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1. 发明专利

CA2092112A1 INDOLE AND INDAZOLE DERIVATIVES, FOR THE TREATMENT AND PROPHYLAXIS OF CEREBRAL DISORDERS, THEIR PREPARATION AND THEIR USE 未知
公开(公告)号：CA2092112A1
公开(公告)日：1993-09-24
申请号：CA2092112
申请日：1993-03-22
申请人： NARUTO SHUNJI , SUGANO YUICHI , MATSUI YOSHIKI , TONOHIRO TOSHIYUKI , KANEKO TSUGIO , IWATA NOBUYOSHI
发明人： NARUTO SHUNJI , SUGANO YUICHI , MATSUI YOSHIKI , TONOHIRO TOSHIYUKI , KANEKO TSUGIO , IWATA NOBUYOSHI
IPC分类号： C07D209/04 , A61K31/40 , A61K31/41 , A61K31/445 , C07D209/12 , C07D209/14 , C07D231/56 , C07D401/06 , C07D403/06 , C07D409/14 , C07D473/00 , C07D405/06 , C07F7/10 , C07D413/14 , C07D417/14 , A61K31/495 , A61K31/535 , A61K31/54 , A61K31/695
摘要： Compounds of formula (I): (I) ¢ wherein R1 and R2 are each hydrogen or various organic groups, p is 0, 1, 2 or 3, U is -CO- or -CH(OR3)- where R3 is hydrogen or a hydroxyprotecting group, V is an optionally unsaturated aliphatic hydrocarbon group and W is a nitrogencontaining group! are useful in the treatment and prophylaxis of dementia especially of the Alzheimer's type.

2. 发明专利

CA2042336A1 PIPERIDYLOXY-AND QUINUCLIDINYLOXY-ISOXAZOLE, DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE 未知
公开(公告)号：CA2042336A1
公开(公告)日：1991-11-12
申请号：CA2042336
申请日：1991-05-10
申请人： NAGANO MITSUO , SAKAI JUNICHI , KOBAYASHI TAKEO , KOZUKA MASAO , IWATA NOBUYOSHI , KUBO YOSHIKO
发明人： NAGANO MITSUO , SAKAI JUNICHI , KOBAYASHI TAKEO , KOZUKA MASAO , IWATA NOBUYOSHI , KUBO YOSHIKO
IPC分类号： A61K31/445 , A61K31/42 , A61P25/28 , C07D261/12 , C07D261/20 , C07D413/04 , C07D413/12 , C07D413/14 , C07D453/02 , A61K31/44
摘要： Compounds of formula (I): (I) ín which: R1 is hydrogen, halogen or alkyl; R2 is hydrogen, alkyl, optionally substituted phenyl or a heterocycle; or R1 and R2 together form a group of formula -CR4=CR5-CR6=CR7-, where R4, R5, R6 and R7 are hydrogen, halogen, alkyl group, alkoxy, halomethyl, alkylamino, dialkylamino, hydroxy, nitro, aliphatic carboxylic acylamino or amino; and R3 is piperidyl, substituted piperidyl or quinuclidinyl! are useful in the treatment and prophylaxis of cognitive disorders, notably senile dementia, including Alzheimer's disease. Processes for preparing the compounds are also provided.

3. 发明专利

CA2022236A1 COUMARIN DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CEREBROVASCULAR DISORDERS 未知
公开(公告)号：CA2022236A1
公开(公告)日：1991-02-01
申请号：CA2022236
申请日：1990-07-30
申请人： YANAGISAWA HIROAKI , FUJIMOTO KOICHI , SHIMOJI YASUO , KANAZAKI TAKURO , IWATA NOBUYOSHI , KUBO YOSHIKO
发明人： YANAGISAWA HIROAKI , FUJIMOTO KOICHI , SHIMOJI YASUO , KANAZAKI TAKURO , IWATA NOBUYOSHI , KUBO YOSHIKO
IPC分类号： A61K31/365 , A61K31/535 , C07D311/16 , C07D311/18 , C07D413/12 , A61K31/37
摘要： Compounds of formula (I): (I) ¢in which: A is a group of formula (II) or (III): (II) (III); R1, R2 and R3 are hydrogen, lower alkyl or halogen; R4 is hydrogen, lower alkyl or aralkyl; R5 and R6 are hydrogen or lower alkyl; R7 and R8 are hydrogen or lower alkyl; or R7 and R8 together represent alkylene; and m is 1 or 2;! and pharmaceutically acceptable salts thereof are useful in the treatment of cardiovascular disorders.

