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1. 发明授权

US5753707A Amide derivatives and their use in cosmetic composition 失效
标题翻译：酰胺衍生物及其在化妆品组合物中的用途
公开(公告)号：US5753707A
公开(公告)日：1998-05-19
申请号：US708974
申请日：1996-09-06
申请人： Masahide Hoshino , Hiroshi Kusuoku , Tadashi Hase , Atsuko Otsuka , Ichiro Tokimitsu , Akira Yamamuro , Yoshiya Sugai , Koji Yoshino , Youichi Arai , Shinichi Meguro
发明人： Masahide Hoshino , Hiroshi Kusuoku , Tadashi Hase , Atsuko Otsuka , Ichiro Tokimitsu , Akira Yamamuro , Yoshiya Sugai , Koji Yoshino , Youichi Arai , Shinichi Meguro
IPC分类号： A61K8/68 , A61K31/16 , A61K31/335 , A61Q17/00 , A61Q19/00 , C07C233/18 , C07C235/08 , C07C237/14 , C07C237/22 , C07D317/30 , A61K6/00 , C07C233/00
CPC分类号： A61Q17/00 , A61K8/68 , A61Q19/00 , C07C237/22 , C07D317/30 , Y10S514/847
摘要： An amide derivative represented by the following formula (1): ##STR1## wherein R.sup.1 represents a C.sub.1-40 hydrocarbon; R.sup.2 represents a C.sub.1-6 alkylene; R.sup.3 represents H, OH or alkoxyl; R.sup.4 represents a C.sub.1-39 hydrocarbon; R.sup.5 represents ##STR2## with the proviso that when R.sup.5 represents ##STR3## R.sup.3 does not represent OH; and a composition of the amide derivative for topical application to human skin. The composition improves the barrier function of the stratum corneum, providing improvement and prevention of dermatitis, skin roughness, or similar disorders.
摘要翻译：由下式（1）表示的酰胺衍生物：其中R1表示C1-40烃; R2代表C1-6亚烷基; R3表示H，OH或烷氧基; R4代表C1-39烃; R5表示，条件是当R 5表示R 3不表示OH时; 以及用于局部施用于人皮肤的酰胺衍生物的组合物。该组合物改善角质层的屏障功能，提供改善和预防皮炎，皮肤粗糙度或类似疾病。

2. 发明授权

US07939563B2 Remedy for hypertension 有权
标题翻译：补救高血压
公开(公告)号：US07939563B2
公开(公告)日：2011-05-10
申请号：US11106428
申请日：2005-04-15
申请人： Atsushi Suzuki , Ryuji Ochiai , Ichiro Tokimitsu
发明人： Atsushi Suzuki , Ryuji Ochiai , Ichiro Tokimitsu
IPC分类号： A61K31/195 , A61K31/19 , A61K31/045 , A61K31/05
CPC分类号： A61K31/216 , A61K31/12 , A61K31/235
摘要： Provided is a method of treating hypertension, which comprises administering an effective amount of a compound represented by the following formula (1) or (2): wherein, R1 and R2 are the same or different and each independently represents hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkoxyalkyl, aryl, alkylaryl, aralkyl, or acyl, R3 represents hydroxyl, ester bond residue, or amide bond residue, R4 represents ester bond residue or amide bond residue, or a pharmaceutically acceptable salt thereof (except ferulic acid). When the preventive or remedy for hypertension according to the present invention is administered, ferulic acid exists in the blood for a long period of time, thereby continuously suppressing a blood pressure rise. Moreover, the hypertension preventive or remedy according to the present invention has reduced in bitterness peculiar to ferulic acid, which enables patients to take it continuously.
摘要翻译：本发明提供一种治疗高血压的方法，其包括给予有效量的下式（1）或（2）表示的化合物：其中，R 1和R 2相同或不同，各自独立地表示氢，烷基，烯基，环烷基，环烯基，烷氧基烷基，芳基，烷基芳基，芳烷基或酰基，R3表示羟基，酯键残基或酰胺键残基，R4表示酯键残基或酰胺键残基，或其药学上可接受的盐（阿魏酸除外）。当施用根据本发明的高血压的预防或治疗方法时，阿魏酸长期存在于血液中，从而持续抑制血压升高。此外，根据本发明的高血压预防或治疗方法已经降低了阿魏酸特有的苦味，这使患者能够连续服用。

