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1. 发明申请

WO2010128388A2 AN IMPROVED PROCESS FOR THE PREPARATION OF INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF CINACALCET 审中-公开
标题翻译：制备适用于制备CINACALCET的中间体化合物的改进方法
公开(公告)号：WO2010128388A2
公开(公告)日：2010-11-11
申请号：PCT/IB2010/001057
申请日：2010-05-10
申请人： AUROBINDO PHARMA LIMITED , DIVVELA, Venkata Naga Srinivasa Rao , GUNTUPALLY, Srikanth , DEEKONDA, Satheesh , RACHA, Lenin , RAY, Uttam Kumar , ISLAM, Aminul , MEENAKSHISUNDERAM, Sivakumaran
发明人： DIVVELA, Venkata Naga Srinivasa Rao , GUNTUPALLY, Srikanth , DEEKONDA, Satheesh , RACHA, Lenin , RAY, Uttam Kumar , ISLAM, Aminul , MEENAKSHISUNDERAM, Sivakumaran
CPC分类号： C07C211/30 , C07B2200/07 , C07C29/147 , C07C45/29 , C07C45/30 , C07C33/483 , C07C47/24
摘要： The present invention provides an improved process for the preparation of 3-[3-(trifluoromethyl)phenyl]-2-propenal (IIIa), (formula IIIa) and 3-[3-(trifluoromethyl)phenyl]-2-propen-1-ol (IVb), (formula IVb) The compounds of Formula IIIa and IVb are key precursors in the preparation of Calcimimetic agent, Cinacalcet hydrochloride of Formula I.
摘要翻译：本发明提供了制备3- [3-（三氟甲基）苯基] -2-丙烯醛（IIIa），（式IIIa）和3- [3-（三氟甲基）苯基] -2-丙烯-1-酮的改进方法（IVb），（式IVb）式Ⅲa和Ⅳb的化合物是制剂中拟钙剂，式Ⅰ的盐酸西那卡塞的关键前体。

2. 发明申请

WO2006010078A2 POLYMORPHIC FORM OF NARATRIPTAN HYDROCHLORIDE 审中-公开
标题翻译：盐酸那拉比坦的多晶型
公开(公告)号：WO2006010078A2
公开(公告)日：2006-01-26
申请号：PCT/US2005/024435
申请日：2005-07-08
申请人： DR. REDDY'S LABORATORIES LTD. , DR. REDDY'S LABORATORIES, INC. , ISLAM, Aminul , SAHADEV, Katam , REDDY, Madadi Vijaypal , KULKARNI, Ruturaj Vijay , LAYEK, Mohammed, Mohosin , BHAR, Chandan
发明人： ISLAM, Aminul , SAHADEV, Katam , REDDY, Madadi Vijaypal , KULKARNI, Ruturaj Vijay , LAYEK, Mohammed, Mohosin , BHAR, Chandan
IPC分类号： A61K31/4178
CPC分类号： C07D401/04
摘要： Naratriptan hydrochloride having a new crystalline form is prepared by providing a solution of naratriptan hydrochloride in a polar solvent, cooling the solution to temperatures about 0 to 20°C to form crystals, and isolating the naratriptan hydrochloride.
摘要翻译：通过提供盐酸那拉曲坦在极性溶剂中的溶液，将溶液冷却至约0至20℃的温度以形成晶体并分离盐酸那拉曲坦来制备具有新结晶形式的盐酸纳曲普坦。

3. 发明申请

WO2021123935A1 AN IMPROVED PROCESS FOR PREPARATION OF AN AZOLE FUNGICIDE 审中-公开
公开(公告)号：WO2021123935A1
公开(公告)日：2021-06-24
申请号：PCT/IB2020/059038
申请日：2020-09-28
申请人： COROMANDEL INTERNATIONAL LIMITED , NARKEDIMILLI, Venkata Krishna Kishore , PERLA, Venkata Balireddy , DURGA, Ramesh Kumar , BHAVANI, Balram , ISLAM, Aminul
发明人： NARKEDIMILLI, Venkata Krishna Kishore , PERLA, Venkata Balireddy , DURGA, Ramesh Kumar , BHAVANI, Balram , ISLAM, Aminul
IPC分类号： A01N43/653 , C07D249/08
摘要： The present invention relates to improved process for the preparation of a fungicide of the class of azoles. The present invention specifically relates to an improved process for the preparation of (2RS,3RS;2SR,3SR)-2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol having the following Formula I.

