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1. 发明授权

US06951632B2 Microfluidic devices for introducing and dispensing fluids from microfluidic systems 失效
公开(公告)号：US06951632B2
公开(公告)日：2005-10-04
申请号：US09998600
申请日：2001-11-16
申请人： Marc A. Unger , Hou-Pu Chou , Ian D. Manger , Dave Fernandes , Yong Yi
发明人： Marc A. Unger , Hou-Pu Chou , Ian D. Manger , Dave Fernandes , Yong Yi
IPC分类号： B01L3/00 , B01L3/02 , B29C65/00 , B29C65/48 , B81B1/00 , F15C5/00 , F16K99/00 , G01N1/00 , B01L9/00 , B01L11/00 , G01N15/06
CPC分类号： B01L3/02 , B01L3/0268 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/027 , B01L2200/0605 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2300/123 , B01L2400/0406 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0688 , B29C65/006 , B29C65/48 , B29C66/112 , B29C66/1122 , B29C66/114 , B29C66/1222 , B29C66/1224 , B29C66/1226 , B29C66/532 , B29C66/54 , B29C66/71 , B29L2031/756 , B81B2201/13 , F16K99/0001 , F16K99/0015 , F16K99/0017 , F16K99/0048 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/008 , F16K2099/0084 , G01N1/14 , Y10T137/0318 , Y10T137/0396 , Y10T436/11 , Y10T436/118339 , Y10T436/119163 , B29K2021/00
摘要： The present invention provides microfluidic devices, systems and methods for using the same, which facilitate the introduction of fluid to and from a microfluidic channel located within the microfluidic devices.

2. 发明授权

US09643178B2 Microfluidic device with reaction sites configured for blind filling 有权
公开(公告)号：US09643178B2
公开(公告)日：2017-05-09
申请号：US13439364
申请日：2012-04-04
申请人： Marc Unger , Ian D. Manger , Michael Lucero , Yong Yi , Emily Miyashita-Lin , Anja Wienecke , Geoffrey Facer
发明人： Marc Unger , Ian D. Manger , Michael Lucero , Yong Yi , Emily Miyashita-Lin , Anja Wienecke , Geoffrey Facer
IPC分类号： B01L3/00 , C12Q1/68 , G01N35/00 , B01F13/00 , C40B60/14
CPC分类号： C12M1/38 , B01F13/0059 , B01J2219/00337 , B01J2219/00353 , B01J2219/00403 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/0072 , B01L3/502707 , B01L3/502715 , B01L3/50851 , B01L2300/0627 , B01L2300/123 , B01L2400/06 , C12Q1/68 , C12Q1/6844 , C40B60/14 , F16K11/20 , G01N35/00029 , G01N35/0098 , G01N2035/00366 , Y10T137/2076 , Y10T137/2496 , Y10T137/86292 , Y10T137/87249 , Y10T436/2575 , C12Q2565/501
摘要： A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyzes. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyzes requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyzes.

3. 发明申请

US20130065773A1 Microfluidic Device and Methods of Using Same 审中-公开
标题翻译：微流控装置及其使用方法
公开(公告)号：US20130065773A1
公开(公告)日：2013-03-14
申请号：US13439364
申请日：2012-04-04
申请人： Marc Unger , Ian D. Manger , Michael Lucero , Yong Yi , Emily Miyashita-Lin , Anja Wienecke , Geoffrey Facer
发明人： Marc Unger , Ian D. Manger , Michael Lucero , Yong Yi , Emily Miyashita-Lin , Anja Wienecke , Geoffrey Facer
IPC分类号： C12M1/40 , B05D7/02 , C40B60/12 , C12Q1/68 , C12Q1/04 , C40B30/04 , F16K24/00 , C12M1/34
CPC分类号： C12M1/38 , B01F13/0059 , B01J2219/00337 , B01J2219/00353 , B01J2219/00403 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/0072 , B01L3/502707 , B01L3/502715 , B01L3/50851 , B01L2300/0627 , B01L2300/123 , B01L2400/06 , C12Q1/68 , C12Q1/6844 , C40B60/14 , F16K11/20 , G01N35/00029 , G01N35/0098 , G01N2035/00366 , Y10T137/2076 , Y10T137/2496 , Y10T137/86292 , Y10T137/87249 , Y10T436/2575 , C12Q2565/501
摘要： A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyses.
摘要翻译：提供了各种基于弹性体的微流体装置和用于使用和制造这种装置的方法。某些设备具有反应位置阵列以便于高通量分析。一些装置还包括位于盲制通道末端的反应位置，在制造过程中试剂已经预先沉积。一旦将样品引入反应部位，试剂就会悬浮。该装置可以与各种加热装置一起使用，因此可用于需要温度控制的各种分析，包括热循环应用，如核酸扩增反应，基因分型和基因表达分析。

