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1. 发明专利

JP2005272354A Dibenzosuberylpiperazine derivative and medicinal composition containing the same 有权
标题翻译：二苯并吡唑并吡啶衍生物和含有它们的药物组合物
公开(公告)号：JP2005272354A
公开(公告)日：2005-10-06
申请号：JP2004088135
申请日：2004-03-25
申请人： Yumiko Cho , Masanori Kobayashi , Pola Chem Ind Inc , Hiroaki Takayanagi , Tsutomu Takeuchi , ポーラ化成工業株式会社 , 正規小林 , 勤竹内 , 由美子長 , 弘明高柳
发明人： TAKEUCHI TSUTOMU , TAKAYANAGI HIROAKI , CHO YUMIKO , KOBAYASHI MASANORI , SATO YOKO , TAKINO KOICHI , SUZUKI YUMIKO , HIKIMA YUKA , SAKAGUCHI SHOICHI , MIYATA YOSHIYUKI
IPC分类号： C07D295/02 , A61K31/495 , A61P33/06 , C07D295/08
CPC分类号： Y02A50/411
摘要： PROBLEM TO BE SOLVED: To provide a compound having antimalaria activities and drug tolerance-overcoming activities.
SOLUTION: The dibenzosuberylpiperazine derivative of a new material, represented by general formula (1) (wherein, R1 and R2 are each independently a hydrogen atom, a 1-3C alkyl group, a 1-3C alkenyl group, a 1-3C alkynyl group, a 1-3C hydroxyalkyl group, a 1-3C hydroxyalkenyl group, a 1-3C hydroxyalkynyl group, a 1-3C alkyloxy-1-3C alkyl group, a 1-3C alkenyloxy-1-3C alkyl group or a 1-3C alkynyloxy-1-3C alkyl group; with the proviso that R1 and R2 may be the same group), or a physiologically acceptable salt thereof is produced, and formulated with an arbitrary component for forming a preparation in the medicinal composition.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供具有抗疟疾活性和耐药性克服活性的化合物。解决方案：由通式（1）表示的新材料的二苯并环庚基哌嗪衍生物（其中，R 1和R 2各自独立地为氢原子，1-3C烷基，1-3C烯基， 3C炔基，1-3C羟基烷基，1-3C羟基烯基，1-3C羟基炔基，1-3C烷氧基1-3C烷基，1-3C烯氧基1-3C烷基或 1-3C烷氧基1-3C烷基;条件是R1和R2可以是相同的基团）或其生理学上可接受的盐，并且与用于在药物组合物中形成制剂的任意成分一起配制。版权所有（C）2006，JPO＆NCIPI

2. 发明专利

JP2004339073A Diphenylacetylpiperazine derivative and resistance-overcoming agent 审中-公开
公开(公告)号：JP2004339073A
公开(公告)日：2004-12-02
申请号：JP2003134282
申请日：2003-05-13
申请人： Yumiko Cho , Masanori Kobayashi , Pola Chem Ind Inc , Hiroaki Takayanagi , Tsutomu Takeuchi , ポーラ化成工業株式会社 , 正規小林 , 勤竹内 , 由美子長 , 弘明高柳
发明人： TAKEUCHI TSUTOMU , TAKAYANAGI HIROAKI , CHO YUMIKO , KOBAYASHI MASANORI , SATO YOKO , TAKINO KOICHI , SAKAGUCHI SHOICHI , MIYATA YOSHIYUKI
IPC分类号： C07D295/18 , A61K31/495 , A61P31/04 , A61P31/06 , A61P33/02 , A61P33/06 , A61P43/00
CPC分类号： Y02A50/409 , Y02A50/411 , Y02A50/481
摘要： PROBLEM TO BE SOLVED: To obtain an orally administrable resistance-overcoming agent suppliable to practical use.
SOLUTION: A diphenylacetylpiperazine derivative which is a compound represented by formula (1) (wherein, R denotes an aliphatic hydrocarbon group which may have a substituent containing a heteroatom) and/or its salt inhibit an ABC transporter and thereby have inhibitory actions on the excretion of a chemotherapeutic agent. The derivative has no adverse effect such as calcium antagonistic actions or monoamine reuptake inhibitory actions which may be possessed by the usual ABC transporter irrespective of the actions.
COPYRIGHT: (C)2005,JPO&NCIPI

