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    • 9. 发明申请
    • PREMIXED BIOLOGICAL HYDRAULIC CEMENT PASTE COMPOSITION AND USING THE SAME
    • 先进的生物水泥浆料组合物和使用它们
    • WO2008128347A1
    • 2008-10-30
    • PCT/CA2008/000744
    • 2008-04-21
    • INNOVATIVE BIOCERAMIX, INC.YANG, QuanzuLU, Donghui
    • YANG, QuanzuLU, Donghui
    • A61L24/02A61K6/06A61L24/00A61L27/00
    • A61L24/0089A61K6/0067A61K6/0612A61L24/0015A61L24/0042A61L27/446A61L27/54A61L27/58A61L2300/406A61L2300/44A61L2300/602A61K6/0038C08L7/00C08L23/20C08L71/02C08L91/005C08L1/284A61K6/0017A61K6/083A61K6/087A61K6/097
    • A premixed cement paste for use in medical or dental applications. The premixed cement paste remains fluid when stored in a hermetically sealed condition, but hydrates and hardens to set when placed in a physiological environment. The cement paste includes at least one calcium silicate compound and at least one substantially water-free liquid carrier mixed with the at least one calcium silicate compound; the substantially water-free liquid carrier avoids hydration of the mixture during storage, but undergoes exchange with aqueous physiological solutions so that the cement past hydrates and hardens to set when placed m a physiological environment. The paste may be placed in the physiological environment by injection, for example. The at least one calcium silicate compound may be, for example, calcium silicate, dicalcium silicate, tricalcium silicate, or mixtures thereof. The substantially water-free liquid may be, for example, ethylene glycol, polyethylene glycol, liquid glycerol, glycerin, ethyl alcohol, vegetable oil, animal oil, silicon oil, hydroxypropyl methylcellulose, or mixtures thereof. The substantially water- free liquid earner preferably includes water in an amount less than about 20% by weight percent of the pate. The paste may include a secondary phase for enhanced properties, such as, for example, a fibrous of particular for enhanced mechanical properties, biodegradable or soluble materials that provide room for bone in growth, bioactive materials such as antibiotics that dilute into the physiological environment from the set cement, and radio-opaque materials that enhance X-ray imaging of the cement.
    • 用于医疗或牙科应用的预混水泥浆。 当密封状态下储存时,预混合水泥糊保持流体状态,但在置于生理环境中时,水合物并固化。 所述水泥糊包括至少一种硅酸钙化合物和与所述至少一种硅酸钙化合物混合的至少一种基本上不含水的液体载体; 基本上无水的液体载体避免在储存期间混合物的水合,但是与水性生理溶液交换,使得当在生理环境中放置时,水泥过去水合并硬化。 例如,可以通过注射将糊状物置于生理环境中。 所述至少一种硅酸钙化合物可以是例如硅酸钙,硅酸二钙,硅酸三钙或其混合物。 基本上无水的液体可以是例如乙二醇,聚乙二醇,液体甘油,甘油,乙醇,植物油,动物油,硅油,羟丙基甲基纤维素或其混合物。 基本上不含水的液体收集器优选包含小于头部的约20重量%的量的水。 糊剂可以包括用于增强性能的第二相,例如特别是用于增强机械性能的纤维,可提供骨生长空间的可生物降解或可溶性材料,生物活性材料例如从生理环境中稀释到生理环境中的抗生素 固定水泥和不透光材料,可增强水泥的X射线成像。