3. 发明授权

US07750053B2 Compositions and methods for alleviating hypertension or preventing a rise in blood pressure 有权
标题翻译：用于缓解高血压或预防血压升高的组合物和方法
公开(公告)号：US07750053B2
公开(公告)日：2010-07-06
申请号：US09922694
申请日：2001-08-07
申请人： Atsushi Suzuki , Ryuji Ochiai , Ichiro Tokimitsu
发明人： Atsushi Suzuki , Ryuji Ochiai , Ichiro Tokimitsu
IPC分类号： A01N33/18 , A01N33/00
CPC分类号： A23L2/52 , A21D2/145 , A23L33/10 , A61K31/19 , A61K31/215 , A61K31/22 , A61K2300/00
摘要： Products and compositions for preventing or reducing the severity of hypertension. These products contain (a) ferulic acid or a ferulate ester, and (b) caffeic acid and/or a chlorogenic acid. The preventive or remedy can suppress a rise in blood pressure and alleviate hypertension, and is usable as a food.
摘要翻译：用于预防或降低高血压严重程度的产品和组合物。这些产品包含（a）阿魏酸或阿魏酸酯，和（b）咖啡酸和/或绿原酸。预防或补救可以抑制血压升高，缓解高血压，可用作食物。

4. 发明授权

US07534815B2 Preventive or remedy for hypertension 失效
标题翻译：预防或补救高血压
公开(公告)号：US07534815B2
公开(公告)日：2009-05-19
申请号：US10810611
申请日：2004-03-29
申请人： Atsushi Suzuki , Ryuji Ochiai , Ichiro Tokimitsu
发明人： Atsushi Suzuki , Ryuji Ochiai , Ichiro Tokimitsu
IPC分类号： A61K31/235 , A61K31/192
CPC分类号： A61K31/216 , A61K31/12 , A61K31/235
摘要： Provided is a method of treating hypertension, which comprises administering an effective amount of a compound represented by the following formula (1) or (2): wherein, R1 and R2 are the same or different and each independently represents hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkoxyalkyl, aryl, alkylaryl, aralkyl, or acyl, R3 represents hydroxyl, ester bond residue, or amide bond residue, R4 represents ester bond residue or amide bond residue, or a pharmaceutically acceptable salt thereof (except ferulic acid).
摘要翻译：本发明提供一种治疗高血压的方法，其包括给予有效量的下式（1）或（2）表示的化合物：其中，R 1和R 2相同或不同，各自独立地表示氢，烷基，烯基，环烷基，环烯基，烷氧基烷基，芳基，烷基芳基，芳烷基或酰基，R3表示羟基，酯键残基或酰胺键残基，R4表示酯键残基或酰胺键残基，或其药学上可接受的盐（阿魏酸除外）。

5. 发明授权

US4868163A Transparent or semitransparent jelly-like cosmetic composition 失效
标题翻译：透明或半透明果冻状化妆品组合物
公开(公告)号：US4868163A
公开(公告)日：1989-09-19
申请号：US102737
申请日：1987-09-30
申请人： Hiroko Takei , Toshiyuki Suzuki , Tsuyoshi Otomo , Ichiro Tokimitsu
发明人： Hiroko Takei , Toshiyuki Suzuki , Tsuyoshi Otomo , Ichiro Tokimitsu
IPC分类号： A61K8/02 , A61K8/06 , A61K8/34 , A61K8/55 , A61K8/58 , A61K8/92 , A61Q3/00 , A61Q5/12 , A61Q17/04 , A61Q19/10
CPC分类号： A61Q19/10 , A61K8/06 , A61K8/55 , A61Q17/04 , A61Q3/00 , A61Q5/12 , A61K2800/262
摘要： A transparent or semitransparent jelly-like cosmetic composition comprises a monoalkyl phosphate having a .beta.-branched alkyl group, water, an oil which is liquid at room temperature, and an alcohol.The cosmetic composition is highly safe and has good moisturizing effect. Therefore, it can be used as a base for a massage cream, a body treatment, a hand cream, a hair conditioner and the like.
摘要翻译：透明或半透明的果冻状化妆品组合物包含具有β-支链烷基的单烷基磷酸酯，水，在室温下为液体的油和醇。化妆品组合物高度安全，保湿效果好。因此，它可以用作按摩霜，身体护理，护手霜，护发素等的基础。

