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1. 发明授权

US08394595B2 Lab-on-a-chip and method of driving the same 有权
标题翻译：芯片实验室及其驱动方法
公开(公告)号：US08394595B2
公开(公告)日：2013-03-12
申请号：US12738683
申请日：2008-10-17
申请人： Moon-Youn Jung , Dong-Ho Shin , Minsuk Jeong , Sanghee Kim , Hye-Yoon Kim , Seon-Hee Park
发明人： Moon-Youn Jung , Dong-Ho Shin , Minsuk Jeong , Sanghee Kim , Hye-Yoon Kim , Seon-Hee Park
IPC分类号： G01N33/53
CPC分类号： G01N33/49
摘要： Provided is a lab-on-a-chip. The lab-on-a-chip includes a first region where a lower substrate and an upper substrate are bonded to each other, a second region where the lower and upper substrates are not bonded, and a gap adjusting member disposed at an end of the second region that is opposite to a boundary between the first and second regions, the gap adjusting member being configured to adjust a gap between the first and second substrates to control a capillary force.
摘要翻译：提供了一个芯片实验室。芯片实验室包括下基板和上基板彼此接合的第一区域，下基板和上基板未接合的第二区域，以及设置在该基板的末端的间隙调节构件所述第二区域与所述第一和第二区域之间的边界相对，所述间隙调节构件被配置为调节所述第一和第二基板之间的间隙以控制毛细管力。

2. 发明申请

US20110151475A1 LAB-ON-A-CHIP AND METHOD OF DRIVING THE SAME 有权
标题翻译： LAB-ON-A-CHIP及其驱动方法
公开(公告)号：US20110151475A1
公开(公告)日：2011-06-23
申请号：US12893898
申请日：2010-09-29
申请人： Hye Yoon KIM
发明人： Hye Yoon KIM
IPC分类号： G01N33/53 , C12M1/34
CPC分类号： G01N33/54366 , B01L3/50273 , B01L2300/0816 , B01L2400/0406 , B01L2400/0481 , B01L2400/082
摘要： Provided are a lab-on-a-chip and a method of driving the same. The lab-on-a-chip includes a first region where a lower substrate and an upper substrate are bonded to each other, a second region where the lower and upper substrates are not bonded to each other, a gap control member disposed at a terminal of the second region facing an interface between the first and second regions, and configured to control a gap between the lower and upper substrates at the terminal of the second region, and a pressure application member disposed at the terminal of the second region facing the interface between the first and second regions, and configured to apply pressure to the upper substrate at the terminal of the second region to reduce a gap between the lower and upper substrates in the center of the second region. Thus, binding events between a fluid sample to be analyzed and a reagent can be maximized so that a high signal can be obtained using only an infinitesimal quantity of sample.
摘要翻译：提供了一种芯片实验室及其驱动方法。芯片实验室包括下基板和上基板彼此接合的第一区域，下基板和上基板彼此不接合的第二区域，设置在端子处的间隙控制构件所述第二区域面向所述第一和第二区域之间的界面，并且被配置为控制在所述第二区域的端子处的所述下基板和所述上基板之间的间隙，以及设置在所述第二区域的面向所述界面的端子处的压力施加构件并且构造成在第二区域的端子处向上基板施加压力，以减小第二区域中心的下基板和上基板之间的间隙。因此，待分析的流体样品与试剂之间的结合事件可以最大化，使得仅使用无穷小量的样品可以获得高信号。

3. 发明申请

US20090152326A1 ULTRASONIC WELDING-BASED MICROFLUIDIC DEVICE AND METHOD OF MANUFACTURING THE SAME 审中-公开
标题翻译：超声焊接微流体装置及其制造方法
公开(公告)号：US20090152326A1
公开(公告)日：2009-06-18
申请号：US12142712
申请日：2008-06-19
申请人： Dong Ho SHIN , Young Jun Kim , Min Suk Jeong , Sang Hee Kim , Hye Yoon Kim , Moon Youn Jung , Seon Hee Park
发明人： Dong Ho SHIN , Young Jun Kim , Min Suk Jeong , Sang Hee Kim , Hye Yoon Kim , Moon Youn Jung , Seon Hee Park
IPC分类号： B23K20/10 , B23K1/06
CPC分类号： B29C65/08 , B29C65/7829 , B29C66/112 , B29C66/114 , B29C66/3022 , B29C66/542 , B29C66/8322 , B29C66/92655 , B29C66/929 , B29L2031/756 , B81B2201/058 , B81B2203/0338 , B81C1/00119 , B81C3/001 , B81C2201/019 , B81C2203/038
摘要： A method of manufacturing an ultrasonic welding-based microfluidic device, the method including: forming a bottom board having two welding stoppers formed right and left and having a certain height and a certain interval; forming a top board having two energy directors formed with an interval greater than the interval between the two welding stoppers; putting the top board on the bottom board to locate the energy directors at the outside of welding stoppers, respectively; and welding the top board to the bottom board by using ultrasonic welding, wherein a channel is formed between the two welding stoppers without additional energy directors. Accordingly, it is possible to prevent a phenomenon that a fluid irregularly flows due to an uneven surface formed on a side of the channel while the energy directors are melted.
摘要翻译：一种制造基于超声波焊接的微流体装置的方法，该方法包括：形成具有左右形成的具有一定高度和一定间隔的两个焊接止动器的底板; 形成具有形成有间隔大于两个焊接止动器之间的间隔的两个能量导向件的顶板; 将顶板放在底板上，分别将能量控制器定位在焊接止动器的外侧; 并且通过使用超声波焊接将顶板焊接到底板，其中在两个焊接停止器之间形成通道，而没有附加的能量引导器。因此，可以防止由于在能量引导器熔化时由于在通道侧形成的不平坦表面而导致流体不规则地流动的现象。

