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1. 发明申请

US20080227212A1 PROCESS FOR IDENTIFYING EXISTENCE OF SINGLE NUCLEOTIDE POLYMORPHISM WITHOUT DNA SEQUENCING 审中-公开
标题翻译：没有DNA序列识别单核多核苷酸存在的方法
公开(公告)号：US20080227212A1
公开(公告)日：2008-09-18
申请号：US12049679
申请日：2008-03-17
申请人： Gafur Zainiev , Inlik Zainiev , Timur Zainiev
发明人： Gafur Zainiev , Inlik Zainiev , Timur Zainiev
IPC分类号： G01N33/00
CPC分类号： C12Q1/6827 , Y10T436/143333 , C12Q2565/629 , C12Q2527/137
摘要： A process for detecting the presence of a mutation in an oligonucleotide strand such as a DNA strand from a gene without the need for DNA sequencing is provided. The inventive process provides a rapid pre-test to screen for the presence or absence of a mutation in a target gene of a subject to determine whether laborious sequencing protocols are required to further characterize a mutation. The inventive process provides a rapid screening protocol for identifying and detecting a genetic mutation in a patient who presents with a disease
摘要翻译：提供了检测寡核苷酸链中的突变的存在的方法，例如来自基因的DNA链，而不需要进行DNA测序。本发明的方法提供了快速预检测以筛选受试者靶基因中突变的存在或不存在，以确定是否需要费力的测序方案来进一步表征突变。本发明的方法提供用于鉴定和检测患有疾病的患者中的遗传突变的快速筛选方案

2. 发明授权

US08153403B1 Process for identifying existence of single nucleotide polymorphism without DNA sequencing 有权
标题翻译：识别单核苷酸多态性存在而不进行DNA测序的方法
公开(公告)号：US08153403B1
公开(公告)日：2012-04-10
申请号：US12714974
申请日：2010-03-01
申请人： Gafur Zainiev , Inlik Zainiev , Timur Zainiev
发明人： Gafur Zainiev , Inlik Zainiev , Timur Zainiev
IPC分类号： C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6827 , C12Q2565/629 , C12Q2527/137
摘要： A process for detecting the presence of a mutation in an oligonucleotide strand such as a DNA strand from a gene without the need for DNA sequencing is provided. The inventive process provides a rapid pre-test to screen for the presence or absence of a mutation in a target gene of a subject to determine whether laborious sequencing protocols are required to further characterize a mutation. The inventive process provides a rapid screening protocol for identifying and detecting a genetic mutation in a patient who presents with a disease.
摘要翻译：提供了检测寡核苷酸链中的突变的存在的方法，例如来自基因的DNA链，而不需要进行DNA测序。本发明的方法提供了快速预检测以筛选受试者靶基因中突变的存在或不存在，以确定是否需要费力的测序方案来进一步表征突变。本发明的方法提供用于鉴定和检测患有疾病的患者中的遗传突变的快速筛选方案。

3. 发明申请

US20090181432A1 PROCESS FOR SELF-ASSEMBLY OF STRUCTURES IN A LIQUID 审中-公开
标题翻译：液体中自组织的方法
公开(公告)号：US20090181432A1
公开(公告)日：2009-07-16
申请号：US11926755
申请日：2007-10-29
申请人： Gafur Zainiev , Inlik Zainiev , Timur Zainiev
发明人： Gafur Zainiev , Inlik Zainiev , Timur Zainiev
IPC分类号： C12P19/34
CPC分类号： C12P19/34 , B01L3/5027 , C12Q1/6874
摘要： A process and apparatus for DNA sequencing is provided. In the field of DNA analysis, an iterative process is disclosed wherein an apparatus with a set of recognition chambers in which a species of recognition element nucleotides are differentially added and subjected to a polymerization reaction allows recognition of which species is next in sequence on a template strand as measured by a detector in a detection area. The position in the sequence is then completed by addition of a saturating amount of building element to complete the polymerization reaction on all structure strands. The process is repeated until the sequence is identified.
摘要翻译：提供了用于DNA测序的方法和装置。在DNA分析领域中，公开了一种迭代方法，其中具有一组识别室的装置，其中识别元件核苷酸的种类被差异添加并进行聚合反应允许在模板上依次识别下一个物种在检测区域中由检测器测量。然后通过加入饱和量的构建元素完成序列中的位置以在所有结构链上完成聚合反应。重复该过程直到序列被识别。

