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1. 发明授权

US08993807B2 Alkoxy compounds for disease treatment 有权
公开(公告)号：US08993807B2
公开(公告)日：2015-03-31
申请号：US13291932
申请日：2011-11-08
申请人： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
发明人： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
IPC分类号： C09B11/02 , C07C211/00 , A01N33/02 , A61K31/135 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C317/28 , C07C323/25 , C07D277/24 , C07D309/06
CPC分类号： A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

2. 发明授权

US08829244B2 Alkoxy compounds for disease treatment 有权
标题翻译：用于疾病治疗的烷氧基化合物
公开(公告)号：US08829244B2
公开(公告)日：2014-09-09
申请号：US13620388
申请日：2012-09-14
申请人： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
发明人： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
IPC分类号： C09B11/02 , C07C211/00 , C07D277/24 , C07C225/16 , C07C323/25 , C07C217/72 , C07C251/86 , C07D309/06 , C07C279/08 , C07C317/28 , C07C233/18 , C07C235/08 , C07C217/62 , C07C229/38 , C07C217/64 , C07C215/20 , C07C217/20 , C07C217/60
CPC分类号： A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
摘要翻译：本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。本文提供的是烷氧基衍生物化合物和包含这些化合物的药物组合物。主题组合物可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和斯塔尔加氏病。

3. 发明申请

US20120041039A1 AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS 失效
公开(公告)号：US20120041039A1
公开(公告)日：2012-02-16
申请号：US13278925
申请日：2011-10-21
申请人： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Feng Hong , Thomas L. Little, JR. , Ryo Kubota
发明人： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Feng Hong , Thomas L. Little, JR. , Ryo Kubota
IPC分类号： A61K31/4406 , A61K31/137 , C07C215/28 , C07C217/48 , C07C217/70 , A61K31/138 , C07C217/74 , C07D335/02 , A61K31/382 , C07C215/38 , C07D213/38 , A61K31/4402 , C07D333/20 , A61K31/381 , C07C237/20 , A61K31/165 , C07D309/06 , A61K31/351 , C12N5/071 , C12N5/079 , A61P27/02 , A61P29/00 , C07C211/27
CPC分类号： A61K31/382 , A61K31/138 , A61K31/165 , A61K31/351 , C07C211/27 , C07C213/00 , C07C215/20 , C07C215/28 , C07C215/30 , C07C215/42 , C07C217/16 , C07C217/48 , C07C217/54 , C07C217/72 , C07C217/74 , C07C219/22 , C07C225/16 , C07C225/18 , C07C233/18 , C07C235/34 , C07C235/54 , C07C237/20 , C07C237/38 , C07C237/40 , C07C257/14 , C07C279/08 , C07C317/28 , C07C323/25 , C07C323/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D213/30 , C07D213/38 , C07D309/06 , C07D333/16 , C07D333/20 , C07D335/02
摘要： Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

4. 发明授权

US07745619B2 Vinca derivatives 有权
标题翻译：长春花衍生物
公开(公告)号：US07745619B2
公开(公告)日：2010-06-29
申请号：US11933259
申请日：2007-10-31
申请人： Ian L. Scott , Jeffrey M. Ralph , Matthew E. Voss
发明人： Ian L. Scott , Jeffrey M. Ralph , Matthew E. Voss
IPC分类号： C07D245/00
CPC分类号： C07D519/04
摘要： The present invention relates to derivatives of vinca alkaloids. Pharmaceutical compositions containing these compounds as well as processes of preparation and treatment of various conditions are also disclosed.
摘要翻译：本发明涉及长春花生物碱的衍生物。还公开了含有这些化合物的药物组合物以及各种条件的制备和处理方法。

5. 发明申请

US20100093865A1 SULPHUR-LINKED COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS 审中-公开
标题翻译：用于治疗眼睛疾病和疾病的硫化合物
公开(公告)号：US20100093865A1
公开(公告)日：2010-04-15
申请号：US12553054
申请日：2009-09-02
申请人： Ian L. Scott , Vladimir A. Kuksa , Ryo Kubota
发明人： Ian L. Scott , Vladimir A. Kuksa , Ryo Kubota
IPC分类号： A61K31/18 , C07C211/28 , C07C215/28 , C07C311/20 , A61K31/137 , A61P27/02
CPC分类号： C07C323/32 , C07B2200/05 , C07C311/37 , C07C317/22 , C07C317/32 , C07C323/20 , C07C323/41 , C07C323/62 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18
摘要： Provided are sulphur-linked compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
摘要翻译：提供硫化合物，其药物组合物，以及使用所述化合物和组合物治疗眼科疾病和病症如老年性黄斑变性和Stargardt氏病的方法。

