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1. 发明申请

WO2011058165A1 LONG-ACTING Y2 RECEPTOR AGONISTS 审中-公开
标题翻译：长期行动Y2受体激素
公开(公告)号：WO2011058165A1
公开(公告)日：2011-05-19
申请号：PCT/EP2010/067454
申请日：2010-11-15
申请人： NOVO NORDISK A/S , KOFOED, Jacob , YNDDAL, Lars , ØSTERGAARD, Søren , JØRGENSEN, Rasmus , NIELSEN, Flemming Sejer , NILSSON, Cecilia , THOMSEN, Jens Kaalby
发明人： KOFOED, Jacob , YNDDAL, Lars , ØSTERGAARD, Søren , JØRGENSEN, Rasmus , NIELSEN, Flemming Sejer , NILSSON, Cecilia , THOMSEN, Jens Kaalby
IPC分类号： A61K38/22 , A61K47/48 , C07K14/575
CPC分类号： C07K14/575 , A61K47/542
摘要： The present invention relates to PYY derivatives comprising a serum albumin binding side chain, wherein said derivative has a half-life of at least 7 hours as determined by Assay (IV) described herein as well as compositions comprising said derivative and its use in therapy.
摘要翻译：本发明涉及包含血清白蛋白结合侧链的PYY衍生物，其中所述衍生物通过本文所述的测定（IV）测定的半衰期为至少7小时，以及包含所述衍生物的组合物及其在治疗中的用途。

2. 发明申请

WO2008138346A1 OMNI ROTATIONAL DRIVING AND STEERING WHEEL 审中-公开
标题翻译： OMNI旋转驱动和转向轮
公开(公告)号：WO2008138346A1
公开(公告)日：2008-11-20
申请号：PCT/DK2008/050103
申请日：2008-05-09
申请人： AARHUS UNIVERSITET , JØRGENSEN, Rasmus, Nyholm , MAAGAARD, Jørgen
发明人： JØRGENSEN, Rasmus, Nyholm , MAAGAARD, Jørgen
IPC分类号： B60K7/00
CPC分类号： B60K7/0007 , B60G3/01 , B60G2200/10 , B60G2200/44 , B60G2202/12 , B60G2202/42 , B60G2204/1244 , B60G2204/15 , B60G2204/182 , B60G2204/30 , B60G2204/419 , B60G2204/4191 , B60G2204/4232 , B60G2300/08 , B60G2300/36 , B60G2300/50 , B60K7/0015 , B60K17/043 , B60K17/046 , B60K2007/0046 , B60K2007/0084 , B60L2220/46 , B62D5/0418 , B62D7/02
摘要： There is disclosed a driving and steering wheel (112) module (102) with an omni rotational part (106), the module comprising a flange part (104) fixable on a robot, and the omni rotational part (106) comprises an upper omni rotational part (105) and a driving and steering wheel part (108), where the omni rotational part (106) is provided for infinite rotation relative to the flange part (104) by both a drive motor (110) and a steering motor (114) being positionable on the flange part (104), and the driving and steering wheel part (108) is suspended from the upper omni rotational part (105) with a suspension (116) such that wheel part (108) can move relatively to the upper omni rotational part (105) in a suspension direction (118), and a reduction gear (120) for gearing the drive torque is provided in the wheel part (108) in order e.g. to assure traction on various surfaces and at various loads.
摘要翻译：公开了具有全方位旋转部分（106）的驱动和方向盘（112）模块（102），该模块包括可固定在机器人上的凸缘部分（104），并且全向旋转部分（106）包括上部全向旋转部分（105）和驱动和方向盘部分（108），其中全方位旋转部分（106）被设置成通过驱动马达（110）和转向马达（...）两者相对于凸缘部分（104）无限旋转 114）可定位在凸缘部分（104）上，并且驱动和方向盘部分（108）利用悬架（116）从上部全方位旋转部分（105）悬挂，使得轮部分（108）可以相对于在悬架方向（118）上的上部全方向旋转部分（105）和用于传递驱动扭矩的减速齿轮（120）按照例如以确保在各种表面和各种载荷下的牵引力。

