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1. 发明专利

IL245848D0 Octahydro fused azadecalin glucocorticoid receptor modulators 未知
公开(公告)号：IL245848D0
公开(公告)日：2016-07-31
申请号：IL24584816
申请日：2016-05-25
申请人： CORCEPT THERAPEUTICS INC , HAZEL HUNT , IAIN WALTERS , BENOIT GOURDET
发明人： HAZEL HUNT , IAIN WALTERS , BENOIT GOURDET
IPC分类号： C07D20060101
摘要： The present invention provides octahydro fused azadecalin compounds having glucocorticoid receptor binding affinity and modulatory activity for pharmaceutical use. Also provided are pharmaceutical compositions containing an effective amount of the fused azadecalin compounds and methods of using the compositions for the-treatment of a glucocorticoid receptor mediated disorder in a subject.

2. 发明专利

IL235868A Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators 未知
公开(公告)号：IL235868A
公开(公告)日：2017-12-31
申请号：IL23586814
申请日：2014-11-23
申请人： CORCEPT THERAPEUTICS INC , TONY JOHNSON , HAZEL HUNT , NICHOLAS RAY , IAIN WALTERS
发明人： TONY JOHNSON , HAZEL HUNT , NICHOLAS RAY , IAIN WALTERS
摘要： The present invention provides heteroaryl ketone fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.

3. 发明专利

IL235868D0 Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators 未知
公开(公告)号：IL235868D0
公开(公告)日：2015-01-29
申请号：IL23586814
申请日：2014-11-23
申请人： CORCEPT THERAPEUTICS INC , TONY JOHNSON , HAZEL HUNT , NICHOLAS RAY , IAIN WALTERS
IPC分类号： A61K20060101
摘要： The present invention provides heteroaryl ketone fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.

4. 发明专利

IL245848A Octahydro fused azadecalin glucocorticoid receptor modulators 未知
公开(公告)号：IL245848A
公开(公告)日：2020-08-31
申请号：IL24584816
申请日：2016-05-25
申请人： CORCEPT THERAPEUTICS INC , HAZEL HUNT , IAIN WALTERS , BENOIT GOURDET
发明人： IAIN WALTERS , BENOIT GOURDET , HAZEL HUNT
IPC分类号： A61K31/5383 , A61K31/4745 , A61P3/04 , A61P3/10 , A61P11/06 , A61P19/02 , A61P25/00 , A61P31/12 , A61P37/02
摘要： The present invention provides octahydro fused azadecalin compounds having glucocorticoid receptor binding affinity and modulatory activity for pharmaceutical use. Also provided are pharmaceutical compositions containing an effective amount of the fused azadecalin compounds and methods of using the compositions for the-treatment of a glucocorticoid receptor mediated disorder in a subject.

5. 发明授权

US07579342B2 Pteridine compounds for the treatment of psoriasis 失效
标题翻译：蝶啶化合物用于治疗牛皮癣
公开(公告)号：US07579342B2
公开(公告)日：2009-08-25
申请号：US10891833
申请日：2004-07-15
申请人： Roger Bonnert , Stewart Gardiner , Fraser Hunt , Iain Walters
发明人： Roger Bonnert , Stewart Gardiner , Fraser Hunt , Iain Walters
IPC分类号： C07D513/04 , A61K31/542
CPC分类号： C07D513/04 , C07D453/02 , C07D475/06
摘要： The invention provides pteridine compounds of formula (I), processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy. Formula (I) in which A is a group of formula (a) or (b).
摘要翻译：本发明提供式（I）的蝶啶化合物，其制备中使用的方法和中间体，含有它们的药物组合物及其在治疗中的用途。式（I）其中A是式（a）或（b）的基团。

6. 发明授权

US07071193B2 7-amino-2-alkylthiopteridin-4-yl-amines for the treatment of chemokine-related diseases 失效
标题翻译： 7-氨基-2-烷基硫代蝶啶-4-基胺，用于治疗趋化因子相关疾病
公开(公告)号：US07071193B2
公开(公告)日：2006-07-04
申请号：US10399570
申请日：2001-10-16
申请人： Roger Bonnert , Iain Walters
发明人： Roger Bonnert , Iain Walters
IPC分类号： A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495 , C07D239/00
CPC分类号： C07D475/06
摘要： Pteridine compounds of formula (I) processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in the treatment of inflammatory diseases such as psoriasis, rheumatoid arthritis, diseases in which angiogenesis is assocated with raised CXCR2 chemokine levels (diabetic retinopathy) and COPD. The compounds are ligands for chemokine receptors and medical indications mentioned in the description include: diseases of the respiratory tract (COPDD, asthma, bronchitis, rhinitis, fibroid lung, pneumonia, etc.), diseases of the bones and joints (arthritis, etc.), skin-diseases (psoriasis, etc), diseases of the gastrointestinal tract, diseases in other tissues and systemic disease (multipe sclerosis, atherosclerosis, AIDS, type 1 diabetes, leprosy, sepsis, etc.), allograft rejection, cancers, cystic fibrosis, stroke, burn wounds, skin ulcers, reproductive disease and more.
摘要翻译：式（I）的蝶啶化合物及其制备中使用的中间体，含有它们的药物组合物及其用于治疗炎性疾病如牛皮癣，类风湿性关节炎，血管发生与升高的CXCR2趋化因子水平（糖尿病性视网膜病变）相关的疾病，和COPD。这些化合物是趋化因子受体的配体，描述中提及的医学指征包括：呼吸道疾病（COPDD，哮喘，支气管炎，鼻炎，纤维瘤肺，肺炎等），骨骼和关节疾病（关节炎等）），皮肤病（牛皮癣等），胃肠道疾病，其他组织中的疾病和全身性疾病（多发性硬化，动脉粥样硬化，艾滋病，1型糖尿病，麻风病，败血症等），同种异体移植物排斥反应，癌症，囊性纤维化，中风，烧伤，皮肤溃疡，生殖疾病等。

