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1. 发明授权

US06268200B1 Biotherapeutic virus attenuation using variable frequency microwave energy 有权
标题翻译：使用变频微波能量的生物治疗病毒衰减
公开(公告)号：US06268200B1
公开(公告)日：2001-07-31
申请号：US09232503
申请日：1999-01-15
申请人： Denise A. Tucker , Roger Lauren Lundblad , Howard M. Reisner , Henry Shannon Kingdon
发明人： Denise A. Tucker , Roger Lauren Lundblad , Howard M. Reisner , Henry Shannon Kingdon
IPC分类号： C12N704
CPC分类号： A61L2/0011 , A61L2/12
摘要： Virus attenuation is performed on a lyophilized biotherapeutic sealed within a microwave permeable container without harming the biotherapeutic and without exposing the biotherapeutic to additional viruses, by subjecting the container and biotherapeutic therewithin to variable frequency microwave energy. The container and biotherapeutic therewithin are swept with at least one range of microwave frequencies. Each range of microwave frequencies has a central frequency selected to break apart helix strands of a nucleic acid of the virus, to modify a capsid enclosing a nucleic acid of the virus, or to selectively couple to water molecules inside the capsid without harming the biotherapeutic or the container.
摘要翻译：在密封在微波可渗透容器内的冻干生物治疗剂上进行病毒衰减，而不会损害生物治疗剂并且不暴露生物治疗剂以增加病毒，通过使容器和生物治疗剂在其中进行可变频率的微波能量。容器和其中的生物治疗用至少一个微波频率范围扫描。微波频率的每个范围具有选择的中心频率以分解病毒核酸的螺旋链，以修饰包围病毒核酸的衣壳，或者选择性地偶联到衣壳内的水分子而不伤害生物治疗或容器

2. 发明授权

US09561196B2 Methods for evaluating and implementing prostate disease treatments 有权
标题翻译：评估和实施前列腺疾病治疗方法
公开(公告)号：US09561196B2
公开(公告)日：2017-02-07
申请号：US13230317
申请日：2011-09-12
申请人： Gary J. Smith , Howard M. Reisner , Danny R. Gray , Wendy Huss
发明人： Gary J. Smith , Howard M. Reisner , Danny R. Gray , Wendy Huss
IPC分类号： A61K31/03 , A61K31/04 , A61K31/055 , A61K31/095 , A61K31/122 , A61K31/24 , A61K31/4164 , A61K38/09 , A61K31/164 , A61K31/337 , A61K31/56 , G01N33/50 , G01N33/574
CPC分类号： A61K31/164 , A61K31/337 , A61K31/4164 , A61K31/56 , G01N33/5011 , G01N33/5088 , G01N33/57434 , G01N2800/342
摘要： Provided is a method for evaluating test agents as candidates for treating prostatic diseases, including benign prostatic hyperplasia and androgen dependent and androgen independent prostate cancer. The method comprises providing a mouse comprising a human prostate primary xenograft, where the xenograft contains blood vessels that include human endothelial cells, initiating androgen deprivation in the mouse, administering to the mouse a test agent within a period of 1-7 days after initiating the androgen deprivation, and determining a reduction in human epithelial cells in the xenografts and/or a reduction in number of the endothelial cells or blood vessels in the xenograft. Also provided is a method for treating an individual for human prostate cancer or benign prostatic hyperplasia. The method comprises initiating androgen deprivation in the individual and administering to the individual an agent capable of inducing apoptosis of vascular endothelial cells within a period of 1-7 days of initiating androgen deprivation.
摘要翻译：本发明提供了作为前列腺疾病前列腺增生和雄激素依赖性和雄激素依赖性前列腺癌的候选物的评价试剂的方法。该方法包括提供包含人类前列腺原代异种移植物的小鼠，其中异种移植物含有包含人内皮细胞的血管，在小鼠中引发雄激素剥夺，在启动之后1-7天的时间内给予小鼠一种测试试剂雄激素剥夺和确定异种移植物中人上皮细胞的减少和/或异种移植物中内皮细胞或血管数量的减少。还提供了用于治疗人前列腺癌或良性前列腺增生的个体的方法。该方法包括在个体中引发雄激素剥夺，并且在引发雄激素剥夺的1-7天的时间内向个体施用能够诱导血管内皮细胞凋亡的药剂。

