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1. 发明申请

US20090253219A1 POSITIVE DETECTION LATERAL-FLOW APPARATUS AND METHOD FOR SMALL AND LARGE ANALYTES 审中-公开
标题翻译：积极检测侧向流动装置及小尺寸分析方法
公开(公告)号：US20090253219A1
公开(公告)日：2009-10-08
申请号：US12396216
申请日：2009-03-02
申请人： Jeffrey S. Bauer , Timothy P. Hyatt , Huiying Wang , Robert L. Buck
发明人： Jeffrey S. Bauer , Timothy P. Hyatt , Huiying Wang , Robert L. Buck
IPC分类号： G01N33/558 , G01N31/22 , C12M1/00
CPC分类号： G01N33/94 , G01N33/54386 , G01N33/558 , G01N33/946
摘要： Methods and devices for the detection and/or quantification of an analyte in a sample are provided. These are positive detection methods and devices, in that the more analyte is present in the sample, the stronger the signal that is provided. Devices of the invention include a mobilization zone including a mobile or mobilizable detectable analyte analog, a sample application area, primary and secondary capture areas each including an immobilized binding partner having a binding affinity for the analyte being tested for a detectable analyte analog. The mobilization zone, sample application area, primary and secondary capture area are in fluid continuous contact with each other. In these devices, the first immobilized binding partner has an equal or lower apparent affinity for the analyte than it has for the detectable analyte analog. Methods of this invention involve introducing a sample (which is suspected of containing the analyte to be tested for) to a device such as those described herein, and permitting the sample to migrate from the application area to and through the first and secondary binding zones. A detectable tracer conjugate is also permitted to migrate through the device, usually slightly behind the sample so that any analyte in the sample contacts the first binding partner before the conjugate. Results of such methods are read based on the presence and/or intensity of the detectable signal given by conjugate that binds in the second capture area.
摘要翻译：提供了用于检测和/或定量样品中分析物的方法和装置。这些是阳性检测方法和装置，因为样品中存在的分析物越多，所提供的信号越强。本发明的装置包括动员区，其包括可移动或可动员的可检测分析物类似物，样品施用区域，初级和次级捕获区域，每个捕获区域包括具有与被检测的可分析物类似物的分析物的结合亲和力的固定结合对象。动员区，样品应用区，初级和次级捕获区彼此流体连续接触。在这些装置中，第一个固定化的结合配偶体与被检测的分析物类似物具有相等或更低的对分析物的表观亲和力。本发明的方法包括将样品（其被怀疑含有要测试的待分析物）引入到如本文所述的装置中，并且允许样品从施用区域迁移到第一和第二结合区域并通过第一和第二结合区。也可允许可检测的示踪剂缀合物迁移穿过该装置，通常稍微在样品后面，使得样品中的任何分析物在缀合物之前与第一结合配偶体接触。基于在第二捕获区域中结合的缀合物给出的可检测信号的存在和/或强度来读取这些方法的结果。