4. 发明授权

US08163492B2 Microfluidic device and methods of using same 有权
标题翻译：微流控装置及其使用方法
公开(公告)号：US08163492B2
公开(公告)日：2012-04-24
申请号：US12858364
申请日：2010-08-17
申请人： Marc Unger , Ian D. Manger , Michael Lucero , Yong Yi , Emily Miyashita-Lin , Anja Wienecke , Geoffrey Facer
发明人： Marc Unger , Ian D. Manger , Michael Lucero , Yong Yi , Emily Miyashita-Lin , Anja Wienecke , Geoffrey Facer
IPC分类号： C12Q1/68
CPC分类号： C12M1/38 , B01F13/0059 , B01J2219/00337 , B01J2219/00353 , B01J2219/00403 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/0072 , B01L3/502707 , B01L3/502715 , B01L3/50851 , B01L2300/0627 , B01L2300/123 , B01L2400/06 , C12Q1/68 , C12Q1/6844 , C40B60/14 , F16K11/20 , G01N35/00029 , G01N35/0098 , G01N2035/00366 , Y10T137/2076 , Y10T137/2496 , Y10T137/86292 , Y10T137/87249 , Y10T436/2575 , C12Q2565/501
摘要： A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyses.
摘要翻译：提供了各种基于弹性体的微流体装置和用于使用和制造这种装置的方法。某些设备具有反应位置阵列以便于高通量分析。一些装置还包括位于盲制通道末端的反应位置，在制造过程中试剂已经预先沉积。一旦将样品引入反应部位，试剂就会悬浮。该装置可以与各种加热装置一起使用，因此可用于需要温度控制的各种分析，包括热循环应用，如核酸扩增反应，基因分型和基因表达分析。

5. 发明申请

US20110053784A1 Microfluidic Device and Methods of Using Same 有权
标题翻译：微流控装置及其使用方法
公开(公告)号：US20110053784A1
公开(公告)日：2011-03-03
申请号：US12858364
申请日：2010-08-17
申请人： Marc Unger , Ian D. Manger , Michael Lucero , Yong Yi , Emily Miyashita-Lin , Anja Wienecke , Geoffrey Facer
发明人： Marc Unger , Ian D. Manger , Michael Lucero , Yong Yi , Emily Miyashita-Lin , Anja Wienecke , Geoffrey Facer
IPC分类号： C12Q1/68 , C12M1/34 , C40B30/00
CPC分类号： C12M1/38 , B01F13/0059 , B01J2219/00337 , B01J2219/00353 , B01J2219/00403 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/0072 , B01L3/502707 , B01L3/502715 , B01L3/50851 , B01L2300/0627 , B01L2300/123 , B01L2400/06 , C12Q1/68 , C12Q1/6844 , C40B60/14 , F16K11/20 , G01N35/00029 , G01N35/0098 , G01N2035/00366 , Y10T137/2076 , Y10T137/2496 , Y10T137/86292 , Y10T137/87249 , Y10T436/2575 , C12Q2565/501
摘要： A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyses.
摘要翻译：提供了各种基于弹性体的微流体装置和用于使用和制造这种装置的方法。某些设备具有反应位置阵列以便于高通量分析。一些装置还包括位于盲制通道末端的反应位置，在制造过程中试剂已经预先沉积。一旦将样品引入反应部位，试剂就会悬浮。该装置可以与各种加热装置一起使用，因此可用于需要温度控制的各种分析，包括热循环应用，如核酸扩增反应，基因分型和基因表达分析。

