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1. 发明授权

US4824603A Amphoteric and zwitter-ionic phosphate surfactants 失效
标题翻译：两性和两性离子磷酸盐表面活性剂
公开(公告)号：US4824603A
公开(公告)日：1989-04-25
申请号：US115003
申请日：1987-10-28
申请人： Hinrich Moller , Ulrich Zeidler
发明人： Hinrich Moller , Ulrich Zeidler
IPC分类号： A61K8/55 , A61Q5/02 , A61Q19/10 , B01F17/14 , B01F17/18 , C07F9/09 , C07F9/40 , C11D1/88 , C11D1/62 , C11D1/94
CPC分类号： C11D1/886 , A61K8/55 , A61Q19/10 , A61Q5/02 , C07F9/091
摘要： Amphoteric and zwitter-ionic phosphate surfactants corresponding to the following formula ##STR1## (a) in which R.sup.1 is a C.sub.6 -C.sub.22 alkyl group, a group R.sup.4 (OC.sub.n H.sub.2n).sub.x --, where n=2 to 4, x=1 to 6, and R.sup.4 is a C.sub.6 -C.sub.22 alkyl group, or a group R.sup.5 --CONH(CH.sub.2).sub.m, where R.sup.5 is a C.sub.5 -C.sub.21 group and m=2 to 4; R.sup.2 is hydrogen; and R.sup.3 is a C.sub.1 -C.sub.4 alkyl group or a group --(C.sub.n H.sub.2n O).sub.x --H or --(C.sub.n H.sub.2n O).sub.x --PO.sub.3 H.sub.2, where n=2 to 4 and x=1 to 6, or(b) in which R.sup.1 is a C.sub.1 -C.sub.4 alkyl group or a C.sub.2 -C.sub.4 2-hydroxyalkyl group; R.sup.2 is a C.sub.6 -C.sub.22 alkyl group; and R.sup.3 is as defined above.to mixtures thereof with correspondingly substituted phosphate surfactants corresponding to formula (I), in which the --PO.sub.3 H.sub.2 group or groups are replaced by hydrogen; and to neutral and basic salts of the foregoing. The invention also relates to processes for the manufacture of the above surfactants, and to their use as skin-compatible washing-active components in body shampoos and hair shampoos.
摘要翻译：对应于下列式（Ⅰ）（a）的两性和两性离子型磷酸酯表面活性剂，其中R 1为C 6 -C 22烷基，R 4（OC n H 2n）x - ，其中n = 2至4，x = 1〜6，R4为C6〜C22烷基，R5〜CONH（CH2）m基，R5为C5-C21基，m = 2〜4; R2是氢; R3为C1-C4烷基或 - （CnH2nO）xH或 - （CnH2nO）x-PO3H2，其中n = 2〜4，x = 1〜6，或（b）其中R1为C1- C4烷基或C2-C42-羟烷基; R2是C6-C22烷基; 并且R 3如上所定义。与对应于式（I）的相应取代的磷酸盐表面活性剂的混合物，其中-PO 3 H 2基团被氢取代; 以及前述的中性和碱性盐。本发明还涉及制造上述表面活性剂的方法，以及它们在人体洗发剂和洗发剂中作为皮肤相容的洗涤活性成分的用途。

