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1. 发明申请

WO2011128623A2 IMPROVEMENTS RELATING TO ANTIVIRAL COMPOSITIONS 审中-公开
标题翻译：关于抗病毒组合物的改进
公开(公告)号：WO2011128623A2
公开(公告)日：2011-10-20
申请号：PCT/GB2011/000549
申请日：2011-04-08
申请人： IOTA NANOSOLUTIONS LIMITED , FOSTER, Alison Jayne , LONG, James , RANNARD, Steven Paul , WANG, Dong , DUNCALF, David John
发明人： FOSTER, Alison Jayne , LONG, James , RANNARD, Steven Paul , WANG, Dong , DUNCALF, David John
IPC分类号： A61K9/51
CPC分类号： A61K9/10 , A61K9/5123 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5192 , A61K31/427 , A61K31/4725 , A61K31/513 , A61K31/536 , A61K47/10 , A61K47/32 , A61K47/38
摘要： The present invention provides a composition and an antiviral drug preparation, each comprising at least one water-insoluble antiviral drug and at least one water-soluble carrier material, wherein the water-insoluble antiviral drug is dispersed through the water-soluble carrier material in nano-disperse form. The present invention further provides processes for preparing the compositions and drug preparations, and also aqueous nano-dispersions obtained by combining water and the compositions.
摘要翻译：本发明提供一种组合物和抗病毒药物制剂，每种组合物和抗病毒药物制剂各自包含至少一种水不溶性抗病毒药物和至少一种水溶性载体材料，其中所述水不溶性抗病毒药物通过纳米级的水溶性载体材料分散 - 分散形式。本发明还提供了制备组合物和药物制剂的方法，以及通过将水和组合物组合获得的水性纳米分散体。

2. 发明申请

WO2013030535A3 METHOD OF PREPARING CARRIER LIQUIDS 审中-公开
公开(公告)号：WO2013030535A3
公开(公告)日：2013-03-07
申请号：PCT/GB2012/052028
申请日：2012-08-20
申请人： IOTA NANOSOLUTIONS LIMITED , FOSTER, Alison Jayne , LONG, James , RANNARD, Steven Paul , WANG, Dong
发明人： FOSTER, Alison Jayne , LONG, James , RANNARD, Steven Paul , WANG, Dong
IPC分类号： A01N25/04 , A61K8/04 , A61K9/107 , A61K47/30 , A61Q19/00 , B82Y5/00
摘要： The invention provides a method for the preparation of a carrier liquid which comprises the steps of: (I) preparing a single phase solution comprising: (a) a solvent or a mixture of miscible solvents, (b) a liquid carrier material, which is soluble in solvent (a), and (c) a dopant material which is also soluble in solvent (a); (II) cooling (preferably freezing) the single phase solution produced in step (I) to a temperature at which at least both the solvent (a) and carrier material (b) become solid; and (III) removing solid solvent (a) from the cooled (frozen) single phase solution in vapour form, such that the remaining cooled (frozen) carrier material (b) and dopant material (c) are returned to ambient temperature thus providing a product of liquid carrier material (b) having dopant material (c) dispersed therein.

3. 发明申请

WO2011141721A3 COMPOSITIONS 审中-公开
公开(公告)号：WO2011141721A3
公开(公告)日：2011-11-17
申请号：PCT/GB2011/000747
申请日：2011-05-13
申请人： IOTA NANOSOLUTIONS LIMITED , ANGUS, Doris , DUNCALF, David, John , FOSTER, Alison, Jayne , COOPER, Andrew, Ian , RANNARD, Steven, Paul , WANG, Dong , ZHANG, Haifei
发明人： ANGUS, Doris , DUNCALF, David, John , FOSTER, Alison, Jayne , COOPER, Andrew, Ian , RANNARD, Steven, Paul , WANG, Dong , ZHANG, Haifei
IPC分类号： A61K9/00 , A61K9/10 , A61K9/70 , A61K9/19
摘要： A method for the preparation of a composition comprising a water-soluble porous matrix having a water-insoluble active ingredient dispersed throughout the matrix in the form of nano-particles having a z-average particle size of up to 1000 nm, which process comprises the steps of: (i) providing a preformed porous, water-soluble matrix; (ii) treating the matrix with a solution of the water-insoluble active ingredient in a solvent, wherein the solvent is a non-aqueous solvent in which the matrix is insoluble, whereby the solution permeates through the pores of the matrix; and (iii) removing the solvent by evaporation, thereby leaving the water-insoluble active ingredient in nano- disperse form throughout the matrix. Also disclosed is an identical method using a water-insoluble porous matrix and a water-soluble active ingredient.

