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1. 发明申请

US20130143236A1 METHOD FOR DETERMINING SENSITIVITY OF TUMOR CELLS TO DASATINIB AND COMPUTER PROGRAM 审中-公开
标题翻译：用于确定肿瘤细胞对DASATINIB和计算机程序的灵敏度的方法
公开(公告)号：US20130143236A1
公开(公告)日：2013-06-06
申请号：US13689193
申请日：2012-11-29
申请人： Masaaki KAWAI , Yasuhiro TORIKOSHI , Keigo GOHDA , Hideki ISHIHARA
发明人： Masaaki KAWAI , Yasuhiro TORIKOSHI , Keigo GOHDA , Hideki ISHIHARA
IPC分类号： C12Q1/02
CPC分类号： C12Q1/025 , C12Q1/485 , G01N33/5011
摘要： The present invention provides a method for determining sensitivity of tumor cells to dasatinib by evaluating inhibitory capacity of a predetermined tyrosine kinase inhibitor in a measurement sample which is prepared from a biological sample containing tumor cells and a computer program.
摘要翻译：本发明提供了一种通过评估由含有肿瘤细胞的生物样品和计算机程序制备的测量样品中预定的酪氨酸激酶抑制剂的抑制能力来确定肿瘤细胞对达沙替丁的敏感性的方法。

2. 发明授权

US08131520B2 Cancer diagnostic device 有权
标题翻译：癌症诊断装置
公开(公告)号：US08131520B2
公开(公告)日：2012-03-06
申请号：US12286699
申请日：2008-10-01
申请人： Hideki Ishihara , Tomoko Matsushima
发明人： Hideki Ishihara , Tomoko Matsushima
IPC分类号： G06F7/60 , G06F19/00 , G06F15/00 , C12Q1/25
CPC分类号： G01N33/57484 , C12Q1/485 , G01N2333/9121 , G01N2800/52 , G06F19/20 , G06F19/24
摘要： A device for supporting a diagnosis of a cancer which provides information useful to decide whether or not an anthracycline anticancer drug should be administered to a cancer patient to be examined is disclosed. Concretely, the device is composed to be able to acquire an activity and an expression of two cyclin dependent kinases (CDK) from a malignant tumor of a cancer patient to be examined, and to acquire a CDK parameters from both of two CDKs. Furthermore the device determines sample data comprising predetermined CDK parameter, and display information of determined sample data. According to the above component, user is easily able to know whether or not a cancer of a cancer patient, whose tumor is similar to the tumor of the cancer patient to be examined, has been recurred in spite of an administration of an anthracycline anticancer drug.
摘要翻译：公开了一种用于支持癌症诊断的装置，其提供用于决定是否向被检查的癌症患者施用蒽环类抗癌药物的信息。具体地说，该装置构成为能够从要检查的癌症患者的恶性肿瘤获得两种细胞周期蛋白依赖性激酶（CDK）的活性和表达，并从两种CDK中获得CDK参数。此外，设备确定包括预定CDK参数的样本数据，以及确定的样本数据的显示信息。根据上述成分，使用者能够容易地知道尽管施用了蒽环类抗癌药物，癌肿瘤患者的肿瘤是否与待检查的癌症患者的肿瘤相似。。

3. 发明申请

US20110246413A1 METHOD FOR JUDGING RISK OF CANCER RECURRENCE, COMPUTER PROGRAM, AND COMPUTER SYSTEM 有权
标题翻译：判断癌症复发风险的方法，计算机程序和计算机系统
公开(公告)号：US20110246413A1
公开(公告)日：2011-10-06
申请号：US13074745
申请日：2011-03-29
申请人： Masaki SHIBAYAMA , Hideki Ishihara , Keigo Gohda , Satoshi Nakayama , Tadashi Kiniwa
发明人： Masaki SHIBAYAMA , Hideki Ishihara , Keigo Gohda , Satoshi Nakayama , Tadashi Kiniwa
IPC分类号： G06N5/04 , C12Q1/48
CPC分类号： G06F19/18 , G01N33/57496 , G01N2800/54
摘要： A method for judging a risk of cancer recurrence comprising: acquiring an activity value and expression level of a first cyclin dependent kinase (CDK) of a cell contained in tissues extracted from cancer patients, an activity value and expression level of a second CDK, and a number of Ki67-expressing cells or an expression level of Ki67; and judging a risk of cancer recurrence based on the acquired activity value and expression level of the first CDK, the activity value and expression level of the second CDK, and a percentage of Ki67-expressing cells or the expression level of Ki67. A computer program product and a computer system are also disclosed.
摘要翻译：一种判断癌症复发风险的方法，包括：获得癌症患者提取的组织中含有的细胞的第一细胞周期蛋白依赖性激酶（CDK）的活性值和表达水平，第二CDK的活性值和表达水平，以及多个Ki67表达细胞或Ki67表达水平; 根据获得的第一CDK的活性值和表达水平，第二CDK的活性值和表达量以及Ki67表达细胞的百分比或Ki67的表达水平来判断癌症复发的风险。还公开了一种计算机程序产品和计算机系统。