2. 发明授权

US4382765A Method of moisturizing the skin with carbamide acid esters 失效
标题翻译：用氨基酸酯保湿皮肤的方法
公开(公告)号：US4382765A
公开(公告)日：1983-05-10
申请号：US206974
申请日：1980-11-14
申请人： Hinrich Moller , Rainer Osberghaus , Manfred Budnowski
发明人： Hinrich Moller , Rainer Osberghaus , Manfred Budnowski
IPC分类号： A61K8/72 , A61K20060101 , A61K8/40 , A61K8/44 , A61K8/49 , A61K8/92 , A61K8/97 , A61K47/00 , A61Q17/00 , A61Q19/00 , C07C20060101 , C07C271/06 , C07D263/20 , C11D3/32 , C11D9/30 , A61K7/42 , A61K7/15
CPC分类号： A61K8/44 , A61K8/0212 , A61K8/49 , A61Q17/00 , A61Q19/00 , A61Q17/04 , A61Q19/002 , A61Q19/10 , Y10S514/938
摘要： Skin-care, skin-protection, and skin-cleaning agent compositions containing as a skin-moisturizing agent at least one substituted carbamide acid ester, said substituted carbamide acid ester having the formula ##STR1## wherein R.sub.1 is a member selected from the group consisting of an alkyl radical, having 1 to 4 carbon atoms, alkylol having 2 to 4 carbon atoms and alkyldiol having 3 to 4 carbon atoms, R.sub.2 is a hydroxyalkyl having 2 to 6 carbon atoms and having 1 to 5 hydroxyl groups, or R.sub.2, together with R.sub.1, is an alkylene having 2 to 4 carbon atoms in its chain, which is optionally substituted by lower alkyl and/or lower hydroxyalkyl radicals, and R.sub.3 is a member selected from the group consisting of hydrogen, alkyl having 1 to 4 carbon atoms and hydroxyalkyl having 2 to 4 carbon atoms, or an N-alkenyl polymer of the above cyclic carbamide acid ester, where R.sub.1 and R.sub.2 are alkylene and R.sub.3 is alkenyl having 2 to 4 carbon atoms, as well as a process for protecting the skin utilizing this composition.
摘要翻译：皮肤保护剂，皮肤保护剂和皮肤清洁剂组合物，其含有至少一种取代的脲酰胺酸酯作为皮肤保湿剂，所述具有式“IMAGE”的取代的脲酰胺酸酯，其中R1是选自的具有1至4个碳原子的烷基，具有2至4个碳原子的烷基醇和具有3至4个碳原子的烷基二醇，R 2是具有2至6个碳原子并具有1至5个羟基的羟烷基，或者R 2一起其中R 1是其链中具有2至4个碳原子的亚烷基，其任选被低级烷基和/或低级羟烷基取代，并且R 3是选自氢，具有1至4个碳原子的烷基和具有2至4个碳原子的羟基烷基，或上述环状氨基甲酸酯的N-烯基聚合物，其中R 1和R 2是亚烷基，R 3是具有2至4个碳原子的烯基，以及利用这个compos 游戏

3. 发明授权

US4146506A Perfume compositions with 4-isopropyl-5,5-dimethyl-1,3-dioxane 失效
标题翻译：含4-异丙基-5,5-二甲基-1,3-二恶烷的香料组合物
公开(公告)号：US4146506A
公开(公告)日：1979-03-27
申请号：US844281
申请日：1977-10-21
申请人： Klaus Bruns , Jens Conrad , Peter Meins , Hinrich Moller , Harald Schnegelberger
发明人： Klaus Bruns , Jens Conrad , Peter Meins , Hinrich Moller , Harald Schnegelberger
IPC分类号： A61K8/49 , A61Q13/00 , C07D319/06 , C11B9/00 , A61K7/46
CPC分类号： C11B9/008 , C07D319/06
摘要： A perfumery composition consisting essentially of from 1% to 50% by weight of a 4-isopropyl-5,5-dimethyl-1,3-dioxane of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually members selected from the group consisting of hydrogen, alkyl having from 1 to 3 carbon atoms and cyclopropyl, and the remainder customary constituents of perfumery compositions; as well as novel 4-isopropyl-5,5-dimethyl-1,3-dioxanes of the above formula wherein both R.sub.1 and R.sub.2 are not simultaneously hydrogen.
摘要翻译：基本上由1重量％至50重量％的式“IMAGE”的4-异丙基-5,5-二甲基-1,3-二恶烷组成的香料组合物，其中R 1和R 2各自独立地选自氢，具有1至3个碳原子的烷基和环丙基，其余是香料组合物的常规成分; 以及上式的新的4-异丙基-5,5-二甲基-1,3-二恶烷，其中R1和R2都不同时为氢。

