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1. 发明专利

JP2001286455A DEVICE HAVING STRUCTURE FOR MODIFYING MAGNETIC FIELD 失效
公开(公告)号：JP2001286455A
公开(公告)日：2001-10-16
申请号：JP2001081139
申请日：2001-03-21
申请人： IMAGE GUIDED NEUROLOGICS INC
发明人： VISWANATHAN RAJU R , RAGAVAHAN RAGHU
IPC分类号： A61B5/055 , G01R33/34
摘要： PROBLEM TO BE SOLVED: To provide a device related to a medical apparatus for receiving electromagnetic radiation, for obtaining various magnetic field responses in a magnetic resonance image in the visual field of a natural organ such as a local part inside a human body. SOLUTION: As coils in the medical device to be inserted into the human body, a pair of micro-coils 8 and 10 opposite from each other are mounted. In each micro-coil, the diameter limited by a first coil is larger than the diameter limited by at least one complete second coil. The second coil is located adjacent to or apart from the center region between the micro-coils defining a pair of the micro-coils. A common connection wire is mounted between the two micro-coils to be used for defining the center region. The shape of the micro-coils whose circumference varies based on the adjacent coil is called dumbbell-shape or hone-shape.

2. 发明申请

US20030187459A1 Placement of chronic micro-catheter device and method 有权
公开(公告)号：US20030187459A1
公开(公告)日：2003-10-02
申请号：US10106773
申请日：2002-03-26
申请人： Image-Guided Neurologics, Inc.
发明人： Matthew S. Solar , Kari Parmer , David Lee , Frank Murdock
IPC分类号： A61B019/00
CPC分类号： A61M25/0668 , A61M2025/0042
摘要： A device and method of placement of a chronic micro-catheter is shown that allows effective guiding of micro-catheters through a host catheter that is later removable while leaving the micro-catheter implanted in place within the patient. The novel configuration allows the micro-catheter to be completely radially enclosed during insertion, and still allows the host catheter to be removed, leaving the micro-catheter behind. Additionally, the configuration allows several micro-catheters to be placed at any number of depths and orientations while still using a minimally invasive host catheter.

3. 发明申请

US20040267284A1 Trajectory guide with instrument immobilizer 有权
标题翻译：带仪表防盗器的轨迹导轨
公开(公告)号：US20040267284A1
公开(公告)日：2004-12-30
申请号：US10894958
申请日：2004-07-20
申请人： Image-Guided Neurologics, Inc.
发明人： Kari Parmer , Thomas I. Miller , John David
IPC分类号： A61B017/00 , A61B019/00
CPC分类号： A61B90/11 , A61B2017/347 , A61B2090/374 , A61B2090/3933 , A61B2090/3954
摘要： A method and apparatus accurately maintains alignment of a surgical instrument. The apparatus includes a base with an attached movable member. The movable member includes a passage forming a portion of a trajectory path. A relaxable or rigid material has a similar passage in common with the passage of the movable member. If a relaxable material is used, the passage portion of the relaxable region is held open by an inserted stem removably attached to the movable member. The instrument is then inserted into the center of the stem and thus into the trajectory path. The stem is removed by withdrawing it from the movable member over the proximal portion of the instrument. This releases the relaxable region to tightly hold the instrument in place. Alternatively, using a relaxable or rigid component, the component is slid laterally to at least partially offset a passage through the component from the passage of the movable member to reduce a combined effective area of the passages and to grasp an instrument.
摘要翻译：一种方法和装置精确地维持外科器械的对准。该装置包括具有附接的可动构件的底座。可动构件包括形成轨迹路径的一部分的通路。可松动或刚性材料具有与可动构件的通过相同的通道。如果使用可松弛的材料，可松动区域的通道部分通过可移除地附接到可动构件的插入杆保持打开。然后将仪器插入杆的中心，从而插入到轨迹路径中。通过从仪器的近端部分上的可移动部件取出来除去杆。这释放了可松弛的区域，以将仪器紧紧地固定到位。或者，使用可松弛或刚性部件，部件被横向滑动以至少部分地偏移通过部件的通道与可移动部件的通道，以减少通道的组合有效面积并且抓住器械。