2. 发明授权

US06699722B2 Positive detection lateral-flow apparatus and method for small and large analytes 有权
标题翻译：用于小型和大型分析物的正检测侧流装置和方法
公开(公告)号：US06699722B2
公开(公告)日：2004-03-02
申请号：US09835304
申请日：2001-04-13
申请人： Jeffrey S. Bauer , Timothy P. Hyatt , Huiying Wang
发明人： Jeffrey S. Bauer , Timothy P. Hyatt , Huiying Wang
IPC分类号： G01N33543
CPC分类号： G01N33/94 , G01N33/54386 , G01N33/558 , G01N33/946
摘要： Methods and devices for the detection and/or quantification of an analyte in a sample are provided. These are positive detection methods and devices, in that the more analyte is present in the sample, the stronger the signal that is provided. Devices of the invention include a mobilization zone including a mobile or mobilizable detectable analyte analog, a sample application area, primary and secondary capture areas each including an immobilized binding partner having a binding affinity for the analyte being tested for a detectable analyte analog. The mobilization zone, sample application area, primary and secondary capture area are in fluid continuous contact with each other. In these devices, the first immobilized binding partner has an equal or lower apparent affinity for the analyte than it has for the detectable analyte analog. Methods of this invention involve introducing a sample (which is suspected of containing the analyte to be tested for) to a device such as those described herein, and permitting the sample to migrate from the application area to and through the first and secondary binding zones. A detectable tracer conjugate is also permitted to migrate through the device, usually slightly behind the sample so that any analyte in the sample contacts the first binding partner before the conjugate. Results of such methods are read based on the presence and/or intensity of the detectable signal given by conjugate that binds in the second capture area.
摘要翻译：提供了用于检测和/或定量样品中分析物的方法和装置。这些是阳性检测方法和装置，因为样品中存在的分析物越多，所提供的信号越强。本发明的装置包括动员区，其包括可移动或可动员的可检测分析物类似物，样品施用区域，初级和次级捕获区域，每个捕获区域包括具有与被检测的可分析物类似物的分析物的结合亲和力的固定结合对象。动员区，样品应用区，初级和次级捕获区彼此流体连续接触。在这些装置中，第一个固定化的结合配偶体与被检测的分析物类似物具有相等或较低的对分析物的表观亲和力。本发明的方法包括将样品（其被怀疑含有要测试的待分析物）引入到如本文所述的装置中，并且允许样品从施用区域迁移到第一和第二结合区域并通过第一和第二结合区。也可允许可检测的示踪剂缀合物迁移穿过该装置，通常稍微在样品后面，使得样品中的任何分析物在缀合物之前与第一结合配偶体接触。基于在第二捕获区域中结合的缀合物给出的可检测信号的存在和/或强度来读取这些方法的结果。

3. 发明申请

US20080311597A1 Modified Cardiolipin and Uses Therefor 有权
标题翻译：改良型心磷脂及其用途
公开(公告)号：US20080311597A1
公开(公告)日：2008-12-18
申请号：US12094144
申请日：2006-11-17
申请人： Arnold R. Castro , Huiying Wang
发明人： Arnold R. Castro , Huiying Wang
IPC分类号： G01N33/569 , C07K14/00 , G01N33/543 , C07F9/09 , G01N33/53 , C12M1/00
CPC分类号： G01N33/571 , G01N33/564 , G01N33/92 , G01N2333/20 , G01N2469/20
摘要： Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, oxidized cardiolipins, which may be conjugated with a variety of attachment molecules, such as BSA, KLH, biotin, synthetic protein MAPS, IgY, streptavidin, or avidin, are described. Such oxidized cardiolipin, alone or complexed with one or more attachment molecules, are useful to detect anti-lipoidal antibodies in subjects, for example, when used in lateral flow devices. Lateral flow devices are described that permit the detection of anti-lipoidal antibodies and that permit the co-detection of nontreponemal and treponemal antibodies in biological samples.
摘要翻译：描述了用于检测抗脂质体抗体的组合物，方法和装置以及疾病的诊断，例如梅毒。特别地，描述了可以与各种附着分子缀合的氧化的心磷脂，例如BSA，KLH，生物素，合成蛋白MAPS，IgY，链霉亲和素或抗生物素蛋白。这种氧化的心磷脂单独或与一个或多个附着分子复合可用于检测受试者中的抗脂质体抗体，例如当用于侧流装置时。描述了允许检测抗脂质体抗体并允许在生物样品中共同检测非延髓和螺旋体抗体的侧流装置。