4. 发明授权

US07754442B2 Reagent kit for determining characteristic of tissue 失效
标题翻译：用于确定组织特征的试剂盒
公开(公告)号：US07754442B2
公开(公告)日：2010-07-13
申请号：US11529998
申请日：2006-09-29
申请人： Hideki Ishihara , Satoshi Nakayama , Yuko Kawasaki , Aya Katayama
发明人： Hideki Ishihara , Satoshi Nakayama , Yuko Kawasaki , Aya Katayama
IPC分类号： G01N33/53
CPC分类号： C12Q1/485 , G01N2333/912 , Y10S435/81 , Y10S436/808
摘要： A reagent kit that is used for determining a characteristic of tissue obtained from a patient is described. The reagent kit comprising expression measurement reagents for measuring expression level of cyclin-dependant kinase (CDK) and activity measurement reagents for measuring activity value of CDK. The expression measurement reagents comprise first reagents and second reagents, and the activity measurement reagents comprise third reagents and fourth reagents. In the reagent kit, a first reagent set of the first and third reagents is stored under a first storage condition relating to temperature, and a second reagent set of the second and fourth reagents is stored under a second storage condition relating to temperature.
摘要翻译：描述了用于确定从患者获得的组织特征的试剂盒。该试剂盒包含用于测量细胞周期蛋白依赖性激酶（CDK）的表达水平的表达测量试剂和用于测量CDK的活性值的活性测量试剂。表达测量试剂包含第一试剂和第二试剂，活性测量试剂包括第三试剂和第四试剂。在试剂盒中，第一和第三试剂的第一试剂组在与温度有关的第一储存条件下储存，第二和第四试剂的第二试剂组在与温度有关的第二储存条件下储存。

5. 发明申请

US20100147132A1 ELECTRONIC KEYBOARD INSTRUMENT 有权
标题翻译：电子键盘仪表
公开(公告)号：US20100147132A1
公开(公告)日：2010-06-17
申请号：US12640632
申请日：2009-12-17
申请人： Akiko Shinjo , Hideki Ishihara , Takashi Kato , Takashi Fujita
发明人： Akiko Shinjo , Hideki Ishihara , Takashi Kato , Takashi Fujita
IPC分类号： G10C3/06
CPC分类号： G10H1/32
摘要： An electronic keyboard instrument in which the efficiency of sound emission is enhanced by preventing a soundboard portion having a large vibration amplitude from being hidden by a musical score plate to make sound emission of the soundboard to be hardly hindered by the musical score plate. A musical stand device is disposed rearward of a key-depression part of a keyboard and right above the soundboard, and has a musical score plate disposed close to and parallel to an upper surface of the soundboard when the musical score plate is in a fallen state. The soundboard is excited for sound production by transducers disposed on a lower surface of the soundboard. The transducers are disposed at positions where the transducers do not overlap, as viewed in plan, the musical score plate which is in the fallen state.
摘要翻译：一种电子键盘乐器，其中通过防止具有较大振动振幅的音板部分被音乐记号板隐藏而增强了声音发射的效率，使得音板的声音发射几乎不受音乐记录板的阻碍。音乐台装置设置在键盘的按键部分的正后方的正上方，并且当乐谱板处于跌落状态时具有靠近并平行于音板上表面的乐谱板。通过放置在音板下表面的传感器，音板可以很好地发声。换能器设置在换能器不重叠的位置，如在计划中所看到的处于坠落状态的乐谱。