4. 发明授权

US4032676A N-polyhydroxyalkyl-amino acids, their manufacture and skin treating agents containing the same 失效
标题翻译： N-聚羟基烷基氨基酸，它们的制造和含有它的皮肤处理剂
公开(公告)号：US4032676A
公开(公告)日：1977-06-28
申请号：US534805
申请日：1974-12-20
申请人： Arnold Heins , Hinrich Moller , Rainer Osberghaus
发明人： Arnold Heins , Hinrich Moller , Rainer Osberghaus
IPC分类号： C07D209/20 , A61K8/44 , A61K31/195 , A61Q19/00 , C07C67/00 , C07C227/00 , C07C227/18 , C07C229/12 , C07C229/54 , C07C275/16 , C07C275/62 , C07C279/14 , C07C313/00 , C07C323/58 , C07D233/54 , C07D233/64 , F02B55/10 , A61K31/415
CPC分类号： A61Q19/00 , A61K8/0212 , A61K8/44 , C07C275/16 , C07D233/64 , A61Q17/04 , A61Q19/002 , A61Q19/005
摘要： The present invention relates to N-polyhydroxyalkyl-amino acids of the formula ##STR1## wherein R.sub.1 represents a phenylene or a group of the general formula --CHR.sub.3 --, wherein R.sub.3 represents hydrogen, alkyl, benzyl possibly substituted by a hydroxyl group, hydroxyalkyl, mercaptoalkyl, methylthioalkyl, aminoalkyl, polyhydroxylalkylaminoalkyl, carboxyalkyl, guanidinoalkyl, N-polyhydroxyalkylguanidinoalkyl or a ureidoalkyl group, R.sub.2 represents a CH.sub.2 OH or COOH group, m stands for the integers of 3 or 4 and n for the integer 0, if m = 3, when R.sub.2 is COOH, or 4, or for the number 1, if m = 3 and R.sub.2 represents a CH.sub.2 OH group, their alkali metal salts or possibly substituted ammonium salts; as well as the process of preparing the same and skin care and protection agents containing an effective amount of said N-polyhydroxyalkyl-amino acids.

5. 发明授权

US4021539A Skin treating cosmetic compositions containing N-polyhydroxyalkyl-amines 失效
标题翻译：皮肤处理含有N-多羟基烷基胺的化妆品组合物
公开(公告)号：US4021539A
公开(公告)日：1977-05-03
申请号：US544859
申请日：1975-01-28
申请人： Hinrich Moller , Rainer Osberghaus , Christian Gloxhuber , Siegfried Braig
发明人： Hinrich Moller , Rainer Osberghaus , Christian Gloxhuber , Siegfried Braig
IPC分类号： A61K8/00 , A61K20060101 , A61K8/30 , A61K8/41 , A61K8/49 , A61K8/92 , A61K8/97 , A61Q5/00 , A61Q19/00 , C07C67/00 , C07C213/00 , C07C215/06 , C07D213/14 , C07D295/08 , C07H5/06 , A61K7/15 , A61K7/48
CPC分类号： A61Q19/00 , A61K8/0212 , A61K8/41 , A61Q17/00 , A61Q17/04 , A61Q19/002 , A61Q19/005 , Y10S514/828
摘要： The present invention relates to compositions for the treatment of the skin containing up to 25% by weight of at least one N-polyhydroxyalkyl-amine of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, hydroxy-lower alkyl or aminoalkyl, as well as heterocyclic aminoalkyl, R is the same as R.sub.1 except that both cannot be hydrogen at the same time, R.sub.2 is --CH.sub.2 OH or --COOH, m is the integer 3 or 4, and n is the integer O, or, when m is 3 and R.sub.2 is --CH.sub.2 OH, 1; and the method of skin treatment therewith.
摘要翻译：本发明涉及用于治疗皮肤的组合物，其含有至多25重量％的至少一种下式的N-多羟基烷基胺：其中R 1是氢，低级烷基，羟基 - 低级烷基或氨基烷基，作为作为杂环氨基烷基，R与R1相同，不同之处在于两者不能同时为氢，R2为-CH2OH或-COOH，m为整数3或4，n为整数O，或者当m为 3和R2是-CH 2 OH，1; 及其皮肤处理方法。

6. 发明授权

US4659824A Acid addition products of N-glycidyl compounds 失效
标题翻译： N-缩水甘油基化合物的酸加成产物
公开(公告)号：US4659824A
公开(公告)日：1987-04-21
申请号：US643611
申请日：1984-08-23
申请人： Hinrich Moller
发明人： Hinrich Moller
IPC分类号： A61K31/41 , A61K31/53 , A61P35/00 , C07D249/12 , C07D405/06 , C07D405/14 , C07D403/06 , C07D233/02 , C07D253/06
CPC分类号： C07D405/14 , C07D405/06
摘要： A process for the selective production of defined, partial reaction products of polyfunctional N-glycidyl compounds with hydrohalic acids, pseudohydrohalic acids or acids of phosphorus; mono- or di-ring opening products are obtainable as required. The process is carried out at a pH of from about 2 to 10 which is kept constant within a band of at most 2 units on the pH-scale. N,N'-diglycidyl-N"-(halohydroxypropyl)-urazoles and N-glycidyl-N,N"-bis(halohydroxypropyl) urazoles having pharmaceutical utility are produced in good yield.
摘要翻译：选择性地制备多官能N-缩水甘油基化合物与氢卤酸，假卤代酸或磷酸的定义的部分反应产物的方法; 可根据需要获得单环或二环开口产品。该过程在约2至10的pH下进行，其在pH范围内保持恒定在至多2个单位的带内。具有药用效用的N，N'-二缩水甘油基-N“ - （卤代羟丙基） - 脲和N-缩水甘油基-N，N” - 双（卤代羟丙基）吖唑以良好的产率生产。