4. 发明申请

WO2012045994A1 PROCESSES FOR PREPARING IMPROVED COMPOSITIONS 审中-公开
标题翻译：制备改进成分的方法
公开(公告)号：WO2012045994A1
公开(公告)日：2012-04-12
申请号：PCT/GB2011/001441
申请日：2011-10-04
申请人： IOTA NANOSOLUTIONS LIMITED , RANNARD, Steven, Paul , DUNCALF, David , FOSTER, Alison, Jayne , LONG, James , WANG, Dong
发明人： RANNARD, Steven, Paul , DUNCALF, David , FOSTER, Alison, Jayne , LONG, James , WANG, Dong
IPC分类号： A61K9/51
CPC分类号： A01N25/04 , A01N25/22 , A01N25/30 , A01N43/40 , A01N43/54 , A01N43/653 , A01N43/90 , A01N47/02 , A01N47/38 , A01N53/00 , A23K20/10 , A23L33/10 , A23V2002/00 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5192
摘要： The invention provides a method for preparing an improved composition comprising at least one active agent and at least one solid carrier material, wherein the active agent is dispersed through the carrier material in nano-disperse form, which method comprises the steps of: (a) forming a liquid mixture comprising the active agent, the carrier material, a stabilizing agent, a first solvent for the active agent and the stabilizing agent and, a second solvent for the carrier material, and (b) drying the liquid mixture to remove the first and second solvents to obtain a substantially solvent-free nano-dispersion of the active agent with the stabilising agent in the carrier material, wherein the stabilizing agent is capable of stabilizing the active agent in the liquid mixture during drying and in a resultant liquid nano-dispersion of the improved composition.
摘要翻译：本发明提供一种制备包含至少一种活性剂和至少一种固体载体材料的改进组合物的方法，其中活性剂以纳米分散形式分散在载体材料中，该方法包括以下步骤：（a）形成包含活性剂，载体材料，稳定剂，活性剂和稳定剂的第一溶剂和载体材料的第二溶剂的液体混合物，和（b）干燥液体混合物以除去第一和第二溶剂，以在载体材料中获得活性剂与稳定剂的基本上无溶剂的纳米分散体，其中所述稳定剂能够在干燥期间稳定液体混合物中的活性剂，并且在所得的液体纳米 - 改进组合物的分散。

5. 发明公开

EP2558080A2 IMPROVEMENTS RELATING TO ANTIVIRAL COMPOSITIONS 有权转让
标题翻译：改进技术具有抗病毒组合物结合
公开(公告)号：EP2558080A2
公开(公告)日：2013-02-20
申请号：EP11715996.2
申请日：2011-04-08
申请人： Iota NanoSolutions Limited
发明人： FOSTER, Alison Jayne , LONG, James , RANNARD, Steven Paul , WANG, Dong , DUNCALF, David John
IPC分类号： A61K9/51
CPC分类号： A61K9/10 , A61K9/5123 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5192 , A61K31/427 , A61K31/4725 , A61K31/513 , A61K31/536 , A61K47/10 , A61K47/32 , A61K47/38
摘要： The present invention provides a composition and an antiviral drug preparation, each comprising at least one water-insoluble antiviral drug and at least one water-soluble carrier material, wherein the water-insoluble antiviral drug is dispersed through the water-soluble carrier material in nano-disperse form. The present invention further provides processes for preparing the compositions and drug preparations, and also aqueous nano-dispersions obtained by combining water and the compositions.

