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1. 发明授权

US07994151B2 Compositions and methods for angiogenic therapy utilizing genes encoding ets-1 有权
标题翻译：使用编码ets-1的基因进行血管生成治疗的组合物和方法
公开(公告)号：US07994151B2
公开(公告)日：2011-08-09
申请号：US12435335
申请日：2009-05-04
申请人： Ryuichi Morishita , Hiromi Koike , Tadashi Tanabe , Motokuni Aoki
发明人： Ryuichi Morishita , Hiromi Koike , Tadashi Tanabe , Motokuni Aoki
IPC分类号： A61K48/00 , A01N63/00 , A01N65/00 , C12N15/00 , C07H21/04
CPC分类号： A61K38/52 , A61K31/5585 , A61K31/711 , A61K38/1709 , A61K38/1833 , A61K38/1858 , A61K48/00 , A61K2300/00
摘要： The present invention provides: (1) pharmaceutical compositions for angiogenic therapy which contain, as the active ingredients, at least one substance selected from substances having vasodilating effect and/or platelet aggregation inhibitory effect, and substances producing them; and a gene encoding an angiogenesis factor; (2) agents for potentiating the angiogenic effect of a gene encoding an angiogenesis factor that contain, as the active ingredient, at least one substance selected from substances having vasodilating effect and/or platelet aggregation inhibitory effect and substances producing them; (3) an angiogenic agent which contains a prostacyclin synthase gene as the active ingredient; (4) pharmaceutical compositions for angiogenic therapy which contain ets-1 gene and another gene encoding an angiogenesis factor as the active ingredients; (4) an agent which contain ets 1 gene as the active ingredient for potentiating the angiogenic effect of another gene encoding an angiogenesis factor; and (5) an angiogenic agent which contains ets-1 gene as the active ingredient.
摘要翻译：本发明提供：（1）血管生成治疗用药物组合物，其含有选自具有血管扩张作用和/或血小板聚集抑制作用的物质中的至少一种物质作为活性成分，以及生成它们的物质; 和编码血管生成因子的基因; （2）增强编码血管生成因子的基因的血管生成作用的药剂，其含有选自具有血管舒张作用和/或血小板聚集抑制作用的物质和/或血小板聚集抑制作用的物质中的至少一种物质作为活性成分; （3）含有前列环素合酶基因作为活性成分的血管生成剂; （4）含有ets-1基因和编码血管生成因子的另一基因作为活性成分的用于血管生成治疗的药物组合物; （4）含有ets1基因作为增强编码血管生成因子的另一基因的血管生成作用的活性成分的药剂; 和（5）含有ets-1基因作为活性成分的血管生成剂。

2. 发明申请

US20070066935A1 Needleless syringe having medical agent accomodated therein 审中-公开
标题翻译：无针注射器，其中含有药剂
公开(公告)号：US20070066935A1
公开(公告)日：2007-03-22
申请号：US10555925
申请日：2004-04-30
申请人： Ryuichi Morishita , Naruya Tomita , Yasuo Kunugiza , Yoshiaki Taniyama , Hiromi Koike , Haruhide Udagawa , Tatsuo Kimura
发明人： Ryuichi Morishita , Naruya Tomita , Yasuo Kunugiza , Yoshiaki Taniyama , Hiromi Koike , Haruhide Udagawa , Tatsuo Kimura
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61K38/1833 , A61K48/00
摘要： The present invention provides a needleless syringe having, accommodated therein, a pharmaceutical preparation containing genes and/or analogues thereof. A needleless syringe comprising: a medical agent chamber 22 having one or multiple nozzle bore(s) 25 and accommodated with a medical agent L, and a syringe main body 12 being provided with pressure application means 32 to apply pressure on the medical agent L toward a direction of the nozzle bore(s) 25 and effect emission of the medical agent L through the nozzle bore(s) 25, wherein the medical agent L is a pharmaceutical preparation containing genes and/or analogues thereof. Examples of the medical agent L include pharmaceutical preparation containing HGF gene and pharmaceutical preparation containing NF-κB decoy oligonucleotide.
摘要翻译：本发明提供一种无针注射器，其中容纳有含有其基因和/或类似物的药物制剂。一种无针注射器，包括：药剂腔室22，其具有一个或多个喷嘴孔25并且容纳有药剂L;以及注射器主体12，其设有施加压力的压力施加装置32，以对药剂L施加压力喷嘴孔25的方向并且通过喷嘴孔25发射药剂L，其中药剂L是含有其基因和/或类似物的药物制剂。药剂L的实例包括含有HGF基因的药物制剂和含有NF-κB诱饵寡核苷酸的药物制剂。

3. 发明申请

US20100240735A1 Pharmaceutical Compositions for Angiogenic Therapy 有权
标题翻译：血管生成治疗药物组合物
公开(公告)号：US20100240735A1
公开(公告)日：2010-09-23
申请号：US12435335
申请日：2009-05-04
申请人： Ryuichi Morishita , Hiromi Koike , Tadashi Tanabe , Motokuni Aoki
发明人： Ryuichi Morishita , Hiromi Koike , Tadashi Tanabe , Motokuni Aoki
IPC分类号： A61K31/7088 , A61P9/10
CPC分类号： A61K38/52 , A61K31/5585 , A61K31/711 , A61K38/1709 , A61K38/1833 , A61K38/1858 , A61K48/00 , A61K2300/00
摘要： The present invention provides: (1) pharmaceutical compositions for angiogenic therapy which contain, as the active ingredients, at least one substance selected from substances having vasodilating effect and/or platelet aggregation inhibitory effect, and substances producing them; and a gene encoding an angiogenesis factor; (2) agents for potentiating the angiogenic effect of a gene encoding an angiogenesis factor that contain, as the active ingredient, at least one substance selected from substances having vasodilating effect and/or platelet aggregation inhibitory effect and substances producing them; (3) an angiogenic agent which contains a prostacyclin synthase gene as the active ingredient; (4) pharmaceutical compositions for angiogenic therapy which contain ets-1 gene and another gene encoding an angiogenesis factor as the active ingredients; (4) an agent which contain ets 1 gene as the active ingredient for potentiating the angiogenic effect of another gene encoding an angiogenesis factor; and (5) an angiogenic agent which contains ets-1 gene as the active ingredient.
摘要翻译：本发明提供：（1）血管生成治疗用药物组合物，其含有选自具有血管扩张作用和/或血小板聚集抑制作用的物质中的至少一种物质作为活性成分，以及生成它们的物质; 和编码血管生成因子的基因; （2）增强编码血管生成因子的基因的血管生成作用的药剂，其含有选自具有血管舒张作用和/或血小板聚集抑制作用的物质和/或血小板聚集抑制作用的物质中的至少一种物质作为活性成分; （3）含有前列环素合酶基因作为活性成分的血管生成剂; （4）含有ets-1基因和编码血管生成因子的另一基因作为活性成分的用于血管生成治疗的药物组合物; （4）含有ets1基因作为增强编码血管生成因子的另一基因的血管生成作用的活性成分的药剂; 和（5）含有ets-1基因作为活性成分的血管生成剂。

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