3. 发明申请

US20140174687A1 BODY WASTE TREATING MATERIAL, METHOD FOR MANUFACTURING BODY WASTE TREATING MATERIAL, AND APPARATUS FOR MANUFACTURING THE SAME 审中-公开
标题翻译：身体废物处理材料，制造身体废物处理材料的方法及其制造装置
公开(公告)号：US20140174687A1
公开(公告)日：2014-06-26
申请号：US13704453
申请日：2012-09-12
申请人： Susumu Okamoto , Takashi Takahashi , Yoshikazu Horihata , Koichi Narita , Akio Takase , Shinichi Matsuo , Toru Shimizu , Hiroaki Takayanagi , Hyunjin Seo , Akihiro Sugiyama , Takashi Murakami
发明人： Susumu Okamoto , Takashi Takahashi , Yoshikazu Horihata , Koichi Narita , Akio Takase , Shinichi Matsuo , Toru Shimizu , Hiroaki Takayanagi , Hyunjin Seo , Akihiro Sugiyama , Takashi Murakami
IPC分类号： D21B1/08
CPC分类号： D21B1/08 , A01K1/0152 , A01K1/0155
摘要： [Technical Problem]In a body waste treating material, a method for manufacturing the body waste treating material, and an apparatus for manufacturing the same, a technical problem is in manufacturing the body waste treating material without a water absorbing agent as a material for complementing a water absorptive property and a water retention property and a wasting step in manufacturing easily at a low cost.[Solution to Problem]The body waste treating material is formed to a certain shape by the steps of: defiberizing used paper as a pulpable raw material to generate a dissolved material, deinking the dissolved material generated in the defiberizing step, dehydrating the dissolved material deinked in the deinking step to generate a fibrous material, classifying the fibrous material generated in the dehydrating step into a non-defective fibrous material suitable for forming paper and a defective fibrous material unsuitable for forming paper and molding the non-defective fibrous material suitable for forming paper classified in the classifying step.
摘要翻译：技术问题在身体废物处理材料，身体废物处理材料的制造方法及其制造装置中，技术问题在于制造没有吸水剂的身体废物处理材料作为补充材料吸水性和保水性以及易于以低成本制造的浪费步骤。 [问题的解决方案]身体废物处理材料通过以下步骤形成为一定形状：将废纸分解为可制浆原料以产生溶解的材料，使在脱纤化步骤中产生的溶解物质脱墨，使溶解的材料脱墨脱水在脱墨步骤中产生纤维材料，将在脱水步骤中生成的纤维材料分类成适合于形成纸的无缺陷纤维材料和不适于形成纸的不合格纤维材料和模制适合于成形的无缺陷纤维材料分类在分类步骤中的纸张。

4. 发明授权

US5885638A Adsorbent, process for producing the same, and method of treating fruit juice 失效
标题翻译：吸附剂，其制造方法以及果汁的处理方法
公开(公告)号：US5885638A
公开(公告)日：1999-03-23
申请号：US734800
申请日：1996-10-23
申请人： Hiroaki Takayanagi , Hiromi Teshima
发明人： Hiroaki Takayanagi , Hiromi Teshima
IPC分类号： A23L2/80 , B01J20/26 , A23C9/14 , C12H1/04 , C12H1/14
CPC分类号： B01J20/26 , A23L2/80
摘要： An adsorbent is described, which has a pore structure suitable for the selective and efficient removal of bitter components from fruit juice, and which does not contain ionic functional groups or the like in the structure thereof and can be easily handle, and more specifically, which comprises a porous crosslinked polymer produced from an aromatic vinyl monomer compound, and in which the specific surface area per dry unit weight, the pore volume per water-wet unit volume, and the specific surface area attributable to pores having a radius not smaller than 50 .ANG. per water-wet unit volume are not smaller than respective specific values. A process for producing the adsorbent and a method of treating fruit juice using the adsorbent are also described.
摘要翻译：描述了一种吸附剂，其具有适于从果汁中选择性和有效地除去苦味成分的孔结构，并且其结构中不含有离子官能团等并且可以容易地处理，更具体地说，哪些包括由芳族乙烯基单体化合物制备的多孔交联聚合物，其中每干燥单位重量的比表面积，每水湿单位体积的孔体积和可归因于半径不小于50的孔的比表面积每个水湿单位体积的ANGSTROM不小于相应的具体值。还描述了用于生产吸附剂的方法和使用吸附剂处理果汁的方法。

