会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 5. 发明授权
    • Production of vitamin K.sub.1 and vitamin K.sub.2
    • 生产维生素K1和维生素K2
    • US4229356A
    • 1980-10-21
    • US15868
    • 1979-02-27
    • Iwao TabushiHiroyuki SugimotoAkira Yazaki
    • Iwao TabushiHiroyuki SugimotoAkira Yazaki
    • C07C45/68C07C46/02C07C49/62C07C39/14
    • C07C45/68C07C46/02
    • A process for producing hydro-precursors for vitamin K.sub.1 and vitamin K.sub.2 which comprises reacting (A) 2-methylhydronaphthoquinone-1,4 with (B) a compound selected from the group consisting of phytyl bromide, isophytyl bromide, geranyl bromide, farnesyl bromide, geranylgeranyl bromide and the corresponding chlorides in a reaction system which comprises an aqueous phase comprising an aqueous solution of an alkali and an oily phase comprising a hydrophobic organic solvent, in the presence of a salt comprising a quaternary ammonium ion or a tetraalkyl phosphonium ion represented by the formula (I) or formula (II): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each represent an alkyl or aralkyl group containing from 1 to 20 carbon atoms and the sum of the carbons in R.sub.1, R.sub.2, R.sub.3 and R.sub.4 groups is at least 12. The resultant hydro-precursor is oxidized to convert it into vitamin K.sub.1 or vitamin K.sub.2.
    • 一种用于生产维生素K1和维生素K2的水解前体的方法,其包括使(A)2-甲基氢醌萘醌-1,4-与(B)选自植物溴,间苯二酚,香叶基溴,法呢基溴, 香叶基香叶基溴化物和反应体系中相应的氯化物,其包含含有包含疏水性有机溶剂的碱和油相的水溶液的水相,所述水相包含季铵离子或四烷基鏻离子 式(I)或式(II):其中R 1,R 2,R 3和R 4各自表示含有1至20个碳原子的烷基或芳烷基, R1,R2,R3和R4基团中的碳原子数至少为12.所得的氢前体被氧化,将其转化成维生素K1或维生素K2。