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1. 发明专利

JP2008149161A Apparatus for heart pacing, and method for operating the apparatus 审中-公开
标题翻译：用于心脏的装置，以及操作装置的方法
公开(公告)号：JP2008149161A
公开(公告)日：2008-07-03
申请号：JP2008022802
申请日：2008-02-01
申请人： Impulse Dynamics Nv , インパルスダイナミクスエヌ.ヴイ.
发明人： BEN-HAIM SHLOMO , DARVISH NISSIM , MIKA YUVAL , FENSTER MAIER
IPC分类号： A61N1/36 , A61N1/368 , A61B17/00 , A61B17/02 , A61N1/32 , A61N1/362 , A61N1/365
CPC分类号： A61N1/36564 , A61B2017/00243 , A61B2017/0243 , A61N1/32 , A61N1/3627 , A61N1/3628 , A61N1/36557 , A61N1/368
摘要： PROBLEM TO BE SOLVED: To provide an apparatus for heart pacing with cardiac output modification.
SOLUTION: The apparatus includes one or more electrodes 27 and 29 which apply electrical signals to a cardiac muscle segment, signal generation circuitry 26 configured to generate stimulation including at least one of excitatory stimulation and non-excitatory stimulation, which is supplied to the one or more electrodes, and control circuitry to control the signal generation circuitry 26 to generate the excitatory stimulation for heart pacing and the non-excitatory stimulation for increasing cardiac output at a time, wherein the non-excitatory stimulation is prevented from generating action potential propagated to the heart, when it is applied to the heart.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供用于心脏起搏的装置，其具有心输出改变。解决方案：该装置包括将电信号施加到心肌段的一个或多个电极27和29，信号产生电路26被配置为产生包括兴奋性刺激和非兴奋性刺激中的至少一种的刺激，其被提供给一个或多个电极和控制电路，以控制信号产生电路26产生用于心脏起搏的兴奋性刺激和一次增加心输出量的非兴奋性刺激，其中防止非兴奋性刺激产生动作电位传播到心脏，当它被应用到心脏。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2008018252A Cardiac output controller 有权
标题翻译：心脏输出控制器
公开(公告)号：JP2008018252A
公开(公告)日：2008-01-31
申请号：JP2007206282
申请日：2007-08-08
申请人： Impulse Dynamics Nv , インパルスダイナミクスエヌ.ヴイ.
发明人： BEN-HAIM SHLOMO , DARVISH NISSIM , MIKA YUVAL , FENSTER MAIER
IPC分类号： A61N1/36 , A61N1/365 , A61B5/01 , A61B5/0215 , A61B5/026 , A61B5/0402 , A61B5/1459 , A61B17/00 , A61B17/02 , A61N1/32 , A61N1/362 , A61N1/368
CPC分类号： A61N1/36564 , A61B2017/00243 , A61B2017/0243 , A61N1/32 , A61N1/3627 , A61N1/3628 , A61N1/36557 , A61N1/368
摘要： PROBLEM TO BE SOLVED: To provide an apparatus and method for regulating a bloodstream kinetics parameter, especially for increasing the heart rate of the heart to increase the cardiac output concerning a heart curing device, particularly concerning an invasive device for dilation of the cardiac function. SOLUTION: This apparatus for modifying cardiac output of the heart of a subject, includes: one or more sensors 29 for sensing signals responsive to cardiac activity; and a stimulation probe 21 including one or more stimulation electrodes which apply non-excitatory stimulation pulses to a cardiac muscle segment. Signal generation circuitry 22 is coupled to the one or more sensors and the stimulation probe, which circuitry receives the signals from the one or more sensors and generates the non-excitatory stimulation pulses responsive to the signals. The non-excitatory pulses do not affect directly on the heart rate, and the cardiac output of the patient's heart is modified. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于调节血流动力学参数的装置和方法，特别是用于增加心脏的心率以增加心脏固化装置的心输出量，特别是涉及用于扩张心脏的侵入性装置心脏功能。解决方案：用于改善对象心脏心脏输出的装置包括：用于感测响应于心脏活动的信号的一个或多个传感器29; 以及刺激探针21，其包括将非兴奋性刺激脉冲施加到心肌段的一个或多个刺激电极。信号产生电路22耦合到一个或多个传感器和刺激探针，该电路接收来自一个或多个传感器的信号，并响应于该信号产生非兴奋性刺激脉冲。非兴奋性脉冲不直接影响心率，改变患者心脏的心输出量。版权所有（C）2008，JPO＆INPIT