3. 发明申请

WO2008095503A1 SYSTEM FOR IMPLEMENT DRAFT REDUCTION 审中-公开
标题翻译：执行减速系统
公开(公告)号：WO2008095503A1
公开(公告)日：2008-08-14
申请号：PCT/DK2008/050026
申请日：2008-02-06
申请人： Aarhus Universitet , GREEN, Ole , JØRGENSEN, Rasmus Nyholm
发明人： GREEN, Ole , JØRGENSEN, Rasmus Nyholm
IPC分类号： A01B63/02 , A01B63/24 , A01B63/28 , A01B63/30 , A01B63/32 , A01B79/00 , A01B63/00
CPC分类号： A01B79/00 , A01B63/245
摘要： There is disclosed a system and method of reducing draft forces when working soil with agricultural soil working implements (206, 211) creating draft forces, the soil working implements (208, 206, 211) beingoperable connectable to a frame (204, 304, 404, 504, 604, 704) and moveable in a working direction, the frame having a working width (212), the method comprising working the soil in a first part (222) of the width (212), the first part of said width being smaller than the width (212), and hereafter working the soil in a second part (220) of the width, the second part of the width comprising an other part of said width (212) than the first part (222), so as e.g. to reduce draft forces compared to working both first and second parts at the same time.
摘要翻译：公开了一种系统和方法，该系统和方法在用农用土工作工具（206,211）施工土壤时减少牵引力，产生牵引力，土壤作业工具（208,206,211）可操作地连接到框架（204,304,404），504,604,704），并且可在工作方向上移动，所述框架具有工作宽度（212），所述方法包括在所述宽度（212）的第一部分（222）中对所述土壤进行加工，所述宽度的第一部分小于宽度（212），并且此后在宽度的第二部分（220）中操作土壤，宽度的第二部分包括比第一部分（222）所述宽度（212）的另一部分，因此例如以减少与第一和第二部分同时工作的牵引力。

4. 发明申请

WO2003056329A3 USE OF A SIGNAL TRANSDUCTION COMPLEX IN DRUG DISCOVERY PROCESSES 审中-公开
公开(公告)号：WO2003056329A3
公开(公告)日：2003-07-10
申请号：PCT/DK2002/000901
申请日：2002-12-20
申请人： 7TM PHARMA A/S , SCHWARTZ, Thue, W. , LANGE, Birgitte, Holst , HEYDORN, Arne , JØRGENSEN, Rasmus
发明人： SCHWARTZ, Thue, W. , LANGE, Birgitte, Holst , HEYDORN, Arne , JØRGENSEN, Rasmus
IPC分类号： G01N33/50
摘要： A drug discovery process for identification of a ligand that is able to bind to a biological target molecule, the process comprising a) constructing a signal transduction complex comprising a biological target molecule, one or more downstream effector molecules and, optionally, an adaptor protein, and b) contacting the ligand with the signal transduction complex, and c) measuring any effect resulting from a signal transduction process relating to the biological target molecule and one or more of the downstream effector molecules. A drug discovery process, wherein the signal transduction complex comprises a first component comprising a biological target molecule, a second component comprising one or more adaptor protein(s) and a third component comprising one or more downstream effector molecule(s), wherein each of the components recognizes or binds at least one of the other components to effect a signal transduction process, and wherein at least one of the components has been modified to contain one or more domains and/or one or more recognition motifs.

5. 发明申请

WO2011069512A1 METHOD AND SYSTEM FOR ESTIMATING HERBAGE UPTAKE OF AN ANIMAL 审中-公开
标题翻译：用于估计动物吃草的方法和系统
公开(公告)号：WO2011069512A1
公开(公告)日：2011-06-16
申请号：PCT/DK2010/050334
申请日：2010-12-10
申请人： SYDDANSK UNIVERSITET , OUDSHOORN, Frank Willem , NADIMI, Esmaeil Shahrak , JØRGENSEN, Rasmus Nyholm
发明人： OUDSHOORN, Frank Willem , NADIMI, Esmaeil Shahrak , JØRGENSEN, Rasmus Nyholm
IPC分类号： A01K29/00
CPC分类号： A01K29/005 , A01K11/008
摘要： The invention relates to a method and a system for estimating the feeding value or the amount of consumed herbage of grazing animals. The estimated herbage uptake is based on measured and possibly estimated data which is supplied as input data to a mathematical model. Measured input data may be acceleration data of the head of the animal, the length of herbage and the quality, i.e. feeding value, of herbage. Estimated input data may be the frequency of the reciprocate head motion of the animal and the in-active or active grazing status of the cow. Alternatively, the estimated data may be determined by the model and possibly provided as output data. Measurements may be obtained by a sensor module carried by the animal and the measurements may be wirelessly transmitted from the sensor module to a receiver, possibly via relay transceivers.
摘要翻译：本发明涉及一种用于估计放牧动物的饲养价值或消费草本数量的方法和系统。估计的草料摄取是基于作为数学模型的输入数据提供的测量和可能估计的数据。测量的输入数据可以是动物头部的加速度数据，草本的长度和质量，即喂食价值。估计的输入数据可以是动物往复运动的频率和母牛的主动或主动放牧状态。或者，估计数据可以由模型确定，并且可以被提供为输出数据。可以通过由动物携带的传感器模块来获得测量，并且测量可以可能经由中继收发器从传感器模块无线地传送到接收器。