4. 发明申请

WO2021024135A1 AN IMPROVED PROCESS FOR PREPARATION OF METHYL (2E)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE 审中-公开
公开(公告)号：WO2021024135A1
公开(公告)日：2021-02-11
申请号：PCT/IB2020/057273
申请日：2020-07-31
申请人： COROMANDEL INTERNATIONAL LIMITED , NARKEDIMILLI, Venkata Krishna Kishore , DURGA, Ramesh Kumar , BHAVANI, Balram , ISLAM, Aminul
发明人： NARKEDIMILLI, Venkata Krishna Kishore , DURGA, Ramesh Kumar , BHAVANI, Balram , ISLAM, Aminul
IPC分类号： C07D401/12 , C07D239/52 , C07C67/327
摘要： The present invention relates to an improved processses for synthesizing preparing substituted cyanophenoxy-pyrimidinyloxy-phenyl acrylate derivatives. The present invention specifically relates to an improved process for the preparation of methyl (2E)-2-(2-{[6-(2-cyanophenoxy)pyrimidin-4-yl]oxy}phenyl)-3-methoxyacrylate having the following Formula I.

5. 发明申请

WO2006010078A3 POLYMORPHIC FORM OF NARATRIPTAN HYDROCHLORIDE 审中-公开
标题翻译： NARATRIPTAN HYDROCHLORIDE的多晶型
公开(公告)号：WO2006010078A3
公开(公告)日：2006-10-05
申请号：PCT/US2005024435
申请日：2005-07-08
申请人： REDDYS LAB LTD DR , REDDYS LAB INC DR , ISLAM AMINUL , SAHADEV KATAM , REDDY MADADI VIJAYPAL , KULKARNI RUTURAJ VIJAY , LAYEK MOHAMMED MOHOSIN , BHAR CHANDAN
发明人： ISLAM AMINUL , SAHADEV KATAM , REDDY MADADI VIJAYPAL , KULKARNI RUTURAJ VIJAY , LAYEK MOHAMMED MOHOSIN , BHAR CHANDAN
IPC分类号： A61K31/445 , C07D401/04
CPC分类号： C07D401/04
摘要： Naratriptan hydrochloride having a new crystalline form is prepared by providing a solution of naratriptan hydrochloride in a polar solvent, cooling the solution to temperatures about 0 to 20°C to form crystals, and isolating the naratriptan hydrochloride.
摘要翻译：通过在极性溶剂中提供盐酸纳拉曲坦溶液制备具有新结晶形式的盐酸纳拉曲坦，将溶液冷却至约0至20℃的温度以形成晶体，并分离盐酸纳拉曲坦。