4. 发明申请

US20120064390A1 LITHIUM ION BATTERY ELECTROLYTE AND LITHIUM BATTERY HAVING THE SAME 审中-公开
标题翻译：锂离子电池电解液和锂电池
公开(公告)号：US20120064390A1
公开(公告)日：2012-03-15
申请号：US13229412
申请日：2011-09-09
申请人： Huiying Wang , Guishu Zhou
发明人： Huiying Wang , Guishu Zhou
IPC分类号： H01M10/056 , H01M2/02
CPC分类号： H01M10/0568 , H01M10/0567 , H01M10/0569
摘要： Electrolytes of lithium ion batteries of the present disclosure comprise: a lithium salt, a non-aqueous solvent, and an additive. The additive further comprises a first and second compound. The first compound is a 4 X1, 5 R1 [1,3]dioxolan-2-one, wherein X1 is selected from the group consisting of: F, Cl, and Br and R1 is selected from the group consisting of hydrogen and linear alkyl compounds having between 1 and 3 carbon atoms. The second compound has a molecular formula of: F(CF2CF2)x—CH2CH2—(CH2CH2O)yH, wherein x is any integer ranging from 1 to 7, and y is any integer ranging from 1 to 15.
摘要翻译：本公开的锂离子电池的电解质包括：锂盐，非水溶剂和添加剂。添加剂还包含第一和第二化合物。第一化合物是4X1，5R1 [1,3]二氧戊环-2-酮，其中X 1选自：F，Cl和Br，R 1选自氢和直链烷基具有1至3个碳原子的化合物。第二化合物具有分子式：F（CF 2 CF 2）x -CH 2 CH 2 - （CH 2 CH 2 O）y H，其中x是1至7的整数，y是1至15的整数。

5. 发明申请

US20110136143A1 MODIFIED CARDIOLIPIN AND USES THEREFOR 有权
标题翻译：改良的药物及其用途
公开(公告)号：US20110136143A1
公开(公告)日：2011-06-09
申请号：US13027224
申请日：2011-02-14
申请人： Arnold R. Castro , Huiying Wang
发明人： Arnold R. Castro , Huiying Wang
IPC分类号： G01N33/53 , C07K1/04
CPC分类号： G01N33/571 , G01N33/564 , G01N33/92 , G01N2333/20 , G01N2469/20
摘要： Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, oxidized cardiolipins, which may be conjugated with a variety of attachment molecules, such as BSA, KLH, biotin, synthetic protein MAPS, IgY, streptavidin, or avidin, are described. Such oxidized cardiolipin, alone or complexed with one or more attachment molecules, are useful to detect anti-lipoidal antibodies in subjects, for example, when used in lateral flow devices. Lateral flow devices are described that permit the detection of anti-lipoidal antibodies and that permit the co-detection of nontreponemal and treponemal antibodies in biological samples.
摘要翻译：描述了用于检测抗脂质体抗体的组合物，方法和装置以及疾病的诊断，例如梅毒。特别地，描述了可以与各种附着分子缀合的氧化的心磷脂，例如BSA，KLH，生物素，合成蛋白MAPS，IgY，链霉亲和素或抗生物素蛋白。这种氧化的心磷脂单独或与一个或多个附着分子复合可用于检测受试者中的抗脂质体抗体，例如当用于侧流装置时。描述了允许检测抗脂质体抗体并允许在生物样品中共同检测非延髓和螺旋体抗体的侧流装置。