6. 发明申请

US20100068743A1 Method for predicting response of cancer patient to anticancer drug treatment 审中-公开
标题翻译：预测癌症患者抗癌药物治疗反应的方法
公开(公告)号：US20100068743A1
公开(公告)日：2010-03-18
申请号：US12584357
申请日：2009-09-02
申请人： Armando E. Giuliano , Dave S. Hoon , Hideki Ishihara
发明人： Armando E. Giuliano , Dave S. Hoon , Hideki Ishihara
IPC分类号： C12Q1/48
CPC分类号： G01N33/5011 , C12Q1/485 , G01N33/57484 , G01N2800/52 , G01N2800/60
摘要： A method predicts a response of a cancer patient to anticancer drug based on a cell cycle profile score obtained by analyzing a malignant tumor of the cancer patient, wherein the method can predict a disease outcome including a complete response, a partial response, stable disease, no response, and time to progression of disease as patient's response to anticancer drug therapy.
摘要翻译：一种方法基于通过分析癌症患者的恶性肿瘤而获得的细胞周期分布评分来预测癌症患者对抗癌药物的反应，其中所述方法可以预测包括完全反应，部分反应，稳定疾病，没有反应，以及随着患者对抗癌药物治疗的反应，疾病进展的时间。

7. 发明申请

US20090248316A1 METHOD FOR SUPPORTING A DIAGNOSIS OF AN EFFECT OF A TREATMENT BY USING ANTHRACYCLINE ANTICANCER DRUGS AND A DEVICE FOR SUPPORTING A DIAGNOSIS FOR AN EFFECT OF A TREATMENT BY USING ANTHRACYCLINE ANTICANCER DRUGS 失效
标题翻译：通过使用蒽环类抗生素药物来治疗治疗效果的诊断方法和用于支持通过使用安非他酮类抗生素治疗药物治疗效果的装置的方法
公开(公告)号：US20090248316A1
公开(公告)日：2009-10-01
申请号：US12242500
申请日：2008-09-30
申请人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
发明人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
IPC分类号： G06F19/00
CPC分类号： G01N33/57484 , G01N2333/912 , G01N2800/52
摘要： A method of supporting a diagnosis of an effect of a treatment by using anthracycline anticancer drugs is disclosed. The method provides a new value for judging an effect, a judgment score, which is calculated based on expression levels and activity values of two cyclin dependent kinases (CDKs). The effect of the treatment by using anthracycline anticancer drugs is judged by comparing the judgment score with a predetermined threshold level.
摘要翻译：公开了一种通过使用蒽环类抗癌药来支持治疗效果的诊断方法。该方法提供了用于判断效果的新值，根据两种细胞周期蛋白依赖性激酶（CDK）的表达水平和活性值计算出的判断评分。通过将判断分数与预定阈值水平进行比较来判断使用蒽环类抗癌药物的治疗效果。

8. 发明申请

US20090246784A1 METHOD OF ANALYZING METHYLATED DNA 有权
标题翻译：分析甲基化DNA的方法
公开(公告)号：US20090246784A1
公开(公告)日：2009-10-01
申请号：US12403167
申请日：2009-03-12
申请人： Ayako SAKAI , Masahiro Kajita , Hideki Ishihara
发明人： Ayako SAKAI , Masahiro Kajita , Hideki Ishihara
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6827 , C12Q2521/331 , C12Q2531/113
摘要： The present invention provides a method of analyzing methylated DNA, comprising steps of: (A) treating a DNA-containing sample with a restriction enzyme to obtain a sample containing a DNA fragment; (B) concentrating methylated DNA contained in the sample obtained in step (A) to obtain a methylated DNA concentrate; (C) subjecting the methylated DNA concentrate obtained in step (B) and a primer set to nucleic acid amplification reaction, wherein the primer set performs the nucleic acid amplification reaction in step (C) by using a template DNA which does not have a CpG site; (D) detecting an amplification product obtained in step (C); (E) judging whether the methylated DNA concentrate obtained in step (B) is appropriate as a sample for detection of methylated DNA, on the basis of the detection result of the amplification product in step (D); and(F) analyzing the methylated DNA contained in the methylated DNA concentrate.
摘要翻译：本发明提供一种分析甲基化DNA的方法，包括以下步骤：（A）用限制酶处理含有DNA的样品，得到含有DNA片段的样品; （B）浓缩步骤（A）中获得的样品中所含的甲基化DNA以获得甲基化DNA浓缩物; （C）使步骤（B）中获得的甲基化DNA浓缩物和引物组进行核酸扩增反应，其中引物组通过使用不具有CpG的模板DNA进行步骤（C）中的核酸扩增反应现场; （D）检测步骤（C）中获得的扩增产物; （E）基于步骤（D）中的扩增产物的检测结果判断步骤（B）中获得的甲基化DNA浓缩物是否适合作为检测甲基化DNA的样品; 和（F）分析甲基化DNA浓缩物中所含的甲基化DNA。