7. 发明授权

US4143159A Skin-care agents containing hydroxyalkyl carboxamides and process 失效
标题翻译：含有羟基羰基羧酸的皮肤护理剂和方法
公开(公告)号：US4143159A
公开(公告)日：1979-03-06
申请号：US814049
申请日：1977-07-08
申请人： Hinrich Moller , Rainer Osberghaus
发明人： Hinrich Moller , Rainer Osberghaus
IPC分类号： A61K8/30 , A61K8/42 , A61K8/97 , A61Q19/00 , C11D3/32 , A61K7/48
CPC分类号： A61Q19/00 , A61K8/0212 , A61K8/42 , A61Q17/00 , A61Q17/04 , A61Q19/005 , A61Q19/10 , A61Q9/02 , C11D3/32 , Y10S514/846 , Y10S514/847 , Y10S514/938
摘要： Skin-care, skin-protection, and skin-cleaning agent compositions containing at least one hydroxyalkyl carboxamide as a skin-moisturizing agent, as well as a process for protecting the skin utilizing this composition.

8. 发明授权

US4038418A Process of skin treating with compositions containing polyhydroxyalkylamines 失效
标题翻译：含有聚羟基木质素的组合物的皮肤处理工艺
公开(公告)号：US4038418A
公开(公告)日：1977-07-26
申请号：US572270
申请日：1975-04-28
申请人： Hinrich Moller , Rainer Osberghaus , Christian Gloxhuber , Siegfried Braig
发明人： Hinrich Moller , Rainer Osberghaus , Christian Gloxhuber , Siegfried Braig
IPC分类号： A61K8/30 , A61K20060101 , A61K8/41 , A61K8/92 , A61K8/97 , A61K31/13 , A61Q19/00 , A61K7/00
CPC分类号： A61Q19/00 , A61K8/0212 , A61K8/41 , A61Q17/00 , A61Q17/04 , A61Q19/002 , A61Q19/005 , Y10S514/847
摘要： The present invention relates to compositions for the treatment of the skin containing from 1 to 20% by weight of a polyhydroxyalkylamine having the formula ##STR1## wherein R.sub.1 is a member having 3 to 6 carbon atoms selected from the group consisting of dihydroxyalkyl and trihydroxyalkyl, and R.sub.2 and R.sub.3 are members selected from the group consisting of hydrogen, alkyl having from 1 to 4 carbon atoms, hydroxyalkyl having from 2 to 4 carbon atoms and dihydroxyalkyl having from 3 to 4 carbon atoms, and salts thereof, and the remainder up to 100% by weight inert cosmetic excipients; as well as the method of skin treatment.

