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1. 发明授权

US07671071B2 Polymorphic Form XVI of fexofenadine hydrochloride 失效
标题翻译：盐酸非索非那定的多形态XVI
公开(公告)号：US07671071B2
公开(公告)日：2010-03-02
申请号：US11243496
申请日：2005-10-03
申请人： Barnaba Krochmal , Dov Diller , Ben-Zion Dolitzky , Judith Aronhime , Shlomit Wizel , Boaz Gome , Igor Lifshitz
发明人： Barnaba Krochmal , Dov Diller , Ben-Zion Dolitzky , Judith Aronhime , Shlomit Wizel , Boaz Gome , Igor Lifshitz
IPC分类号： A61K31/445 , C07D211/22
CPC分类号： C07D211/22
摘要： Provided is a crystalline (polymorphic) form of fexofenadine hydrochloride, denominated fexofenadine hydrochloride Form XVI.
摘要翻译：提供盐酸非索非那定的结晶（多晶型）形式，称为盐酸非索非那定形式XVI。

2. 发明申请

US20090054486A1 POLYMORPHIC FORM XVI OF FEXOFENADINE HYDROCHLORIDE 审中-公开
标题翻译： FEXOFENADINE HYDROCHLORIDE的多晶型XVI
公开(公告)号：US20090054486A1
公开(公告)日：2009-02-26
申请号：US12208768
申请日：2008-09-11
申请人： Barnaba Krochmal , Dov Diller , Ben-Zion Dolitzky , Judith Aronhime , Shlomit Wizel , Boaz Gome , Igor Lifshitz
发明人： Barnaba Krochmal , Dov Diller , Ben-Zion Dolitzky , Judith Aronhime , Shlomit Wizel , Boaz Gome , Igor Lifshitz
IPC分类号： A61K31/445
CPC分类号： C07D211/22
摘要： Provided is a crystalline (polymorphic) form of fexofenadine hydrochloride, denominated fexofenadine hydrochloride Form XVI.
摘要翻译：提供盐酸非索非那定的结晶（多晶型）形式，称为盐酸非索非那定形式XVI。

3. 发明授权

US06350870B2 Process for preparing pure crystalline lorazepam 失效
标题翻译：制备纯结晶劳拉西泮的方法
公开(公告)号：US06350870B2
公开(公告)日：2002-02-26
申请号：US09799318
申请日：2001-03-05
申请人： Igor Lifshitz
发明人： Igor Lifshitz
IPC分类号： C07D24324
CPC分类号： C07D243/24
摘要： The present invention provides a process for preparing crystalline lorazepam substantially free of bound solvent from a lorazepam alcohol solvate or hydrate by suspending the lorazepam solvate in an organic medium selected from ethyl acetate, cyclohexane, dichloromethane, toluene and mixtures thereof. This process is useful in producing the anti-anxiety and sedative agent lorazepam in increased yields. A process for converting lorazepam lower alcohol solvates to lorazepam hydrate is also disclosed.
摘要翻译：本发明提供了一种通过将劳拉西泮溶剂化物悬浮在选自乙酸乙酯，环己烷，二氯甲烷，甲苯及其混合物的有机介质中来制备基本上不含结合的溶剂的劳拉西泮醇溶剂化物或水合物的结晶性劳拉西泮的方法。该方法可用于产生抗焦虑和镇静剂劳拉西泮的产量增加。还公开了将劳拉西泮低级醇溶剂化物转化为水合氯雷他平的方法。

4. 发明授权

US4362497A Food press form 失效
标题翻译：食品新闻形式
公开(公告)号：US4362497A
公开(公告)日：1982-12-07
申请号：US293513
申请日：1981-08-14
申请人： Igor Lifshitz
发明人： Igor Lifshitz
IPC分类号： A21C11/00 , A21C11/10 , B29C1/00
CPC分类号： A21C11/106 , A21C11/00
摘要： Food products are processed prior to consumption in a press form having multiple, separate, pre-selected planar food product molds, each having tapered walls, providing easy food product removal. The food products can have pastry dough exteriors and can be filled with selected food fillings held in position and shaped by dough crust exteriors. Multiple press form food product molds have regular planar shapes disposed multiple in a tray. One face of each product mold has a cutting-edge knife disposed thereon, conforming to the mold interior shape. The cutting-edge knife can be disposed at either mold wall taper terminus. A cooperatively shaped, one-piece negative pusher plug mold, sized to intercept each one of the multiple food product molds disposed in the tray, is used to cooperatively push each food product out of the molds in the tray simultaneously. Additional, easily insertable and removable partitions of single and double cross-wise edge-knife units can be disposed in the molds, further dividing the food products.
摘要翻译：食品在消费之前被加工成具有多个分开的，预选的平面食品模具的压榨形式，每个模具具有锥形壁，从而提供容易的食品移除。食品可以有糕点面团外观，并且可以填充保持在适当位置的选定的食物馅料，并通过面外皮成型。多重冲压成型食品模具在托盘中具有多个布置的规则的平面形状。每个产品模具的一个面具有设置在其上的切割刀，符合模具内部形状。前刀可以设置在任何一个模具壁锥形终点。用于协调地设置成拦截设置在托盘中的多个食品模具中的每一个的协同成形的单件式负推塞模具用于将每个食品同时推出托盘中的模具。另外，可以在模具中设置单个和两个交叉边缘刀单元的容易插入和移除的隔板，进一步分割食品。