6. 发明申请

US20130144067A1 PROCESS FOR THE PREPARATION OF VALSARTAN 有权
标题翻译：制备VALSARTAN的方法
公开(公告)号：US20130144067A1
公开(公告)日：2013-06-06
申请号：US13261552
申请日：2011-06-24
申请人： Raveendra Reddy Chinta , Gangadhara Bhima Shankar Nangi , Mahendar Reddy Nayini , Somappa Somannavar Yallapa , Shankar Reddy Budidet , Islam Aminul , Sivakumaran Meenakshisunderam
发明人： Raveendra Reddy Chinta , Gangadhara Bhima Shankar Nangi , Mahendar Reddy Nayini , Somappa Somannavar Yallapa , Shankar Reddy Budidet , Islam Aminul , Sivakumaran Meenakshisunderam
IPC分类号： C07D257/04
CPC分类号： C07D257/04
摘要： The present invention relates to a process for the preparation of pure Valsartan (I) substantially free from impurities of formulae (Ia), (Ib), and (Ic), which comprises: (i) condensing 2-(4′-bromomethylphenyl)benzonitrile of formula (II) with L-valine methyl ester hydrochloride of formula (V) in the presence of a base in a solvent to produce N-[(2′-cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester of formula (VI); (ii) treating the compound VI of step (i) with acid followed by treating with base to produce pure compound VI substantially free from dimeric impurity of formula (Via); (iii) reacting the pure compound of formula (VI) with n-valeryl chloride in the presence of a base to produce pure N-valeryl-N-[(2′-cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester (VII) substantially free from alkene impurity of formula (Vila); (iv) reacting the compound of formula (VII) with trialkyltin chloride and a metal azide in a solvent at a reflux temperature to produce N-(1-oxopentyl)-N-[[2′-(2-tributyltinte-trazol-5-yl)-(1,1′-biphenyl)-4-yl]methyl]-(L)-valine methyl ester of formula (VHIb) free from thermal degradation impurity (Villa); (v) hydrolyzing the compound of formula (VHIb) in the presence of alkaline conditions to produce Valsartan (I).
摘要翻译：本发明涉及制备基本上不含式（Ia），（Ib）和（Ic）杂质的纯缬沙坦（I）的方法，其包括：（i）将2-（4'-溴甲基苯基）（II）的苄腈与式（V）的L-缬氨酸甲酯盐酸盐在碱的存在下在溶剂中反应，得到N - [（2'-氰基联苯-4-基）甲基] - （L） - 缬氨酸（VI）的甲酯; （ii）用酸处理步骤（i）的化合物VI，然后用碱处理以产生基本上不含式（VIa）的二聚杂质的纯化合物VI; （ⅲ）在碱的存在下使式（Ⅵ）的纯的化合物与正戊酰氯反应，得到纯的N-戊酰基-N - [（2'-氰基联苯-4-基）甲基] - （L） - 缬氨酸甲酯（VII）基本上不含式（VIIa）的烯烃杂质; （ⅳ）使式（Ⅶ）化合物与氯化三烷基锡和金属叠氮化物在溶剂中在回流温度下反应，得到N-（1-氧代戊基）-N - [[2' - （2-三丁基锡 - （1,1'-联苯基）-4-基]甲基] - （L）缬氨酸甲酯（VHIb）不含热降解杂质（Villa）; （v）在碱性条件存在下水解式（VHIb）化合物以制备缬沙坦（I）。

7. 发明申请

WO2022149077A1 AZADIRACHTIN FORMULATIONS AND PROCESS FOR PREPARING AND USE THEREOF 审中-公开
公开(公告)号：WO2022149077A1
公开(公告)日：2022-07-14
申请号：PCT/IB2022/050077
申请日：2022-01-06
申请人： COROMANDEL INTERNATIONAL LIMITED , ISLAM, Aminul , BHAVANI, Balaram , PAWAR, Kiran , CHINAGA, Suresh Kumar , MANIKANDAN, Manoj , PONNUSAMY, Manimaran , NAGARAJAN, Deebana , POOMALAI, Karthick , CHELLAMUTHU, Prabakaran
发明人： ISLAM, Aminul , BHAVANI, Balaram , PAWAR, Kiran , CHINAGA, Suresh Kumar , MANIKANDAN, Manoj , PONNUSAMY, Manimaran , NAGARAJAN, Deebana , POOMALAI, Karthick , CHELLAMUTHU, Prabakaran
IPC分类号： A61K36/58
摘要： The present invention relates to stable Azadirachtin formulations comprising Azadirachtin as active ingredient and other agronomic additives. The present invention also relates to stable Azadirachtin microemulsion formulation comprising Azadirachtin as active ingredient, other agronomic additives selected from a surfactant and one or more solvents. The present invention more specifically relates to stable Azadirachtin microemulsion formulation comprising Azadirachtin as active ingredient, a surfactant, solvent, wherein the said formulation is devoid of additional plant extract/oils. The present invention also relates to a process for the preparation of Azadirachtin formulations and other agronomic additives comprising steps of dissolving all ingredients and stirring to get clear solution.