3. 发明申请

US20120115781A1 Methods For Evaluating and Implementing Prostate Disease Treatments 审中-公开
标题翻译：评估和实施前列腺疾病治疗方法
公开(公告)号：US20120115781A1
公开(公告)日：2012-05-10
申请号：US13230317
申请日：2011-09-12
申请人： Gary J. Smith , Howard M. Reisner , Danny R. Gray , Wendy Huss
发明人： Gary J. Smith , Howard M. Reisner , Danny R. Gray , Wendy Huss
IPC分类号： A61K38/22 , A61P35/00 , A61K31/167 , A61K31/4166 , G01N33/53 , C12Q1/68
CPC分类号： A61K31/164 , A61K31/337 , A61K31/4164 , A61K31/56 , G01N33/5011 , G01N33/5088 , G01N33/57434 , G01N2800/342
摘要： Provided is a method for evaluating test agents as candidates for treating prostatic diseases, including benign prostatic hyperplasia and androgen dependent and androgen independent prostate cancer. The method comprises providing a mouse comprising a human prostate primary xenograft, where the xenograft contains blood vessels that include human endothelial cells, initiating androgen deprivation in the mouse, administering to the mouse a test agent within a period of 1-7 days after initiating the androgen deprivation, and determining a reduction in human epithelial cells in the xenografts and/or a reduction in number of the endothelial cells or blood vessels in the xenograft. Also provided is a method for treating an individual for human prostate cancer or benign prostatic hyperplasia. The method comprises initiating androgen deprivation in the individual and administering to the individual an agent capable of inducing apoptosis of vascular endothelial cells within a period of 1-7 days of initiating androgen deprivation.
摘要翻译：本发明提供了作为前列腺疾病前列腺增生和雄激素依赖性和雄激素依赖性前列腺癌的候选物的评价试剂的方法。该方法包括提供包含人类前列腺原代异种移植物的小鼠，其中异种移植物含有包含人内皮细胞的血管，在小鼠中引发雄激素剥夺，在启动之后1-7天的时间内给予小鼠一种测试试剂雄激素剥夺和确定异种移植物中人上皮细胞的减少和/或异种移植物中内皮细胞或血管数量的减少。还提供了用于治疗人前列腺癌或良性前列腺增生的个体的方法。该方法包括在个体中引发雄激素剥夺，并且在引发雄激素剥夺的1-7天的时间内向个体施用能够诱导血管内皮细胞凋亡的药剂。

4. 发明授权

US08048640B2 Methods for evaluating and implementing prostate disease treatments 有权
标题翻译：评估和实施前列腺疾病治疗方法
公开(公告)号：US08048640B2
公开(公告)日：2011-11-01
申请号：US12011929
申请日：2008-01-30
申请人： Gary J. Smith , Howard M. Reisner , Danny R. Gray , Wendy Huss
发明人： Gary J. Smith , Howard M. Reisner , Danny R. Gray , Wendy Huss
IPC分类号： G01N33/53 , G01N33/567 , G01N33/541 , G01N33/577
CPC分类号： A61K31/164 , A61K31/337 , A61K31/4164 , A61K31/56 , G01N33/5011 , G01N33/5088 , G01N33/57434 , G01N2800/342
摘要： Provide is a method for evaluating test agents as candidates for treating prostatic diseases, including benign prostatic hyperplasia (BPH) and androgen dependent and androgen independent prostate cancer. The method comprises providing a mouse comprising a human prostate primary xenograft, where the xenograft contains blood vessels that include human endothelial cells, initiating androgen deprivation in the mouse, administering to the mouse a test agent within a period of 1-7 days after initiating the androgen deprivation, and determining a reduction in human epithelial cells in the xenografts and/or a reduction in number of the endothelial cells or blood vessels in the xenograft. Also provided is a method for treating an individual for human prostate cancer or benign prostatic hyperplasia. The method comprises initiating androgen deprivation in the individual and administering to the individual an agent capable of inducing apoptosis of vascular endothelial cells within a period of 1-7 days of initiating androgen deprivation.
摘要翻译：提供是一种评估测试药物作为治疗前列腺疾病（包括良性前列腺增生（BPH））和雄激素依赖性和雄激素非依赖性前列腺癌的候选物的方法。该方法包括提供包含人类前列腺原代异种移植物的小鼠，其中异种移植物含有包含人内皮细胞的血管，在小鼠中引发雄激素剥夺，在启动之后1-7天的时间内给予小鼠一种测试试剂雄激素剥夺和确定异种移植物中人上皮细胞的减少和/或异种移植物中内皮细胞或血管数量的减少。还提供了用于治疗人前列腺癌或良性前列腺增生的个体的方法。该方法包括在个体中引发雄激素剥夺，并且在引发雄激素剥夺的1-7天的时间内向个体施用能够诱导血管内皮细胞凋亡的药剂。

