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1. 发明专利

JP2021126513A 極低温ポンプ审中-公开
公开(公告)号：JP2021126513A
公开(公告)日：2021-09-02
申请号：JP2021012530
申请日：2021-01-28
申请人：アイスキュアメディカルリミテッド , IceCure Medical Ltd.
发明人：ロン、ヒレリィ , シャイ、カウフマン , ナウム、マックニック
IPC分类号： F04B49/06 , A61B18/02
摘要：【課題】プローブを低温定常状態に冷却するために必要な極低温液体の量を減らすことができる極低温ポンプを提供する。【解決手段】装置20は、管腔を含み、そして生きている被験者28の組織に接触するように構成された遠位端を有するプローブ60を有する。温度センサは遠位端に配置され、ポンプモータを含むポンプ56は、管腔を通してプローブの遠位端に極低温流体52を送達し、そしてプローブから戻り極低温流体を受け取るように結合される。戻り極低温流体を戻り極低温液体と戻り極低温ガスに分離するように結合された分離器と、戻り極低温ガスの流量を測定するように結合された流量計を備える。プロセッサは、温度センサによって測定された温度と戻り極低温ガスの流量に応答してポンプモータのポンプ速度を制御するように構成される。【選択図】図1

2. 发明申请

WO2012121786A1 CRYOSURGICAL INSTRUMENT WITH REDIRECTED FLOW 审中-公开
标题翻译：具有重流流量的晶状体仪器
公开(公告)号：WO2012121786A1
公开(公告)日：2012-09-13
申请号：PCT/US2011/067858
申请日：2011-12-29
申请人： SHARON, Assaf , BERZAK, Nir , HILLELI, Ron , ICECURE MEDICAL LTD.
发明人： SHARON, Assaf , BERZAK, Nir , HILLELI, Ron
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/00166 , A61B2018/0212 , A61B2018/0262 , A61B2018/0281
摘要： A cryosurgical instrument that includes: an external shaft with a cryotip; a heat exchanger that cools a portion of the external shaft and the tip when cryogen is received thereby; and a flow diverter that receives a flow of cryogen, that splits the received flow of cryogen into two or more split cryogen flows, and that delivers the split cryogen flows to the heat exchanger, the flow diverter including a first passage with one or more inlet ports at an upstream side of the diverter that receive the flow of cryogen and two or more outlet ports at a downstream side of the diverter and in fluid communication with the heat exchanger.
摘要翻译：一种冷冻手术器械，包括：具有低温液位的外部轴; 当接收冷冻剂时，冷却外部轴和末端的一部分的热交换器; 以及分流器，其接收冷冻剂流，其将所接收的冷冻剂流分解成两个或更多个分裂的冷冻剂流，并将分离的冷冻剂流输送到热交换器，所述分流器包括具有一个或多个入口在转向器的上游侧的端口，其在分流器的下游侧接收冷冻剂流和两个或更多个出口，并且与热交换器流体连通。

3. 发明申请

WO2010105158A1 COMBINED CRYOTHERAPY AND BRACHYTHERAPY DEVICE AND METHOD 审中-公开
标题翻译：组合式CRYOTHERAPY和BRACHYTHERAPY装置及方法
公开(公告)号：WO2010105158A1
公开(公告)日：2010-09-16
申请号：PCT/US2010/027142
申请日：2010-03-12
申请人： SHAI, Eyal , BERZAK, Nir , ICECURE MEDICAL LTD.
发明人： SHAI, Eyal , BERZAK, Nir
IPC分类号： A61B18/02 , A61N5/10
CPC分类号： A61B18/02 , A61B2018/0262 , A61N5/1015
摘要： Combined brachytherapy and ablation devices and methods. A combined brachytherapy and cryotherapy method, includes: inserting an ablation device into tissue of a subject; ablating tissue within an ablation zone of the device; detaching and removing a first part of the device while leaving a second part of the device in the tissue, the first part contacting the ablation zone; and inserting a brachytherapy rod into the second part of the device when the second part is detached from the first part, the brachytherapy rod connected to base at one end and retaining at least one radioactive seed at an opposing end, the brachytherapy rod configured and dimensioned so that when it is inserted into the device up to the base, the at least one radioactive seed is in the ablation zone.
摘要翻译：联合近距离放射治疗和消融装置及方法。联合近距离放射治疗和冷冻治疗方法包括：将消融装置插入受试者的组织中; 在装置的消融区内消融组织; 在将装置的第二部分留在组织中时分离和移除装置的第一部分，第一部分接触消融区; 以及当所述第二部分从所述第一部分分离时，将近距离放射治疗杆插入所述装置的第二部分中，所述近距离放射治疗杆在一端连接到基部并且在相对端保持至少一个放射性种子，所述近距离放射治疗杆被构造和确定使得当其插入设备直到基部时，至少一个放射性种子在消融区域中。