6. 发明公开

EP2326309A2 IMPROVEMENTS RELATING TO NANODISPERSE COMPOSITIONS 审中-公开
标题翻译：纳米分散的组合物改进
公开(公告)号：EP2326309A2
公开(公告)日：2011-06-01
申请号：EP09781022.0
申请日：2009-07-24
申请人： Iota NanoSolutions Limited
发明人： ANGUS, Doris , DUNCALF, David John , FOSTER, Alison Jayne , RANNARD, Steven Paul , WANG, Dong
IPC分类号： A61K9/16 , A61K31/00
CPC分类号： A61K9/1694 , A61K9/1623 , A61K9/1635 , B01J2/04
摘要： A process for the production of a soluble composition comprising a water- insoluble active which comprises either the steps of: a) providing a liquid mixture comprising: i) a dissolved water-insoluble active, ii) a dissolved water-soluble carrier, iii) a solvent for each of the active and the carrier, and b) spray-granulating the mixture to remove the, or each, solvent and obtain a substantially solvent-free nano-dispersion of the water-insoluble active in the carrier said water-insoluble active being in nano-particles having a size range of 999-20 nm; or, the steps of: a) providing a substantially solvent-free powder comprising a water-insoluble active dispersed in a water soluble carrier, said water-insoluble active being in nano-particles having a size range of 999-20 nm, and, b) spray-granulating the powder to obtain larger and denser particles. The invention also relates to solvent-free, granular products with a particle size in the range 20 microns to 10mm and a bulk-density of greater than 0.4g/cm3 comprising a water-soluble carrier material, the carrier material having dispersed therein a water-insoluble active, wherein on addition of water the carrier dissolves to form an aqueous dispersion of the active with a peak (z-average) particle size of below 800nm, preferably below 500nm and more preferably below 200nm. The invention also relates to an analogous "reverse" process in which the active is water soluble and the carrier is oil soluble.

7. 发明公开

EP2624819A1 PROCESSES FOR PREPARING IMPROVED COMPOSITIONS 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG VON VERBESSERTEN ZUSAMMENSETZUNGEN
公开(公告)号：EP2624819A1
公开(公告)日：2013-08-14
申请号：EP11778932.1
申请日：2011-10-04
申请人： Iota NanoSolutions Limited
发明人： RANNARD, Steven, Paul , DUNCALF, David , FOSTER, Alison, Jayne , LONG, James , WANG, Dong
IPC分类号： A61K9/51
CPC分类号： A01N25/04 , A01N25/22 , A01N25/30 , A01N43/40 , A01N43/54 , A01N43/653 , A01N43/90 , A01N47/02 , A01N47/38 , A01N53/00 , A23K20/10 , A23L33/10 , A23V2002/00 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5192
摘要： The invention provides a method for preparing an improved composition comprising at least one active agent and at least one solid carrier material, wherein the active agent is dispersed through the carrier material in nano-disperse form, which method comprises the steps of: (a) forming a liquid mixture comprising the active agent, the carrier material, a stabilizing agent, a first solvent for the active agent and the stabilizing agent and, a second solvent for the carrier material, and (b) drying the liquid mixture to remove the first and second solvents to obtain a substantially solvent-free nano-dispersion of the active agent with the stabilising agent in the carrier material, wherein the stabilizing agent is capable of stabilizing the active agent in the liquid mixture during drying and in a resultant liquid nano-dispersion of the improved composition.
摘要翻译：本发明提供一种制备包含至少一种活性剂和至少一种固体载体材料的改进组合物的方法，其中活性剂以纳米分散形式分散通过载体材料，该方法包括以下步骤：（a）形成包含活性剂，载体材料，稳定剂，活性剂和稳定剂的第一溶剂和载体材料的第二溶剂的液体混合物，和（b）干燥液体混合物以除去第一和第二溶剂，以在载体材料中获得活性剂与稳定剂的基本上无溶剂的纳米分散体，其中所述稳定剂能够在干燥期间稳定液体混合物中的活性剂，并且在所得的液体纳米 - 改进组合物的分散。

8. 发明公开

EP2387992A1 Improvements relating to nanodispersions 审中-公开
标题翻译： Verbesserungen im Zusammenhang mit Nanodispersionen
公开(公告)号：EP2387992A1
公开(公告)日：2011-11-23
申请号：EP11005053.1
申请日：2007-06-29
申请人： Iota NanoSolutions Limited
发明人： Angus, Doris , Duncalf, David John , Foster, Alison Jayne , Long, James , Rannard, Steven Paul , Wang, Dong , Elphick, James Andrew
IPC分类号： A61K9/16 , A61K31/366
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , Y02A50/411 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： The invention provides process for making water-soluble nano-dispersions of water-insoluble materials in a water-soluble carrier material comprising the steps of:
(i) providing a single phase mixture of:
(a) a non-aqueous solvent or a mixture of miscible non-aqueous solvents,
(b) at least one carrier material soluble in non-aqueous solvent (a), said carrier material being also soluble in water and solid at ambient temperature,
(c) at least one water-insoluble payload material which is soluble in non-solvent (a), and,

