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    • 1. 发明授权
    • Buffer composition for catalyzing the preparation of calcitriol or calcifediol and method for preparing calcitriol or calcifediol using same
    • 用于催化骨化三醇或钙二十二醇的制备的缓冲液组合物及使用其制备骨化三醇或钙非二醇的方法
    • US08530205B2
    • 2013-09-10
    • US13162246
    • 2011-06-16
    • Dae-Jung KangJong-Hyuk ImHyun-Jung JungJae-Hoon Kang
    • Dae-Jung KangJong-Hyuk ImHyun-Jung JungJae-Hoon Kang
    • C12P15/00C12N9/52
    • C12P7/22C12N1/38
    • The present invention relates to a buffer composition for promoting production of calcitriol or calcifediol, and a method for producing calcitriol or calcifediol using the same. More particularly, the present invention relates to a buffer composition for promoting production of calcitriol or calcifediol comprising a metallic compound, an organic solvent, cyclodextrin, tris(hydroxymethyl)aminomethane, sodium succinate, sodium chloride, magnesium chloride, and water, and a method for producing calcitriol or calcifediol using the same. In the method for producing calcitiriol or calcifediol, the production yield of calcitriol or calcifediol is high, and the bioconversion is carried out in an enzyme reaction system instead of in a microorganism culture system. Thus, it is not required to maintain a sterile state. Also, the separation/purification following the completion of a biocatalytic reaction can be carried out in a cleaner state than the microorganism culture method. Accordingly, there is an advantage in that a cost required for separation is low and the quality is improved. Furthermore, the buffer composition for promoting production of calcitriol or calcifediol can provide a high productivity of calcitriol or calcifediol.
    • 本发明涉及一种用于促进骨化三醇或钙二十二醇的生产的缓冲组合物,以及使用该缓冲组合物生产骨化三醇或钙二十二醇的方法。 更具体地说,本发明涉及一种用于促进骨化三醇或钙非二醇的生产的缓冲组合物,其包含金属化合物,有机溶剂,环糊精,三(羟甲基)氨基甲烷,琥珀酸钠,氯化钠,氯化镁和水) 用于使用其生产骨化三醇或calcifediol。 在生产calcitiriol或calcifediol的方法中,骨化三醇或calcifediol的产量高,生物转化在酶反应体系中而不是在微生物培养系统中进行。 因此,不需要保持无菌状态。 此外,生物催化反应完成后的分离/纯化可以比微生物培养方法更清洁的状态进行。 因此,存在分离所需的成本低,质量提高的优点。 此外,用于促进骨化三醇或calcifediol的生产的缓冲组合物可以提供高三氧化三萜或calcifediol的生产率。
    • 2. 发明申请
    • BUFFER COMPOSITION FOR CATALYZING THE PREPARATION OF CALCITRIOL OR CALCIFEDIOL AND METHOD FOR PREPARING CALCITRIOL OR CALCIFEDIOL USING SAME
    • 用于催化制备计算机或计算机的缓冲剂组合物及其制备计算机或计算机的方法
    • US20120064584A1
    • 2012-03-15
    • US13162246
    • 2011-06-16
    • Dae-Jung KangJong-Hyuk ImHyun-Jung JungJae-Hoon Kang
    • Dae-Jung KangJong-Hyuk ImHyun-Jung JungJae-Hoon Kang
    • B01J31/32C12P15/00B01J31/26B01J31/30B01J31/28
    • C12P7/22C12N1/38
    • The present invention relates to a buffer composition for promoting production of calcitriol or calcifediol, and a method for producing calcitriol or calcifediol using the same. More particularly, the present invention relates to a buffer composition for promoting production of calcitriol or calcifediol comprising a metallic compound, an organic solvent, cyclodextrin, tris(hydroxymethyl)aminomethane, sodium succinate, sodium chloride, magnesium chloride, and water, and a method for producing calcitriol or calcifediol using the same. In the method for producing calcitiriol or calcifediol, the production yield of calcitriol or calcifediol is high, and the bioconversion is carried out in an enzyme reaction system instead of in a microorganism culture system. Thus, it is not required to maintain a sterile state. Also, the separation/purification following the completion of a biocatalytic reaction can be carried out in a cleaner state than the microorganism culture method. Accordingly, there is an advantage in that a cost required for separation is low and the quality is improved. Furthermore, the buffer composition for promoting production of calcitriol or calcifediol can provide a high productivity of calcitriol or calcifediol.