5. 发明授权

US06881841B2 Dibenzosuberanyl piperazine derivatives and drug-resistance overcoming agents containing the derivatives 失效
标题翻译：二苄钴基哌嗪衍生物和含有衍生物的耐药性克服剂
公开(公告)号：US06881841B2
公开(公告)日：2005-04-19
申请号：US10416514
申请日：2001-11-20
申请人： Tsutomu Takeuchi , Hiroaki Takayanagi , Seiki Kobayashi , Yumiko Osa , Yumiko Suzuki , Yoko Sato , Masakazu Sakaguchi , Yoshiyuki Miyata
发明人： Tsutomu Takeuchi , Hiroaki Takayanagi , Seiki Kobayashi , Yumiko Osa , Yumiko Suzuki , Yoko Sato , Masakazu Sakaguchi , Yoshiyuki Miyata
IPC分类号： A61K31/495 , A61P33/06 , A61P43/00 , C07D295/084 , C07D295/088 , C07D295/00
CPC分类号： C07D295/088 , A61K31/495 , C07D295/084 , Y02A50/409 , Y02A50/411 , Y02A50/473 , A61K31/00 , A61K2300/00
摘要： Dibenzosuberanyl piperazine derivatives represented by the following formula (I): wherein R represents an aliphatic hydrocarbon group, which may contain one or more heteroatom-containing substituent groups and may preferably contain 2 to 30 carbon atoms, and physiologically acceptable salts thereof; and medicinal compositions containing these dibenzosuberanyl piperazine derivatives and/or physiologically acceptable salts thereof. These compounds show effectiveness in allowing resistance-acquired causes of diseases to restore sensitivity to drug, that is, a resistance overcoming effect.
摘要翻译：由下式（I）表示的二苄钴基哌嗪衍生物：其中R表示脂族烃基，其可以含有一个或多个含杂原子的取代基，并且可以优选含有2至30个碳原子，及其生理上可接受的盐; 以及含有这些二苯并二恶烷基哌嗪衍生物和/或其生理学上可接受的盐的药物组合物。这些化合物显示了使抗性获得性疾病的原因恢复对药物的敏感性的有效性，即抵抗效应的抵抗力。

6. 发明授权

US5254634A Crosslinked copolymer particles and process for producing the same 失效
标题翻译：交联共聚物颗粒及其制备方法
公开(公告)号：US5254634A
公开(公告)日：1993-10-19
申请号：US773572
申请日：1991-11-08
申请人： Tsuyoshi Ito , Hiroaki Takayanagi , Go Honda
发明人： Tsuyoshi Ito , Hiroaki Takayanagi , Go Honda
IPC分类号： B01D15/08 , B01D15/34 , B01J20/26 , B01J20/32 , C08F8/00 , C08F20/20
CPC分类号： B01D15/08 , B01D15/34 , B01J20/26 , B01J20/261 , B01J20/264 , B01J20/265 , B01J20/267 , B01J20/28004 , B01J20/28019 , B01J20/28057 , B01J20/285 , B01J20/286 , B01J20/3092 , B01J20/321 , B01J20/3248 , B01J20/3251 , B01J20/3253 , B01J20/3255 , B01J20/3274 , C08F8/00 , B01J2220/54 , B01J2220/58
摘要： Crosslinked copolymer particles comprising hydrophilic crosslinked copolymer particles with a hydrophobic functional group being bonded thereto via an oxygen atom derived from a hydroxyl group of said hydrophilic crosslinked copolymer, which are obtained by reacting hydrophilic crosslinked copolymer particles with a reagent for introducing a hydrophobic functional group in an organic solvent capable of swelling said hydrophilic crosslinked copolymer particles, said hydrophilic crosslinked copolymer particles being prepared by suspension polymerization of glycerol monomethacrylate and a crosslinking polyvinyl compound in the presence of an organic solvent, such as a monohydric alcohol having from 5 to 14 carbon atoms. The polymer particles are useful as a carrier for gel-filtration of hydrophilic biopolymers such as proteins and nucleic acids.
摘要翻译： PCT No.PCT / JP90 / 01583 Sec。 371日期：1991年11月8日 102（e）1991年11月8日PCT PCT 1990年12月6日PCT公布。第WO92 / 01721号公报日本1992年2月6日。包含疏水官能团的亲水性交联共聚物颗粒的交联共聚物颗粒通过亲水性交联共聚物颗粒与试剂反应获得的亲水交联共聚物的羟基衍生的氧原子与其结合为了在能够溶胀所述亲水性交联共聚物颗粒的有机溶剂中引入疏水性官能团，所述亲水性交联共聚物颗粒是通过在一种有机溶剂如一元醇的存在下将单体甲基丙烯酸甘油酯和交联的聚乙烯基化合物进行悬浮聚合来制备的具有5至14个碳原子。聚合物颗粒可用作亲水性生物聚合物如蛋白质和核酸的凝胶过滤载体。