6. 发明申请

WO2010003421A1 METHOD FOR OPTIMIZING HARVESTING OF CROPS 审中-公开
标题翻译：优化采收方法
公开(公告)号：WO2010003421A1
公开(公告)日：2010-01-14
申请号：PCT/DK2009/050150
申请日：2009-06-26
申请人： Aarhus Universitet , Syddansk Universitet , GREEN, Ole , JØRGENSEN, Rasmus Nyholm , GISLUM, René , SØRENSEN, Claus Aage Grøn
发明人： GREEN, Ole , JØRGENSEN, Rasmus Nyholm , GISLUM, René , SØRENSEN, Claus Aage Grøn
IPC分类号： A01B79/00 , A01D41/127
CPC分类号： A01D91/04 , A01B79/005
摘要： In order e.g. to optimize harvesting crops of the kind which may be self dried on a field prior to a harvesting step (116, 118), there is disclosed a method of providing a mobile unit (102) for working (114, 116, 118) the field with crops, equipping the mobile unit (102) with crop biomass measuring means (108) and with crop moisture content measurement means (106), measuring crop biomass (107a, 107b) and crop moisture content (109a, 109b) of the crop, providing a spatial crop biomass and crop moisture content characteristics map of the field based on the biomass data (107a, 107b) provided from moving the mobile unit on the field and the moisture content (109a, 109b), and determining an optimised drying time (104a, 104b) prior to the following harvesting step (116, 118) in response to the spatial crop biomass and crop moisture content characteristics map and in response to a weather forecast (110).
摘要翻译：例如为了优化在收获步骤（116,118）之前在田地上可能自干的种类的收割作物，公开了一种提供用于工作的移动单元（114,116,118）的方法，用作物装备移动单元（102）作物生物量测量装置（108）和用作物水分含量测量装置（106），测量作物的作物生物量（107a，107b）和作物水分含量（109a，109b）基于从现场移动移动单元和水分含量（109a，109b）提供的生物量数据（107a，107b）提供空间作物生物量和作物水分含量特征图，并确定优化的干燥时间（ 104a，104b），在响应于空间作物生物量和作物水分含量特征图以及响应于天气预报（110）之后，在随后的收获步骤（116,118）之前。

7. 发明申请

WO2011033068A1 LONG-ACTING Y2 RECEPTOR AGONISTS 审中-公开
标题翻译：长期行动Y2受体激素
公开(公告)号：WO2011033068A1
公开(公告)日：2011-03-24
申请号：PCT/EP2010/063707
申请日：2010-09-17
申请人： NOVO NORDISK A/S , KOFOED, Jacob , OLSEN, Jørgen , ØSTERGAARD, Søren , JØRGENSEN, Rasmus
发明人： KOFOED, Jacob , OLSEN, Jørgen , ØSTERGAARD, Søren , JØRGENSEN, Rasmus
IPC分类号： A61K38/22 , A61K47/48 , C07K14/575
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention relates to PYY analogues or derivatives thereof comprising at least one alteration selected from the group consisting of substitutions, insertions, deletions and modifications and optionally a serum albumin binding side chain comprising an alkyl chain with at least 14 carbon atoms. Moreover, the invention relates to compositions hereof and methods of treatment of conditions responsive to Y2 receptor modulation.
摘要翻译：本发明涉及包含至少一种选自取代，插入，缺失和修饰的改变的PYY类似物或其衍生物，以及任选地包含具有至少14个碳原子的烷基链的血清白蛋白结合侧链。此外，本发明涉及本发明的组合物和治疗对Y2受体调节作用的病症的方法。