4. 发明申请

US20080032330A1 PROCESS FOR SELF-ASSEMBLY OF STRUCTURES IN A LIQUID 审中-公开
标题翻译：液体中自组织的方法
公开(公告)号：US20080032330A1
公开(公告)日：2008-02-07
申请号：US11835054
申请日：2007-08-07
申请人： Gafur Zainiev , Inlik Zainiev , Timur Zainiev
发明人： Gafur Zainiev , Inlik Zainiev , Timur Zainiev
IPC分类号： C12P21/00 , C12M1/00 , C12P19/34
CPC分类号： C12P19/34 , B01L3/5027 , C12Q1/6869
摘要： A process and apparatus for self-assembling a number of elements and determining their sequence is provided. In the field of DNA analysis, an iterative process is disclosed wherein an apparatus with a set of reaction chambers in which a species of recognition element nucleotides are differentially added and subjected to a polymerization reaction allows recognition of which species is next in sequence on a template strand as measured by a detector in a detection area. Fractional concentration stepwise addition of the identified species then determines if an element repeat exists. The position in the sequence is then completed by addition of a saturating amount of building element to complete the polymerization reaction on all structure strands. The process is repeated until the entire structure is complete and the sequence identified.
摘要翻译：提供了一种用于自组装多个元件并确定其顺序的过程和装置。在DNA分析领域中，公开了一种迭代方法，其中具有一组反应室的装置，其中识别元件核苷酸的种类被差异添加并进行聚合反应允许在模板上依次识别下一个物种在检测区域中由检测器测量。分数浓度逐步添加所识别的物种然后确定元素重复是否存在。然后通过加入饱和量的构建元素完成序列中的位置以在所有结构链上完成聚合反应。重复该过程，直到整个结构完成并确定序列。

5. 发明申请

US20080241836A1 PROCESS FOR SELF-ASSEMBLY OF STRUCTURES IN A LIQUID 审中-公开
标题翻译：液体中自组织的方法
公开(公告)号：US20080241836A1
公开(公告)日：2008-10-02
申请号：US11927891
申请日：2008-03-31
申请人： Gafur Zainiev , Inlik Zainiev , Timur Zainiev
发明人： Gafur Zainiev , Inlik Zainiev , Timur Zainiev
IPC分类号： C12Q1/68 , C12P19/34 , C12M1/00
CPC分类号： C12P19/34 , B01L3/5027 , C12Q1/6869 , C12Q2565/501 , C12Q2521/101
摘要： A process and apparatus for self-assembling a number of elements and determining their sequence is provided. In the field of DNA analysis, an iterative process is disclosed wherein an apparatus with a set of reaction chambers in which a species of recognition element nucleotides are differentially added and subjected to a polymerization reaction allows recognition of which species is next in sequence on a template strand by the effect that synthesis has on a detecting template as measured by a detector in a detection area. Stepwise addition of the identified species then determines if an element repeat exists. The process is repeated until the entire structure is complete and the sequence identified.
摘要翻译：提供了一种用于自组装多个元件并确定其顺序的过程和装置。在DNA分析领域中，公开了一种迭代方法，其中具有一组反应室的装置，其中识别元件核苷酸的种类被差异添加并进行聚合反应允许在模板上依次识别下一个物种通过检测区域中的检测器测量的合成对检测模板的影响。逐步添加所识别的物种然后确定元素重复是否存在。重复该过程，直到整个结构完成并确定序列。

