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1. 发明申请

WO2008069069A8 AMIDE COMPOUND AND SALT THEREOF, AND BIOFILM FORMATION INHIBITOR OR BIOFILM REMOVER USING THE SAME 审中-公开
标题翻译：酰胺化合物及其盐，以及使用其生物体形成抑制剂或生物膜去除
公开(公告)号：WO2008069069A8
公开(公告)日：2008-08-14
申请号：PCT/JP2007072930
申请日：2007-11-28
申请人： UNIV TOKYO , OTSUKA CHEMICAL CO LTD , SUGA HIROAKI , IGARASHI JUN
发明人： SUGA HIROAKI , IGARASHI JUN
IPC分类号： C07D231/52 , A61K8/49 , A61K31/4152 , A61P1/02 , A61P31/04 , A61Q11/00
CPC分类号： C07D231/52 , A61K8/4946 , A61Q11/00 , A61Q15/00 , A61Q17/005
摘要： Disclosed is a novel amide compound or a salt thereof, which has a biofilm formation inhibitory activity or an activity of removing an already formed biofilm. Also disclosed is a biofilm formation inhibitor or a biofilm remover, which contains the amide compound or a salt thereof as an active ingredient. The amide compound or a salt thereof is represented by the following general formula (1). (In the formula, R represents a C 1-11 alkyl group.)
摘要翻译：公开了具有生物膜形成抑制活性或去除已经形成的生物膜的活性的新型酰胺化合物或其盐。还公开了含有酰胺化合物或其盐作为活性成分的生物膜形成抑制剂或生物膜去除剂。酰胺化合物或其盐由以下通式（1）表示。（式中，R表示C 1-11烷基。）

2. 发明申请

WO1994005179A1 AUTOMATIC HAIR-WASHING APPARATUS 审中-公开
标题翻译：自动洗发设备
公开(公告)号：WO1994005179A1
公开(公告)日：1994-03-17
申请号：PCT/JP1993001212
申请日：1993-08-26
申请人： TOTO LTD. , IGARASHI, Jun , AISO, Kazuya , AZUMA, Tsutomu , NAKANO, Koji
发明人： TOTO LTD.
IPC分类号： A45D19/00
CPC分类号： A45D19/14
摘要： An automatic hair-washing apparatus comprises: a washbowl, and a plurality of nozzle heads for selectively spraying washing water, a shampoo solution or a mixture of the shampoo solution and washing water, and a rinse solution or a mixture of the rinse solution and washing water; and characterized by a washing water supply system for supplying washing water to the nozzle heads to spray washing water, a mixture of the shampoo solution and washing water or a mixture of the rinse solution and washing water on hair, a shampoo/rinse supply system for selectively supplying the shampoo solution and the rinse solution to the nozzle heads, valves connected to the nozzle heads and provided respectively in branch lines branched from a washing water supply line for supplying washing water to the nozzle heads, and a control unit for controlling the washing water supply system, the shampoo/rinse supply system and the valves according to a control program to carry out a hair-washing operation comprising sequential steps of wetting hair with washing water, shampooing hair with the shampoo solution or a mixture of the shampoo solution and washing water, rinsing hair with the rinse solution or a mixture of the rinsing solution and washing water, and rinsing hair with washing water.
摘要翻译：自动洗发装置包括：洗脸盆和用于选择性地喷淋洗涤水，洗发剂溶液或洗发水溶液和洗涤水的混合物的多个喷嘴头，以及冲洗溶液或冲洗溶液和洗涤剂的混合物水; 其特征在于用于向喷嘴头供应洗涤水以喷洗洗涤水，洗发剂溶液和洗涤水的混合物或冲洗溶液与头发上的洗涤水的混合物的洗涤水供应系统，洗发/冲洗供应系统选择性地将洗发剂溶液和冲洗溶液供应到喷嘴头，连接到喷嘴头并分别设置在从用于向喷嘴头供应洗涤水的洗涤水供应管线分支的分支管线中的阀以及用于控制洗涤的控制单元供水系统，洗发/冲洗供应系统和根据控制程序的阀进行洗发操作，其包括用洗涤水润湿毛发，用洗发剂溶液洗发或与洗发剂溶液和洗涤水，用漂洗溶液冲洗头发或冲洗溶液和洗涤水的混合物，并用洗涤水冲洗头发呃。

