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1. 发明授权

US08785195B2 Covered micro gel fiber 有权
标题翻译：覆盖微凝胶纤维
公开(公告)号：US08785195B2
公开(公告)日：2014-07-22
申请号：US13501634
申请日：2010-10-12
申请人： Shoji Takeuchi , Hiroaki Onoe , Yukiko Matsunaga , Daisuke Kiriya , Riho Gojo , Midori Negishi
发明人： Shoji Takeuchi , Hiroaki Onoe , Yukiko Matsunaga , Daisuke Kiriya , Riho Gojo , Midori Negishi
IPC分类号： A61K38/00
CPC分类号： D06M15/03 , D01D5/06 , D01D5/34 , D01F8/02 , D01F8/18 , D03D15/0061 , D06M15/13 , D06M15/277 , D06M15/576 , D06M2101/14 , Y10T442/614
摘要： A microfiber showing improved mechanical strength, which comprises a micro gel fiber consisting of collagen gel or the like covered with high strength hydrogel such as alginate gel.
摘要翻译：显示改善的机械强度的微纤维，其包含由胶原凝胶等构成的微胶囊纤维，所述胶原凝胶等用高强度水凝胶如藻酸盐凝胶覆盖。

2. 发明申请

US20130071948A1 PROCESS FOR PRODUCING SUPRAMOLECULAR FIBER 有权
标题翻译：生产分光纤的方法
公开(公告)号：US20130071948A1
公开(公告)日：2013-03-21
申请号：US13522155
申请日：2010-09-17
申请人： Shoji Takeuchi , Hiroaki Onoe , Daisuke Kiriya , Itaru Hamachi , Masato Ikeda
发明人： Shoji Takeuchi , Hiroaki Onoe , Daisuke Kiriya , Itaru Hamachi , Masato Ikeda
IPC分类号： G01N21/76
CPC分类号： G01N21/76 , D01D5/00 , D01D5/34 , D01F6/94 , D01F8/18
摘要： A method for preparing a linearly extended supramolecular fiber or a plurality of linearly aligned supramolecular fibers, which comprises the step of allowing supramolecular monomers to be self-assembled in a microfluidic channel.
摘要翻译：一种制备线性延伸的超分子纤维或多种线性排列的超分子纤维的方法，其包括允许超分子单体在微流体通道中自组装的步骤。

3. 发明申请

US20120301963A1 COVERED MICRO GEL FIBER 有权
标题翻译：覆盖的微胶凝纤维
公开(公告)号：US20120301963A1
公开(公告)日：2012-11-29
申请号：US13501634
申请日：2010-10-12
申请人： Shoji Takeuchi , Hiroaki Onoe , Yukiko Matsunaga , Daisuke Kiriya , Riho Gojo , Midori Negishi
发明人： Shoji Takeuchi , Hiroaki Onoe , Yukiko Matsunaga , Daisuke Kiriya , Riho Gojo , Midori Negishi
IPC分类号： C12N5/071
CPC分类号： D06M15/03 , D01D5/06 , D01D5/34 , D01F8/02 , D01F8/18 , D03D15/0061 , D06M15/13 , D06M15/277 , D06M15/576 , D06M2101/14 , Y10T442/614
摘要： A microfiber showing improved mechanical strength, which comprises a micro gel fiber consisting of collagen gel or the like covered with high strength hydrogel such as alginate gel.
摘要翻译：显示改善的机械强度的微纤维，其包含由胶原凝胶等构成的微胶囊纤维，所述胶原凝胶等用高强度水凝胶如藻酸盐凝胶覆盖。

4. 发明申请

US20100279398A1 INSTRUMENT AND METHOD FOR TREATING MINOR AMOUNT OF BIOLOGICAL MATERIAL 审中-公开
标题翻译：用于处理少量生物材料的仪器和方法
公开(公告)号：US20100279398A1
公开(公告)日：2010-11-04
申请号：US12812332
申请日：2009-01-09
申请人： Shoji Takeuchi , Hiroaki Onoe
发明人： Shoji Takeuchi , Hiroaki Onoe
IPC分类号： C12N5/00 , C12M1/00
CPC分类号： C12M25/08 , B01L3/502761 , B01L3/5085 , B01L3/5088 , B01L2200/0668 , B01L2300/0819
摘要： Provided is a technique for handling a minor amount of a biological material with the purpose of observing selectively the interaction between single cells by controlling cell number and two- or three-dimensional configurations of each of the different cell types. The present invention provides an instrument and a method for handling a minor amount of a biological material. The instrument of the present invention for handling a minor amount of a biological material comprises a construct and a base, wherein: the base holds the construct in a releasable manner; the construct is held on a surface of the base in such a manner that a part of the construct is exposed externally on the outer face of the instrument; and at least a part of a surface of the constructs is exposed externally on the outer face of the instrument being fabricated so as to allow the adhesion of the minor amount of the biological material thereto.
摘要翻译：提供了一种用于处理少量生物材料的技术，其目的是通过控制每种不同细胞类型的细胞数量和二维或三维构型来选择性地观察单细胞之间的相互作用。本发明提供了一种用于处理少量生物材料的仪器和方法。用于处理少量生物材料的本发明的仪器包括构建体和基底，其中：所述基座以可释放的方式保持构造; 构造体以使得构件的一部分在仪器的外表面外部暴露的方式被保持在基座的表面上; 并且所述构造体的表面的至少一部分在外部暴露在被制造的器械的外表面上，以便允许少量的生物材料粘附到其上。

