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1. 发明授权

US08343994B2 Fluorene compound and pharmaceutical use thereof 有权
标题翻译：芴类化合物及其药物用途
公开(公告)号：US08343994B2
公开(公告)日：2013-01-01
申请号：US12576605
申请日：2009-10-09
申请人： Takahisa Motomura , Hironobu Nagamori , Koichi Suzawa , Hirotsugu Ito , Toru Morita , Satoru Kobayashi , Hisashi Shinkai
发明人： Takahisa Motomura , Hironobu Nagamori , Koichi Suzawa , Hirotsugu Ito , Toru Morita , Satoru Kobayashi , Hisashi Shinkai
IPC分类号： A61K31/44 , C07D221/16
CPC分类号： C07D205/04 , A61K31/045 , A61K31/05 , A61K31/085 , A61K31/10 , A61K31/121 , A61K31/136 , A61K31/166 , A61K31/167 , A61K31/192 , A61K31/235 , A61K31/277 , A61K31/381 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/41 , A61K31/415 , A61K31/4155 , A61K31/4196 , A61K31/421 , A61K31/4245 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4439 , A61K31/4453 , A61K31/4523 , A61K31/5375 , C07C35/52 , C07C39/42 , C07C43/23 , C07C43/253 , C07C49/83 , C07C59/56 , C07C59/72 , C07C65/17 , C07C69/712 , C07C69/732 , C07C69/76 , C07C215/44 , C07C215/70 , C07C217/20 , C07C233/18 , C07C233/25 , C07C235/42 , C07C235/66 , C07C255/12 , C07C255/53 , C07C259/10 , C07C271/16 , C07C271/30 , C07C311/04 , C07C317/22 , C07C2603/18 , C07D207/04 , C07D211/06 , C07D213/30 , C07D213/56 , C07D231/12 , C07D239/26 , C07D249/08 , C07D257/04 , C07D263/32 , C07D271/06 , C07D271/10 , C07D275/02 , C07D295/08 , C07D295/18 , C07D295/192 , C07D333/22 , C07D401/06 , C07D401/12 , C07D403/12 , C07F7/081
摘要： The present invention provides an agent for the prophylactic or treatment of diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, cardiac failure, cardiomyopathy, myocardial ischemia, brain ischemia, cerebral apoplexy, pulmonary hypertension, hyperlactacidemia, mitochondrial disease, mitochondrial encephalomyopathy or cancer, namely, a PDHK inhibitor and the like. A compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein each symbol is as defined in the specification.
摘要翻译：本发明提供了用于预防或治疗糖尿病，糖尿病并发症，胰岛素抵抗综合征，代谢综合征，高血糖症，血脂异常，动脉粥样硬化，心力衰竭，心肌病，心肌缺血，脑缺血，脑中风，肺动脉高压，高乳酸血症，线粒体疾病，线粒体性脑病或癌症，即PDHK抑制剂等。由下式[I]表示的化合物或其药学上可接受的盐或其溶剂化物：其中每个符号如说明书中所定义。

2. 发明申请

US20100240634A1 Fluorene Compound and Pharmaceutical Use Thereof 有权
标题翻译：芴类化合物及其药物用途
公开(公告)号：US20100240634A1
公开(公告)日：2010-09-23
申请号：US12576605
申请日：2009-10-09
申请人： Takahisa Motomura , Hironobu Nagamori , Koichi Suzawa , Hirotsugu Ito , Toru Morita , Satoru Kobayashi , Hisashi Shinkai
发明人： Takahisa Motomura , Hironobu Nagamori , Koichi Suzawa , Hirotsugu Ito , Toru Morita , Satoru Kobayashi , Hisashi Shinkai
IPC分类号： A61K31/397 , C07C35/38 , A61K31/045 , C07D231/12 , A61K31/415 , C07D401/12 , A61K31/435 , A61P3/10 , A61P9/10 , A61P9/04 , A61P9/12 , A61P35/00
CPC分类号： C07D205/04 , A61K31/045 , A61K31/05 , A61K31/085 , A61K31/10 , A61K31/121 , A61K31/136 , A61K31/166 , A61K31/167 , A61K31/192 , A61K31/235 , A61K31/277 , A61K31/381 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/41 , A61K31/415 , A61K31/4155 , A61K31/4196 , A61K31/421 , A61K31/4245 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4439 , A61K31/4453 , A61K31/4523 , A61K31/5375 , C07C35/52 , C07C39/42 , C07C43/23 , C07C43/253 , C07C49/83 , C07C59/56 , C07C59/72 , C07C65/17 , C07C69/712 , C07C69/732 , C07C69/76 , C07C215/44 , C07C215/70 , C07C217/20 , C07C233/18 , C07C233/25 , C07C235/42 , C07C235/66 , C07C255/12 , C07C255/53 , C07C259/10 , C07C271/16 , C07C271/30 , C07C311/04 , C07C317/22 , C07C2603/18 , C07D207/04 , C07D211/06 , C07D213/30 , C07D213/56 , C07D231/12 , C07D239/26 , C07D249/08 , C07D257/04 , C07D263/32 , C07D271/06 , C07D271/10 , C07D275/02 , C07D295/08 , C07D295/18 , C07D295/192 , C07D333/22 , C07D401/06 , C07D401/12 , C07D403/12 , C07F7/081
摘要： The present invention provides an agent for the prophylactic or treatment of diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, cardiac failure, cardiomyopathy, myocardial ischemia, brain ischemia, cerebral apoplexy, pulmonary hypertension, hyperlactacidemia, mitochondrial disease, mitochondrial encephalomyopathy or cancer, namely, a PDHK inhibitor and the like. A compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein each symbol is as defined in the specification.
摘要翻译：本发明提供了用于预防或治疗糖尿病，糖尿病并发症，胰岛素抵抗综合征，代谢综合征，高血糖症，血脂异常，动脉粥样硬化，心力衰竭，心肌病，心肌缺血，脑缺血，脑中风，肺动脉高压，高乳酸血症，线粒体疾病，线粒体性脑病或癌症，即PDHK抑制剂等。由下式[I]表示的化合物或其药学上可接受的盐或其溶剂化物：其中每个符号如说明书中所定义。