(ii) drying the mixture to remove solvent (a) and thereby obtain the carrier material (b) in solid form with payload (c) dispersed therein as nanoparticles,

wherein the product of the drying step is water dispersible to give an aqueous solution of (b) and an aqueous nano-dispersion of (c).
摘要翻译：本发明提供了在水溶性载体材料中制备水不溶性材料的水溶性纳米分散体的方法，其包括以下步骤：（i）提供单相混合物：（a）非水溶剂或混合物可混溶的非水溶剂，（b）至少一种可溶于非水溶剂（a）的载体材料，所述载体材料在环境温度下也可溶于水和固体，（c）至少一种不溶于水的有效载荷材料其可溶于非溶剂（a），和（ii）干燥混合物以除去溶剂（a），从而获得固体形式的载体材料（b），其中有效载荷（c）作为纳米颗粒分散在其中，其中产物的干燥步骤是水分散，得到（b）的水溶液和（c）的水性纳米分散体。

9. 发明公开

EP2750500A2 METHOD OF PREPARING CARRIER LIQUIDS 有权转让
标题翻译： VERFAHREN ZUR HERSTELLUNG VONTRÄGERFLÜSSIGKEITEN
公开(公告)号：EP2750500A2
公开(公告)日：2014-07-09
申请号：EP12753233.1
申请日：2012-08-20
申请人： Iota NanoSolutions Limited
发明人： FOSTER, Alison Jayne , LONG, James , RANNARD, Steven Paul , WANG, Dong
IPC分类号： A01N25/04 , A61K8/04 , A61K9/107 , A61K47/30 , A61Q19/00 , B82Y5/00
CPC分类号： B01F3/2064 , A01N25/04 , A01N31/12 , A01N47/38 , A01N53/00 , A23L27/30 , A23L27/82 , A61K8/04 , A61K9/10 , A61K9/145 , A61K9/146 , A61K9/19 , A61K2800/10 , A61K2800/412 , A61K2800/413 , A61K2800/84 , A61Q19/00 , B82Y40/00 , A01N2300/00
摘要： The invention provides a method for the preparation of a carrier liquid which comprises the steps of: (I) preparing a single phase solution comprising: (a) a solvent or a mixture of miscible solvents, (b) a liquid carrier material, which is soluble in solvent (a), and (c) a dopant material which is also soluble in solvent (a); (II) cooling (preferably freezing) the single phase solution produced in step (I) to a temperature at which at least both the solvent (a) and carrier material (b) become solid; and (III) removing solid solvent (a) from the cooled (frozen) single phase solution in vapor form, such that the remaining cooled (frozen) carrier material (b) and dopant material (c) are returned to ambient temperature thus providing a product of liquid carrier material (b) having dopant material (c) dispersed therein.
摘要翻译：本发明提供了制备载体液体的方法，其包括以下步骤：（I）制备单相溶液，其包括：（a）溶剂或混溶溶剂的混合物，（b）液体载体材料，溶于溶剂（a），和（c）也可溶于溶剂（a）的掺杂剂材料; （II）将步骤（I）中制备的单相溶液冷却（优选冷冻）至少至少溶剂（a）和载体材料（b）均为固体的温度; 和（III）从蒸气形式的冷却（冷冻）单相溶液中除去固体溶剂（a），使得剩余的冷冻（冷冻）载体材料（b）和掺杂剂材料（c）返回到环境温度，从而提供具有分散在其中的掺杂剂材料（c）的液体载体材料（b）的产物。

10. 发明公开

EP2326308A2 IMPROVEMENTS RELATING TO PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：药物组合物的的改进
公开(公告)号：EP2326308A2
公开(公告)日：2011-06-01
申请号：EP09781401.6
申请日：2009-08-03
申请人： Iota NanoSolutions Limited
发明人： ANGUS, Doris , DUNCALF, David, John , FOSTER, Alison, Jayne , RANNARD, Steven, Paul , WANG, Dong
IPC分类号： A61K9/16
CPC分类号： A61K9/1694 , A61K9/1652 , A61K9/5161
摘要： The present invention provides a substantially solvent-free nano-dispersion of an active in a carrier, wherein the carrier comprises an enteric carrier soluble at intestinal pH, but insoluble at stomach pH, and wherein the enteric carrier comprises at least 50% by weight of the nano-dispersion; and processes for the preparation of a substantially solvent-free nano-dispersion of an active in a carrier.

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