4. 发明申请

WO2011119279A2 CRYOSURGICAL INSTRUMENT WITH ENHANCED HEAT TRANSFER 审中-公开
标题翻译：具有增强热传递的CRYOSURGICAL INSTRUMENT
公开(公告)号：WO2011119279A2
公开(公告)日：2011-09-29
申请号：PCT/US2011/025663
申请日：2011-02-22
申请人： BERZAK, Nir , SHARON, Simon , ICECURE MEDICAL LTD. , SHTEIMAN, Igal , SHILDER, Eytan
发明人： BERZAK, Nir , SHARON, Simon , SHTEIMAN, Igal , SHILDER, Eytan
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/0268
摘要： Cryosurgical instruments and methods utilizing improved heat transfer characteristics. A cryosurgical device includes: a tubular housing; a cryogen supply passage; a heat exchange enhancing member in the housing, disposed along a longitudinal axis of the housing; an annular cooling passage between the heat exchange enhancing member and the tubular housing; a tip cooling and cryogen flow directing section that transmits a temperature of a cryogen flow to the tip, and an insulation element in the tubular housing.
摘要翻译：使用改善的传热特性的冷冻手术器械和方法。冷冻手术装置包括：管状壳体; 制冷剂供应通道; 所述壳体中的热交换增强构件沿着所述壳体的纵向轴线设置; 在所述热交换增强构件和所述管状壳体之间的环形冷却通道; 尖端冷却和冷冻剂流引导部分，其将冷冻剂流的温度传递到尖端，以及管状壳体中的绝缘元件。

5. 发明申请

WO2010138303A1 DEVICE AND METHOD FOR THREE-DIMENSIONAL GUIDANCE AND THREE-DIMENSIONAL MONITORING OF CRYOABLATION 审中-公开
标题翻译：三维指导装置和方法，三维结构监测
公开(公告)号：WO2010138303A1
公开(公告)日：2010-12-02
申请号：PCT/US2010/034467
申请日：2010-05-12
申请人： SHAI, Eyal , SHARON, Shimon , BERZAK, Nir , ICECURE MEDICAL LTD.
发明人： SHAI, Eyal , SHARON, Shimon , BERZAK, Nir
IPC分类号： A61B18/02 , A61B19/00
CPC分类号： A61B18/02 , A61B34/20 , A61B2034/2051 , A61B2090/378
摘要： Systems and methods for three-dimensional guidance and monitoring of a cryotherapy procedure, including virtually performing the procedure. A method of virtually performing a cryotherapy procedure includes: selecting a target object from three-dimensional image data displayed in three dimensions; selecting a three-dimensional ablation zone; selecting, from a library of virtual cryoprobe needles, a cryoprobe needle with a three-dimensional ablation zone that corresponds to the selected ablation zone; comparing the location of the target object with the selected ablation zone; determining, via a processor, a virtual trajectory for the virtual cryoprobe needle from an entry site to the target object when the ablation zone of the virtual cryoprobe needle is in the optimal position; and calculating a result of the procedure based on the target object, the selected ablation zone, the selected needle, and a duration of treatment.
摘要翻译：三维指导和监测冷冻治疗程序的系统和方法，包括虚拟执行程序。一种虚拟执行冷冻治疗程序的方法包括：从三维显示的三维图像数据中选择目标对象; 选择三维消融区; 从虚拟冷冻探针针库中选择具有对应于所选择的消融区的三维消融区的冷冻针针; 将目标物体的位置与所选择的消融区域进行比较; 当所述虚拟冷冻探针针的消融区处于最佳位置时，经由处理器确定所述虚拟冷冻探针针从进入位置到所述目标对象的虚拟轨迹; 以及基于所述目标对象，所选择的消融区域，所选择的针头和所述治疗持续时间来计算所述过程的结果。