6. 发明授权

US06262084B1 Compounds that inhibit the binding of integrins to their receptors 有权
标题翻译：抑制整联蛋白与其受体结合的化合物
公开(公告)号：US06262084B1
公开(公告)日：2001-07-17
申请号：US09417886
申请日：1999-10-14
申请人： Ronald J. Biediger , Vanessa O. Grabbe , George W. Holland , Jamal Kassir , Karin M. Keller , Timothy P. Kogan , Shuqun Lin , Robert V. Market , Bore G. Raju , Ian L. Scott , Chengde Wu
发明人： Ronald J. Biediger , Vanessa O. Grabbe , George W. Holland , Jamal Kassir , Karin M. Keller , Timothy P. Kogan , Shuqun Lin , Robert V. Market , Bore G. Raju , Ian L. Scott , Chengde Wu
IPC分类号： A61K31192
CPC分类号： C07D417/14 , C07D317/60 , C07D333/20 , C07D333/24 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14
摘要： A method for the inhibition of the binding of &agr;4&bgr;1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions thereof; and the use of the compounds either as above, or in formulations for the control or prevention of diseases states in which &agr;4&bgr;1 is involved.
摘要翻译：抑制α4β1整联蛋白与其受体结合的方法，例如VCAM-1（血管细胞粘附分子-1）和纤连蛋白; 抑制这种结合的化合物; 其药物活性组合物; 以及如上所述的化合物或用于控制或预防涉及α4β1的疾病状态的制剂中的用途。

7. 发明授权

US5444050A Binding of E-selectin or P-selectin to sialyl Lewis.sup.x or sialyl-Lewis.sup.a 失效
公开(公告)号：US5444050A
公开(公告)日：1995-08-22
申请号：US235293
申请日：1994-04-29
申请人： Timothy P. Kogan , Brian Dupre , Ian L. Scott , Karin Keller , Huong Dao , Pamela J. Beck
发明人： Timothy P. Kogan , Brian Dupre , Ian L. Scott , Karin Keller , Huong Dao , Pamela J. Beck
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61P1/00 , A61P9/00 , A61P11/08 , A61P17/00 , A61P29/00 , A61P35/00 , A61P37/06 , C07H15/18 , C07H15/203 , C07H15/20
CPC分类号： C07H15/18 , C07H15/203
摘要： This invention relates to compounds that inhibit the binding of E-selectin and/or P-selectin to sialyl-Lewis.sup.x or sialyl-Lewis.sup.a presented on a cell surface having the general structure ##STR1## wherein X is selected from the group consisting of --(CH.sub.2).sub.n CO.sub.2 H, --O(CH.sub.2).sub.m CO.sub.2 H, --(CH.sub.2).sub.n O(CH.sub.2).sub.m CO.sub.2 H, --CONH(CH.sub.2).sub.m CO.sub.2 H, --CH(OZ)(CO.sub.2 H), --CH(Z)(CO.sub.2 H), --(CH.sub.2).sub.n SO.sub.3 H, --(CH.sub.2).sub.n PO.sub.3 D.sub.1 D.sub.2, --NH(CH.sub.2).sub.m CO.sub.2 H, --CONH(CHR.sub.6)CO.sub.2 H, (1-H-tetrazolyl-5-alkyl-), and --OH;R.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen, alkyl, halogen, --OZ, --NO.sub.2, --NH.sub.2 and --NHZ;R.sub.3 is selected from the group consisting of hydrogen, halogen, alkyl, --OZ and --NHZ;R.sub.4 is selected from the group consisting of hydrogen, halogen, alkyl, hydroxyl, hydroxyl-O-sulfate and --OZ;R.sub.5 is selected from the group consisting of hydroxyl, --CN, --N.sub.3, --NH.sub.2, --NHNH.sub.2, --NE.sub.1 E.sub.2, --NHE.sub.1, --NHCO(CH.sub.2).sub.n CO.sub.2 H, --S(CH.sub.2).sub.m CO.sub.2 H and --NHCHNHNH.sub.2 ;R.sub.6 is selected from the group consisting of hydrogen, alkyl, aralkyl, hydroxyalkyl, aminoalkyl, alkyl carboxylic acid and alkyl carboxamide;wherein n is 0 to 6, m is 1 to 6, p is 0 to 6, b is 0 to 2, Z is alkyl, aryl or aralkyl, D.sub.1 and D.sub.2 are independantly hydrogen or alkyl, E.sub.1 is alkyl or --(CH.sub.2).sub.8 CO.sub.2 H, and E.sub.2 is alkyl, and the pharmaceutically acceptable salts, esters, amides, and prodrugs thereof. This invention also relates to methods of inhibiting the binding of E-selectin and/or P-selectin to sialyl-Lewis.sup.x or sialyl-Lewis.sup.a presented on a cell surface using said compounds and to pharmaceutically active compositions comprising compounds that inhibit the binding of E-selectin to sialyl-Lewis.sup.x and to methods of treatment of septic shock, ARDS, Crohn's disease, chronic inflammatory diseases, such as psoriasis and rheumatoid arthritis, and reperfusion injuries that occur following heart attacks, strokes and organ transplants.

