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1. 发明申请

US20170333487A1 METHODS OF CARDIAC REPAIR 审中-公开
公开(公告)号：US20170333487A1
公开(公告)日：2017-11-23
申请号：US15662755
申请日：2017-07-28
申请人： Hina W. Chaudhry
发明人： Hina W. Chaudhry
IPC分类号： A61K35/50 , A61K35/12
CPC分类号： A61K35/50 , A61K35/12
摘要： Provided herein is a new method to isolate and expand cardiac progenitor/stem cells from a placenta, which produces a cell population enriched in multipotent functional progenitor/stem cells. Cardiac progenitor/stem cells isolated by this method maintain their self-renewal character in vitro and differentiate into normal cells in myocardium, including cardiomyocytes, endothelial cells, and smooth muscle cells, after transplantation into ischemic hearts. Also provided in this application are substantially pure populations of multipotent cardiac progenitor/stem cells, and their use to treat and prevent diseases and injuries, including those resulting from myocardial infarction. A model for assessing the potential of cardiac stem cells for treatment of myocardial infarction is also provided.

2. 发明授权

US07645734B2 Compositions and methods for treating and preventing heart tissue degeneration and uses thereof 有权
标题翻译：用于治疗和预防心脏组织变性的组合物和方法及其用途
公开(公告)号：US07645734B2
公开(公告)日：2010-01-12
申请号：US11267431
申请日：2005-11-04
申请人： Hina W. Chaudhry , Debra J. Wolgemuth
发明人： Hina W. Chaudhry , Debra J. Wolgemuth
IPC分类号： A61K38/00 , C07K14/00
CPC分类号： A61K38/1703 , A61K38/12 , A61K38/1709 , G01N33/567 , G01N33/6893 , G01N2333/4739 , G01N2800/32
摘要： The present invention provides compositions useful for cardiac therapy comprising a cyclin-associated agent. The present invention also provides kits for use in delivering a cyclin-associated agent to cardiac cells in a subject, comprising the composition of the present invention and a catheter. The present invention additionally provides a methods for enhancing cardiac function; promoting regeneration of cardiac tissue; inducing endogenous myocardial regeneration; and preventing or treating heart failure in a subject in need thereof by augmenting cyclin in cells.
摘要翻译：本发明提供了可用于包括细胞周期蛋白相关药物的心脏治疗的组合物。本发明还提供用于将细胞周期蛋白相关试剂递送至受试者心脏细胞的试剂盒，其包含本发明的组合物和导管。本发明另外提供了增强心脏功能的方法; 促进心脏组织再生; 诱导内源性心肌再生; 并通过增加细胞中的细胞周期蛋白来预防或治疗有需要的受试者的心力衰竭。

3. 发明授权

US08221740B2 Side population cells in cardiac repair 有权
标题翻译：侧面细胞在心脏修复
公开(公告)号：US08221740B2
公开(公告)日：2012-07-17
申请号：US11535444
申请日：2006-09-26
申请人： Hina W. Chaudhry , Debra J. Wolgemuth
发明人： Hina W. Chaudhry , Debra J. Wolgemuth
IPC分类号： A61K48/00 , A61K43/04 , A01N63/00 , A01N43/04
CPC分类号： C12N5/0663 , A61K35/34 , A61K38/1709 , A61K48/005 , A61K48/0075 , A61K2300/00
摘要： It has been discovered that side-population cells induce cardiac tissue repair of infarcted myocardium. Provided herein are methods directed to treatment of cardiac injury using side-population cells.
摘要翻译：已发现侧群细胞诱导梗死心肌的心脏组织修复。本文提供了使用侧群细胞治疗心脏损伤的方法。