6. 发明申请

WO2015138010A1 PHASE SEPARATION OF CRYOGEN IN CRYOSURGICAL INSTRUMENT 审中-公开
标题翻译： CRYOSURGICAL INSTRUMENT中的CRYOG相分离
公开(公告)号：WO2015138010A1
公开(公告)日：2015-09-17
申请号：PCT/US2014/064292
申请日：2014-11-06
申请人： ICECURE MEDICAL LTD.
发明人： BERZAK, Nir , HILLELI, Ron
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/0212 , A61B2018/0281 , A61B2018/0287
摘要： A cryosurgical instrument including: a shaft having a closed distal end defining an expansion chamber and a proximal end that receives an inflow of cryogen and to exhaust a flow of expanded cryogen; and a heat exchanger with a cryogen delivery tube that spirals around a core disposed along a longitudinal axis thereof. The cryogen delivery tube, where it spirals, is in fluid tight contact with the inner surface of the shaft so as to form spiraling cryogen exhaust pathways that extend along a portion of a length of the cryosurgical instrument from the distal end of the shaft. The cryogen delivery tube forces a two-phase flow of cryogen to undergo phase separation by centrifugal forces and urges the liquid phase against the external walls of the spiral coil and the outer surface of the spiral gap. Heat exchanging occurs close to the external wall of the instrument.
摘要翻译：一种冷冻手术器械，包括：具有限定膨胀室的封闭远端的轴和接收冷冻剂流入并排出膨胀冷冻剂流的近端; 以及具有冷却剂输送管的热交换器，所述冷冻剂输送管围绕沿其纵向轴线设置的芯线螺旋形。其螺旋形的冷冻剂输送管与轴的内表面流体紧密接触，以便形成从轴远端沿冷冻手术器具长度的一部分延伸的螺旋式冷冻剂排放通道。冷冻剂输送管迫使冷冻剂的两相流动通过离心力进行相分离，并将液相推向螺旋线圈的外壁和螺旋间隙的外表面。热交换发生在仪器外壁附近。

7. 发明申请

WO2012154195A1 COILED HEAT EXCHANGER FOR CRYOSURGICAL INSTRUMENT 审中-公开
标题翻译：用于结缔组织的换热器
公开(公告)号：WO2012154195A1
公开(公告)日：2012-11-15
申请号：PCT/US2011/051529
申请日：2011-09-14
申请人： BERZAK, Nir , HILLELI, Ron , ICECURE MEDICAL LTD.
发明人： BERZAK, Nir , HILLELI, Ron
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/0218 , A61B2018/0212 , A61B2018/0281 , A61B2018/0287 , A61B2018/0293
摘要： A cryosurgical instrument including: a shaft having a closed distal end defining an expansion chamber and an open proximal end adapted and configured to receive an inflow of cryogen and to exhaust a flow of expanded cryogen; and a heat exchanger. The heat exchanger includes: a plurality of cryogen delivery tubes that spiral around a longitudinal axis thereof; and a diffuser having a plurality of branches, each of the branches supplying received cryogen to a respective one of the delivery tubes. The cryogen delivery tubes, where they spiral, are spaced from each other and in fluid tight contact with the inner surface of the shaft so as to form spiraling cryogen exhaust pathways that extend along a portion of a length of the cryosurgical instrument from the distal end of the shaft.
摘要翻译：一种冷冻手术器械，包括：具有限定膨胀室的封闭远端的轴和适于并构造成接收冷冻剂流入并排出膨胀冷冻剂流的开口近端; 和热交换器。热交换器包括：围绕其纵向轴线螺旋的多个冷冻剂输送管; 以及具有多个分支的扩散器，每个分支将接收的冷冻剂供应到相应的一个输送管。其中它们是螺旋状的冷冻剂输送管彼此间隔开并与轴的内表面流体紧密接触，以便形成螺旋形冷冻剂排气通道，其沿冷冻手术器械长度的一部分从远端延伸的轴。

8. 发明申请

US20170100184A1 PHASE SEPARATION OF CRYOGEN IN CRYOSURGICAL INSTRUMENT 有权
公开(公告)号：US20170100184A1
公开(公告)日：2017-04-13
申请号：US15125258
申请日：2014-11-06
申请人： ICECURE MEDICAL LTD.
发明人： Nir BERZAK , Ron HILLELI
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/0218 , A61B2018/0212 , A61B2018/0281 , A61B2018/0287 , A61B2018/0293
摘要： A cryosurgical instrument including: a shaft having a closed distal end defining an expansion chamber and a proximal end that receives an inflow of cryogen and to exhaust a flow of expanded cryogen; and a heat exchanger with a cryogen delivery tube that spirals around a core disposed along a longitudinal axis thereof. The cryogen delivery tube, where it spirals, is in fluid tight contact with the inner surface of the shaft so as to form spiraling cryogen exhaust pathways that extend along a portion of a length of the cryosurgical instrument from the distal end of the shaft The cryogen delivery tube forces a two-phase flow of cryogen to undergo phase separation by centrifugal forces and urges the liquid phase against the external walls of the spiral coil and the outer surface of the spiral gap. Heat exchanging occurs close to the external wall of the instrument.

