates to novel diazabicyclic biaryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

5. 发明申请

WO2003094831A2 NOVEL DIAZABICYCLIC BIARYL DERIVATIVES 审中-公开
标题翻译：新型双歧双歧杆菌衍生物
公开(公告)号：WO2003094831A2
公开(公告)日：2003-11-20
申请号：PCT/DK2003/000295
申请日：2003-05-06
申请人： NEUROSEARCH A/S , PETERS, Dan , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , JØRGENSEN, Tino, Dyhring , AHRING, Philip, K.
发明人： PETERS, Dan , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , JØRGENSEN, Tino, Dyhring , AHRING, Philip, K.
IPC分类号： A61K
CPC分类号： C07D487/08
摘要： This invention relates to novel diazabicyclic biaryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
摘要翻译：本发明涉及新的二氮杂双环联芳基衍生物，其被发现是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状有关的疾病或病症。

6. 发明申请

WO2003094830A2 NOVEL AZACYCLIC ETHYNYL DERIVATIVES 审中-公开
标题翻译：新乙酰胆碱衍生物
公开(公告)号：WO2003094830A2
公开(公告)日：2003-11-20
申请号：PCT/DK2003/000294
申请日：2003-05-06
申请人： NEUROSEARCH A/S , PETERS, Dan , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , JØRGENSEN, Tino, Dyhring , AHRING, Philip, K.
发明人： PETERS, Dan , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , JØRGENSEN, Tino, Dyhring , AHRING, Philip, K.
IPC分类号： A61K
CPC分类号： C07D451/02 , C07D211/70 , C07D453/02
摘要： This invention relates to novel azacyclic ethynyl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
摘要翻译：本发明涉及新颖的氮杂环乙炔衍生物，其被发现是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状有关的疾病或病症。

7. 发明申请

WO2006058879A1 NOVEL DIAZABICYCLIC ARYL DERIVATIVES AS CHOLINERGY LIGANDS 审中-公开
标题翻译：新奇的双歧杆糖衍生物作为胆固醇配体
公开(公告)号：WO2006058879A1
公开(公告)日：2006-06-08
申请号：PCT/EP2005/056300
申请日：2005-11-29
申请人： NEUROSEARCH A/S , PETERS, Dan , TIMMERMANN, Daniel, B. , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , JØRGENSEN, Tino, Dyhring
发明人： PETERS, Dan , TIMMERMANN, Daniel, B. , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , JØRGENSEN, Tino, Dyhring
IPC分类号： C07D487/08 , A61K31/4995 , A61P25/00
CPC分类号： C07D487/08
摘要： This invention relates to novel diazabicyclic aryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
摘要翻译：本发明涉及新的二氮杂双环芳基衍生物，其被发现是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状有关的疾病或病症。

8. 发明申请

WO2005075479A1 DIMERIC AZACYCLIC COMPOUNDS AND THEIR USE 审中-公开
标题翻译：二甲基铝化合物及其用途
公开(公告)号：WO2005075479A1
公开(公告)日：2005-08-18
申请号：PCT/EP2005/050403
申请日：2005-02-01
申请人： NeuroSearch A/S , PETERS, Dan , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , JØRGENSEN, Tino, Dyhring , TIMMERMANN, Daniel, B.
发明人： PETERS, Dan , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , JØRGENSEN, Tino, Dyhring , TIMMERMANN, Daniel, B.
IPC分类号： C07D487/04
摘要： This invention relates to azacyclic derivatives according of formula (I) and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or. disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the' termination of abuse of chemical substances. Formula (I) Aza-X'-A'-Y'-L-Y-A"-X"-Aza Aza:Azabicyclic group A',A":Aromatic monocyclic and/or polycyclic, carbocyclic and /or heterocyclic group Y',Y": Linker or absent (covalent bond) L: Monocyclic or polycyclic, carbocyclic or heterocyclic group or is absent X',X": Linker or absent (covalent bond)
摘要翻译：本发明涉及式（I）的氮杂环十二烷基衍生物及其作为药物的用途。由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍平滑肌肉收缩，内分泌疾病或疾病，疾病或。与“终止化学物质的滥用”引起的与炎症，疼痛和戒断症状有关的神经变性，疾病或病症相关的疾病。式（I）Aza-X'-A'-Y'-LYA“-X”-Aza氮杂：氮杂双环基A'，A“：芳族单环和/或多环，碳环和/或杂环基Y'，Y” ：连接子或不存在（共价键）L：单环或多环，碳环或杂环基团或不存在X'，X“：连接基或不存在（共价键）

9. 发明申请

WO2004076453A1 NOVEL DIAZABICYCLIC ARYL DERIVATIVES 审中-公开
标题翻译：新型DIAZABICYCLIC ARYL DERIVATIVES
公开(公告)号：WO2004076453A1
公开(公告)日：2004-09-10
申请号：PCT/EP2004/050079
申请日：2004-02-04
申请人： NEUROSEARCH A/S , PETERS, Dan , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , JØRGENSEN, Tino, Dyhring , AHRING, Philip, K.
发明人： PETERS, Dan , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , JØRGENSEN, Tino, Dyhring , AHRING, Philip, K.
IPC分类号： C07D471/08
CPC分类号： C07D471/08
摘要： This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
摘要翻译：本发明涉及在尼古丁乙酰胆碱受体中被发现是胆碱能配体的新的二氮杂双环芳基衍生物。由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状有关的疾病或病症。

10. 发明申请

WO2003094830A3 NOVEL AZACYCLIC ETHYNYL DERIVATIVES 审中-公开
公开(公告)号：WO2003094830A3
公开(公告)日：2003-11-20
申请号：PCT/DK2003/000294
申请日：2003-05-06
申请人： NEUROSEARCH A/S , PETERS, Dan , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , JØRGENSEN, Tino, Dyhring , AHRING, Philip, K.
发明人： PETERS, Dan , OLSEN, Gunnar, M. , NIELSEN, Elsebet, Østergaard , JØRGENSEN, Tino, Dyhring , AHRING, Philip, K.
IPC分类号： C07D521/00
摘要： This invention relates to novel azacyclic ethynyl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式