4. 发明授权

US08628951B2 Lab-on-a-chip and method of driving the same 有权
标题翻译：芯片实验室及其驱动方法
公开(公告)号：US08628951B2
公开(公告)日：2014-01-14
申请号：US12893898
申请日：2010-09-29
申请人： Hye Yoon Kim
发明人： Hye Yoon Kim
IPC分类号： C12M1/34
CPC分类号： G01N33/54366 , B01L3/50273 , B01L2300/0816 , B01L2400/0406 , B01L2400/0481 , B01L2400/082
摘要： Provided are a lab-on-a-chip and a method of driving the same. The lab-on-a-chip includes a first region where a lower substrate and an upper substrate are bonded to each other, a second region where the lower and upper substrates are not bonded to each other, a gap control member disposed at a terminal of the second region facing an interface between the first and second regions, and configured to control a gap between the lower and upper substrates at the terminal of the second region, and a pressure application member disposed at the terminal of the second region facing the interface between the first and second regions, and configured to apply pressure to the upper substrate at the terminal of the second region to reduce a gap between the lower and upper substrates in the center of the second region. Thus, binding events between a fluid sample to be analyzed and a reagent can be maximized so that a high signal can be obtained using only an infinitesimal quantity of sample.
摘要翻译：提供了一种芯片实验室及其驱动方法。芯片实验室包括下基板和上基板彼此接合的第一区域，下基板和上基板彼此不接合的第二区域，设置在端子处的间隙控制构件所述第二区域面向所述第一和第二区域之间的界面，并且被配置为控制在所述第二区域的端子处的所述下基板和所述上基板之间的间隙，以及设置在所述第二区域的面向所述界面的端子处的压力施加构件并且构造成在第二区域的端子处向上基板施加压力，以减小第二区域中心的下基板和上基板之间的间隙。因此，待分析的流体样品与试剂之间的结合事件可以最大化，使得仅使用无穷小量的样品可以获得高信号。

5. 发明申请

US20100227419A1 LAB-ON-A-CHIP AND METHOD OF DRIVING THE SAME 有权
标题翻译： LAB-ON-A-CHIP及其驱动方法
公开(公告)号：US20100227419A1
公开(公告)日：2010-09-09
申请号：US12738683
申请日：2008-10-17
申请人： Moon-Youn Jung , Dong-Ho Shin , Minsuk Jeong , Sanghee Kim , Hye-Yoon Kim , Seon-Hee Park
发明人： Moon-Youn Jung , Dong-Ho Shin , Minsuk Jeong , Sanghee Kim , Hye-Yoon Kim , Seon-Hee Park
IPC分类号： G01N33/543 , G01N33/53 , G01N30/00
CPC分类号： G01N33/49
摘要： Provided is a lab-on-a-chip. The lab-on-a-chip includes a first region where a lower substrate and an upper substrate are bonded to each other, a second region where the lower and upper substrates are not bonded, and a gap adjusting member disposed at an end of the second region that is opposite to a boundary between the first and second regions, the gap adjusting member being configured to adjust a gap between the first and second substrates to control a capillary force.
摘要翻译：提供了一个芯片实验室。芯片实验室包括下基板和上基板彼此接合的第一区域，下基板和上基板未接合的第二区域，以及设置在该基板的末端的间隙调节构件所述第二区域与所述第一和第二区域之间的边界相对，所述间隙调节构件被配置为调节所述第一和第二基板之间的间隙以控制毛细管力。

6. 发明申请

US20090152187A1 FILTER CHIP AND METHOD OF MANUFACTURING THE SAME 审中-公开
标题翻译：过滤芯片及其制造方法
公开(公告)号：US20090152187A1
公开(公告)日：2009-06-18
申请号：US12142701
申请日：2008-06-19
申请人： Dong Ho SHIN , Young Jun KIM , Min Suk JEONG , Sang Hee KIM , Hye Yoon KIM , Moon Youn JUNG , Seon Hee PARK
发明人： Dong Ho SHIN , Young Jun KIM , Min Suk JEONG , Sang Hee KIM , Hye Yoon KIM , Moon Youn JUNG , Seon Hee PARK
IPC分类号： B01D35/30 , B23P11/00
CPC分类号： G01N33/491 , Y10T29/49826
摘要： There are provided a filter chip in which a filter is mounted on a microfluidic device as a hybrid form, and a method of manufacturing the filter chip. The method includes: forming a bottom structure where a groove for stably mounting a filter is formed; mounting the filter on the groove; forming a top structure forming a fluid inlet for injecting a fluid into the filter; and covering the top structure on a top area of the groove to attach to the bottom structure, wherein the groove and the filter have a shape becoming narrow from the fluid inlet to a fluid outlet in such a way that the fluid receives a rapid change of a capillary force while passing through the filter. Accordingly, blood plasma is capable of being separated at a higher speed by increasing the capillary force of the fluid outlet, thereby obtaining the blood plasma as large amount as possible.
摘要翻译：提供了一种过滤器芯片，其中过滤器作为混合形式安装在微流体装置上，以及制造过滤芯片的方法。该方法包括：形成底部结构，其中形成用于稳定地安装过滤器的槽; 将过滤器安装在凹槽上; 形成顶部结构，形成用于将流体注入过滤器的流体入口; 并且覆盖所述凹槽的顶部区域上的顶部结构以附接到所述底部结构，其中所述凹槽和所述过滤器具有从所述流体入口到流体出口变窄的形状，使得所述流体接收到快速变化通过过滤器时的毛细作用力。因此，血浆能够通过增加流体出口的毛细管力而以更高的速度分离，从而尽可能多地获得血浆。

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