3. 发明专利

JP2021528936A パワーカップリング変調伝送审中-公开
公开(公告)号：JP2021528936A
公开(公告)日：2021-10-21
申请号：JP2021519014
申请日：2019-06-12
申请人：インパルスダイナミクスエヌヴイ , IMPULSE DYNAMICS NV
发明人：プラッチデビッド , マイヤーズジェイソン
IPC分类号： A61N1/378 , H04L9/08
摘要：移植デバイスIDと外部デバイスEDとの間の通信を保護するための通信システムの実施形態が開示されている。例えば、無線チャネル上の双方向通信を保護するために、一方向の経皮的エネルギー伝送TETリンクが使用されてもよい。任意選択で、TETリンクは悪意のある者による侵入から保護されてもよい。例えば、TETリンクは、距離を経て非常に急速に減衰する媒体上であってもよい。いくつかの実施形態では、TETリンクは、暗号化鍵を渡すために、および/または双方向無線チャネル上の通信を検証するために使用される。TETチャネルは認証されてもよい。例えば、認証は、最小限のエネルギーおよび/または電力の伝達を含んでいてもよい。

4. 发明公开

US20240181269A1 DEVICE AND METHOD FOR ANTI-TACHYCARDIA PACING 审中-公开
公开(公告)号：US20240181269A1
公开(公告)日：2024-06-06
申请号：US18285504
申请日：2022-04-04
申请人： Impulse Dynamics NV
发明人： Tamir BEN DAVID , David PRUTCHI
IPC分类号： A61N1/39 , A61N1/05 , A61N1/362 , A61N1/365
CPC分类号： A61N1/39622 , A61N1/0563 , A61N1/3622 , A61N1/365 , A61N1/3987
摘要： A method of anti-tachycardia pacing via an implanted cardiac device, comprising: positioning at least one electrode of the implanted cardiac device at an intra-cardiac location; detecting a tachycardia episode; delivering, via the at least one electrode, anti-tachycardia pacing pulses, wherein an anti-tachycardia pacing pulse comprises at least one of: a duration of between 5-10 msec and an amplitude of between 7.5-10V.

5. 发明公开

US20240100349A1 COMBINED IMPLANTABLE PULSE GENERATOR DEVICE 审中-公开
公开(公告)号：US20240100349A1
公开(公告)日：2024-03-28
申请号：US18266334
申请日：2021-12-13
申请人： IMPULSE DYNAMICS NV
发明人： David PRUTCHI , Jason MEYERS , Tamir BEN DAVID
IPC分类号： A61N1/39 , A61N1/05 , A61N1/365 , A61N1/37 , G16H20/30
CPC分类号： A61N1/39622 , A61N1/0563 , A61N1/36585 , A61N1/3702 , G16H20/30
摘要： A method of treating a heart, the method including providing an Implantable Pulse Generator (IPG) adapted to provide a combination of at least two treatment modalities including Cardiac Contractility Modulation therapy and one more modality selected from a group consisting of Cardiac pacing, Cardioversion, Defibrillation, Cardioversion and Defibrillation, and Cardiac Resynchronization Therapy (CRT), detecting a patient's physical condition, and selecting a combination of Cardiac Contractility Modulation therapy and at least one treatment modality from the group, and providing the combination of the Cardiac Contractility Modulation therapy and the at least one treatment modality. Related apparatus and methods are also described.

6. 发明公开

US20240042214A1 PROTEIN ACTIVITY MODIFICATION 审中-公开
公开(公告)号：US20240042214A1
公开(公告)日：2024-02-08
申请号：US18377857
申请日：2023-10-09
申请人： Impulse Dynamics NV
发明人： Benny ROUSSO , Yuval MIKA , Shlomo BEN-HAIM , Hani N. SABBAH
IPC分类号： A61N1/362 , A61N1/32 , C12N13/00 , A61N2/00
CPC分类号： A61N1/3627 , A61N1/32 , C12N13/00 , A61N1/3628 , A61N2/004 , A61N1/3629 , A61N1/205
摘要： A method of modifying tissue behavior, comprising:

determining a desired modification of tissue behavior for at least one of treatment of a disease, short or long term modification of tissue behavior, assessing tissue state and assessing tissue response to stimulation;
selecting an electric field having an expected effect of modifying protein activity of at least one protein as an immediate response of a tissue to the field, said expected effect correlated with said desired modification; and
applying said field to said tissue.

