专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2004003010A2 NUCLEAR HORMONE RECEPTOR 审中-公开
标题翻译：核激素受体包含蛋白质的结合域
公开(公告)号：WO2004003010A2
公开(公告)日：2004-01-08
申请号：PCT/GB2003/002807
申请日：2003-07-01
申请人： INPHARMATICA LIMITED , PHELPS, Christopher, Benjamin , FAGAN, Richard, Joseph , ALLEN, Janet, Marjorie , ALLEN, Kathryn, Elizabeth , STANCOVSKI, Ilana , HUNT, Caroline, Ann , PIERRON, Valerie, Nathalie , PHILLIPS, Tom , ENAYAT, Zinat, Ellaheh
发明人： PHELPS, Christopher, Benjamin , FAGAN, Richard, Joseph , ALLEN, Janet, Marjorie , ALLEN, Kathryn, Elizabeth , STANCOVSKI, Ilana , HUNT, Caroline, Ann , PIERRON, Valerie, Nathalie , PHILLIPS, Tom , ENAYAT, Zinat, Ellaheh
IPC分类号： C07K14/00
CPC分类号： C07K14/72 , A61K38/00
摘要： This invention relates to a protein, termed hCP41042.2 (or LBDG7), herein identified as containing a novel Nuclear Hormone Receptor Ligand Binding Domain and to the use of this protein and nucleic acid sequence from the encoding genes in the diagnosis, prevention and treatment.
摘要翻译：本发明涉及一种称为hCP41042.2（或LBDG7）的蛋白质，其在本文中被鉴定为含有新的核激素受体配体结合结构域，并且在诊断，预防和治疗中使用来自编码基因的该蛋白质和核酸序列。

2. 发明申请

WO2003089469A3 CATION CHANNEL PROTEINS 审中-公开
公开(公告)号：WO2003089469A3
公开(公告)日：2003-10-30
申请号：PCT/GB2003/001655
申请日：2003-04-16
申请人： INPHARMATICA LIMITED , LOBLEY, Anna, Elizabeth , MICHALOVICH, David , ALLEN, Kathryn, Elizabeth , REYNOLDS, Lindsey , PIERRON, Valerie, Nathalie , ALLEN, Janet, Marjorie
发明人： LOBLEY, Anna, Elizabeth , MICHALOVICH, David , ALLEN, Kathryn, Elizabeth , REYNOLDS, Lindsey , PIERRON, Valerie, Nathalie , ALLEN, Janet, Marjorie
IPC分类号： C07K14/47
摘要： This invention relates to novel proteins, termed INPIONCH03 and INPIONCH04, herein identified as members of the PKD/REJ family of cation channels and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.

3. 发明申请

WO2003072605A1 NUCLEAR HORMONE RECEPTOR LIGAND BINDING DOMAIN-CONTAINING PROTEIN 审中-公开
标题翻译：核激素受体配体结合域含蛋白
公开(公告)号：WO2003072605A1
公开(公告)日：2003-09-04
申请号：PCT/GB2003/000819
申请日：2003-02-26
申请人： INPHARMATICA LIMITED , PHELPS, Christopher, Benjamin , FAGAN, Richard, Joseph , HÖSS, Matthias, Markus , ALLEN, Janet, Marjorie
发明人： PHELPS, Christopher, Benjamin , FAGAN, Richard, Joseph , HÖSS, Matthias, Markus , ALLEN, Janet, Marjorie
IPC分类号： C07K14/705
CPC分类号： C07K14/72 , C07K14/70567
摘要： This invention relates to a novel protein (INTP009), herein identified as containing a Nuclear Hormone Receptor Ligand Binding Domain and to the use of this protein and nucleic acid sequences from the encoding gene in the diagnosis, prevention and treatment of disease.
摘要翻译：本发明涉及本文中鉴定为含有核激素受体配体结合结构域的新型蛋白质（INTP009），以及来自该编码基因的该蛋白质和核酸序列在诊断，预防和治疗疾病中的用途。

4. 发明申请

WO2003054178A3 METALLOPROTEASE PROTEINS 审中-公开
公开(公告)号：WO2003054178A3
公开(公告)日：2003-07-03
申请号：PCT/GB2002/005866
申请日：2002-12-20
申请人： INPHARMATICA LIMITED , MITTER, Richard, James , FAGAN, Richard, Joseph , PHELPS, Christopher, Benjamin
发明人： MITTER, Richard, James , FAGAN, Richard, Joseph , PHELPS, Christopher, Benjamin
IPC分类号： C07K14/435
摘要： This invention relates to novel proteins identified herein as secreted proteins (in particular as members of the metalloprotease family) and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.