4. 发明申请

WO1994018201A1 ISOXAZOLEOXY DERIVATIVE 审中-公开
公开(公告)号：WO1994018201A1
公开(公告)日：1994-08-18
申请号：PCT/JP1994000201
申请日：1994-02-10
申请人： SANKYO COMPANY, LIMITED , SATO, Susumu , SAKAI, Junichi , OHKAWA, Nobuyuki , KOZUKA, Masao , IWATA, Nobuyoshi , NAGANO, Mitsuo
发明人： SANKYO COMPANY, LIMITED
IPC分类号： C07D487/08
CPC分类号： C07D453/02
摘要： An isoxazole compound represented by general formula (I) or an acid-addition salt thereof, wherein R represents hydrogen, halogen, lower alkyl or cycloalkyl; R represents hydrogen, lower alkyl, cycloalkyl, a phenyl group which may have substituent(s) selected from the following substituent group A, or an aromatic heterocyclic group which may have substituent(s) selected from the following substituent group A; or alternatively R and R may be combined together to represent -CR =CR -CR = CR -, wherein R through R may be the same or different from one another and each represents hydrogen, halogen, lower alkyl, lower alkoxy, halomethyl, lower alkylamino, lower alkanoylamino, hydroxy, nitro or amino. [Substituent group A] lower alkyl, hydroxy, lower alkoxy, halogen, nitro, amino, and lower alkylamino. The above compound has the effects of treating dementia, ameliorating the cerebral functions, and so forth.
摘要翻译：由通式（I）表示的异恶唑化合物或其酸加成盐，其中R 1表示氢，卤素，低级烷基或环烷基; R 2表示氢，低级烷基，环烷基，可具有选自下述取代基组A的取代基的苯基或可具有选自下述取代基组A的取代基的芳香族杂环基; 或者R 1和R 2可以组合在一起表示-CR 4 = CR 5 -CR 6 = CR 7 - ，其中R 4至R 7可以各自表示氢，卤素，低级烷基，低级烷氧基，卤代甲基，低级烷基氨基，低级烷酰氨基，羟基，硝基或氨基。 [取代基A]低级烷基，羟基，低级烷氧基，卤素，硝基，氨基和低级烷基氨基。上述化合物具有治疗痴呆，改善脑功能等的作用。

5. 发明专利

CA2026177A1 3-ISOXAZOLONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USES 未知
公开(公告)号：CA2026177A1
公开(公告)日：1991-03-27
申请号：CA2026177
申请日：1990-09-25
申请人： NAGANO MITSUO , SAKAI JUNICHI , IWATA NOBUYOSHI
发明人： NAGANO MITSUO , SAKAI JUNICHI , IWATA NOBUYOSHI
IPC分类号： C07D261/12 , C07D261/20 , C07D413/06 , A61K31/395
摘要： Compounds of formula (I): (I) ¢in which R1 is hydrogen, halogen, alkyl, alkenyl, alkynyl, optionally substituted benzyl or optionally substituted phenyl; R2 is hydrogen, alkyl, optionally substituted phenyl, or a heterocycle having from 5 to 7 ring atoms; or R1 and R2, together with the carbons to which they are attached, form an optionally substituted; hydrocarbon ring fused to the isoxazole ring; -NR3R4 represents an alicyclic amino group; and A is optionally substituted phenyl, optionally substituted benzyl, alkyl, alkoxy, optionally substituted benzyloxy, or optionally substituted phenoxy; and acid addition salts thereof! have valuable activity for the treatment of cerebrovascular disorders and for use as centrally acting muscle relaxants.

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