6. 发明授权

US07820427B2 Microfluidic device and methods of using same 有权
公开(公告)号：US07820427B2
公开(公告)日：2010-10-26
申请号：US11531147
申请日：2006-09-12
申请人： Marc Unger , Ian D. Manger , Michael Lucero , Yong Yi , Emily Miyashita-Lin , Anja Wienecke , Geoffrey Facer
发明人： Marc Unger , Ian D. Manger , Michael Lucero , Yong Yi , Emily Miyashita-Lin , Anja Wienecke , Geoffrey Facer
IPC分类号： C12M1/38
CPC分类号： C12M1/38 , B01F13/0059 , B01J2219/00337 , B01J2219/00353 , B01J2219/00403 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/0072 , B01L3/502707 , B01L3/502715 , B01L3/50851 , B01L2300/0627 , B01L2300/123 , B01L2400/06 , C12Q1/68 , C12Q1/6844 , C40B60/14 , F16K11/20 , G01N35/00029 , G01N35/0098 , G01N2035/00366 , Y10T137/2076 , Y10T137/2496 , Y10T137/86292 , Y10T137/87249 , Y10T436/2575 , C12Q2565/501
摘要： A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyses.

7. 发明授权

US07118910B2 Microfluidic device and methods of using same 有权
公开(公告)号：US07118910B2
公开(公告)日：2006-10-10
申请号：US10306798
申请日：2002-11-27
申请人： Marc Unger , Ian D. Manger , Michael Lucero , Yong Yi , Emily Miyashita-Lin , Anja Weinecke , Geoffrey Facer
发明人： Marc Unger , Ian D. Manger , Michael Lucero , Yong Yi , Emily Miyashita-Lin , Anja Weinecke , Geoffrey Facer
IPC分类号： F16K11/20
CPC分类号： C12M1/38 , B01F13/0059 , B01J2219/00337 , B01J2219/00353 , B01J2219/00403 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/0072 , B01L3/502707 , B01L3/502715 , B01L3/50851 , B01L2300/0627 , B01L2300/123 , B01L2400/06 , C12Q1/68 , C12Q1/6844 , C40B60/14 , F16K11/20 , G01N35/00029 , G01N35/0098 , G01N2035/00366 , Y10T137/2076 , Y10T137/2496 , Y10T137/86292 , Y10T137/87249 , Y10T436/2575 , C12Q2565/501
摘要： A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyses.

8. 发明授权

US5212298A Method for producing synthetic N-linked glycoconjugates 失效
标题翻译：生产合成N-连接糖缀合物的方法
公开(公告)号：US5212298A
公开(公告)日：1993-05-18
申请号：US776911
申请日：1991-10-15
申请人： Thomas W. Rademacher , Ian D. Manger , Simon Wong , Raymond A. Dwek
发明人： Thomas W. Rademacher , Ian D. Manger , Simon Wong , Raymond A. Dwek
IPC分类号： A61K47/48 , C07H13/04
CPC分类号： C07H13/04 , A61K47/48092 , A61K47/4823
摘要： A method is disclosed for derivatizing oligosaccharides to form synthetic N-linked glycoconjugates by converting a glycosylamine derivative of the oligosaccharide to a haloacetylated derivative as an intermediate compound prior to formation of the synthetic N-linked glycoconjugate to thereby directly maintain the .beta.-anomeric configuration of said N-linked glycoconjugate.
摘要翻译：公开了一种通过在形成合成的N-连接的糖缀合物之前将低聚糖的糖胺衍生物转变为卤代乙酰化衍生物作为中间体化合物，从而直接维持β-连接糖缀合物的β-异构体构型，从而衍生寡糖以形成合成的N-连接的糖缀合物的方法所述N-连接的糖缀合物。