8. 发明申请

WO2022043938A1 SYNERGISTIC PHENOXY HERBICIDAL COMBINATION FORMULATIONS, PROCESS FOR PREPARING AND USE THEREOF 审中-公开
公开(公告)号：WO2022043938A1
公开(公告)日：2022-03-03
申请号：PCT/IB2021/057867
申请日：2021-08-27
申请人： COROMANDEL INTERNATIONAL LIMITED , DOSETTY, Sai Kiran , BHAVANI, Balaram , TRIVEDI, Rajan Kumar , EDOLIYA, Rajul , ISLAM, Aminul , DSOUZA, Jaison Joyal , DURGA, Ramesh Kumar
发明人： DOSETTY, Sai Kiran , BHAVANI, Balaram , TRIVEDI, Rajan Kumar , EDOLIYA, Rajul , ISLAM, Aminul , DSOUZA, Jaison Joyal , DURGA, Ramesh Kumar
IPC分类号： A61K45/06
摘要： The present invention relates to synergistic herbicidal composition comprising combination of a phenoxy herbicide and imidazolinone herbicide. The present invention also relates to synergistic herbicidal composition comprising combination of a phenoxy herbicide, imidazolinone herbicide and other agrochemical auxiliaries. The present invention also relates to synergistic herbicidal composition comprising combination of a phenoxy herbicide, imidazolinone herbicide, an emulsifier and other agrochemical auxiliaries, wherein said phenoxy herbicide is selected from Fenoxaprop-P-ethyl and Clodinafop-propargyl, said imidazolinone herbicide is Imazethapyr. The present invention also relates to a process for the preparation of synergistic herbicidal composition comprising combination of phenoxy herbicide and imidazolinone herbicide, wherein the composition is prepared by simple blending and milling process.

9. 发明申请

WO2022029706A1 SYNERGISTIC FUNGICIDAL COMPOSITION 审中-公开
公开(公告)号：WO2022029706A1
公开(公告)日：2022-02-10
申请号：PCT/IB2021/057258
申请日：2021-08-06
申请人： COROMANDEL INTERNATIONAL LIMITED , DSOUZA, Jaison Joyal , BHAVANI, Balaram , EDOLIYA, Rajul , ISLAM, Aminul
发明人： DSOUZA, Jaison Joyal , BHAVANI, Balaram , EDOLIYA, Rajul , ISLAM, Aminul
IPC分类号： A01P3/00 , A01N43/40 , A01N43/54 , A01N43/56 , A01N43/78 , A01N43/90 , A01N37/44 , A01N43/80 , C07D417/14
摘要： The present invention relates to stable synergistic triple combination fungicidal composition comprising of a) strobilurin fungicide, b) systemic fungicide and c) polymeric dithiocarbamate fungicide complex with zinc salt. The present invention specifically relates to stable synergistic fungicidal composition comprising combination of Picoxystrobin, Dimethomorph, Mancozeb and agrochemical auxiliaries. The present invention more specifically relates to stable synergistic fungicidal composition comprising combination of Picoxystrobin, Dimethomorph and Mancozeb at a weight in the ratio of 1 : 5 : 15 to 1 : 10 : 50, wetting agent, dispersing agent, rheology modifier and other agrochemical auxiliaries. The present invention also relates to a process for the preparation of synergistic fungicidal composition by simple blending and milling.

10. 发明申请

WO2021255664A1 INSECTICIDAL WDG FORMULATIONS AND PROCESS FOR PREPARING AND USE THEREOF 审中-公开
公开(公告)号：WO2021255664A1
公开(公告)日：2021-12-23
申请号：PCT/IB2021/055309
申请日：2021-06-16
申请人： COROMANDEL INTERNATIONAL LIMITED , PAWAR, Kiran , DURGA, Ramesh Kumar , BHAVANI, Balaram , ISLAM, Aminul
发明人： PAWAR, Kiran , DURGA, Ramesh Kumar , BHAVANI, Balaram , ISLAM, Aminul
IPC分类号： A01N25/12
摘要： The present invention relates to insecticidal water dispersible granule (WDG) composition comprising combination of a) thiourea derivative, and b) thiazox acaricide. The present invention specifically relates to insecticidal water dispersible granule composition comprising combination of diafenthiuron and hexythiazox, wetting agent, dispersing agent and other agrochemical auxiliaries. The present invention also relates to a process for the preparation of insecticidal water dispersible granule composition comprising combination of diafenthiuron and hexythiazox, wherein the granules are prepared by extrusion process.

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