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1. 发明申请

US20080131430A1 Therapeutic Administration Of The Scrambled Anti-Angiogenic Peptide C16Y 有权
标题翻译：加扰抗血管生成肽C16Y的治疗作用
公开(公告)号：US20080131430A1
公开(公告)日：2008-06-05
申请号：US10588884
申请日：2004-02-12
申请人： Karl G. Csaky , Hynda Kleinman , Lourdes Ponce
发明人： Karl G. Csaky , Hynda Kleinman , Lourdes Ponce
IPC分类号： A61K39/44 , A61K38/10 , A61P35/00 , A61P27/02 , A61K38/08
CPC分类号： A61K38/08 , A61K38/10 , C07K5/101 , C07K5/1016 , C07K14/78
摘要： Unregulated angiogenesis is associated with a variety of pathological conditions. Tumor growth and metastasis is dependent on the development of new blood vessels. The development of new blood vessels in the eye, or ocular neovascularization, has been implicated in a variety of serious ocular diseases. For instance, choroidal neovascularization is linked to age-related macular degeneration, while retinal neovascularization is linked to diabetic retinopathy. The present invention is based on the discovery of a peptide sequence, C16Y, which inhibits ocular neovascularization and tumor growth in vivo. C16Y is a scrambled version of the C16 peptide sequence from the y1 chain of laminin-1. Unlike C16, which is an angiogenic stimulator, C16Y has been shown to inhibit angiogenesis. The present invention discloses methods of treating ocular neovascularization and cancer using both full-length and truncated versions of the C16Y.
摘要翻译：不规则的血管发生与多种病理状况有关。肿瘤生长和转移取决于新血管的发育。眼睛中新血管的发展或眼睛新血管形成已经涉及各种严重的眼部疾病。例如，脉络膜新生血管形成与年龄相关的黄斑变性相关，而视网膜新生血管形成与糖尿病性视网膜病变相关。本发明基于肽体系C16Y的发现，C16Y抑制体内新生血管形成和肿瘤生长。 C16Y是来自层粘连蛋白-1的y1链的C16肽序列的加扰版本。不同于作为血管生成刺激物的C16，C16Y已显示出抑制血管发生。本发明公开了使用全长和截短版本的C16Y治疗眼新生血管形成和癌症的方法。

2. 发明申请

US20070009469A1 Treatment of skin, and wound repair, with thymosin beta 4 有权
公开(公告)号：US20070009469A1
公开(公告)日：2007-01-11
申请号：US11284430
申请日：2005-11-22
申请人： Hynda Kleinman , Allan Goldstein , Katherine Malinda , Gabriel Sosne
发明人： Hynda Kleinman , Allan Goldstein , Katherine Malinda , Gabriel Sosne
IPC分类号： A61K38/17 , A61K8/64
CPC分类号： A61K38/2292 , A61K9/0048 , A61K38/08 , A61K38/1841 , A61K45/06 , Y10S930/18 , A61K2300/00
摘要： Compositions and methods for treatment of skin utilizing thymosin β4.

3. 发明申请

US20070015698A1 Treatment of skin, and wound repair, with thymosin beta 4 审中-公开
标题翻译：用胸腺素β4治疗皮肤和伤口修复
公开(公告)号：US20070015698A1
公开(公告)日：2007-01-18
申请号：US11284408
申请日：2005-11-22
申请人： Hynda Kleinman , Allan Goldstein , Katherine Malinda , Gabriel Sosne
发明人： Hynda Kleinman , Allan Goldstein , Katherine Malinda , Gabriel Sosne
IPC分类号： A61K38/18 , A61K8/64 , A61K31/366 , A61K31/57 , A61K31/56 , A61K31/35 , A61K31/375
CPC分类号： A61K8/64 , A61K31/35 , A61K31/366 , A61K31/375 , A61K31/56 , A61K31/57 , A61K38/1841 , A61K38/1866 , A61K38/2292 , A61Q19/08 , A61K2300/00
摘要： Compositions and methods for treatment of skin utilizing thymosin β4.
摘要翻译：使用胸腺素β4治疗皮肤的组合物和方法。