9. 发明授权

US07452726B2 Microfluidic particle-analysis systems 有权
标题翻译：微流控粒子分析系统
公开(公告)号：US07452726B2
公开(公告)日：2008-11-18
申请号：US10734963
申请日：2003-12-11
申请人： Hou-Pu Chou , Antoine Daridon , Kevin Farrell , Brian Fowler , Yish-Hann Liau , Ian D. Manger , Hany Ramez Nassef , William Throndset
发明人： Hou-Pu Chou , Antoine Daridon , Kevin Farrell , Brian Fowler , Yish-Hann Liau , Ian D. Manger , Hany Ramez Nassef , William Throndset
IPC分类号： G01N35/00 , G01N33/48 , G01N1/10 , G01N15/06 , G01N33/00
CPC分类号： G01N35/00 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L2200/0636 , B01L2200/0647 , B01L2200/0652 , B01L2200/0668 , B01L2200/10 , B01L2200/12 , B01L2300/0645 , B01L2300/0681 , B01L2300/0861 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/123 , B01L2400/0409 , B01L2400/0481 , B01L2400/0655 , G01N15/1456 , G01N15/1468 , G01N15/1484 , G01N2015/0288 , G01N2015/1075 , G01N2015/149 , G01N2015/1493 , Y10T436/11 , Y10T436/2575
摘要： The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or detection of particles, such as cells and/or beads. The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or analysis of particles, such as cells, viruses, organelles, beads, and/or vesicles. The invention also provides microfluidic mechanisms for carrying out these manipulations and analyses. These mechanisms may enable controlled input, movement/positioning, retention/localization, treatment, measurement, release, and/or output of particles. Furthermore, these mechanisms may be combined in any suitable order and/or employed for any suitable number of times within a system. Accordingly, these combinations may allow particles to be sorted, cultured, mixed, treated, and/or assayed, among others, as single particles, mixed groups of particles, arrays of particles, heterogeneous particle sets, and/or homogeneous particle sets, among others, in series and/or in parallel. In addition, these combinations may enable microfluidic systems to be reused. Furthermore, these combinations may allow the response of particles to treatment to be measured on a shorter time scale than was previously possible. Therefore, systems of the invention may allow a broad range of cell and particle assays, such as drug screens, cell characterizations, research studies, and/or clinical analyses, among others, to be scaled down to microfluidic size. Such scaled-down assays may use less sample and reagent, may be less labor intensive, and/or may be more informative than comparable macrofluidic assays.
摘要翻译：本发明提供了用于微流体操纵和/或检测诸如细胞和/或珠粒的装置，方法和试剂盒的系统。本发明提供了用于微粒操作和/或分析颗粒例如细胞，病毒，细胞器，珠粒和/或囊泡的装置，方法和试剂盒的系统。本发明还提供用于进行这些操作和分析的微流体机理。这些机制可以实现颗粒的控制输入，运动/定位，保留/定位，处理，测量，释放和/或输出。此外，这些机制可以以任何合适的顺序组合和/或在系统内任何适当次数使用。因此，这些组合可以允许将粒子分类，培养，混合，处理和/或测定为单粒子，粒子的混合组，粒子阵列，非均匀粒子组和/或均匀粒子组，其中其他，串联和/或并行。此外，这些组合可以使微流体系统能够重复使用。此外，这些组合可以允许在比以前可能的更短的时间尺度上测量颗粒对治疗的反应。因此，本发明的系统可以允许广泛范围的细胞和颗粒测定，例如药物筛选，细胞特征化，研究研究和/或临床分析等，以缩小到微流体大小。这种按比例缩小的测定可能使用较少的样品和试剂，可能较少的劳动密集型和/或可能比可比较的大流控测定更具信息性。

