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1. 发明授权

US07365174B2 Azalide and azalactam derivatives and method for producing the same 失效
标题翻译：氮杂吲哚衍生物及其制备方法
公开(公告)号：US07365174B2
公开(公告)日：2008-04-29
申请号：US10569063
申请日：2004-08-20
申请人： Tomoaki Miura , Kenichi Kanemoto , Satomi Natsume , Naoto Ohkura , Yumiko Fujihira , Takashi Watanabe , Hideki Fushimi , Kunio Atsumi , Keiichi Ajito
发明人： Tomoaki Miura , Kenichi Kanemoto , Satomi Natsume , Naoto Ohkura , Yumiko Fujihira , Takashi Watanabe , Hideki Fushimi , Kunio Atsumi , Keiichi Ajito
IPC分类号： C07H17/08
CPC分类号： A61K31/7052 , C07H15/04 , C07H17/00
摘要： Compounds represented by the general formula (1) or pharmaceutically acceptable salts thereof, effective in the prevention and/or treatment of infections with microbes: (1) (a) wherein R1 is hydrogen or straight-chain C1-6 alkylcarbonyl; R2 is hydrogen or C1-6 alkylcarbonyl; R3 is hydrogen, C1-6 alkyl, C1-6 alkylcarbonyl, C1-6 alkenyl, C2-6 alkenylcarbonyl, C2-6 alkynyl, or an Ar—B— group (wherein Ar is aryl or a heterocyclic group; and B is C1-6 alkyl, C1-6 alkylcarbonyl, C2-6 alkenyl, C2-6 alkenylcarbonyl, or C2-6 alkynyl); R5, R6, R7 and R8 are each hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, or an Ar—B′— group (wherein B′ is C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl); X is oxygen or —NR4— (wherein R4 is hydrogen, C1-6 alkyl or C1-6 alkyl which may be substituted with Ar); and R4′ is hydrogen or a group represented by the general formula (a) (wherein R3″ and R4″ are each hydrogen or straight-chain or branched C1-6 alkylcarbonyl)
摘要翻译：由通式（1）表示的化合物或其药学上可接受的盐在预防和/或治疗微生物感染方面有效：（1）（a）其中R 1是氢或直链 C 1-6烷基羰基; R 2是氢或C 1-6烷基羰基; R 3是氢，C 1-6烷基，C 1-6 - 烷基羰基，C 1-6 - 烯基，C 2-6链烯基羰基，C 2-6炔基或Ar-B基（其中Ar为芳基或杂环基; B为C

2. 发明申请

US20070042974A1 Nozel azalide and azalactam derivatives and method for producing the same 失效
标题翻译：诺贝尔氮杂和吖内酰胺衍生物及其制备方法
公开(公告)号：US20070042974A1
公开(公告)日：2007-02-22
申请号：US10569063
申请日：2004-08-20
申请人： Tomoaki Miura , Kenichi Kanemoto , Satomi Natsume , Naoto Ohkura , Yumiko Fujihira , Takashi Watanabe , Hideki Fushimi , Kunio Atsumi , Keiichi Ajito
发明人： Tomoaki Miura , Kenichi Kanemoto , Satomi Natsume , Naoto Ohkura , Yumiko Fujihira , Takashi Watanabe , Hideki Fushimi , Kunio Atsumi , Keiichi Ajito
IPC分类号： A61K31/7052 , C07H17/08
CPC分类号： A61K31/7052 , C07H15/04 , C07H17/00
摘要： A compound represented by the following general formula (1) or a pharmaceutically acceptable salt thereof, which is useful for a prophylactic and/or therapeutic treatment of a microbial infectious disease. [R1 is hydrogen atom, or a linear C1-6 alkylcarbonyl group; R2 is hydrogen atom, or a C1-6 alkylcarbonyl group; R3 is hydrogen atom, a C1-6 alkyl group, a C1-6 alkylcarbonyl group, a C1-6 alkenyl group, a C2-6 alkenylcarbonyl group, a C2-6 alkynyl group, or an Ar—B— group (Ar represents an aryl group, or a heterocyclic group, and B is a C1-6 alkyl group, a C1-6 alkylcarbonyl group, a C2-6 alkenyl group, a C2-6 alkenylcarbonyl group, or a C2-6 alkynyl group); R5, R6, R7, and R8 represent hydrogen atom, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, or an Ar—B′— group (B′ is a C1-6 alkyl group, a C2-6 alkenyl group, or a C2-6 alkynyl group); X is oxygen atom, or an —NR4— group (R4 is hydrogen atom, a C1-6 alkyl group, or a C1-6 alkyl group which may be substituted with an Ar group); and R4′ is hydrogen atom, or a group represented by the aforementioned formula (a) (R3″ and R4″ represent hydrogen atom, or a linear or branched C1-6 alkylcarbonyl group)]
摘要翻译：由以下通式（1）表示的化合物或其药学上可接受的盐，其可用于预防和/或治疗微生物感染性疾病。 R 1是氢原子或直链C 1-6烷基羰基; R 2是氢原子或C 1-6烷基羰基; R 3是氢原子，C 1-6烷基，C 1-6烷基羰基，C 1-6烯基，C 2-6烯基羰基，C 2-6炔基或 Ar-B-基（Ar表示芳基或杂环基，B为C1-6烷基，C1-6烷基羰基，C2-6烯基，C2-6链烯基羰基或 C 2-6炔基）; R 5，R 6，R 7和R 8表示氢原子，C 1-6烷基，C2-6烯基，C2-6炔基或Ar-B'-基（B'是C1-6烷基，C2-6链烯基或C2-6炔基）; X是氧原子或-NR 4 - 基团（R 4）是氢原子，C 1-6烷基或可以是C 1-6烷基的C 1-6烷基被Ar基团取代）; 和R 4'是氢原子，或由上述式（a）表示的基团（R 3'和R 4“ 代表氢原子，或直链或支链C 1-6烷基羰基）]

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