4. 发明授权

US08217157B2 Compositions and methods for treating and preventing heart tissue degeneration, and uses thereof 有权
标题翻译：用于治疗和预防心脏组织变性的组合物和方法及其用途
公开(公告)号：US08217157B2
公开(公告)日：2012-07-10
申请号：US10557873
申请日：2004-05-18
申请人： Hina W. Chaudhry , Debra J. Wolgemuth
发明人： Hina W. Chaudhry , Debra J. Wolgemuth
IPC分类号： C07H21/02 , C07H21/04 , A61K48/00
CPC分类号： A61K38/1703 , A61K38/12 , A61K38/1709 , G01N33/567 , G01N33/6893 , G01N2333/4739 , G01N2800/32
摘要： The present invention provides methods for promoting generation of heart tissue, and for treating and preventing heart tissue degeneration. Additionally, the present invention provides a therapeutic composition comprising a cyclin-associated agent, and a kit comprising the composition. The present invention further provides a heart tissue cell, a sidepopulation progenitor cell, and a stem cell in which cyclin is augmented. Also provided are cell lines comprising these cells, screening methods using the cell lines, and drugs identified by these methods. The present invention further provides in vitro systems for use in screening candidate drugs for at least one cardiotoxic effect and/or for synergy with cyclin in the treatment and prevention of heart tissue degeneration. Finally, the present invention provides use of a cyclin-associated agent in the generation of heart tissue, and use of a cyclin associated agent in the treatment or prevention of heart tissue degeneration.
摘要翻译：本发明提供促进心脏组织产生，以及治疗和预防心脏组织变性的方法。另外，本发明提供了包含细胞周期蛋白相关药物的治疗组合物和包含该组合物的试剂盒。本发明还提供了一种心脏组织细胞，侧支祖细胞和其中增殖细胞周期蛋白的干细胞。还提供了包含这些细胞的细胞系，使用细胞系的筛选方法以及通过这些方法鉴定的药物。本发明进一步提供用于筛选候选药物至少一种心脏毒性作用的体外系统和/或用于与细胞周期蛋白协同治疗和预防心脏组织变性的体外系统。最后，本发明提供细胞周期蛋白相关药物在产生心脏组织中的用途，以及细胞周期蛋白相关药物在治疗或预防心脏组织变性中的用途。

5. 发明申请

US20130142762A1 METHODS OF CARDIAC REPAIR 审中-公开
标题翻译：心脏修复方法
公开(公告)号：US20130142762A1
公开(公告)日：2013-06-06
申请号：US13671396
申请日：2012-11-07
申请人： Hina W. CHAUDHRY
发明人： Hina W. CHAUDHRY
IPC分类号： A61K35/50 , A61K35/12
CPC分类号： A61K35/50 , A61K35/12
摘要： Provided herein is a new method to isolate and expand cardiac progenitor/stem cells from a placenta, which produces a cell population enriched in multipotent functional progenitor/stem cells. Cardiac progenitor/stem cells isolated by this method maintain their self-renewal character in vitro and differentiate into normal cells in myocardium, including cardiomyocytes, endothelial cells, and smooth muscle cells, after transplantation into ischemic hearts. Also provided in this application are substantially pure populations of multipotent cardiac progenitor/stem cells, and their use to treat and prevent diseases and injuries, including those resulting from myocardial infarction. A model for assessing the potential of cardiac stem cells for treatment of myocardial infarction is also provided.
摘要翻译：本文提供了一种从胎盘分离和扩增心脏祖细胞/干细胞的新方法，其产生富含多能功能性祖细胞/干细胞的细胞群。通过该方法分离的心脏祖细胞/干细胞在体外维持其自我更新特征，并在移植到缺血性心脏中后分化成心肌中的正常细胞，包括心肌细胞，内皮细胞和平滑肌细胞。本申请中还提供了基本上纯粹的多能心脏祖细胞/干细胞群，以及它们用于治疗和预防疾病和损伤的用途，包括由心肌梗死引起的疾病和损伤。还提供了用于评估心脏干细胞用于治疗心肌梗塞的潜力的模型。

6. 发明申请

US20130011373A1 SIDE POPULATION CELLS IN CARDIAC REPAIR 审中-公开
标题翻译： CARDIAC修复中的侧面人口细胞
公开(公告)号：US20130011373A1
公开(公告)日：2013-01-10
申请号：US13523010
申请日：2012-06-14
申请人： Hina W. Chaudhry , Debra J. Wolgemuth
发明人： Hina W. Chaudhry , Debra J. Wolgemuth
IPC分类号： A61K35/12 , A61K35/32 , A61P9/12 , A61K35/34 , A61P9/00 , A61P9/10
CPC分类号： C12N5/0663 , A61K35/34 , A61K38/1709 , A61K48/005 , A61K48/0075 , A61K2300/00
摘要： It has been discovered that side-population cells induce cardiac tissue repair of infarcted myocardium. Provided herein are methods directed to treatment of cardiac injury using side-population cells.
摘要翻译：已发现侧群细胞诱导梗死心肌的心脏组织修复。本文提供了使用侧群细胞治疗心脏损伤的方法。

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