4. 发明申请

US20070111931A9 Compositions and methods for promoting wound healing and tissue repair 审中-公开
标题翻译：用于促进伤口愈合和组织修复的组合物和方法
公开(公告)号：US20070111931A9
公开(公告)日：2007-05-17
申请号：US09772445
申请日：2001-01-29
申请人： Hynda Kleinman , Allan Goldstein , Katherine Malinda , Gabriel Sosne
发明人： Hynda Kleinman , Allan Goldstein , Katherine Malinda , Gabriel Sosne
IPC分类号： A61K38/18 , A61K38/08
CPC分类号： A61K38/2292 , A61K9/0048 , A61K38/08 , A61K38/1841 , A61K45/06 , Y10S930/18 , A61K2300/00
摘要： The present invention relates to methods for promoting tissue repair, angiogenesis and cell migration. The method of the invention utilizes thymosin β4 (Tβ4) peptide to promote tissue repair, angiogenesis and cell migration. The invention further relates to modulating Tβ4 activity in tissues.
摘要翻译：本发明涉及促进组织修复，血管生成和细胞迁移的方法。本发明的方法利用胸腺素β4（Tbeta4）肽促进组织修复，血管生成和细胞迁移。本发明还涉及调节组织中的Tbeta4活性。

5. 发明授权

US08039585B2 Therapeutic administration of the scrambled anti-angiogenic peptide C16Y 有权
标题翻译：加扰的抗血管生成肽C16Y的治疗施用
公开(公告)号：US08039585B2
公开(公告)日：2011-10-18
申请号：US10588884
申请日：2004-02-12
申请人： Karl G. Csaky , Hynda Kleinman , Lourdes Ponce
发明人： Karl G. Csaky , Hynda Kleinman , Lourdes Ponce
IPC分类号： A61K38/04 , A61K38/00 , A61K51/00 , A61P35/00 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： A61K38/08 , A61K38/10 , C07K5/101 , C07K5/1016 , C07K14/78
摘要： Unregulated angiogenesis is associated with a variety of pathological conditions. Tumor growth and metastasis is dependent on the development of new blood vessels. The development of new blood vessels in the eye, or ocular neovascularization, has been implicated in a variety of serious ocular diseases. For instance, choroidal neovascularization is linked to age-related macular degeneration, while retinal neovascularization is linked to diabetic retinopathy. The present invention is based on the discovery of a peptide sequence, C16Y, which inhibits ocular neovascularization and tumor growth in vivo. C16Y is a scrambled version of the C16 peptide sequence from the y1 chain of laminin-1. Unlike C16, which is an angiogenic stimulator, C16Y has been shown to inhibit angiogenesis. The present invention discloses methods of treating ocular neovascularization and cancer using both full-length and truncated versions of the C16Y.
摘要翻译：不规则的血管发生与多种病理状况有关。肿瘤生长和转移取决于新血管的发育。眼睛中新血管的发展或眼睛新血管形成已经涉及各种严重的眼部疾病。例如，脉络膜新生血管形成与年龄相关的黄斑变性相关，而视网膜新生血管形成与糖尿病性视网膜病变相关。本发明基于肽体系C16Y的发现，C16Y抑制体内新生血管形成和肿瘤生长。 C16Y是来自层粘连蛋白-1的y1链的C16肽序列的加扰版本。不同于作为血管生成刺激物的C16，C16Y已显示出抑制血管发生。本发明公开了使用全长和截短版本的C16Y治疗眼新生血管形成和癌症的方法。

6. 发明申请

US20050239697A1 Methods and compositions for the promotion of hair growth utilizing actin binding peptides 失效
标题翻译：使用肌动蛋白结合肽促进毛发生长的方法和组合物
公开(公告)号：US20050239697A1
公开(公告)日：2005-10-27
申请号：US10502115
申请日：2003-01-22
申请人： Deborah Philp , Hynda Kleinman , Michael Elkin
发明人： Deborah Philp , Hynda Kleinman , Michael Elkin
IPC分类号： A61K8/64 , A61K38/08 , A61K38/10 , A61K38/22 , A61Q7/00
CPC分类号： A61K8/64 , A61K38/2292 , A61Q7/00
摘要： Disclosed herein are methods and compositions suitable for the promotion of hair growth on humans and other animals. Disclosed embodiments include compositions comprising actin-binding peptides. In some embodiments, the actin-binding peptides comprise fragments of thymosin β4. In other embodiments, the disclosure provides compositions comprising fragments of thymosin β4 and/or other actin-binding peptides that are suitable for the treatment of alopecia and other conditions associated with hair loss. In still further embodiments, the disclosure provides compositions comprising the sequence of approximately six or seven amino acids of the thymosin β4 sequence that bind actin.
摘要翻译：本文公开了适用于促进人和其它动物毛发生长的方法和组合物。公开的实施方案包括包含肌动蛋白结合肽的组合物。在一些实施方案中，肌动蛋白结合肽包含胸腺素β4的片段。在其它实施方案中，本公开提供了包含胸腺素β4和/或其它肌动蛋白结合肽片段的组合物，其适用于治疗脱发和与脱发相关的其它病症。在另外的实施方案中，本公开提供包含结合肌动蛋白的胸腺素β4序列的约六个或七个氨基酸的序列的组合物。

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