5. 发明申请

WO2003052633A2 ANNOTATION METHOD 审中-公开
标题翻译：注意事项
公开(公告)号：WO2003052633A2
公开(公告)日：2003-06-26
申请号：PCT/GB2002/005667
申请日：2002-12-13
申请人： INPHARMATICA LIMITED , SWINDELLS, Mark, Basil , CUFF, James , COUCH, Matthew
发明人： SWINDELLS, Mark, Basil , CUFF, James , COUCH, Matthew
IPC分类号： G06F17/30
CPC分类号： G06F19/22
摘要： The invention relates to a method for annotating protein sequences consistently, using disparate secondary database protein family information. In the method, information relating to the family to which a protein belongs is derived from two or more secondary databases (2DBs), each 2DB being generated by a different modelling approach and wherein at least one 2DB provides no single alignment of protein sequences in each family. The method involves the steps of extracting protein family information from said at least two 2DBs; and incorporating this information into a single modelling infrastructure.
摘要翻译：本发明涉及使用不同的次级数据库蛋白质家族信息一致地注释蛋白质序列的方法。在该方法中，与蛋白质所属的家族相关的信息来自两个或更多个次级数据库（2DB），每个2DB由不同的建模方法产生，并且其中至少一个2DB不提供每个2DB中的蛋白质序列的单一比对家庭。该方法包括从所述至少两个2DB提取蛋白质家族信息的步骤; 并将此信息合并到一个建模基础设施中。

6. 发明申请

WO2002088341A2 P450 PROTEINS 审中-公开
标题翻译： P450蛋白
公开(公告)号：WO2002088341A2
公开(公告)日：2002-11-07
申请号：PCT/GB2002/001913
申请日：2002-04-26
申请人： INPHARMATICA LIMITED , FAGAN, Richard, Joseph , PHELPS, Christopher, Benjamin , PHILLIPS, Tom , PIERRON, Valerie, Nathalie , ALLEN, Kathryn, Elizabeth , GUTTERIDGE, Alex
发明人： FAGAN, Richard, Joseph , PHELPS, Christopher, Benjamin , PHILLIPS, Tom , PIERRON, Valerie, Nathalie , ALLEN, Kathryn, Elizabeth , GUTTERIDGE, Alex
IPC分类号： C12N9/00
CPC分类号： C12N9/0071 , A61K38/00
摘要： This invention relates to novel proteins, termed BAA92678.1 and BAA31683.1, herein identified as P450 enzymes and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译：本发明涉及称为BAA92678.1和BAA31683.1，本文中鉴定为P450酶的蛋白质，以及来自编码基因的这些蛋白质和核酸序列在诊断，预防和治疗疾病中的用途。

7. 发明申请

WO2002070561A2 NUCLEAR HORMONE RECEPTOR LIGAND BINDING DOMAIN 审中-公开
标题翻译：核激素受体配体结合域
公开(公告)号：WO2002070561A2
公开(公告)日：2002-09-12
申请号：PCT/GB2002/000961
申请日：2002-03-05
申请人： INPHARMATICA LIMITED , FAGAN, Richard, Joseph , PHELPS, Christopher, Benjamin
发明人： FAGAN, Richard, Joseph , PHELPS, Christopher, Benjamin
IPC分类号： C07K14/705
CPC分类号： C07K14/72 , A61K38/00
摘要： This invention relates to novel proteins, termed BAA31618.1, herein identified as a Nuclear Hormone Receptor Ligand Binding Domain and to the use of this proteins and nucleic acid sequence from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译：本发明涉及称为BAA31618.1的新蛋白质，其在本文中被鉴定为核激素受体配体结合结构域并且涉及来自编码基因的该蛋白质和核酸序列在诊断，预防中的用途和治疗疾病。

8. 发明申请

WO2002062976A2 SERINE PROTEASES 审中-公开
标题翻译：丝氨酸蛋白酶
公开(公告)号：WO2002062976A2
公开(公告)日：2002-08-15
申请号：PCT/GB2002/000505
申请日：2002-02-06
申请人： INPHARMATICA LIMITED , FAGAN, Richard, Joseph , PHELPS, Christopher, Benjamin , RODRIGUES, Tania, Maria
发明人： FAGAN, Richard, Joseph , PHELPS, Christopher, Benjamin , RODRIGUES, Tania, Maria
IPC分类号： C12N9/00
CPC分类号： C12N9/6424 , A01K2217/05 , A01K2217/075 , A61K39/00
摘要： This invention relates to novel proteins, termed AAF384335.1, CAB00991.1, CAB73737.1 and AAC67798.1, herein identified as serine proteases and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译：本发明涉及新的蛋白质，称为AAF384335.1，CAB00991.1，CAB73737.1和AAC67798.1，本文中鉴定为丝氨酸蛋白酶，以及来自编码基因的这些蛋白质和核酸序列在诊断，预防和治疗疾病。

