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1. 发明申请

WO1997009312A1 PROCESS FOR PRODUCING 3-(AMINOMETHYL)-6-CHLOROPYRIDINES 审中-公开
标题翻译：制备3-（氨基甲基）-6-氯吡啶的方法
公开(公告)号：WO1997009312A1
公开(公告)日：1997-03-13
申请号：PCT/JP1996002535
申请日：1996-09-06
申请人： NIPPON SODA CO., LTD. , INOUE, Tsutomu , TAKAHASHI, Jun , IMAGAWA, Tsutomu , HATANAKA, Kazuhiro
发明人： NIPPON SODA CO., LTD.
IPC分类号： C07D213/61
CPC分类号： C07D213/89 , C07D213/61
摘要： A process for producing 3-(aminomethyl)-6-chloropyridines represented by general formula (II) (wherein R represents hydrogen or lower alkyl; and R represents hydrogen, lower alkyl or halogeno), which comprises treating a 3-(substituted aminomethyl)pyridine 1-oxide represented by general formula (I) (wherein R represents alkyl, aryl, aralkyl or alkoxy; and R and R are each as defined above) in the presence of an electrophilic agent having at least one chlorine atom with a base represented by the following general formula (a): R'R"R'"N (wherein R', R" and R'" may be the same or different and each represents lower alkyl or an aromatic group, or R', R", R'" and N together form optionally substituted pyridine), followed by the treatment with hydrogen chloride and water. The compounds thus produced are useful as the materials of medicines and pesticides, in particular, insecticides.
摘要翻译：一种制备由通式（II）表示的3-（氨基甲基）-6-氯吡啶的方法（其中R 2表示氢或低级烷基，R 3表示氢，低级烷基或卤代），其包括处理由通式（I）表示的3-（取代的氨基甲基）吡啶1-氧化物（其中R 1表示烷基，芳基，芳烷基或烷氧基，R 2和R 3各自如上所定义）存在具有至少一个氯原子的亲电子与由以下通式（a）表示的碱：R'R“R”“N（其中R'，R”和R“可以相同或不同，各自表示低级烷基或芳基，或者R'，R“，R”和N一起形成任选取代的吡啶），然后用氯化氢和水处理。由此生产的化合物可用作药物和杀虫剂的材料，特别是杀虫剂。

2. 发明授权

US5744608A Method for manufacturing 3-(aminomethyl)-6-chloropyridines 失效
标题翻译： 3-（氨基甲基）-6-氯吡啶的制备方法
公开(公告)号：US5744608A
公开(公告)日：1998-04-28
申请号：US836658
申请日：1997-05-01
申请人： Inoue Tsutomu , Takahashi Jun , Imagawa Tsutomu , Kazuhiro Hatanaka
发明人： Inoue Tsutomu , Takahashi Jun , Imagawa Tsutomu , Kazuhiro Hatanaka
IPC分类号： C07D213/61 , C07D213/89 , C07D213/38 , C07D213/26
CPC分类号： C07D213/89 , C07D213/61
摘要： The present invention is directed to methods for manufacturing 3-(aminomethyl)-6-chloropyridines represented by a general formula �II!; ##STR1## wherein R.sup.2 represents hydrogen or a lower alkyl and R.sup.3 represents hydrogen, a lower alkyl or an halogen atom, characterized in that the compound represented by the general formula �II! is manufactured by allowing 3-(substituted-aminomethyl)pyridine 1-oxide represented by a general formula �I!; ##STR2## wherein R.sup.1 represents alkyl, aryl, aralkyl or alkoxy, R.sup.2 and R.sup.3 are as described above, to react with a base represented by a general formula �a!; R'R"R'"N �a! wherein R', R" and R'" may be the same or different one another and represent each independently a lower alkyl or an aromatic group, or R', R" , R'" and N may form together an optionally-substituted pyridine ring, in the presence of an electrophilic reagent having at least one chlorine atom, and subsequently treating the reaction product with hydrogen chloride and water. The compounds manufactured according to the present invention are useful as the raw materials used for the manufacturing of agricultural chemicals and pharmaceuticals, and particularly useful for the raw materials for manufacturing insecticides.
摘要翻译： PCT No.PCT / JP96 / 02535 Sec。 371日期1997年5月1日 102（e）日期1997年5月1日PCT提交1996年9月6日PCT公布。出版物WO97 / 09312 日期1997年3月13日本发明涉及通式[II]表示的3-（氨基甲基）-6-氯吡啶的制造方法。其中R 2表示氢或低级烷基，R 3表示氢，低级烷基或卤素原子，其特征在于通式[II]表示的化合物是通过使3-（取代氨基甲基）由通式[I]表示的吡啶1-氧化物; 其中R 1表示烷基，芳基，芳烷基或烷氧基，R 2和R 3如上所述，与由通式[a]表示的碱反应; R'R'''N [a]其中R'，R“和R”'可以彼此相同或不同，并且各自独立地表示低级烷基或芳基，或者R'，R“ 在存在具有至少一个氯原子的亲电试剂的存在下，R'和N可以一起形成任选取代的吡啶环，随后用氯化氢和水处理反应产物。根据本发明制造的化合物可用作用于制造农药和药物的原料，特别适用于制造杀虫剂的原料。

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