8. 发明申请

WO2003055914A3 MODIFIED RECEPTORS FOR THE DISCOVERY OF THERAPEUTIC LIGANDS 审中-公开
公开(公告)号：WO2003055914A3
公开(公告)日：2003-07-10
申请号：PCT/DK2002/000900
申请日：2002-12-20
申请人： 7TM PHARMA A/S , SCHWARTZ, Thue, W. , MARTINI, Lene , HEYDORN, Arne , JØRGENSEN, Rasmus
发明人： SCHWARTZ, Thue, W. , MARTINI, Lene , HEYDORN, Arne , JØRGENSEN, Rasmus
IPC分类号： C07K14/705
摘要： A drug discovery method for selecting a compound selected from the group consisting of a small organic substance, a biopharmaceutical and an antibody or part thereof. The method comprises the steps of i) expressing one or more receptors on a cell membrane, such as, e.g., an exterior cell surface of a cell, ii) contacting one or more expressed receptors with a test compound or a selection of test compounds (libraries) and iii) selecting one or more compounds based on its ability to bind one or more receptors. The step of expressing the one or more receptors comprises capturing one or more receptors on the exterior cell surface in a conformation that predominantly enables binding or interaction with a ligand, and the conformation that predominantly enables binding or interaction with a ligand is provided by modification of one or more receptors by a method comprising at least one of the following: (a) fusion with any protein which keeps the receptor in the desired conformation such as, e.g. an arrestin, a modified arrestin, a G-protein or a modified G-protein, (b) site-directed mutagenesis, and (c) deletion. The receptors may be captured on the exterior cell surface by at least one of the following: (d) interaction of the receptor with a scaffolding protein, optionally, with a scaffolding protein network and (e) means for blocking receptor internalization, e.g. by co-expression of a mutated dynamin or a modified arrestin or by use of chemicals such as, e.g., sucrose and/or Tris.

9. 发明申请

WO2009138511A1 LONG-ACTING Y2 AND/OR Y4 RECEPTOR AGONISTS 审中-公开
标题翻译：长期行动Y2和/或Y4受体激素
公开(公告)号：WO2009138511A1
公开(公告)日：2009-11-19
申请号：PCT/EP2009/055989
申请日：2009-05-18
申请人： NOVO NORDISK A/S , ØSTERGAARD, Søren , KNUDSEN, Sanne Møller , SPETZLER, Jane , JØRGENSEN, Rasmus , KOFOED, Jacob
发明人： ØSTERGAARD, Søren , KNUDSEN, Sanne Møller , SPETZLER, Jane , JØRGENSEN, Rasmus , KOFOED, Jacob
IPC分类号： C07K14/575 , A61K38/17
CPC分类号： C07K14/575 , A61K47/542
摘要： The present invention relates to a PYY or PP peptide derivative or analogue thereof derivatised with one or more serum albumin binding side chains comprising a dis-tal tetrazole or carboxylic acid group. Moreover, the invention relates to compositions hereof and methods of treatment of conditions responsive to Y receptor modulation.
摘要翻译：本发明涉及用包含四唑或羧酸基团的一种或多种血清白蛋白结合侧链衍生的PYY或PP肽衍生物或其类似物。此外，本发明涉及本发明的组合物和治疗对Y受体调节作用的病症的方法。

10. 发明申请

WO2003056329A2 USE OF A SIGNAL TRANSDUCTION COMPLEX IN DRUG DISCOVERY PROCESSES 审中-公开
标题翻译：在药物发现过程中使用信号传导复合物
公开(公告)号：WO2003056329A2
公开(公告)日：2003-07-10
申请号：PCT/DK2002/000901
申请日：2002-12-20
申请人： 7TM PHARMA A/S , SCHWARTZ, Thue, W. , LANGE, Birgitte, Holst , HEYDORN, Arne , JØRGENSEN, Rasmus
发明人： SCHWARTZ, Thue, W. , LANGE, Birgitte, Holst , HEYDORN, Arne , JØRGENSEN, Rasmus
IPC分类号： G01N33/50
CPC分类号： C12Q1/00 , G01N33/50
摘要： A drug discovery process for identification of a ligand that is able to bind to a biological target molecule, the process comprising a) constructing a signal transduction complex comprising a biological target molecule, one or more downstream effector molecules and, optionally, an adaptor protein, and b) contacting the ligand with the signal transduction complex, and c) measuring any effect resulting from a signal transduction process relating to the biological target molecule and one or more of the downstream effector molecules. A drug discovery process, wherein the signal transduction complex comprises a first component comprising a biological target molecule, a second component comprising one or more adaptor protein(s) and a third component comprising one or more downstream effector molecule(s), wherein each of the components recognizes or binds at least one of the other components to effect a signal transduction process, and wherein at least one of the components has been modified to contain one or more domains and/or one or more recognition motifs.
摘要翻译：用于鉴定能够结合生物靶分子的配体的药物发现方法，所述方法包括构建包含生物靶分子，一个或多个下游效应分子和任选的衔接蛋白的信号转导复合物，和 b使配体与信号转导复合体接触，以及c测量由与生物靶分子和一个或多个下游效应分子相关的信号转导过程产生的任何影响。一种药物发现方法，其中所述信号转导复合物包含包含生物靶分子的第一组分，包含一种或多种衔接蛋白的第二组分和包含一种或多种下游效应分子的第三组分，其中每种组分识别或结合于影响信号转导过程的其它组分中的至少一种，并且其中至少一种组分已被修饰以含有一个或多个结构域和/或一个或多个识别基序。

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