7. 发明申请

US20140203208A1 BODY WASTE TREATING MATERIAL, METHOD FOR MANUFACTURING BODY WASTE TREATING MATERIAL, AND APPARATUS FOR MANUFACTURING THE SAME 审中-公开
标题翻译：身体废物处理材料，制造身体废物处理材料的方法及其制造装置
公开(公告)号：US20140203208A1
公开(公告)日：2014-07-24
申请号：US13704503
申请日：2012-09-12
申请人： Susumu Okamoto , Takashi Takahashi , Yoshikazu Horihata , Koichi Narita , Akio Takase , Shinichi Matsuo , Toru Shimizu , Hiroaki Takayanagi , Hyunjin Seo , Akihiro Sugiyama , Takashi Murakami
发明人： Susumu Okamoto , Takashi Takahashi , Yoshikazu Horihata , Koichi Narita , Akio Takase , Shinichi Matsuo , Toru Shimizu , Hiroaki Takayanagi , Hyunjin Seo , Akihiro Sugiyama , Takashi Murakami
IPC分类号： B01J20/28 , B01J20/30
CPC分类号： B01J20/28042 , A01K1/0155 , B01J20/3007 , D21C5/02 , D21C5/025 , D21C9/10 , Y02W30/648
摘要： [Technical Problem]In a body waste treating material, a method for manufacturing the body waste treating material, and an apparatus for manufacturing the same, a technical problem is in manufacturing the body waste treating material without a water absorbing agent as a material for complementing a water absorptive property and a water retention property and a wasting step in manufacturing easily at a low cost.[Solution to Problem]The body waste treating material is formed to a certain shape by the steps of: defiberizing used paper as a pulpable raw material to generate a dissolved material, deinking the dissolved material generated in the defiberizing step, dehydrating the dissolved material deinked in the deinking step to generate a fibrous material, classifying the fibrous material generated in the dehydrating step into a non-defective fibrous material suitable for forming paper and a defective fibrous material unsuitable for forming paper, mixing the non-defective fibrous material suitable for forming paper with the defective fibrous material unsuitable for forming paper, and molding a fibrous material mixed in the mixing step.
摘要翻译：技术问题在身体废物处理材料，身体废物处理材料的制造方法及其制造装置中，技术问题在于制造没有吸水剂的身体废物处理材料作为补充材料吸水性和保水性以及易于以低成本制造的浪费步骤。 [问题的解决方案]身体废物处理材料通过以下步骤形成为一定形状：将废纸分解为可制浆原料以产生溶解的材料，使在脱纤化步骤中产生的溶解物质脱墨，使溶解的材料脱墨脱水在脱墨步骤中产生纤维材料，将在脱水步骤中生成的纤维材料分类成适合于形成纸的无缺陷纤维材料和不适于形成纸的不合格纤维材料，混合适合于成型的无缺陷纤维材料具有不适合于形成纸的有缺陷的纤维材料的纸，以及在混合步骤中混合的纤维材料的成型。