9. 发明授权

US4545984A Arene-carboxylic acid derivatives as antiseborrheic additives for cosmetic agents 失效
标题翻译：芳纶羧酸衍生物作为化妆品用抗滑脂添加剂
公开(公告)号：US4545984A
公开(公告)日：1985-10-08
申请号：US444587
申请日：1982-11-15
申请人： Hinrich Moller , Siegfried Wallat , Friedhelm Bartnik
发明人： Hinrich Moller , Siegfried Wallat , Friedhelm Bartnik
IPC分类号： A61F7/00 , A61K8/37 , A61K31/215 , A61K31/235 , A61Q5/00 , A61Q19/00 , C11D3/48 , A61K7/06
CPC分类号： A61Q5/00 , A61K8/37 , A61Q19/008 , A61F2007/0056 , Y10S424/04
摘要： The invention concerns cosmetic agents containing compounds of the general formula (I) ##STR1## in which R.sup.1, R.sup.2 and R.sup.3 represent independently of one another a hydrogen atom, an intermediate alkyl group with 3 to 10 carbon atoms, a halogen atom, preferably a chlorine atom, a hydroxy group, an aryl group, an alkoxy group with 1 to 20 carbon atoms, substituted, if needed, with aryl, hydroxy, amino, alkoxy as well as aryloxy groups, or a carboxyl group esterified with an intermediate-chain alkyl group with 2 to 12 carbon atoms or with an aralkyl group, or two of the radicals R.sup.1 --R.sup.3 represent a naphthalene ring together with the benzene ring, and Y stands for an alkoxy group with 1 to 12 carbon atoms or an aralkoxy group. The compounds are used in amounts of 0.01 to 20, preferably 1 to 10, percent by weight, calculated with regard to the total preparation.
摘要翻译： PCT No.PCT / EP82 / 00109 Sec。 371日期：1982年11月15日 102（e）1982年11月15日日期PCT提交1982年5月21日PCT公布。公开号WO82 / 04189 日本1982年12月9日。本发明涉及含有通式（I）化合物（I）的化妆品，其中R 1，R 2和R 3彼此独立地表示氢原子，中间体烷基具有3〜 10个碳原子，卤素原子，优选氯原子，羟基，芳基，具有1至20个碳原子的烷氧基，如果需要，与芳基，羟基，氨基，烷氧基以及芳氧基取代，或具有2〜12个碳原子的中间链烷基或芳烷基酯化的羧基，或者R 1〜R 3中的两个与苯环一起表示萘环，Y表示与 1至12个碳原子或芳烷氧基。相对于总制剂计算，化合物的用量为0.01至20重量份，优选1至10重量％。

10. 发明授权

US4528286A Method of using certain aryl-mercapto-lower-alkanamides as antiseborrheic agents 失效
标题翻译：使用某些芳基 - 巯基 - 低级烷酰胺作为抗脂溢剂的方法
公开(公告)号：US4528286A
公开(公告)日：1985-07-09
申请号：US444588
申请日：1982-11-15
申请人： Hinrich Moller , Siegfried Wallat
发明人： Hinrich Moller , Siegfried Wallat
IPC分类号： C07C323/60 , A61K8/00 , A61K8/46 , A61K8/49 , A61K31/16 , A61Q5/00 , A61Q5/02 , C07C67/00 , C07C313/00 , C07C323/52 , C07C323/59 , C07D213/00 , C07D213/70 , C07D213/89 , C07D235/28 , C07D263/00 , C07D263/58 , C07D277/74 , C11D3/48 , A61K7/06 , A61K7/48
CPC分类号： C07D277/74 , A61K8/46 , A61K8/49 , A61K8/4933 , A61K8/4946 , A61Q19/008 , A61Q5/00 , C07C323/00 , C07D213/70 , C07D235/28 , C07D263/58
摘要： Aryl-mercapto-lower-alkanamides having the following formula ##STR1## wherein R.sup.1 is selected from the group consisting of phenyl, C.sub.1-4 -alkylphenyl, halophenyl, hydroxyphenyl, C.sub.1-4 -alkoxyphenyl, aminophenyl, acetamidophenyl, naphthyl, diphenyl; R.sup.2 and R.sup.3, independently represent hydrogen or C.sub.1-14 -alkyl; Y represents NR.sup.4 R.sup.5 wherein R.sup.4 and R.sup.5 independently represent hydrogen, C.sub.1 -6-alkyl, C.sub.2-3 -hydroxyalkyl, benzyl, anilyl, and taken together represent piperidyl or morpholinyl are useful for reducing cell sebum production in a mammal in the form of a topical cosmetic preparation.
摘要翻译： PCT No.PCT / EP82 / 00111 Sec。 371日期：1982年11月15日 102（e）1982年11月15日日期PCT提交1982年5月21日PCT公布。第WO82 / 04391号公报日本1982年12月23日。具有下式的酰基 - 巯基 - 低级烷酰胺：其中R 1选自苯基，C 1-4 - 烷基苯基，卤代苯基，羟基苯基，C 1-4烷氧基苯基，氨基苯基，乙酰氨基苯基，萘基，二苯基; R2和R3独立地表示氢或C1-14烷基; Y表示NR4R5，其中R4和R5独立地表示氢，C1-6-烷基，C2-3-羟基烷基，苄基，苯乙烯基，并且代表哌啶基或吗啉基可用于以局部的形式减少哺乳动物的细胞皮脂产生化妆品制剂。

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