3. 发明申请

WO1998014430A1 PYRIMIDINE DERIVATIVES 审中-公开
标题翻译：吡嗪衍生物
公开(公告)号：WO1998014430A1
公开(公告)日：1998-04-09
申请号：PCT/JP1997003476
申请日：1997-09-29
申请人： SUMITOMO PHARMACEUTICALS CO., LTD. , IGARASHI, Jun-etsu , KATSUMI, Hiroyuki , NISHIMURA, Tamiki
发明人： SUMITOMO PHARMACEUTICALS CO., LTD.
IPC分类号： C07D215/38
CPC分类号： C07D215/38 , C07D401/12
摘要： Novel pyrimidine derivatives represented by general formula (I) wherein W represents optionally substituted aryl, etc.; X represents halogeno, etc.; Y represents sulfur, etc.; and A, G and Z have the meaning as defined in the following case (1) or (2): (1) A represents optionally substituted amino, etc.; G represents nitrogen; and Z represents a group represented by general formula (II) (wherein A represents hydrogen or optionally substituted alkyl; W represents optionally substituted aryl, etc.; and m and n are the same or different and each represents 0, 1 or 2); or (2) A and G form together with the carbon atom to which they are bonded an optionally substituted benzene ring; and Z represents a group represented by the following general formula: -N(Q )Q (wherein Q and Q are the same or different and each represents hydrogen, optionally substituted lower alkyl, etc.), which are psychotropic drugs having a potent affinity for the D4 receptor but no affinity for the alpha l receptor and being useful as remedies for, e.g., mental symptoms of schizophrenia, periodic psychosis, Parkinson's disease or drug abuse or those accompanying senile dementia or Alzheimer's disease.
摘要翻译：由通式（I）表示的新型嘧啶衍生物，其中W表示任选取代的芳基等; X表示卤素等; Y表示硫等; 和A，G和Z具有以下情况（1）或（2）中定义的含义：（1）A表示任选取代的氨基等; G表示氮; Z表示由通式（II）表示的基团（其中A 2表示氢或任选取代的烷基; W 1表示任选取代的芳基等; m和n相同或不同，表示0 ，1或2）; 或（2）A和G与它们所键合的碳原子一起形成任选取代的苯环; 并且Z表示由以下通式表示的基团：-N（Q 1）Q 2（其中Q 1和Q 2相同或不同，各自表示氢，任选取代的低级烷基，等等），其是对D4受体具有强力亲和力但对α1受体没有亲和力的精神药物，并且可用作例如精神分裂症，周期性精神病，帕金森病或药物滥用的精神症状或伴随老年人的补救痴呆或阿尔茨海默病。

4. 发明申请

WO1996031488A1 NOVEL PYRIMIDINE DERIVATIVES EFFICACIOUS AS PSYCHOTROPIC DRUG AND PROCESS FOR THE PRODUCTION THEREOF 审中-公开
标题翻译：新型吡咯烷酮衍生物作为心血管药物有效，其生产方法
公开(公告)号：WO1996031488A1
公开(公告)日：1996-10-10
申请号：PCT/JP1996000895
申请日：1996-04-02
申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , IGARASHI, Jun-etsu , NISHIMURA, Tamiki , SUNAGAWA, Makoto
发明人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
IPC分类号： C07D239/47
CPC分类号： C07D239/47 , C07D239/38 , C07D239/48 , C07D401/12
摘要： Compound represented by general formula (I) or pharmacologically acceptable salts thereof: wherein A represents halogeno, optionally substituted lower alkyl or optionally substituted cycloalkyl; B and B are the same or different and each represents hydrogen or optionally substituted amino; X represents sulfur or oxygen; and Y , Y , Y , Y and Y are the same or different and each represents hydrogen, halogeno, optionally substituted lower alkyl, optionally substituted cycloalkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted aryl or optionally substituted heterocycle. The compounds have a potent interaction with central nervous system receptors such as dopamine or serotonin and are excellent in absorbability in vivo, stability, etc. Thus they are highly useful as a psychotropic drug with relieved side effects.
摘要翻译：由通式（I）表示的化合物或其药理学上可接受的盐：其中A 1表示卤代，任选取代的低级烷基或任选取代的环烷基; B 1和B 2相同或不同，各自表示氢或任选取代的氨基; X表示硫或氧; Y 1，Y 2，Y 3，Y 4和Y 5相同或不同，各自代表氢，卤代，任选取代的低级烷基，任选取代的环烷基，任选取代的低级烯基，任选取代的低级炔基，任选取代的芳基或任选取代的杂环。这些化合物与中枢神经系统受体如多巴胺或5-羟色胺具有强烈的相互作用，并且在体内的吸收性，稳定性等方面优异。因此，它们作为具有减轻副作用的精神药物是非常有用的。

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