6. 发明授权

US07888043B2 Modified cardiolipin and uses therefor 有权
标题翻译：改良的心磷脂及其用途
公开(公告)号：US07888043B2
公开(公告)日：2011-02-15
申请号：US12094144
申请日：2006-11-17
申请人： Arnold R. Castro , Huiying Wang
发明人： Arnold R. Castro , Huiying Wang
IPC分类号： G01N33/53 , G01N33/573
CPC分类号： G01N33/571 , G01N33/564 , G01N33/92 , G01N2333/20 , G01N2469/20
摘要： Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, oxidized cardiolipins, which may be conjugated with a variety of attachment molecules, such as BSA, KLH, biotin, synthetic protein MAPS, IgY, streptavidin, or avidin, are described. Such oxidized cardiolipin, alone or complexed with one or more attachment molecules, are useful to detect anti-lipoidal antibodies in subjects, for example, when used in lateral flow devices. Lateral flow devices are described that permit the detection of anti-lipoidal antibodies and that permit the co-detection of nontreponemal and treponemal antibodies in biological samples.
摘要翻译：描述了用于检测抗脂质体抗体的组合物，方法和装置以及疾病的诊断，例如梅毒。特别地，描述了可以与各种附着分子缀合的氧化的心磷脂，例如BSA，KLH，生物素，合成蛋白MAPS，IgY，链霉亲和素或抗生物素蛋白。这种氧化的心磷脂单独或与一个或多个附着分子复合可用于检测受试者中的抗脂质体抗体，例如当用于侧流装置时。描述了允许检测抗脂质体抗体并允许在生物样品中共同检测非延髓和螺旋体抗体的侧流装置。

7. 发明授权

US07517699B2 Positive detection lateral-flow apparatus and method for small and large analytes 失效
公开(公告)号：US07517699B2
公开(公告)日：2009-04-14
申请号：US11359666
申请日：2006-02-21
申请人： Jeffrey S. Bauer , Timothy P. Hyatt , Huiying Wang , Robert L. Buck
发明人： Jeffrey S. Bauer , Timothy P. Hyatt , Huiying Wang , Robert L. Buck
IPC分类号： G01N33/543
CPC分类号： G01N33/94 , G01N33/54386 , G01N33/558 , G01N33/946
摘要： Methods and devices for the detection and/or quantification of an analyte in a sample are provided. These are positive detection methods and devices, in that the more analyte is present in the sample, the stronger the signal that is provided. Devices of the invention include a mobilization zone including a mobile or mobilizable detectable analyte analog, a sample application area, primary and secondary capture areas each including an immobilized binding partner having a binding affinity for the analyte being tested for a detectable analyte analog. The mobilization zone, sample application area, primary and secondary capture area are in fluid continuous contact with each other. In these devices, the first immobilized binding partner has an equal or lower apparent affinity for the analyte than it has for the detectable analyte analog. Methods of this invention involve introducing a sample (which is suspected of containing the analyte to be tested for) to a device such as those described herein, and permitting the sample to migrate from the application area to and through the first and secondary binding zones. A detectable tracer conjugate is also permitted to migrate through the device, usually slightly behind the sample so that any analyte in the sample contacts the first binding partner before the conjugate. Results of such methods are read based on the presence and/or intensity of the detectable signal given by conjugate that binds in the second capture area.

8. 发明申请

US20060141639A1 Positive detection lateral-flow apparatus and method for small and large analytes 失效
公开(公告)号：US20060141639A1
公开(公告)日：2006-06-29
申请号：US11359666
申请日：2006-02-21
申请人： Jeffrey Bauer , Timothy Hyatt , Huiying Wang , Robert Buck
发明人： Jeffrey Bauer , Timothy Hyatt , Huiying Wang , Robert Buck
IPC分类号： G01N33/558
CPC分类号： G01N33/94 , G01N33/54386 , G01N33/558 , G01N33/946
摘要： Methods and devices for the detection and/or quantification of an analyte in a sample are provided. These are positive detection methods and devices, in that the more analyte is present in the sample, the stronger the signal that is provided. Devices of the invention include a mobilization zone including a mobile or mobilizable detectable analyte analog, a sample application area, primary and secondary capture areas each including an immobilized binding partner having a binding affinity for the analyte being tested for a detectable analyte analog. The mobilization zone, sample application area, primary and secondary capture area are in fluid continuous contact with each other. In these devices, the first immobilized binding partner has an equal or lower apparent affinity for the analyte than it has for the detectable analyte analog. Methods of this invention involve introducing a sample (which is suspected of containing the analyte to be tested for) to a device such as those described herein, and permitting the sample to migrate from the application area to and through the first and secondary binding zones. A detectable tracer conjugate is also permitted to migrate through the device, usually slightly behind the sample so that any analyte in the sample contacts the first binding partner before the conjugate. Results of such methods are read based on the presence and/or intensity of the detectable signal given by conjugate that binds in the second capture area.