4. 发明申请

US20020156372A1 Deep organ access device and method 有权
公开(公告)号：US20020156372A1
公开(公告)日：2002-10-24
申请号：US10175668
申请日：2002-06-20
申请人： Image-Guided Neurologics, Inc.
发明人： James G. Skakoon , Robert Wharen , Matthew S. Solar , Kari Parmer , Rudy A. Mazzocchi , John David , Frank Murdock , David Hatcher , Thomas I. Miller , Timothy Alan Parmer , Charles L. Truwit
IPC分类号： A61B006/00
CPC分类号： A61N1/0539 , A61B34/20 , A61B90/11 , A61B2017/0023 , A61B2017/00398 , A61B2017/00911 , A61B2017/3407 , A61B2017/3409 , A61B2017/3411 , A61B2017/347 , A61B2034/2051 , A61B2034/2055 , A61B2090/103 , A61B2090/363 , A61B2090/374 , A61B2090/3762 , A61B2090/3983 , A61N1/0534
摘要： Devices and methods provide accurate targeting, placement, and/or stabilization of an electrode or other instrument(s) into the brain or other body organ, such as to treat severe tremor or other neurological disorders. Targeting is performed using any form of image-guidance, including real-time MRI, CT, or frameless surgical navigation systems.

5. 发明申请

US20020072668A1 Microcoil construction 有权
标题翻译：微线圈结构
公开(公告)号：US20020072668A1
公开(公告)日：2002-06-13
申请号：US09736529
申请日：2000-12-13
申请人： Image-Guided Neurologics, Inc.
发明人： Gerald W. Mills
IPC分类号： A61B005/05
CPC分类号： A61B5/055 , G01R33/285
摘要： A microcoil is manufactured by rolling a trace unit in such a way as to form at least one winding. The trace unit is comprised of a conductive trace attached to a flexible insulating film. A preferred embodiment of the microcoil contains both a first winding and a second winding electrically connected and spaced apart by a joining portion. The microcoil may be used for internal magnetic resonance imaging of patient by attaching the microcoil to a catheter.
摘要翻译：微线圈通过以形成至少一个绕组的方式滚动跟踪单元来制造。迹线单元由连接到柔性绝缘膜的导电迹线组成。微线圈的优选实施例包含电连接并由接合部分间隔开的第一绕组和第二绕组。微线圈可以用于通过将微线圈附接到导管来进行患者的内部磁共振成像。

6. 发明申请

US20020019641A1 Trajectory guide 审中-公开
标题翻译：轨迹指南
公开(公告)号：US20020019641A1
公开(公告)日：2002-02-14
申请号：US09970262
申请日：2001-10-03
申请人： Image-Guided Neurologics, Inc.
发明人： Charles L. Truwit
IPC分类号： A61B019/00
CPC分类号： A61B90/11 , A61B34/10 , A61B90/36 , A61B2017/00243 , A61B2017/00398 , A61B2017/00539 , A61B2017/00911 , A61B2090/3954
摘要： A surgical method and apparatus for accurately aligning the trajectory of, guiding of, and introducing or withdrawal of an instrument is disclosed. The apparatus includes a base which has a movable member movably attached to the base. The movable member has a passage therein which forms a portion of the trajectory path. A positioning stem further includes a first locator and a second locator. The first and second locators are associated with two different portions of the positioning stem so that they are essentially two points on a line. The first and second locators are also locatable by a scanning or imaging system. The positioning stem is removably attached to said movable member and used to position the movable member. Moving the movable member also moves the passage therein to different trajectories. Once the passage within the movable member more or less is aligned with a target within the body, a locking member locks the movable member into a fixed position. The movable member can be moved to different trajectories using a first hydraulic system. A second hydraulic system can be used to introduce or withdraw an instrument to or from the patient. A mechanical advancement tool can be substituted for the second hydraulic system. The surgical instrument may also be provided with a remote portion for controlling the instrument from a remote location. The instrument can also be computer controlled.
摘要翻译：公开了一种用于精确对准仪器的轨迹，引导和引入或撤回的手术方法和装置。该装置包括具有可移动地附接到基座的可动构件的底座。可移动部件具有形成轨迹路径的一部分的通道。定位杆还包括第一定位器和第二定位器。第一和第二定位器与定位杆的两个不同部分相关联，使得它们基本上是一条直线上的两个点。第一和第二定位器也可由扫描或成像系统定位。定位杆可移除地附接到所述可动构件并用于定位可动构件。移动可移动构件还将其中的通道移动到不同的轨迹。一旦可动构件中的通道或多或少地与主体内的靶对准，则锁定构件将可动构件锁定在固定位置。使用第一液压系统可移动构件可移动到不同的轨迹。可以使用第二液压系统将仪器引入或者从患者身上引出或从患者身上取出。机械推进工具可以代替第二液压系统。手术器械还可以设置有用于从远程位置控制仪器的远程部分。仪器也可以由电脑控制。