5. 发明申请

US20130136863A1 METHOD FOR FABRICATING A MICROARRAY OF SOFT MATERIALS 有权
标题翻译：微软材料制作方法
公开(公告)号：US20130136863A1
公开(公告)日：2013-05-30
申请号：US13814588
申请日：2012-03-27
申请人： Satoshi Hiyama , Kaori Kuribayashi , Hiroaki Onoe , Shoji Takeuchi
发明人： Satoshi Hiyama , Kaori Kuribayashi , Hiroaki Onoe , Shoji Takeuchi
IPC分类号： B05D1/32
CPC分类号： B05D1/325 , B01J2219/00317 , B01J2219/00529 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B81B2201/0214 , B81B2201/058 , B81C1/00206 , C12N15/09 , G01N33/543 , G01N37/00
摘要： A method for fabricating a microarray of plural soft materials includes: vapor-depositing a first layer poly(para-xylylene) resin on a substrate, forming a first micro pattern in the poly(para-xylylene) resin; obtaining a substrate including a first microarray formed by pouring a first soft material solution, freeze-drying the first soft material to obtain a micro-arrayed substrate of the freeze-dried first soft material; vapor-depositing a second layer poly(para-xylylene) resin on the micro-arrayed substrate of the freeze-dried first soft material, forming a second micro pattern placed differently from the first micro pattern by penetrating the poly(para-xylylene) resin of the first and second layers, forming a second microarray on the substrate by pouring a second soft material solution; and forming a microarray of the first and second soft materials on the substrate by peeling off the poly(para-xylylene) resin of the first and second layers.
摘要翻译：一种制备多种软材料的微阵列的方法包括：在基材上蒸镀第一层聚（对二甲苯）树脂，在聚（对二甲苯）树脂中形成第一微图案; 获得包括通过倾倒第一软质材料溶液形成的第一微阵列的基板，冷冻干燥第一软质材料以获得冷冻干燥的第一软质材料的微阵列基板; 在冷冻干燥的第一软质材料的微阵列基底上气相沉积第二层聚（对二甲苯）树脂，通过穿透聚（对二甲苯）树脂形成不同于第一微图案的第二微图案的第一和第二层，通过倾倒第二软材料溶液在基底上形成第二微阵列; 以及通过剥离第一层和第二层的聚（对二甲苯）树脂，在基材上形成第一和第二软材料的微阵列。

6. 发明授权

US09476834B2 Process for producing supramolecular fiber 有权
标题翻译：超分子纤维生产工艺
公开(公告)号：US09476834B2
公开(公告)日：2016-10-25
申请号：US13522155
申请日：2010-09-17
申请人： Shoji Takeuchi , Hiroaki Onoe , Daisuke Kiriya , Itaru Hamachi , Masato Ikeda
发明人： Shoji Takeuchi , Hiroaki Onoe , Daisuke Kiriya , Itaru Hamachi , Masato Ikeda
IPC分类号： D01D5/00 , D01D5/34 , D01F8/18 , G01N21/76 , D01F6/94
CPC分类号： G01N21/76 , D01D5/00 , D01D5/34 , D01F6/94 , D01F8/18
摘要： A method for preparing a linearly extended supramolecular fiber or a plurality of linearly aligned supramolecular fibers, which comprises the step of allowing supramolecular monomers to be self-assembled in a microfluidic channel.
摘要翻译：一种制备线性延伸的超分子纤维或多种线性排列的超分子纤维的方法，其包括允许超分子单体在微流体通道中自组装的步骤。