    • 本发明涉及一种用于促进骨化三醇或钙二十二醇的生产的缓冲组合物,以及使用该缓冲组合物生产骨化三醇或钙二十二醇的方法。 更具体地说,本发明涉及一种用于促进骨化三醇或钙非二醇的生产的缓冲组合物,其包含金属化合物,有机溶剂,环糊精,三(羟甲基)氨基甲烷,琥珀酸钠,氯化钠,氯化镁和水) 用于使用其生产骨化三醇或calcifediol。 在生产calcitiriol或calcifediol的方法中,骨化三醇或calcifediol的产量高,生物转化在酶反应体系中而不是在微生物培养系统中进行。 因此,不需要保持无菌状态。 此外,生物催化反应完成后的分离/纯化可以比微生物培养方法更清洁的状态进行。 因此,存在分离所需的成本低,质量提高的优点。 此外,用于促进骨化三醇或calcifediol的生产的缓冲组合物可以提供高三氧化三萜或calcifediol的生产率。
    • 7. 发明授权
    • Method of preparing biodegradable dual pore polymer scaffolds for tissue engineering
    • 制备用于组织工程的可生物降解双孔聚合物支架的方法
    • US07842305B2
    • 2010-11-30
    • US11526280
    • 2006-09-21
    • Dong Keun HanKwang-Duk AhnHyun Jung JungKwideok Park
    • Dong Keun HanKwang-Duk AhnHyun Jung JungKwideok Park
    • A61F2/00
    • A61L27/56A61L27/18A61L27/58C08L67/04
    • There is provided a method of preparing biodegradable dual pore polymer scaffolds, comprising the steps of: maintaining a polymer solution containing a biodegradable polymer, an effervescent mixture of carbonate and organic acid, and solvent at a temperature range of −196° C. to ambient temperature so as to evaporate the solvent and produce a polymer sample; and foaming the polymer sample in a mixed solution of water and alcohol.According to the present invention, the pore size of the polymer scaffolds can be easily controlled, and biodegradable polymer scaffolds can be more simply prepared compared to conventional methods such as salt leaching technique, phase separation technique or gas foaming technique. Further, since the biodegradable polymer scaffolds prepared according to the present invention have a high surface area and porosity without formation of skin layer, secretion of toxic substances and remnant phenomenon, they can be advantageously used for regenerating almost all living tissues and organs in tissue engineering.
    • 提供了一种制备可生物降解的双孔聚合物支架的方法,包括以下步骤:将含有可生物降解的聚合物,碳酸盐和有机酸的泡腾混合物和溶剂的聚合物溶液在-196℃的温度范围内保持至环境温度 温度以蒸发溶剂并产生聚合物样品; 并将聚合物样品在水和酒精的混合溶液中发泡。 根据本发明,与常规方法如盐浸技术,相分离技术或气体发泡技术相比,可以容易地控制聚合物支架的孔径,并且可以更简单地制备可生物降解的聚合物支架。 此外,由于根据本发明制备的可生物降解的聚合物支架具有高的表面积和孔隙率,而没有形成皮肤层,有毒物质的分泌和残留现象,因此它们可有利地用于组织工程中几乎所有活组织和器官的再生 。
    • 8. 发明申请
    • Apparatus and method for reproducing digital multimedia broadcast and card for receiving digital multimedia broadcast
    • 用于再现数字多媒体广播的装置和方法以及用于接收数字多媒体广播的卡
    • US20060190617A1
    • 2006-08-24
    • US11348716
    • 2006-02-07
    • Hyun-Jung Jung
    • Hyun-Jung Jung
    • G06F15/16
    • H04N5/4401H04N5/46H04N21/4183H04N21/443H04N21/4622H04N21/6112H04N21/6143
    • Disclosed is an apparatus for enabling a user to selectively view satellite digital multimedia broadcasts or terrestrial digital multimedia broadcasts through a single terminal, a control method thereof, and a card for receiving the digital multimedia broadcasts. The apparatus includes a first card for receiving a terrestrial digital multimedia broadcast, a second card for receiving a satellite digital multimedia broadcast, and a terminal adapted to receive either card so as to receive a digital multimedia broadcast from the inserted card and to reproduce the digital multimedia broadcast. Each card includes a receiving unit for receiving and processing a digital multimedia broadcast signal, a memory for temporarily storing data from the digital multimedia broadcast signal, an interface unit for interfacing the card and a terminal for reproducing the digital multimedia broadcast when the card is inserted into the terminal, and a node for transmitting the data to the terminal.
    • 公开了一种用于使用户能够通过单个终端选择性地观看卫星数字多媒体广播或地面数字多媒体广播的装置,其控制方法和用于接收数字多媒体广播的卡。 该装置包括用于接收地面数字多媒体广播的第一卡,用于接收卫星数字多媒体广播的第二卡和适于接收任一卡的终端,以便从插入的卡接收数字多媒体广播并再现数字 多媒体广播 每个卡包括用于接收和处理数字多媒体广播信号的接收单元,用于临时存储来自数字多媒体广播信号的数据的存储器,用于接口卡的接口单元和用于在插入卡时再现数字多媒体广播的终端 进入终端,以及用于将数据发送到终端的节点。