7. 发明申请

US20230041857A1 IMPLANTABLE CARDIOVERTER DEFIBRILLATOR (ICD) DEVICE WITH HIGH LONGEVITY 有权
公开(公告)号：US20230041857A1
公开(公告)日：2023-02-09
申请号：US17790770
申请日：2021-01-05
申请人： Impulse Dynamics NV
发明人： David PRUTCHI
IPC分类号： A61N1/378 , A61N1/39
摘要： An implantable device containing a plurality of batteries, the plurality of batteries including at least one first non-rechargeable battery, and at least one second rechargeable battery. A method for providing power for a Cardiac Contractility Modulation Implantable Cardioverter Defibrillator (ICD) device, the method including providing power for cardioversion or defibrillation operation by a first, non-rechargeable battery, and providing power for Cardiac Contractility Modulation operation by a second, rechargeable battery. A method for controlling power for an implantable device having a rechargeable battery, a non-rechargeable battery and a Cardioverter Defibrillator module, the method including measuring electric power level of the rechargeable battery, comparing the rechargeable battery level to a threshold, if the electric power level of the rechargeable battery is less than the threshold, then providing power for the device from the non-rechargeable battery. Related apparatus and methods are also described.

8. 发明申请

US20220387790A1 INCREASING PEAK VO2 IN PATIENTS WITH HF USING CARDIAC CONTRACTILITY MODULATION STIMULATION 有权
公开(公告)号：US20220387790A1
公开(公告)日：2022-12-08
申请号：US17770318
申请日：2020-10-22
申请人： Impulse Dynamics NV
发明人： David PRUTCHI , Simeon Ioannis KEDIKOGLOU , Angela CONNOLLY STAGG
IPC分类号： A61N1/362
摘要： A method of increasing peak VO2 including selecting a patient having impaired peak VO2 and estimated to have a potential for improving peak VO2, and applying cardiac contractility modulation stimulation to the patient's heart. A method of increasing peak VO2 including detecting ventricle contraction using one or more leads in a patient's ventricle, and applying Cardiac Contractility Modulation stimulation to the patient's ventricle, after a delay from a time of the detecting, thereby increasing the patient's peak VO2. Related apparatus and methods are also described.

9. 发明授权

US11020598B2 Simple control of complex bio-implants 有权
公开(公告)号：US11020598B2
公开(公告)日：2021-06-01
申请号：US16257125
申请日：2019-01-25
申请人： Impulse Dynamics NV
发明人： Shlomo Ben-Haim , David Prutchi , Yuval Ben-Haim
IPC分类号： A61N1/00 , A61N1/372 , G05B15/02 , A61N1/36 , A61N1/362 , A61N1/39 , A61N1/02 , A61N2/00 , A61M5/172 , G16H40/67 , G16H40/40 , G16H20/40 , A61M60/00 , A61M60/148 , A61M60/205 , A61N7/00
摘要： Methods and devices for tying management of an implantable medical device to the activities of a primary care physician are described, including access control, simplified parameter optimization, support for tuning a device in response to the effects of other treatments in parallel, and support for helping a primary physician and a patient work together to tune device configuration to the activity and performance needs of the patient. In some embodiments, a medical device is self-configuring in a device parameter domain, based on inputs provided in a patient performance domain. The self-configuring of the medical device is based, for example, on an automatically applied transformation of inputs derived from patient performance domain observations into changes in the configuration of the medical device which affect technical parameters of its operation.

10. 发明授权

US10352948B2 Protein activity modification 审中-公开
公开(公告)号：US10352948B2
公开(公告)日：2019-07-16
申请号：US15249506
申请日：2016-08-29
申请人： Impulse Dynamics NV
发明人： Benny Rousso , Yuval Mika , Shlomo Ben Haim , Hani N. Sabbah
IPC分类号： G01N33/68 , A61N1/32 , C12N13/00 , A61N1/20 , A61N2/00 , A61N1/362 , C12Q1/68 , C12Q1/6883
CPC分类号： G01N33/6893 , A61N1/205 , A61N1/32 , A61N1/362 , A61N1/3627 , A61N1/3628 , A61N2/004 , C12N13/00 , C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , G01N2800/325
摘要： A method of modifying tissue behavior, comprising: determining a desired modification of tissue behavior for at least one of treatment of a disease, short or long term modification of tissue behavior, assessing tissue state and assessing tissue response to stimulation; selecting an electric field having an expected effect of modifying protein activity of at least one protein as an immediate response of a tissue to the field, said expected effect correlated with said desired modification; and applying said field to said tissue.

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