9. 发明授权

US06306665B1 Covalent bonding of molecules to an activated solid phase material 失效
标题翻译：分子与活化的固相材料共价键合
公开(公告)号：US06306665B1
公开(公告)日：2001-10-23
申请号：US09417957
申请日：1999-10-13
申请人： Robert Lee Buck , Huiying Wang , Timothy Patrick Hyatt , Paul Andrew Mueggler
发明人： Robert Lee Buck , Huiying Wang , Timothy Patrick Hyatt , Paul Andrew Mueggler
IPC分类号： G01N33544
CPC分类号： G01N33/54353 , G01N33/558
摘要： Microporous solid phase materials that are suitable for lateral flow and other assays for detecting the presence of analytes in test samples, that are stable under variations in humidity and, even after storage for extended periods of time, can form stable covalent bonds with molecules containing a free primary or secondary amine group or sulfhydryl group are described. The invention further concerns chemically derivatized solid phase materials, and conjugates comprising such materials. Examples of lateral flow devices for the quantitative or semi-quantitative determination of an analyte in a biological sample are described.
摘要翻译：适用于横向流动的微孔固相材料和用于检测测试样品中分析物的存在的其他测定法，其在湿度变化下是稳定的，并且甚至在长时间储存后可以与含有描述了游离的伯胺或仲胺基或巯基。本发明还涉及化学衍生的固相材料和包含这些材料的共轭物。描述了用于定量或半定量测定生物样品中分析物的侧流装置的实例。

10. 发明申请

US20140242407A1 In-situ Compressed Specimen for Evaluating Mechanical Property of Copper Interconnection Micro Column and Preparation Method thereof 审中-公开
标题翻译：用于评估铜互连微柱的机械性能的原位压缩试样及其制备方法
公开(公告)号：US20140242407A1
公开(公告)日：2014-08-28
申请号：US14345392
申请日：2013-03-25
申请人： Hong Wang , Zhaoyu Wang , Ping Cheng , Guifu Ding , Ting Gu , Huiying Wang , Congchun Zhang
发明人： Hong Wang , Zhaoyu Wang , Ping Cheng , Guifu Ding , Ting Gu , Huiying Wang , Congchun Zhang
IPC分类号： B81C1/00
CPC分类号： B81C1/00111 , B81C2201/032 , G01N3/08 , G01N2203/0298 , Y10T428/12389
摘要： An in-situ compressed specimen of copper interconnection micro column, which is a circular metal column formed in a PDMS hole, includes: a specimen part and a fixed end part for fixing the specimen; wherein the fixed end part is a circular or square plate structure, the specimen part is an upper part of the fixed end part; a main body of the present invention is of micron order, a forced direction of the specimen is consistent with a growth direction of the metal column. A method of electroplating copper column by adopting PDMS as template substrate is applied to overcome a problem that TSV is corrosive to the copper column during a silicon etching process so as to affect a mechanical property accuracy test, the method is advanced in shortening test process period, achieving good reproducibility and high yield.
摘要翻译：在PDMS孔中形成的圆形金属柱的铜互连微柱的原位压缩样品包括：样品部分和用于固定样品的固定端部; 所述固定端部为圆形或方形板状结构，所述检体部为所述固定端部的上部; 本发明的主体是微米级的，试样的强制方向与金属柱的生长方向一致。应用PDMS作为模板基板电镀铜柱的方法，以克服在硅蚀刻过程中TSV对铜柱腐蚀的问题，从而影响机械性能精度试验，该方法在缩短试验过程周期，实现良好的再现性和高产量。

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