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    • 2. 发明申请
    • PROCESS FOR THE PRODUCTION OF PLATINUM (II) COMPLEXES
    • 制备铂(II)络合物的方法
    • WO1996034000A1
    • 1996-10-31
    • PCT/JP1996001142
    • 1996-04-25
    • TORAY INDUSTRIES, INC.KAWAI, HidekiIMAOKA, TakayukiHATA, Go
    • TORAY INDUSTRIES, INC.
    • C07F15/00
    • C07C209/88C07C209/84C07C211/36C07C2601/14C07D307/60C07F15/0093
    • A process for the production of a platinum (II) complex represented by general formula (A) which comprises reacting a dichloroplatinum (II) complex of general formula (B) with a tetronic acid derivative of general formula (C) in the coexistence of a silver salt and a barium salt. In the formulae (A) and (C), R1 represents lower (C1-3) hydrocarbon group; and R2 and R3 represent each hydrogen or lower (C1-3) hydrocarbon group. Another process for producing in a high yield trans-1,2-diaminocyclohexane having a high optical purity which comprises mixing trans-1,2-diaminocyclohexane, which is the starting material in the production of a platinum (II) complex, with an acid having no optically active site followed by the recrystallization from a water-soluble organic solvent optionally mixed with water.
    • 一种制备由通式(A)表示的铂(II)配合物的方法,其包括使通式(B)的二氯铂(II)络合物与通式(C)的特硝酸衍生物在 银盐和钡盐。 在式(A)和(C)中,R 1表示低级(C 1-3)烃基; 并且R 2和R 3表示每个氢或低级(C 1-3)烃基。 制备具有高光学纯度的高产率反式1,2-二氨基环己烷的另一种方法,其包括将作为铂(II)络合物生产中的起始原料的反式-1,2-二氨基环己烷与酸 没有光学活性部位,然后用任选与水混合的水溶性有机溶剂重结晶。