8. 发明授权

US5839258A Storing method for adsorbent particles 失效
标题翻译：吸附剂颗粒的储存方法
公开(公告)号：US5839258A
公开(公告)日：1998-11-24
申请号：US756578
申请日：1996-11-27
申请人： Hiroaki Takayanagi , Naoko Takasaki , Takashi Mikawa
发明人： Hiroaki Takayanagi , Naoko Takasaki , Takashi Mikawa
IPC分类号： C08J3/28 , B65B55/02
CPC分类号： C08J3/28 , C08J2325/08
摘要： A method for storing adsorbent particles of synthetic resin porous particles for a long period of time without causing decrease in the adsorbing performance and without attaching fungi, which method can be effected by irradiation of the porous particles hermetically sealed in a packing material such as a bag with radioactive rays at a dose of 5 to 20 kGy and storage of the resulting adsorbent particles in the hermetically sealed condition.
摘要翻译：合成树脂多孔质粒子的吸附剂颗粒长时间储存而不会降低吸附性能而不附着真菌的方法，该方法可以通过照射密封在包装材料如袋中的多孔颗粒以5至20kGy的剂量放射线，并将所得吸附剂颗粒储存在密封状态。

9. 发明授权

US5114577A Composite separating agent 失效
标题翻译：复合分离剂
公开(公告)号：US5114577A
公开(公告)日：1992-05-19
申请号：US651117
申请日：1991-02-05
申请人： Hiroshi Kusano , Tsuyoshi Ito , Takayuki Tashiro , Hiroaki Takayanagi , Eiji Miyata
发明人： Hiroshi Kusano , Tsuyoshi Ito , Takayuki Tashiro , Hiroaki Takayanagi , Eiji Miyata
IPC分类号： B01D15/08 , B01J20/28
CPC分类号： B01J20/28097 , B01D15/08 , B01J20/28014
摘要： A composite separating agent which comprises a hydrophilic polymer separating agent showing a degree of swelling in water of 10 to 100 ml/g-dry and having a giant network structure incorporated within pores of an organic polymer substrate showing a degree of swelling in water of 20 ml/g-dry or below and a degree of crosslinking of 4% to 100% by mol and having a porous structure as well as a process for producing the same are disclosed.When packed within a column, this composite separating agent having a high mechanical strength is hardly compacted and exhibits an excellent separation performance. Thus it is highly useful in chromatographic separation of biopolymers including proteins.

10. 发明申请

US20140305608A1 BODY WASTE TREATING MATERIAL, METHOD FOR MANUFACTURING BODY WASTE TREATING MATERIAL, AND APPARATUS FOR MANUFACTURING THE SAME 审中-公开
标题翻译：身体废物处理材料，制造身体废物处理材料的方法及其制造装置
公开(公告)号：US20140305608A1
公开(公告)日：2014-10-16
申请号：US13704682
申请日：2012-09-12
申请人： Susumu Okamoto , Takashi Takahashi , Yoshikazu Horihata , Koichi Narita , Akio Takase , Shinichi Matsuo , Toru Shimizu , Hiroaki Takayanagi , Hyunjin Seo , Akihiro Sugiyama , Takashi Murakami
发明人： Susumu Okamoto , Takashi Takahashi , Yoshikazu Horihata , Koichi Narita , Akio Takase , Shinichi Matsuo , Toru Shimizu , Hiroaki Takayanagi , Hyunjin Seo , Akihiro Sugiyama , Takashi Murakami
IPC分类号： D21J3/00
CPC分类号： D21J3/00 , A01K1/0155 , D21C5/02 , D21C5/025 , Y02W30/648
摘要： An object of the present invention is in that a body waste treating material can be manufactured by using a defective fibrous material unsuitable for forming paper generated upon treating a pulpable raw material without materials for complementing a water absorptive property and a water retention property and a wasting step in manufacturing at a low cost, and resources may be efficiently used.[Solution to Problem]This invention is characterized by molding a defective fibrous material unsuitable for forming paper that is a fibrous material obtained by defiberizing and dehydrating a pulpable raw material to a certain shape. The defective fibrous material is characterized by including thin and/or short fibers.
摘要翻译：本发明的目的在于，可以通过使用不适合于形成纸浆处理原料产生的纸而不适于补充吸水性和保水性的物质和浪费的不良纤维材料来制造身体废物处理材料低成本的制造步骤，可以有效地利用资源。 [问题的解决方案]本发明的特征在于，将不适合于形成纸的有缺陷的纤维材料成型为将可打浆原料脱水并脱水得到的纤维材料成形为一定形状。缺陷纤维材料的特征在于包括薄纤维和/或短纤维。

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