6. 发明授权

US06310100B1 Method of treating hypertension 有权
标题翻译：治疗高血压的方法
公开(公告)号：US06310100B1
公开(公告)日：2001-10-30
申请号：US09667794
申请日：2000-09-22
申请人： Atsushi Suzuki , Ryuji Ochiai , Ichiro Tokimitsu
发明人： Atsushi Suzuki , Ryuji Ochiai , Ichiro Tokimitsu
IPC分类号： A61K3119
CPC分类号： A61K9/0095 , A23L33/10 , A61K9/4858 , A61K31/192 , A61K45/06 , A61K2300/00
摘要： A method for treating hypertension, a cardiac disease, or a cerebrovascular disease comprising administration of ferulic acid or a derivative thereof, to a subject in need of treatment. Therapeutic compositions comprising ferulic acid and its derivatives may comprise pharmaceutical products, nutritional supplements or products, and foods. Such compositions may further comprising diglycerides in combination with ferulic acid and its derivatives.
摘要翻译：一种治疗高血压，心脏病或脑血管疾病的方法，包括向需要治疗的受试者施用阿魏酸或其衍生物。包含阿魏酸及其衍生物的治疗组合物可包含药物产品，营养补充剂或产品和食品。这样的组合物还可以包含与阿魏酸及其衍生物组合的甘油二酯。

7. 发明授权

US06991812B2 Agent for preventing, improving or treating hypertension 有权
公开(公告)号：US06991812B2
公开(公告)日：2006-01-31
申请号：US09944079
申请日：2001-09-04
申请人： Atsushi Suzuki , Ryuji Ochiai , Ichiro Tokimitsu
发明人： Atsushi Suzuki , Ryuji Ochiai , Ichiro Tokimitsu
IPC分类号： A61K35/78
CPC分类号： A61K31/19 , A61K31/192 , A61K36/67 , A61K36/81 , A61K36/82 , A61K36/906 , A61K2300/00
摘要： The invention relates to an agent for preventing, improving or treating hypertension, which exhibits a hypotensive effect, inhibits the rise of blood pressure and improves hypertension, and food for preventing or improving hypertension, which does not become a burden in daily intake, has a higher antihypertensive effect and is useful as a diet during treatment for patients of hypertension. The agent for preventing, improving or treating hypertension contains the following components (A) and (B): (A) a compound selected from the group consisting of caffeic acid, chlorogenic acid and ferulic acid, and esters and pharmaceutically acceptable salts thereof; and (B) a component selected from the group consisting of central nervous system stimulating components, food fibers, extracts of perennial evergreen leaves of the genus Camellia, Theaceae, or Eucommia ulmoides Oliver, Eucommiae, organic acids having a molecular weight of 60 to 300 (excluding citric acid) and pharmaceutically acceptable salts thereof, and sugar alcohols.

8. 发明申请

US20050281897A1 Agent for preventing, improving or treating hypertension 审中-公开
标题翻译：用于预防，改善或治疗高血压的药物
公开(公告)号：US20050281897A1
公开(公告)日：2005-12-22
申请号：US11209672
申请日：2005-08-24
申请人： Atsushi Suzuki , Ryuji Ochiai , Ichiro Tokimitsu
发明人： Atsushi Suzuki , Ryuji Ochiai , Ichiro Tokimitsu
IPC分类号： A61K31/19 , A61K31/192 , A61K31/216 , A61K31/235 , A61K36/81 , A61K36/82 , A61P9/12 , A61K35/78
CPC分类号： A61K31/19 , A61K31/192 , A61K36/67 , A61K36/81 , A61K36/82 , A61K36/906 , A61K2300/00
摘要： The invention relates to an agent for preventing, improving or treating hypertension, which exhibits a hypotensive effect, inhibits the rise of blood pressure and improves hypertension, and food for preventing or improving hypertension, which does not become a burden in daily intake, has a higher antihypertensive effect and is useful as a diet during treatment for patients of hypertension. The agent for preventing, improving or treating hypertension contains the following components (A) and (B): (A) a compound selected from the group consisting of caffeic acid, chlorogenic acid and ferulic acid, and esters and pharmaceutically acceptable salts thereof; and (B) a component selected from the group consisting of central nervous system stimulating components, food fibers, extracts of perennial evergreen leaves of the genus Camellia, Theaceae, or Eucommia ulmoides Oliver, Eucommiae, organic acids having a molecular weight of 60 to 300 (excluding citric acid) and pharmaceutically acceptable salts thereof, and sugar alcohols.
摘要翻译：本发明涉及一种用于预防，改善或治疗高血压的药物，其具有低血压作用，抑制血压升高和改善高血压，并且用于预防或改善不会成为每日摄取负担的高血压的食品具有更高的抗高血压作用，在治疗高血压患者期间作为饮食有用。用于预防，改善或治疗高血压的药物含有以下组分（A）和（B）：（A）选自咖啡酸，绿原酸和阿魏酸的化合物及其酯和药学上可接受的盐; 和（B）选自中枢神经系统刺激成分，食用纤维，山茶花多年生常绿叶提取物，禾本科或杜仲杜仲，杜仲，分子量为60〜300的有机酸的成分（不含柠檬酸）及其药学上可接受的盐，以及糖醇。