7. 发明申请

US20040082905A1 Indexing cell delivery catheter 有权
标题翻译：索引细胞输送导管
公开(公告)号：US20040082905A1
公开(公告)日：2004-04-29
申请号：US10282584
申请日：2002-10-29
申请人： Image-Guided Neurologics, Inc.
发明人： Matthew S. Solar , Kari Parmer , Philip Smith , Frank C. Murdock
IPC分类号： A61M003/00
CPC分类号： A61M25/0097 , A61M25/0009 , A61M25/0045 , A61M25/0662 , A61M2025/0008
摘要： An insertion device and method of using and manufacturing an insertion device is shown, wherein the insertion device is capable of distributing a media over a large distribution volume inside a patient while reducing the amount of tissue disturbed by the procedure. Also shown is a computer-readable medium with instructions stored thereon, the instructions when executed operable to cause generation of a set of data for use with an insertion device. An insertion device and methods are shown that allows a series of iterations to be performed within a single insertion procedure that distributes media, such as cells for cell therapy, over a large volume.
摘要翻译：示出了使用和制造插入装置的插入装置和方法，其中插入装置能够在减少由该过程干扰的组织量的情况下在患者体内分布介质在大分布体积上。还示出了具有存储在其上的指令的计算机可读介质，所述指令被执行时可操作以引起生成用于插入设备的一组数据。示出了插入装置和方法，其允许在单个插入程序中执行一系列迭代，所述插入程序在大体积上分布介质，例如用于细胞治疗的细胞。

8. 发明申请

US20030028090A1 Method for dynamic characterization of density fields in a compound structure 审中-公开
标题翻译：复合结构中密度场的动态表征方法
公开(公告)号：US20030028090A1
公开(公告)日：2003-02-06
申请号：US09745039
申请日：2000-12-20
申请人： Image-Guided Neurologics, Inc.
发明人： Raghu Raghavan , Timothy Poston , John Kucharczyk
IPC分类号： A61B005/05
CPC分类号： G06F19/3481 , A61B5/055 , A61B6/03 , G06F19/3456 , G16H50/50
摘要： A method supplies a dynamic vector map of properties within a region or a unified suite of quantification functionality for property functions, such as density functions, conduction functions (e.g., thermal conduction, electrical conduction, atomic or subatomic mass conduction, macromolecular mass conduction), defined on, defined in or defining a three-dimensional space, which functions may optionally vary in time. There should be at least two services assisting in the definition of the map or suite, even in a dynamic modality, selected from: (a) Computation of the volume of the region where the density lies above or below a specified threshold, or between two specified values; (b) Computation of the integral of the density (that is, determining a total amount of material within the region); (c) Estimation of the rate of change of the density with respect to time, optionally restricted to a specified region. The rate may be with respect to any property such as concentration changes, conductivity rates, temperature changes, optical density changes, viscosity changes, or any other observable property; (d) Estimation of the local or global failure of conservation represented by changes with time in the density, whether or not the method is given an implemented transport model; (e) Estimation of the local or global rate at which material with a changing density is passing through a specified surface (e.g., boundary), whether or not the method is provided with an implemented transport model; (f) Separation of the density of a material with a changing density, given an implemented transport model, into nullfreenull and nullboundnull densities.
摘要翻译：一种方法提供属性功能范围内的属性的动态向量图或属性函数的统一的量化功能，例如密度函数，传导函数（例如，热传导，导电，原子或亚原子质量传导，大分子质量传导）定义在，定义或定义三维空间，哪些功能可以可选地在时间上变化。至少有两项服务可以帮助定义地图或套件，即使在动态模式中也可以选择：（a）计算密度高于或低于指定阈值的地区或二者之间的体积指定值（b）密度积分的计算（即确定区域内材料的总量）; （c）密度相对于时间的变化率的估计，可选地限于指定区域。速率可以是任何属性，如浓度变化，电导率，温度变化，光密度变化，粘度变化或任何其他可观察到的性质; （d）无论方法是否给予实施的运输模式，估计由密度随时间变化表示的保护的局部或全局失效; （e）估计具有变化密度的材料经过指定表面（例如边界）的局部或全局速率，无论该方法是否具有实施的运输模型; （f）鉴于实施的运输模式，将密度变化的材料的密度分离为“自由”和“限制”密度。