9. 发明申请

WO2007036727A1 CONDENSED PYRAZOLE DERIVATIVES AS PPAR AGONISTS II 审中-公开
标题翻译：浓缩的吡唑衍生物作为PPAR激动剂II
公开(公告)号：WO2007036727A1
公开(公告)日：2007-04-05
申请号：PCT/GB2006/003608
申请日：2006-09-28
申请人： INPHARMATICA LIMITED , AYSCOUGH, Andrew , THOMPSON, Stephen , TAYLOR, Susanne , KHAN, Nawaz, Mohammed
发明人： AYSCOUGH, Andrew , THOMPSON, Stephen , TAYLOR, Susanne , KHAN, Nawaz, Mohammed
IPC分类号： C07D231/56 , C07D471/04 , A61K31/416 , A61K31/437 , A61P3/00
CPC分类号： C07D471/04 , C07D231/56
摘要： The invention discloses compounds of formula (I) wherein: R is a carboxylic acid or a derivative thereof; R 1 and R 2 are independently H or alkyl, or together R 1 and R 2 form an alkylene group; L 1 is a single bond, NH, NCH 3 , O, S, CH 2 or CH, wherein when L 1 is CH the dashed line indicates a double bond and R 2 is absent, otherwise the dashed line is a single bond; R 8 and R 9 are independently H, halo, alkyl or alkoxy; L 2 is O or S; L 3 is CH 2 or CH 2 CH 2 ; R 10 and R 11 are independently H, halo, CF 3 , OCF 3 , alkyl or alkoxy; Y 1 is CH or N; Y 2 is CH or N; and R 12 and R 13 are independently H, halo, CF 3 , OCF 3 , alkyl or alkoxy; or a pharmaceutically acceptable derivative thereof, useful for treating disorders mediated by peroxisome-proliferator-activated receptor (PPAR) subtype δ (PPARδ). The compounds of the invention are therefore useful in the treatment of metabolic syndrome, obesity, type-II diabetes, dyslipidemia, wound healing, inflammation, neurodegenerative disorders and multiple sclerosis.
摘要翻译：本发明公开了式（I）的化合物，其中：R是羧酸或其衍生物; R 1和R 2独立地是H或烷基，或者一起R 1和R 2形成亚烷基 ; L 1是单键，NH，NCH 3，O，S，CH 2或CH，其中当L 1， / SUP>是CH，虚线表示双键并且R 2不存在，否则虚线是单键; R 8和R 9独立地是H，卤素，烷基或烷氧基; L 2是O或S; CH 3是CH 2或CH 2 CH 2; R 10和R 11独立地为H，卤素，CF 3，OCF 3，烷基或烷氧基; Y 1是CH或N; Y 2是CH或N; R 12和R 12独立地为H，卤素，CF 3，OCF 3，烷基或烷氧基; 或其药学上可接受的衍生物，其可用于治疗由过氧化物酶体增殖物激活受体（PPAR）亚型d（PPARd）介导的病症。因此，本发明的化合物可用于治疗代谢综合征，肥胖症，II型糖尿病，血脂异常，伤口愈合，炎症，神经变性疾病和多发性硬化。

10. 发明申请

WO2005073251A1 SEROTONIN RECEPTOR 审中-公开
标题翻译：丝氨酸蛋白酶受体
公开(公告)号：WO2005073251A1
公开(公告)日：2005-08-11
申请号：PCT/GB2005/000292
申请日：2005-01-28
申请人： INPHARMATICA LIMITED , LOBLEY, Anna, Elizabeth , MICHALOVICH, David , STANCOVSKI, Ilana , ALLEN, Kathryn, Elizabeth , ALLEN, Janet, Marjorie , OSYPENKO, Vadym, Nikolaevich , GURNEY, Alison, Marion
发明人： LOBLEY, Anna, Elizabeth , MICHALOVICH, David , STANCOVSKI, Ilana , ALLEN, Kathryn, Elizabeth , ALLEN, Janet, Marjorie , OSYPENKO, Vadym, Nikolaevich , GURNEY, Alison, Marion
IPC分类号： C07K14/705
CPC分类号： C07K14/70571
摘要： This invention relates to a protein, termed INPIONCH1, herein identified as a 5-HT3 receptor and to the use of this protein and nucleic acid sequence from the encoding gene in the diagnosis, prevention and treatment of disease.
摘要翻译：本发明涉及称为INPIONCH1的蛋白质，本文鉴定为5-HT 3受体，以及在诊断，预防和治疗疾病中使用该蛋白质和来自编码基因的核酸序列。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式