6. 发明申请

US20080044821A1 NUCLEIC ACID ARRAY HAVING FIXED NUCLEIC ACID ANTI-PROBES AND COMPLEMENTARY FREE NUCLEIC ACID PROBES 审中-公开
标题翻译：具有固定核酸抗原探针和完全免费的核酸探针的核酸阵列
公开(公告)号：US20080044821A1
公开(公告)日：2008-02-21
申请号：US11465870
申请日：2006-08-21
申请人： Gafur Zainiev , Inlik Zainiev
发明人： Gafur Zainiev , Inlik Zainiev
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6837 , C12Q2537/161
摘要： A process for identifying a complementary nucleic acid probe to a target nucleic acid involves forming an array of spots where each spot of the array has an immobilized nucleic acid anti-probe to which is hybridized a nucleic acid probe. The array of the anti-probe-probe complex is denatured. The nucleic acid probes are then moved into a target chamber that includes a target nucleic acid. Hybridization conditions are established to form double-stranded complexation between the target nucleic acid and nucleic acid probes in instances where the target nucleic acid has a sequence complementary. The nucleic acid probes noncomplementary to the target nucleic acid are allowed to rehybridize with anti-probes. Determining whether the anti-probe spots exposed to nucleic acid probes noncomplementary to the target nucleic acid are single stranded after exposure to noncomplementary nucleic acid probes provides information as to target nucleic acid sequence.
摘要翻译：用于鉴定靶核酸的互补核酸探针的方法包括形成阵列阵列，其中阵列的每个点具有与核酸探针杂交的固定的核酸抗探针。抗探针 - 探针复合物的阵列变性。然后将核酸探针移动到包括靶核酸的靶室中。建立杂交条件以在目标核酸具有序列互补性的情况下在靶核酸和核酸探针之间形成双链复合。允许与靶核酸不互补的核酸探针用抗探针重新杂化。确定在暴露于非互补核酸探针之后，暴露于与靶核酸不互补的核酸探针的抗探针点是单链提供关于靶核酸序列的信息。

7. 发明申请

US20100240119A1 MICROSEPARATION STRUCTURE AND DEVICES FORMED THEREWITH 审中-公开
标题翻译：微结构及其形成的器件
公开(公告)号：US20100240119A1
公开(公告)日：2010-09-23
申请号：US12708256
申请日：2010-02-18
申请人： Inlik Zainiev
发明人： Inlik Zainiev
IPC分类号： B01D11/04 , C12M1/34 , B01D15/08
CPC分类号： B01L3/502753 , B01D15/34 , B01L3/5023 , B01L2300/041 , B01L2300/0681 , B01L2300/0825 , B01L2300/087 , B01L2400/0406 , B01L2400/0481 , B01L2400/0683 , B01L2400/0694
摘要： A microseparation structure is provided that includes a top surface defining a first chamber. A second chamber is provided that is in fluid communication with the first chamber and characterized by a volume less than the volume of the first chamber. At least one hole extends in fluid communication with the second chamber to transmit fluids into a capillary draw void volume filled with a capillary draw-inducing agent such that liquid placed in the first chamber is drawn through the second chamber and through the hole to the capillary draw void volume filled with capillary draw-inducing agent. Particles of interest within the liquid are unable to pass into the hole and are therefore isolated within the second chamber. This structure is amenable to forming into a compact chromatographic filtration media made up of multiple such structures that is well suited for sealed testing for diseases such as malaria.
摘要翻译：提供了一种微分离结构，其包括限定第一室的顶表面。提供了与第一室流体连通的第二室，其特征在于体积小于第一室的体积。至少一个孔与第二室流体连通地延伸，以将流体传输到填充有毛细管牵引诱导剂的毛细管抽取空隙体积中，使得放置在第一腔室中的液体被抽吸通过第二腔室并通过该孔进入毛细管绘制填充有毛细管牵引诱导剂的空隙体积。液体内感兴趣的颗粒不能进入孔，因此在第二室内被隔离。该结构适于形成由多种这样的结构组成的紧密色谱过滤介质，其非常适合于诸如疟疾的疾病的密封测试。