7. 发明授权

US08999443B2 Method for fabricating a microarray of soft materials 有权
标题翻译：软材料微阵列的制造方法
公开(公告)号：US08999443B2
公开(公告)日：2015-04-07
申请号：US13814588
申请日：2012-03-27
申请人： Satoshi Hiyama , Kaori Kuribayashi , Hiroaki Onoe , Shoji Takeuchi
发明人： Satoshi Hiyama , Kaori Kuribayashi , Hiroaki Onoe , Shoji Takeuchi
IPC分类号： C23C16/00 , B05D1/32 , C12N15/09 , G01N37/00 , G01N33/543 , B81C1/00
CPC分类号： B05D1/325 , B01J2219/00317 , B01J2219/00529 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B81B2201/0214 , B81B2201/058 , B81C1/00206 , C12N15/09 , G01N33/543 , G01N37/00
摘要： A method for fabricating a microarray of plural soft materials includes: vapor-depositing a first layer poly(para-xylylene) resin on a substrate, forming a first micro pattern in the poly(para-xylylene) resin; obtaining a substrate including a first microarray formed by pouring a first soft material solution, freeze-drying the first soft material to obtain a micro-arrayed substrate of the freeze-dried first soft material; vapor-depositing a second layer poly(para-xylylene) resin on the micro-arrayed substrate of the freeze-dried first soft material, forming a second micro pattern placed differently from the first micro pattern by penetrating the poly(para-xylylene) resin of the first and second layers, forming a second microarray on the substrate by pouring a second soft material solution; and forming a microarray of the first and second soft materials on the substrate by peeling off the poly(para-xylylene) resin of the first and second layers.
摘要翻译：一种制备多种软材料的微阵列的方法包括：在基材上蒸镀第一层聚（对二甲苯）树脂，在聚（对二甲苯）树脂中形成第一微图案; 获得包括通过倾倒第一软质材料溶液形成的第一微阵列的基板，冷冻干燥第一软质材料以获得冷冻干燥的第一软质材料的微阵列基板; 在冷冻干燥的第一软质材料的微阵列基底上气相沉积第二层聚（对二甲苯）树脂，通过穿透聚（对二甲苯）树脂形成不同于第一微图案的第二微图案的第一和第二层，通过倾倒第二软材料溶液在基底上形成第二微阵列; 以及通过剥离第一层和第二层的聚（对二甲苯）树脂，在基材上形成第一和第二软材料的微阵列。

8. 发明授权

US09327036B2 DNA-cell conjugates 有权
标题翻译： DNA细胞缀合物
公开(公告)号：US09327036B2
公开(公告)日：2016-05-03
申请号：US13263129
申请日：2010-04-08
申请人： Shih-Chia Hsiao , Matthew B. Francis , Carolyn Bertozzi , Richard Mathies , Ravi Chandra , Erik Douglas , Amy Twite , Nicholas Toriello , Hiroaki Onoe
发明人： Shih-Chia Hsiao , Matthew B. Francis , Carolyn Bertozzi , Richard Mathies , Ravi Chandra , Erik Douglas , Amy Twite , Nicholas Toriello , Hiroaki Onoe
IPC分类号： C12N5/07 , C12N5/0789 , C07H21/00 , A61K47/48 , C12N5/00
CPC分类号： C12N5/0006 , A61K47/6901
摘要： The present invention provides conjugates of DNA and cells by linking the DNA to a native functional group on the cell surface. The cells can be without cell walls or can have cell walls. The modified cells can be linked to a substrate surface and used in assay or bioreactors.
摘要翻译：本发明通过将DNA与细胞表面上的天然官能团连接来提供DNA和细胞的结合物。细胞可以没有细胞壁或可以具有细胞壁。修饰的细胞可以连接到底物表面并用于测定或生物反应器中。

9. 发明申请

US20120142088A1 DNA-CELL CONJUGATES 有权
标题翻译： DNA-细胞结合
公开(公告)号：US20120142088A1
公开(公告)日：2012-06-07
申请号：US13263129
申请日：2010-04-08
申请人： Shih-Chia Hsiao , Matthew B. Francis , Carolyn Bertozzi , Richard Mathies , Ravi Chandra , Erik Douglas , Amy Twite , Nicholas Toriello , Hiroaki Onoe
发明人： Shih-Chia Hsiao , Matthew B. Francis , Carolyn Bertozzi , Richard Mathies , Ravi Chandra , Erik Douglas , Amy Twite , Nicholas Toriello , Hiroaki Onoe
IPC分类号： C12N5/07 , C07H21/00 , C12N5/0789 , C12N5/04
CPC分类号： C12N5/0006 , A61K47/6901
摘要： The present invention provides conjugates of DNA and cells by linking the DNA to a native functional group on the cell surface. The cells can be without cell walls or can have cell walls. The modified cells can be linked to a substrate surface and used in assay or bioreactors.
摘要翻译：本发明通过将DNA与细胞表面上的天然官能团连接来提供DNA和细胞的缀合物。细胞可以没有细胞壁或可以具有细胞壁。修饰的细胞可以连接到底物表面并用于测定或生物反应器中。

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