3. 发明授权

US5811013A Oil separating method 失效
标题翻译：油分离方法
公开(公告)号：US5811013A
公开(公告)日：1998-09-22
申请号：US578731
申请日：1995-12-26
申请人： Hirotsugu Ito
发明人： Hirotsugu Ito
IPC分类号： B01D19/04 , B01D17/02 , B01D17/035 , B01D17/05 , B01D21/00 , B01F13/02 , C02F1/24
CPC分类号： B01D17/0205 , B01D21/0018 , B01D21/0021 , B01D21/0027 , B01D21/01 , B01D21/2405 , B01D21/2488 , B01D21/26 , B01D21/286 , B01F13/0233 , B03D1/247 , C02F1/24 , C02F2101/32 , C02F2303/12 , C02F2305/04
摘要： Disclosed is an oil separating method in which oil-contaminated water in a separation tank is mixed with air bubbles in a bubble-generating apparatus provided at the bottom of the separation tank to jet out said air-water mixture into the separation tank, wherein a surfactant and/or an antifoamer are(is) previously added to the oil-contaminated water.
摘要翻译：公开了一种油分离方法，其中分离槽中的油污染的水与设置在分离罐底部的气泡产生装置中的气泡混合，以将所述空气 - 水混合物喷射到分离罐中，其中表面活性剂和/或消泡剂预先加入油污水中。

4. 发明授权

US5177857A Method for holding an object to a surface using valve controlled vacuum force 失效
标题翻译：使用阀控真空力将物体保持在表面上的方法
公开(公告)号：US5177857A
公开(公告)日：1993-01-12
申请号：US734638
申请日：1991-07-23
申请人： Hirotsugu Ito
发明人： Hirotsugu Ito
IPC分类号： B25B11/00
CPC分类号： B25B11/005 , Y10T29/49998
摘要： A technique of holding an object, wherein an object (10) to be held is placed on a holding surface (3) having a plurality of suction holes (4), each of which has a valve (6) therein which is operated in accordance with the difference between the pressure in the upper or outer space and the pressure in the lower or inner space demarcated by the valve (6). The valve (6) is opened by utilizing the phenomena that such pressure difference in those suction holes (4) closed by the object (10) becomes smaller, whereas the valves (6) are closed by utilizing the phenomena that such pressure difference in those suction holes (4) which are not closed by the object (10) and remain open becomes greater, to thereby prevent reduction of the suction force to be exerted on the object (10).
摘要翻译：一种保持物体的技术，其中要保持的物体（10）被放置在具有多个吸入孔（4）的保持表面（3）上，每个吸入孔具有根据其操作的阀（6）其中上部或外部空间中的压力与由阀（6）划分的下部或内部空间中的压力之间的差异。通过利用由物体（10）关闭的那些吸入孔（4）中的这种压力差变小的现象来打开阀（6），而阀（6）通过利用这些压力差未被物体（10）闭合并保持打开的吸入孔（4）变大，从而防止施加在物体（10）上的吸力减小。

5. 发明授权

US5048804A Apparatus for holding an object to a surface using valve controlled vacuum force 失效
标题翻译：使用阀控真空力将物体保持在表面上的装置
公开(公告)号：US5048804A
公开(公告)日：1991-09-17
申请号：US595357
申请日：1990-10-09
申请人： Hirotsugu Ito
发明人： Hirotsugu Ito
IPC分类号： B23Q3/08 , B25B11/00
CPC分类号： B25B11/005
摘要： A technique of holding an object, wherein an object (10) to be held is placed on a holding surface (3) having a plurality of suction holes (4), each of which has a valve (6) therein which is operated in accordance with the difference between the pressure in the upper or outer space and the pressure in the lower or inner space demarcated by the valve (6). The valve (6) is opened by utilizing the phenomena that such pressure difference in those suction holes (4) closed by the object (10) becomes smaller, whereas the valves (6) are closed by utilizing the phenomena that such pressure difference in those suction holes (4) which are not closed by the object (10) and remain open becomes greater, to thereby prevent reduction of the suction force to be exerted on the object (10).

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