8. 发明申请

US20100056388A1 NUCLEIC ACID ARRAY HAVING FIXED NUCLEIC ACID ANTI-PROBES AND COMPLEMENTARY FREE NUCLEIC ACID PROBES 审中-公开
标题翻译：具有固定核酸抗原探针和完全免费的核酸探针的核酸阵列
公开(公告)号：US20100056388A1
公开(公告)日：2010-03-04
申请号：US12571676
申请日：2009-10-01
申请人： Gafur Zainiev , Inlik Zainiev
发明人： Gafur Zainiev , Inlik Zainiev
IPC分类号： C40B30/04 , C40B40/06
CPC分类号： C12Q1/6837 , C12Q2537/161
摘要： A process for identifying a complementary nucleic acid probe to a target nucleic acid involves forming an array of spots where each spot of the array has an immobilized nucleic acid anti-probe to which is hybridized a nucleic acid probe. The array of the anti-probe-probe complex is denatured. The nucleic acid probes are then moved into a target chamber that includes a target nucleic acid. Hybridization conditions are established to form double-stranded complexation between the target nucleic acid and nucleic acid probes in instances where the target nucleic acid has a sequence complementary. The nucleic acid probes noncomplementary to the target nucleic acid are allowed to rehybridize with anti-probes. Determining whether the anti-probe spots exposed to nucleic acid probes noncomplementary to the target nucleic acid are single stranded after exposure to noncomplementary nucleic acid probes provides information as to target nucleic acid sequence.
摘要翻译：用于鉴定靶核酸的互补核酸探针的方法包括形成阵列阵列，其中阵列的每个点具有与核酸探针杂交的固定的核酸抗探针。抗探针 - 探针复合物的阵列变性。然后将核酸探针移动到包括靶核酸的靶室中。建立杂交条件以在目标核酸具有序列互补性的情况下在靶核酸和核酸探针之间形成双链复合。允许与靶核酸不互补的核酸探针用抗探针重新杂化。确定在暴露于非互补核酸探针之后，暴露于与靶核酸不互补的核酸探针的抗探针点是单链提供关于靶核酸序列的信息。

9. 发明申请

US20090047191A1 CLOSED SPACE DISPOSABLE MICRO-REACTOR AND USES THEREOF 审中-公开
标题翻译：封闭空间可置换微反应器及其用途
公开(公告)号：US20090047191A1
公开(公告)日：2009-02-19
申请号：US12135597
申请日：2008-06-09
申请人： Gafur Zainiev , Inlik Zainiev
发明人： Gafur Zainiev , Inlik Zainiev
IPC分类号： B01J19/00
CPC分类号： B01L3/50273 , B01L3/502715 , B01L2300/0627 , B01L2300/0838 , B01L2400/0487
摘要： A closed space disposable micro-reactor is provided with a capillary vessel with a first end and a second end, a first closed air chamber wherein said first end of the capillary vessel opens into the first closed air chamber; and a second closed air chamber wherein the second end of the capillary chamber opens into said second closed air chamber. The capillary vessel is pre-filled with a liquid sample. A droplet of reagent set in proximity to the first end of the capillary vessel is provided. Also provided is a partner capillary vessel with a first partner end and a second partner end, and a third closed air chamber wherein the first partner end of the partner capillary vessel opens into the second closed air chamber, and the second partner end opens to the second air chamber.
摘要翻译：封闭空间一次性微反应器设置有具有第一端和第二端的毛细管容器，第一封闭空气室，其中所述毛细管的所述第一端通入第一封闭空气室; 以及第二封闭空气室，其中毛细管室的第二端通向所述第二封闭空气室。毛细血管预先填充有液体样品。设置在毛细血管的第一端附近设置的一滴试剂。还提供了具有第一伴侣端和第二伙伴端的伴侣毛细管，以及第三封闭空气室，其中配对毛细血管的第一配对端打开到第二封闭空气室中，并且第二配对端打开至第二个空气室。

10. 发明授权

US06584691B1 Electric shaver having orbitally moving blades 失效
标题翻译：具有轨道运动叶片的电动剃须刀
公开(公告)号：US06584691B1
公开(公告)日：2003-07-01
申请号：US09679749
申请日：2000-10-05
申请人： Vladimir Gerasimov , Gafur Zainiev , Ivan Gerasimov , Inlik Zainiev , Boris Zlotin
发明人： Vladimir Gerasimov , Gafur Zainiev , Ivan Gerasimov , Inlik Zainiev , Boris Zlotin
IPC分类号： B26B1914
CPC分类号： B26B19/145 , B26B19/14 , B26B19/26
摘要： An electric shaver, and in particular an electric shaver wherein are included blades which while rotating around their own centers also orbit around another axis, thus providing that the blades sweep a large area.
摘要翻译：一种电动剃须刀，特别是一种电动剃须刀，其中包括叶片，其围绕其自身的中心旋转也围绕另一轴线轨道，从而提供叶片扫掠大面积。

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