7. 发明申请

US20050203172A1 Novel compounds 审中-公开
标题翻译：新型化合物
公开(公告)号：US20050203172A1
公开(公告)日：2005-09-15
申请号：US10521727
申请日：2003-07-15
申请人： Antonio Mete , Iain Walters
发明人： Antonio Mete , Iain Walters
IPC分类号： A61P29/00 , C07D333/38 , A61K31/381
CPC分类号： C07D333/38
摘要： There are provided novel compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, M, T, U, Y, V an W am as defined in die specification and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.
摘要翻译：提供了新的式（I）化合物，其中R 1，R 2，R 3，R 4， R 5，R 6，R 7，M，T，U，Y，V如在模具规格中所定义的，并且药学上可接受的盐; 以及其制备方法，含有它们的组合物及其在治疗中的用途。这些化合物是一氧化氮合酶的抑制剂，因此特别可用于治疗或预防炎性疾病和疼痛。

8. 发明申请

US20060122195A1 Sulphonamide compounds that modulate chemokine receptor activity (ccr4) 审中-公开
标题翻译：调节趋化因子受体活性的磺酰胺化合物（ccr4）
公开(公告)号：US20060122195A1
公开(公告)日：2006-06-08
申请号：US10559312
申请日：2004-06-02
申请人： Richard Harrison , Antonio Mete , Barry Teobald , Iain Walters
发明人： Richard Harrison , Antonio Mete , Barry Teobald , Iain Walters
IPC分类号： A61K31/4965 , A61K31/497 , C07D409/02
CPC分类号： C07D401/12 , C07D241/22 , C07D403/12 , C07D413/12 , C07D417/12
摘要： The invention relates to sulphonamide compounds, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明涉及用于其制备中的磺酰胺化合物，方法和中间体，含有它们的药物组合物及其在治疗中的用途。

9. 发明申请

US20060019999A1 Novel compounds 失效
标题翻译：新型化合物
公开(公告)号：US20060019999A1
公开(公告)日：2006-01-26
申请号：US10521728
申请日：2003-07-15
申请人： Antonio Mete , Iain Walters
发明人： Antonio Mete , Iain Walters
IPC分类号： A61K31/426 , A61K31/421 , A61K31/4172
CPC分类号： C07D333/34
摘要： There are provided novel compounds of formula (I) wherein R1, R2, R3, R10, M, Q, T, U, Y, V and W are as defined in the specification and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.
摘要翻译：提供了式（I）的新化合物，其中R 1，R 2，R 3，R 10，，M，Q，T，U，Y，V和W如说明书及其药学上可接受的盐所定义; 以及其制备方法，含有它们的组合物及其在治疗中的用途。这些化合物是一氧化氮合酶的抑制剂，因此特别可用于治疗或预防炎性疾病和疼痛。

10. 发明申请

US20050234077A1 Pyrimidine compounds and their use as modulators of chemokine receptor activity 审中-公开
标题翻译：嘧啶化合物及其作为趋化因子受体活性调节剂的用途
公开(公告)号：US20050234077A1
公开(公告)日：2005-10-20
申请号：US11036682
申请日：2005-01-14
申请人： Roger Bonnert , Peter Cage , Fraser Hunt , Iain Walters , Paul Willis
发明人： Roger Bonnert , Peter Cage , Fraser Hunt , Iain Walters , Paul Willis
IPC分类号： A61K31/522 , A61P1/04 , A61P3/10 , A61P5/14 , A61P7/04 , A61P9/10 , A61P9/14 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P17/14 , A61P19/02 , A61P25/00 , A61P25/06 , A61P25/14 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/08 , A61P31/18 , A61P35/00 , A61P35/04 , A61P37/02 , A61P37/06 , A61P37/08 , A61P41/00 , A61P43/00 , C07D473/24 , C07D487/04 , A61K31/519
CPC分类号： C07D473/24
摘要： The invention provides certain heterocyclic compounds, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy; in formula (I), A is a group of formula (a) or (b).
摘要翻译：本发明提供某些杂环化合物，其制备中使用的方法和中间体，含有它们的药物组合物及其在治疗中的用途; 在式（I）中，A是式（a）或（b）的基团。

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