10. 发明授权

US07312085B2 Microfluidic particle-analysis systems 有权
标题翻译：微流控粒子分析系统
公开(公告)号：US07312085B2
公开(公告)日：2007-12-25
申请号：US10405953
申请日：2003-04-01
申请人： Hou-Pu Chou , Antoine Daridon , Kevin Farrell , Brian Fowler , Yish-Hann Liau , Ian D. Manger , Hany Ramez Nassef , William Throndset
发明人： Hou-Pu Chou , Antoine Daridon , Kevin Farrell , Brian Fowler , Yish-Hann Liau , Ian D. Manger , Hany Ramez Nassef , William Throndset
IPC分类号： G01N35/00 , G01N33/48 , G01N1/10 , G01N15/06 , G01N33/00
CPC分类号： G01N35/00 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L2200/0636 , B01L2200/0647 , B01L2200/0652 , B01L2200/0668 , B01L2200/10 , B01L2200/12 , B01L2300/0645 , B01L2300/0681 , B01L2300/0861 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/123 , B01L2400/0409 , B01L2400/0481 , B01L2400/0655 , G01N15/1456 , G01N15/1468 , G01N15/1484 , G01N2015/0288 , G01N2015/1075 , G01N2015/149 , G01N2015/1493 , Y10T436/11 , Y10T436/2575
摘要： The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or detection of particles, such as cells and/or beads. The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or analysis of particles, such as cells, viruses, organelles, beads, and/or vesicles. The invention also provides microfluidic mechanisms for carrying out these manipulations and analyses. These mechanisms may enable controlled input, movement/positioning, retention/localization, treatment, measurement, release, and/or output of particles. Furthermore, these mechanisms may be combined in any suitable order and/or employed for any suitable number of times within a system. Accordingly, these combinations may allow particles to be sorted, cultured, mixed, treated, and/or assayed, among others, as single particles, mixed groups of particles, arrays of particles, heterogeneous particle sets, and/or homogeneous particle sets, among others, in series and/or in parallel. In addition, these combinations may enable microfluidic systems to be reused. Furthermore, these combinations may allow the response of particles to treatment to be measured on a shorter time scale than was previously possible. Therefore, systems of the invention may allow a broad range of cell and particle assays, such as drug screens, cell characterizations, research studies, and/or clinical analyses, among others, to be scaled down to microfluidic size. Such scaled-down assays may use less sample and reagent, may be less labor intensive, and/or may be more informative than comparable macrofluidic assays.
摘要翻译：本发明提供了用于微流体操纵和/或检测诸如细胞和/或珠粒的装置，方法和试剂盒的系统。本发明提供了用于微粒操作和/或分析颗粒例如细胞，病毒，细胞器，珠粒和/或囊泡的装置，方法和试剂盒的系统。本发明还提供用于进行这些操作和分析的微流体机理。这些机制可以实现颗粒的控制输入，运动/定位，保留/定位，处理，测量，释放和/或输出。此外，这些机制可以以任何合适的顺序组合和/或在系统内任何适当次数使用。因此，这些组合可以允许将粒子分类，培养，混合，处理和/或测定为单粒子，粒子的混合组，粒子阵列，非均匀粒子组和/或均匀粒子组，其中其他，串联和/或并行。此外，这些组合可以使微流体系统能够重复使用。此外，这些组合可以允许在比以前可能的更短的时间尺度上测量颗粒对治疗的反应。因此，本发明的系统可以允许广泛范围的细胞和颗粒测定，例如药物筛选，细胞特征化，研究研究和/或临床分析等，以缩小到微流体大小。这种按比例缩小的测定可能使用较少的样品和试剂，可能较少的劳动密集型和/或可能比可比较的大流控测定更具信息性。

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