9. 发明申请

WO2007079222A2 POSITION DETECTION IN A MAGNETIC FIELD 审中-公开
标题翻译：磁场中的位置检测
公开(公告)号：WO2007079222A2
公开(公告)日：2007-07-12
申请号：PCT/US2006/049572
申请日：2006-12-29
申请人： IMAGE-GUIDED NEUROLOGICS, INC. , WURMFELD, David , SOLAR, Matthew, S.
发明人： WURMFELD, David , SOLAR, Matthew, S.
IPC分类号： G01D5/26
CPC分类号： G01D5/34723 , A61B34/20 , A61B90/11 , A61B90/37 , A61B90/39 , A61B2017/3409 , A61B2034/2059 , A61B2090/062 , A61B2090/374 , A61B2090/3945 , Y10T29/49826
摘要： Assemblies and methods for remotely detecting a position of a surgical instrument (102) in the presence of a magnetic field. An encoder (126) is coupled to move in concert with the instrument (102). A translucent substrate and light blocking indicia (406) are disposed on the encoder (126). A light source (128) and a light detector array (130) are effectively disposed outside of the magnetic field. Light from the light source (128) is carried to the encoder first side using an input optical fiber (120). Light passing through the encoder (126) is received at an encoder second side by an output optical fiber (122), and thus transmitted to the light detector array (130), which converts the received light to position representative electrical signals. Such signals are subsequently transmitted to a control module (134) that formulates and conveys a position of the instrument (102).
摘要翻译：用于在存在磁场的情况下远程检测手术器械（102）的位置的组件和方法。编码器（126）被耦合以与仪器（102）协调地移动。半透明衬底和光阻标记（406）设置在编码器（126）上。光源（128）和光检测器阵列（130）被有效地布置在磁场的外部。使用输入光纤（120）将来自光源（128）的光输送到编码器第一侧。穿过编码器（126）的光在编码器第二侧由输出光纤（122）接收，并且因此被发送到光检测器阵列（130），光检测器阵列（130）将接收到的光转换为位置代表性电信号。这些信号随后被传送到控制模块（134），该控制模块（134）制定和传送仪器（102）的位置。

10. 发明申请

WO2004075768A2 FIDUCIAL MARKER DEVICES, TOOLS, AND METHODS 审中-公开
标题翻译： FIDUCAL MARKER设备，工具和方法
公开(公告)号：WO2004075768A2
公开(公告)日：2004-09-10
申请号：PCT/US2004/005470
申请日：2004-02-25
申请人： IMAGE-GUIDED NEUROLOGICS, INC. , SOLAR, Matthew, S. , BRIDGES, Thomas, L. , LEE, David , FREAS, Mark , MAZZOCCHI, Rudy, A.
发明人： SOLAR, Matthew, S. , BRIDGES, Thomas, L. , LEE, David , FREAS, Mark , MAZZOCCHI, Rudy, A.
IPC分类号： A61B19/00
CPC分类号： A61B34/20 , A61B17/685 , A61B17/8605 , A61B90/39 , A61B2034/107 , A61B2034/2051 , A61B2034/2055 , A61B2034/2068 , A61B2034/207 , A61B2034/2072 , A61B2090/0801 , A61B2090/3937 , A61B2090/3954 , A61B2090/3983 , A61B2090/3987 , A61B2090/3995
摘要： A combined computed tomography (CT) imagable fiducial locator head, an integral bone screw, and an integral divot receives a positioning wand of an image-guided surgical (IGS) workstation. A fluid/gel-absorbing coating or cover receives a magnetic resonance (MR) imagable fluid, thereby permitting both CT and MR imaging. Protective caps and collars may protect the fiducial marker from mechanical impact and/or to guide the fiducial marker during affixation. A bull's-eye or other template selects a center of a substantially spherical fiducial marker head on an image, such as during patient registration. A positioning instrument has a cap that mates directly to an imageable sphere to perform registration. A jointed positioning instrument, when placed in a base, pivots about a location defined by a center of the imageable sphere when it was in the base. A fiducial marker has two imageable spheres defining a line intersecting a desired point on the base. A base has a receptacle for receiving a positioning instrument. An imageable sphere has a removable imageable portion to allow access to a center of the imageable sphere by a positioning instrument.
摘要翻译：组合计算机断层扫描（CT）可成像的基准定位头，整体骨螺钉和整体式牙齿接收图像引导手术（IGS）工作站的定位棒。液体/凝胶吸收涂层或盖接收磁共振（MR）可成像流体，从而允许CT和MR成像。保护帽和衣领可以保护基准标记物免受机械冲击和/或在固定期间引导基准标记。公牛眼或其他模板，例如在患者登记期间，选择图像上基本上球形的基准标记头的中心。定位仪器具有与可成像球体直接配合以进行配准的帽盖。连接的定位仪器放置在基座中时，可绕着可成像球体的中心限定在位于基座中心的位置。基准标记具有两个可成像的球体，其界定与基底上所需点相交的线。基座具有用于接收定位仪器的容器。可成像球体具有可拆卸的可成像部分，以允许通过定位仪器进入可成像球体的中心。

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