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1. 发明授权

US10912646B2 Methods, apparatus and devices to treat heart valves 有权
公开(公告)号：US10912646B2
公开(公告)日：2021-02-09
申请号：US16987927
申请日：2020-08-07
申请人： Invalve Therapeutics, Inc.
发明人： Paul A Spence
IPC分类号： A61F2/24
摘要： Apparatus for treating blood flow regurgitation through a native heart valve (16) includes a selective occlusion device sized and configured to be implanted in the native heart valve (16) and selectively operating with at least one of the first or second native leaflets (16a, 16b) to allow blood flow through the native heart valve (16) when the heart cycle is in diastole and reduce blood flow regurgitation through the native heart valve (16) when the heart cycle is in systole. A clip structure (50) is coupled with the selective occlusion device. The clip structure (50) is configured to be affixed to a margin of at least one of the first or second native leaflets (16a, 16b) to secure the selective occlusion device to the native heart valve (16).

2. 发明公开

US20230329866A1 METHODS, APPARATUS AND DEVICES TO TREAT HEART VALVES 审中-公开
公开(公告)号：US20230329866A1
公开(公告)日：2023-10-19
申请号：US18083710
申请日：2022-12-19
申请人： InValve Therapeutics, Inc.
发明人： Paul A. SPENCE
IPC分类号： A61F2/24
CPC分类号： A61F2/246 , A61F2/2412 , A61F2/2418 , A61F2/2463 , A61F2/2466 , A61F2220/0016
摘要： Apparatus for treating blood flow regurgitation through a native heart valve includes a selective occlusion device sized and configured to be implanted in the native heart valve and selectively operating with at least one of the first or second native leaflets to allow blood flow through the native heart valve when the heart cycle is in diastole and reduce blood flow regurgitation through the native heart valve when the heart cycle is in systole. A clip structure is coupled with the selective occlusion device. The clip structure is configured to be affixed to a margin of at least one of the first or second native leaflets to secure the selective occlusion device to the native heart valve.

3. 发明申请

US20220142772A1 METHODS, APPARATUS AND DEVICES TO TREAT HEART VALVES 有权
公开(公告)号：US20220142772A1
公开(公告)日：2022-05-12
申请号：US17582855
申请日：2022-01-24
申请人： InValve Therapeutics, Inc.
发明人： Paul A. SPENCE
IPC分类号： A61F2/24
摘要： Apparatus for treating blood flow regurgitation through a native heart valve includes a selective occlusion device sized and configured to be implanted in the native heart valve and selectively operating with at least one of the first or second native leaflets to allow blood flow through the native heart valve when the heart cycle is in diastole and reduce blood flow regurgitation through the native heart valve when the heart cycle is in systole. A clip structure is coupled with the selective occlusion device. The clip structure is configured to be affixed to a margin of at least one of the first or second native leaflets to secure the selective occlusion device to the native heart valve.

4. 发明授权

US11559401B2 Methods, apparatus and devices to treat heart valves 有权
公开(公告)号：US11559401B2
公开(公告)日：2023-01-24
申请号：US17582855
申请日：2022-01-24
申请人： InValve Therapeutics, Inc.
发明人： Paul A. Spence
IPC分类号： A61F2/24
摘要： Apparatus for treating blood flow regurgitation through a native heart valve includes a selective occlusion device sized and configured to be implanted in the native heart valve and selectively operating with at least one of the first or second native leaflets to allow blood flow through the native heart valve when the heart cycle is in diastole and reduce blood flow regurgitation through the native heart valve when the heart cycle is in systole. A clip structure is coupled with the selective occlusion device. The clip structure is configured to be affixed to a margin of at least one of the first or second native leaflets to secure the selective occlusion device to the native heart valve.

5. 发明申请

US20210128296A1 METHODS, APPARATUS AND DEVICES TO TREAT HEART VALVES 有权
公开(公告)号：US20210128296A1
公开(公告)日：2021-05-06
申请号：US17144510
申请日：2021-01-08
申请人： InValve Therapeutics, Inc.
发明人： Paul A. SPENCE
IPC分类号： A61F2/24
摘要： Apparatus for treating blood flow regurgitation through a native heart valve (16) includes a selective occlusion device sized and configured to be implanted in the native heart valve (16) and selectively operating with at least one of the first or second native leaflets (16a, 16b) to allow blood flow through the native heart valve (16) when the heart cycle is in diastole and reduce blood flow regurgitation through the native heart valve (16) when the heart cycle is in systole. A clip structure (50) is coupled with the selective occlusion device. The clip structure (50) is configured to be affixed to a margin of at least one of the first or second native leaflets (16a, 16b) to secure the selective occlusion device to the native heart valve (16).

6. 发明申请

WO2022006375A1 HEART VALVE PROSTHESES AND RELATED METHODS 审中-公开
公开(公告)号：WO2022006375A1
公开(公告)日：2022-01-06
申请号：PCT/US2021/040053
申请日：2021-07-01
申请人： INVALVE THERAPEUTICS, INC. , SPENCE, Paul , PAOLITTO, Anthony
发明人： SPENCE, Paul , PAOLITTO, Anthony
IPC分类号： A61F2/24 , A61F2/2412 , A61F2/246 , A61F2/2463 , A61F2/2466
摘要： Prosthetic valves for treating blood flow regurgitation through a native heart valve can include a body including an inlet portion and an outlet portion having a first limb and a second limb, and defining a flow passage having an inlet in the inlet portion, a first outlet in the first limb and a second outlet in the second limb, a flow control device disposed in the flow passage within the inlet portion, and a clip connector coupled to the body. The prosthetic valve is configured to be disposed in a native valve of a heart that has been clipped to create a first flow control portion and a second flow control portion, with the inlet disposed in an atrium of the heart, and with the first outlet and the second outlet disposed in the ventricle of the heart, with the limbs configured to be disposed in the flow control portions in substantially sealing relationship with the first leaflet and the second leaflet. The prosthetic valve is further configured to permit blood to flow from the atrium to the ventricle through the flow passage, and to substantially prevent blood to flow from the ventricle to the atrium though the flow passage or between the body and the leaflets during systole of the heart. The clip connector is configured to be selectively coupled to the clip and to resist displacement of the body towards the atrium during systole.

7. 发明公开

EP4175589A1 HEART VALVE PROSTHESES AND RELATED METHODS 审中-实审转让
公开(公告)号：EP4175589A1
公开(公告)日：2023-05-10
申请号：EP21749406.1
申请日：2021-07-01
申请人： Invalve Therapeutics, Inc. , Spence, Paul , Paolitto, Anthony
发明人： SPENCE, Paul , PAOLITTO, Anthony
IPC分类号： A61F2/24

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