9. 发明申请

US20050215632A1 Preventive or remedy for hypertension 有权
标题翻译：预防或补救高血压
公开(公告)号：US20050215632A1
公开(公告)日：2005-09-29
申请号：US11106428
申请日：2005-04-15
申请人： Atsushi Suzuki , Ryuji Ochiai , Ichiro Tokimitsu
发明人： Atsushi Suzuki , Ryuji Ochiai , Ichiro Tokimitsu
IPC分类号： A61K31/12 , A61K31/216 , A61K31/235 , A61P9/12
CPC分类号： A61K31/216 , A61K31/12 , A61K31/235
摘要： Provided is a method of treating hypertension, which comprises administering an effective amount of a compound represented by the following formula (1) or (2): wherein, R1 and R2 are the same or different and each independently represents hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkoxyalkyl, aryl, alkylaryl, aralkyl, or acyl, R3 represents hydroxyl, ester bond residue, or amide bond residue, R4 represents ester bond residue or amide bond residue, or a pharmaceutically acceptable salt thereof (except ferulic acid). When the preventive or remedy for hypertension according to the present invention is administered, ferulic acid exists in the blood for a long period of time, thereby continuously suppressing a blood pressure rise. Moreover, the hypertension preventive or remedy according to the present invention has reduced in bitterness peculiar to ferulic acid, which enables patients to take it continuously.
摘要翻译：提供一种治疗高血压的方法，其包括给予有效量的由下式（1）或（2）表示的化合物：其中R 1和R 2 2 >相同或不同，并且各自独立地表示氢，烷基，烯基，环烷基，环烯基，烷氧基烷基，芳基，烷基芳基，芳烷基或酰基，R 3表示羟基，酯键残基或酰胺键残基R 4表示酯键残基或酰胺键残基，或其药学上可接受的盐（阿魏酸除外）。当施用根据本发明的高血压的预防或治疗方法时，阿魏酸长期存在于血液中，从而持续抑制血压升高。此外，根据本发明的高血压预防或治疗方法已经降低了阿魏酸特有的苦味，这使患者能够连续服用。

10. 发明授权

US06894077B2 Preventive or remedy for hypertension 失效
公开(公告)号：US06894077B2
公开(公告)日：2005-05-17
申请号：US10161739
申请日：2002-06-05
申请人： Atsushi Suzuki , Ryuji Ochiai , Ichiro Tokimitsu
发明人： Atsushi Suzuki , Ryuji Ochiai , Ichiro Tokimitsu
IPC分类号： A61K31/12 , A61K31/216 , A61K31/235 , A61P9/12 , A61K31/24
CPC分类号： A61K31/216 , A61K31/12 , A61K31/235
摘要： Provided is a method of treating hypertension, which comprises administering an effective amount of a compound represented by the following formula (1) or (2): wherein, R1 and R2 are the same or different and each independently represents hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkoxyalkyl, aryl, alkylaryl, aralkyl, or acyl, R3 represents hydroxyl, ester bond residue, or amide bond residue, R4 represents ester bond residue or amide bond residue, or a pharmaceutically acceptable salt thereof (except ferulic acid). When the preventive or remedy for hypertension according to the present invention is administered, ferulic acid exists in the blood for a long period of time, thereby continuously suppressing a blood pressure rise. Moreover, the hypertension preventive or remedy according to the present invention has reduced in bitterness peculiar to ferulic acid, which enables patients to take it continuously.

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