9. 发明申请

US20090105960A1 Device for supporting diagnosis of a cancer and a device for predicting an effects of anthracycline anticancer drugs 有权
标题翻译：用于支持癌症诊断的装置和用于预测蒽环类抗癌药物的作用的装置
公开(公告)号：US20090105960A1
公开(公告)日：2009-04-23
申请号：US12286699
申请日：2008-10-01
申请人： Hideki Ishihara , Tomoko Matsushima
发明人： Hideki Ishihara , Tomoko Matsushima
IPC分类号： G01N33/48
CPC分类号： G01N33/57484 , C12Q1/485 , G01N2333/9121 , G01N2800/52 , G06F19/20 , G06F19/24
摘要： A device for supporting a diagnosis of a cancer which provides information useful to decide whether or not an anthracycline anticancer drug should be administered to a cancer patient to be examined is disclosed. Concretely, the device is composed to be able to acquire an activity and an expression of two cyclin dependent kinases (CDK) from a malignant tumor of a cancer patient to be examined, and to acquire a CDK parameters from both of two CDKs. Furthermore the device determines sample data comprising predetermined CDK parameter, and display information of determined sample data. According to the above component, user is easily able to know whether or not a cancer of a cancer patient, whose tumor is similar to the tumor of the cancer patient to be examined, has been recurred in spite of an administration of an anthracycline anticancer drug.
摘要翻译：公开了一种用于支持癌症诊断的装置，其提供用于决定是否向被检查的癌症患者施用蒽环类抗癌药物的信息。具体地说，该装置构成为能够从要检查的癌症患者的恶性肿瘤获得两种细胞周期蛋白依赖性激酶（CDK）的活性和表达，并从两种CDK中获得CDK参数。此外，设备确定包括预定CDK参数的样本数据，以及确定的样本数据的显示信息。根据上述成分，使用者能够容易地知道尽管施用了蒽环类抗癌药物，癌肿瘤患者的肿瘤是否与待检查的癌症患者的肿瘤相似。。

10. 发明申请

US20080273842A1 Optical Connector 有权
标题翻译：光连接器
公开(公告)号：US20080273842A1
公开(公告)日：2008-11-06
申请号：US11990026
申请日：2006-08-30
申请人： Hiroshi Tanaka , Mitsuo Kama , Hiroshi Aoyama , Yasuo Oda , Ryo Nagase , Hideki Ishihara , Fumihiro Ashiya , Shinichi Iwano
发明人： Hiroshi Tanaka , Mitsuo Kama , Hiroshi Aoyama , Yasuo Oda , Ryo Nagase , Hideki Ishihara , Fumihiro Ashiya , Shinichi Iwano
IPC分类号： G02B6/36
CPC分类号： G02B6/3849 , G02B6/3821 , G02B6/3869
摘要： An optical connector comprising: first and second movable members 7, 8 held on an optical connector body 6 to be axially movable in a longitudinal direction; locking means for locking the first and second movable members when the first movable member is located at a predetermined locking position in a tip part of the optical connector body, and integrally moving the first and second movable members; and unlocking means formed in the optical connector body 6, and including a locking acting portion which acts on the locking means when the first movable member is located rearwardly of a predetermined unlocking position in a rear part of the optical connector body, to unlock the first and second movable members, and which locks the first and second movable members when the first movable member is located forwardly of the unlocking position, and a second movable member hooking portion 10 for inhibiting rearward movement of the second movable member after the first and second movable members are unlocked, and wherein the second movable member has a functional portion having a predetermined function, and when the second movable member is located at a predetermined position in the optical connector body, the function acts on a ferrule 2 or an optical fiber 1 to fulfill the function.
摘要翻译：一种光学连接器，包括：保持在光学连接器主体6上的第一和第二可动构件7,8，以沿纵向轴向移动; 锁定装置，用于当第一可移动部件位于光连接器主体的顶端部分中的预定锁定位置时锁定第一和第二可移动部件，并且一体地移动第一和第二可移动部件; 以及形成在光连接器主体6中的解锁装置，并且包括当第一可移动部件位于光连接器主体的后部中的预定解锁位置的后方时作用在锁定装置上的锁定作用部分，以解锁第一和第二可动构件，并且当第一可动构件位于解锁位置的前方时锁定第一和第二可移动构件;以及第二可动构件钩部10，用于在第一和第二可移动构件之后禁止第二可动构件的向后运动构件被解锁，并且其中第二可移动构件具有具有预定功能的功能部分，并且当第二可移动构件位于光学连接器主体中的预定位置时，该功能作用在套圈2或光纤1至履行功能。

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