5. 发明申请

US20070043099A1 Crystalline forms of carvedilol and processes for their preparation 审中-公开
标题翻译：卡维地洛的结晶形式及其制备方法
公开(公告)号：US20070043099A1
公开(公告)日：2007-02-22
申请号：US11450699
申请日：2006-06-09
申请人： Igor Lifshitz , Shlomit Wizel
发明人： Igor Lifshitz , Shlomit Wizel
IPC分类号： A61K31/403 , C07D209/82
CPC分类号： C07D209/88
摘要： This invention relates to a novel crystalline form of carvedilol, to processes for its preparation, to compositions containing it and to its use in medicine. This invention further relates to a novel process for preparing crystalline carvedilol Form II.
摘要翻译：本发明涉及一种新颖的卡维地洛结晶形式，其制备方法，含有它的组合物及其在药物中的用途。本发明还涉及制备结晶卡维地洛II型的新方法。

6. 发明申请

US20060241161A1 Process for preparing losartan potassium with improved flowability 审中-公开
标题翻译：具有改善流动性的制备氯沙坦钾的方法
公开(公告)号：US20060241161A1
公开(公告)日：2006-10-26
申请号：US11404368
申请日：2006-04-13
申请人： Igor Lifshitz , Ilan Kor , Shalom Shabat
发明人： Igor Lifshitz , Ilan Kor , Shalom Shabat
IPC分类号： A61K31/4178 , C07D403/02
CPC分类号： C07D403/10 , A61K31/4178
摘要： Provided is a method of improving the flowability of losartan potassium powder having an initial Hausner ratio of 1.45 or more, which method includes reslurrying the losatrtan potassium in a reslurry solvent.
摘要翻译：提供一种提高初始Haasner比为1.45以上的氯沙坦钾粉末的流动性的方法，该方法包括在再浆化溶剂中重新洗脱氯化钾。

7. 发明申请

US20060217557A1 Polymorphic form XVI of fexofenadine hydrochloride 失效
标题翻译：盐酸非索非那定的多形态XVI
公开(公告)号：US20060217557A1
公开(公告)日：2006-09-28
申请号：US11243496
申请日：2005-10-03
申请人： Barnaba Krochmal , Dov Diller , Ben-Zion Dolitzky , Judith Aronhime , Shlomit Wizel , Boaz Gome , Igor Lifshitz
发明人： Barnaba Krochmal , Dov Diller , Ben-Zion Dolitzky , Judith Aronhime , Shlomit Wizel , Boaz Gome , Igor Lifshitz
IPC分类号： C07D211/34
CPC分类号： C07D211/22
摘要： Provided is a crystalline (polymorphic) form of fexofenadine hydrochloride, denominated fexofenadine hydrochloride Form XVI.
摘要翻译：提供盐酸非索非那定的结晶（多晶型）形式，称为盐酸非索非那定形式XVI。

8. 发明申请

US20050059684A1 Method for reducing residual alcohols in crystalline valacyclovir hydrochloride 审中-公开
标题翻译：降低结晶盐酸伐昔洛韦中残留醇的方法
公开(公告)号：US20050059684A1
公开(公告)日：2005-03-17
申请号：US10880862
申请日：2004-06-30
申请人： Ben-Zion Dolitzky , Igor Lifshitz
发明人： Ben-Zion Dolitzky , Igor Lifshitz
IPC分类号： C07D473/00 , A61K31/522 , C07D473/12
CPC分类号： C07D473/00
摘要： Provided is valacyclovir hydrochloride stable against formation of N′-formylvalacyclovir upon storage at elevated humidity and pharmaceutical compositions including such valacyclovir hydrochloride.
摘要翻译：本发明提供盐酸伐昔洛韦在高湿度储存时对N-甲酰喹诺酮的形成和盐酸伐昔洛韦等药物组合物的稳定性。

9. 发明授权

US06624292B2 Processes for preparing clarithromycin polymorphs 失效
公开(公告)号：US06624292B2
公开(公告)日：2003-09-23
申请号：US09736446
申请日：2000-12-15
申请人： Igor Lifshitz , Ilya Avrutov , Edi Schwartz , Basem Masarwa
发明人： Igor Lifshitz , Ilya Avrutov , Edi Schwartz , Basem Masarwa
IPC分类号： C07H100
CPC分类号： C07H17/08
摘要： The present invention relates to processes for converting clarithromycin Form I to clarithromycin Form II, which include slurrying clarithromycin the Form I in water. The present invention also relates to processes for the preparation of clarithromycin Form II by converting erythromycin A to clarithromycin and thereafter converting clarithromycin Form I to clarithromycin Form II by slurrying.

10. 发明授权

US4516923A Food press forms 失效
标题翻译：食品新闻形式
公开(公告)号：US4516923A
公开(公告)日：1985-05-14
申请号：US594740
申请日：1984-03-29
申请人： Igor Lifshitz , Ifim Lifshitz
发明人： Igor Lifshitz , Ifim Lifshitz
IPC分类号： A21C9/06 , A21C11/00 , B29C1/00 , A21C5/00 , A21C11/10
CPC分类号： A21C9/066 , A21C11/00
摘要： Food products are processed prior to consumption in a press form, comprising two hinged together trays, rows of multiple separate food product molding apertures arranged staggered relative to one another in the trays, feet members mounted for support of and underneath the trays, respectively arranged in alignment with and adjacent to a molding aperture, said feet members being utilized to intercept and eject food products from the molding apertures, when the trays are swung inwardly from an aligned into a superposed position.
摘要翻译：食品在消费之前以压制形式加工，包括两个铰接在一起的托盘，多个单独的食品成型孔的行，在托盘中相对于彼此错开排列，脚部件安装用于支撑托盘和托盘下面，分别布置在与成型孔对准并邻近模制孔，当托盘从对准的重叠位置向内摆动时，所述脚构件用于拦截和从模制孔中排出食品。

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