9. 发明申请

US20140194863A1 PHASE SEPARATION OF CRYOGEN IN CRYOSURGICAL INSTRUMENT 有权
标题翻译： CRYOSURGICAL INSTRUMENT中的CRYOG相分离
公开(公告)号：US20140194863A1
公开(公告)日：2014-07-10
申请号：US14204175
申请日：2014-03-11
申请人： ICECURE MEDICAL LTD.
发明人： Nir BERZAK , Ron HILLELI
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/0218 , A61B2018/0212 , A61B2018/0281 , A61B2018/0287 , A61B2018/0293
摘要： A cryosurgical instrument including: a shaft having a closed distal end defining an expansion chamber and an open proximal end that receives an inflow of cryogen and to exhaust a flow of expanded cryogen; and a heat exchanger with a cryogen delivery tube that spirals around a core disposed along longitudinal axis thereof. The cryogen delivery tube, at least where it spirals, is in fluid tight contact with the inner surface of the shaft so as to form spiraling cryogen exhaust pathways that extend along a portion of a length of the cryosurgical instrument from the distal end of the shaft. The cryogen delivery tube forces a two-phase flow of cryogen to undergo phase separation by centrifugal forces and urges the liquid phase against the external walls of the spiral coil and the outer surface of the spiral gap. Heat exchanging, through boiling, occurs close to the external wall of the instrument.
摘要翻译：一种冷冻手术器械，包括：轴，其具有限定膨胀室的封闭远端和容纳冷冻剂流入并排出膨胀冷冻剂流的开口近端; 以及具有冷却剂输送管的热交换器，所述冷冻剂输送管围绕沿其纵向轴线设置的芯线螺旋形。冷冻剂输送管至少在其螺旋状的位置处与轴的内表面流体紧密接触，以便形成螺旋形的冷冻剂排放通道，其沿着冷冻外科器械长度的一部分从轴的远端延伸。冷冻剂输送管迫使冷冻剂的两相流动通过离心力进行相分离，并将液相推向螺旋线圈的外壁和螺旋间隙的外表面。热交换通过煮沸发生在仪器的外壁附近。

10. 发明申请

US20140169993A1 CRYOGEN PUMP 审中-公开
标题翻译：低温泵
公开(公告)号：US20140169993A1
公开(公告)日：2014-06-19
申请号：US13718220
申请日：2012-12-18
申请人： ICECURE MEDICAL LTD.
发明人： Nir Berzak , Simon Sharon , Michael Voloshin , Ron Hilleli
IPC分类号： F04B15/08
CPC分类号： F04B43/028 , B01D8/00 , F04B15/08 , F04B37/08 , F04B45/02 , F04B53/10 , F04B53/14 , F04B2015/0824
摘要： A cryogen pump, including: a pump section that includes: a bellow with an inlet opening at a first end and an exit opening, the inlet opening in direct fluid communication with a volume of a cryogen, the exit opening at least in fluid communication with a second end of the bellow opposing the first end, a pair of plugs configured to sealingly close the opposing ends of the bellow, the pair of plugs cooperating so that when one plug sealingly closes one of the ends, the other end of the bellow is open; and a drive section configured to drive the pump section in a reciprocating manner so as to move the plugs.
摘要翻译： 1.一种冷冻剂泵，包括：泵部分，其包括：波纹管，其具有在第一端处的入口开口和出口开口，所述入口开口与一定体积的冷冻剂直接流体连通，所述出口至少与波纹管的与第一端相对的第二端，一对栓被构造成密封地封闭波纹管的相对端，所述一对插塞配合，使得当一个塞子密封地封闭其中一个端部时，波纹管的另一端是打开; 以及驱动部，其构造成以往复方式驱动所述泵部，以使所述塞移动。

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