5. 发明授权

US06451355B1 Composition to treat diabetes 失效
标题翻译：组合治疗糖尿病
公开(公告)号：US06451355B1
公开(公告)日：2002-09-17
申请号：US09906379
申请日：2001-07-16
申请人： Howard M. Reisner
发明人： Howard M. Reisner
IPC分类号： A01N6800
CPC分类号： A61K36/235 , A61K35/413 , A61K36/48 , A61K2300/00
摘要： A composition for treating diabetes is disclosed. The composition includes fenugreek and bile from the gallbladder of ruminant mammals. The composition is used to treat diabetes through regular periodic dose administration.
摘要翻译：公开了一种用于治疗糖尿病的组合物。该组合物包括来自反刍哺乳动物胆囊的胡芦巴和胆汁。该组合物用于通过定期定期剂量给药治疗糖尿病。

6. 发明申请

US20080234204A1 Methods for evaluating and implementing prostate disease treatments 有权
标题翻译：评估和实施前列腺疾病治疗方法
公开(公告)号：US20080234204A1
公开(公告)日：2008-09-25
申请号：US12011929
申请日：2008-01-30
申请人： Gary J. Smith , Howard M. Reisner , Danny R. Gray , Wendy Huss
发明人： Gary J. Smith , Howard M. Reisner , Danny R. Gray , Wendy Huss
IPC分类号： A61K38/08 , G01N33/00 , A61K31/164 , A61K31/56 , A61P35/00 , A61K31/4164 , A61K31/337
CPC分类号： A61K31/164 , A61K31/337 , A61K31/4164 , A61K31/56 , G01N33/5011 , G01N33/5088 , G01N33/57434 , G01N2800/342
摘要： Provide is a method for evaluating test agents as candidates for treating prostatic diseases, including benign prostatic hyperplasia (BPH) and androgen dependent and androgen independent prostate cancer. The method comprises providing a mouse comprising a human prostate primary xenograft, where the xenograft contains blood vessels that include human endothelial cells, initiating androgen deprivation in the mouse, administering to the mouse a test agent within a period of 1-7 days after initiating the androgen deprivation, and determining a reduction in human epithelial cells in the xenografts and/or a reduction in number of the endothelial cells or blood vessels in the xenograft. Also provided is a method for treating an individual for human prostate cancer or benign prostatic hyperplasia. The method comprises initiating androgen deprivation in the individual and administering to the individual an agent capable of inducing apoptosis of vascular endothelial cells within a period of 1-7 days of initiating androgen deprivation.
摘要翻译：提供是一种评估测试药物作为治疗前列腺疾病（包括良性前列腺增生（BPH））和雄激素依赖性和雄激素非依赖性前列腺癌的候选物的方法。该方法包括提供包含人类前列腺原代异种移植物的小鼠，其中异种移植物含有包含人内皮细胞的血管，在小鼠中引发雄激素剥夺，在启动之后1-7天的时间内给予小鼠一种测试试剂雄激素剥夺和确定异种移植物中人上皮细胞的减少和/或异种移植物中内皮细胞或血管数量的减少。还提供了用于治疗人前列腺癌或良性前列腺增生的个体的方法。该方法包括在个体中引发雄激素剥夺，并且在引发雄激素剥夺的1-7天的时间内向个体施用能够诱导血管内皮细胞凋亡的药剂。

7. 发明授权

US06872927B2 Systems and methods for processing pathogen-contaminated mail pieces 失效
标题翻译：用于处理病原体污染的邮件的系统和方法
公开(公告)号：US06872927B2
公开(公告)日：2005-03-29
申请号：US10217710
申请日：2002-08-12
申请人： William L. Geisler , Howard M. Reisner , Richard S. Garard
发明人： William L. Geisler , Howard M. Reisner , Richard S. Garard
IPC分类号： B07C1/00 , H05B6/78
CPC分类号： B07C1/00 , H05B6/78 , H05B2206/045
摘要： Systems and methods for neutralizing pathogen-contaminated mail pieces via variable frequency microwave processing are provided. Mail pieces are initially screened to identify suspicious characteristics or indications of potentially harmful contents. Mail pieces are swept with variable frequency microwaves selected to neutralize pathogens contained within each mail piece without harming the mail piece or other contents thereof. The temperature of each mail piece may be monitored during microwave processing to identify mail pieces containing potentially harmful substances and/or devices. Mail pieces can be irradiated via additional forms of radiation to neutralize pathogenic material on outside surfaces thereof.
摘要翻译：提供了通过可变频率微波处理中和病原体污染邮件的系统和方法。邮件最初被筛选以识别可疑的特征或潜在的有害内容的迹象。用可变频率微波扫描邮件，以中和每个邮件中包含的病原体，而不损害邮件或其他内容。可以在微波处理期间监测每个邮件的温度，以识别含有潜在有害物质和/或装置的邮件。可以通过另外形式的辐射照射邮件，以中和其外表面上的致病物质。

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