8. 发明授权

US08981153B2 Alkoxy compounds for disease treatment 有权
公开(公告)号：US08981153B2
公开(公告)日：2015-03-17
申请号：US13111679
申请日：2011-05-19
申请人： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
发明人： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
IPC分类号： C07C211/00 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C317/28 , C07C323/25 , C07D277/24 , C07C309/06
CPC分类号： A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

9. 发明授权

US08895543B2 Vinca derivatives 有权
标题翻译：长春花衍生物
公开(公告)号：US08895543B2
公开(公告)日：2014-11-25
申请号：US11697415
申请日：2007-04-06
申请人： Ian L. Scott , Jeffrey M. Ralph , Matthew E. Voss
发明人： Ian L. Scott , Jeffrey M. Ralph , Matthew E. Voss
IPC分类号： A61K31/33 , A61K31/395 , C07D519/04
CPC分类号： C07D519/04
摘要： The present invention relates to derivatives of vinca alkaloids. Pharmaceutical compositions containing these compounds as well as processes of preparation and treatment of various conditions are also disclosed.
摘要翻译：本发明涉及长春花生物碱的衍生物。还公开了含有这些化合物的药物组合物以及各种条件的制备和处理方法。

10. 发明授权

US08076516B2 Amine derivative compounds for treating ophthalmic diseases and disorders 有权
标题翻译：用于治疗眼科疾病和病症的胺衍生物化合物
公开(公告)号：US08076516B2
公开(公告)日：2011-12-13
申请号：US12256415
申请日：2008-10-22
申请人： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Feng Hong , Thomas L. Little, Jr. , Ryo Kubota
发明人： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Feng Hong , Thomas L. Little, Jr. , Ryo Kubota
IPC分类号： A61K31/135 , C07C211/00
CPC分类号： A61K31/382 , A61K31/138 , A61K31/165 , A61K31/351 , C07C211/27 , C07C213/00 , C07C215/20 , C07C215/28 , C07C215/30 , C07C215/42 , C07C217/16 , C07C217/48 , C07C217/54 , C07C217/72 , C07C217/74 , C07C219/22 , C07C225/16 , C07C225/18 , C07C233/18 , C07C235/34 , C07C235/54 , C07C237/20 , C07C237/38 , C07C237/40 , C07C257/14 , C07C279/08 , C07C317/28 , C07C323/25 , C07C323/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D213/30 , C07D213/38 , C07D309/06 , C07D333/16 , C07D333/20 , C07D335/02
摘要： Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
摘要翻译：提供的是胺衍生物化合物，其药物组合物，以及使用所述化合物和组合物治疗眼科疾病和疾病如老年性黄斑变性和Stargardt氏病的方法。

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