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1. 发明申请

US20100216204A1 NUCLEIC ACID SEQUENCES TO PROTEINS INVOLVED IN TOCOPHEROL SYNTHESIS 有权
标题翻译：核苷酸合成中涉及蛋白质的核酸序列
公开(公告)号：US20100216204A1
公开(公告)日：2010-08-26
申请号：US12147409
申请日：2008-06-26
申请人： Sai S. Subramaniam , Steven C. Slater , Katherine Karberg , Ridong Chen , Henry E. Valentin , Yun-Hua Huang Wong
发明人： Sai S. Subramaniam , Steven C. Slater , Katherine Karberg , Ridong Chen , Henry E. Valentin , Yun-Hua Huang Wong
IPC分类号： C12P5/02 , C12N15/82 , C12N15/74
CPC分类号： C12N9/1085 , A23D9/007 , A23K20/174 , C11B3/001 , C11B3/12 , C12N9/88 , C12N15/8243 , C12N15/8247 , C12P17/06
摘要： Nucleic acid sequences and methods are provided for producing plants and seeds having altered tocopherol content and compositions. The methods find particular use in increasing the tocopherol levels in plants, and in providing desirable tocopherol compositions in a host plant cell.
摘要翻译：提供核酸序列和方法用于产生具有改变的生育酚含量和组成的植物和种子。该方法特别用于增加植物中的生育酚水平，以及在宿主植物细胞中提供期望的生育酚组合物。

2. 发明授权

US07605244B2 Gamma tocopherol methyltransferase coding sequence from Brassica and uses thereof 有权
公开(公告)号：US07605244B2
公开(公告)日：2009-10-20
申请号：US11776441
申请日：2007-07-11
申请人： Alison Van Eenennaam , Henry E. Valentin , Balasulojini Karunanandaa , Ming Hao , Eric Aasen , Charlene Levering
发明人： Alison Van Eenennaam , Henry E. Valentin , Balasulojini Karunanandaa , Ming Hao , Eric Aasen , Charlene Levering
IPC分类号： C07H21/04 , C12N15/82 , A01H5/00
CPC分类号： C12N9/1007 , C12N15/8243
摘要： The present invention relates to genes associated with the tocopherol biosynthesis pathway. More particularly, the present invention provides and includes nucleic acid molecules, proteins, and antibodies associated with genes that encode polypeptides that have methyltransferase activity. The present invention also provides methods for utilizing such agents, for example in gene isolation, gene analysis and the production of transgenic plants. Moreover, the present invention includes transgenic plants modified to express the aforementioned polypeptides. In addition, the present invention includes methods for the production of products from the tocopherol biosynthesis pathway.

3. 发明申请

US20080244790A1 METHYL-D-ERYTHRITOL PHOSPHATE PATHWAY GENES 审中-公开
标题翻译：甲基-D-谷维素磷酸盐路径基因
公开(公告)号：US20080244790A1
公开(公告)日：2008-10-02
申请号：US12101833
申请日：2008-04-11
申请人： Albert Boronat , Narciso Campos , Manual Rodriguez-Concepcion , Michel Rohmer , Myriam Seemann , Henry E. Valentin , Tyamagondlu V. Venkatesh , Mylavarapu Venkatramesh
发明人： Albert Boronat , Narciso Campos , Manual Rodriguez-Concepcion , Michel Rohmer , Myriam Seemann , Henry E. Valentin , Tyamagondlu V. Venkatesh , Mylavarapu Venkatramesh
IPC分类号： C12N15/29 , C07K16/00 , C12N5/10 , A01H5/00
CPC分类号： C12N15/8243 , C12N15/52 , C12N15/825
摘要： The present invention provides and includes nucleic acids, proteins and antibodies associated with novel genes in the MEP pathway. The invention further encompasses methods utilizing such molecules, for example in gene isolation, gene analysis and the production of transgenic plants. The present invention also includes transgenic plants modified to express proteins associated with the MEP pathway.
摘要翻译：本发明提供并包括与MEP途径中的新基因相关的核酸，蛋白质和抗体。本发明还包括利用这种分子的方法，例如在基因分离，基因分析和转基因植物的生产中。本发明还包括被修饰以表达与MEP途径相关的蛋白质的转基因植物。

4. 发明授权

US07238855B2 TyrA genes and uses thereof 有权
标题翻译： TyrA基因及其用途
公开(公告)号：US07238855B2
公开(公告)日：2007-07-03
申请号：US10137310
申请日：2002-05-03
申请人： Henry E. Valentin , Timothy A. Mitsky , Ming Hao , Balasulojini Karunanandaa , Qungang Qi
发明人： Henry E. Valentin , Timothy A. Mitsky , Ming Hao , Balasulojini Karunanandaa , Qungang Qi
IPC分类号： C12N15/82 , A01H5/00
CPC分类号： C12N9/001 , C07K14/47 , C12N9/90 , C12N15/8243
摘要： The present invention is in the field of plant genetics and biochemistry. More specifically, the invention relates to genes associated with the tocopherol biosynthesis pathway. The present invention provides and includes nucleic acid molecules, proteins, and antibodies associated with the genes of the tocopherol biosynthesis pathway. The present invention also provides methods for utilizing such agents, for example in gene isolation, gene analysis and the production of transgenic plants. Moreover, the present invention includes transgenic plants modified to express proteins associated with the tocopherol pathway. In addition, the present invention includes methods for the production of products from the tocopherol biosynthesis pathway.
摘要翻译：本发明在植物遗传学和生物化学领域。更具体地，本发明涉及与生育酚生物合成途径相关的基因。本发明提供并包括与生育酚生物合成途径的基因相关的核酸分子，蛋白质和抗体。本发明还提供了利用这些试剂的方法，例如在基因分离，基因分析和转基因植物的生产中。此外，本发明包括被修饰以表达与生育酚途径相关的蛋白质的转基因植物。此外，本发明包括从生育酚生物合成途径生产产物的方法。

5. 发明授权

US07230165B2 Tocopherol biosynthesis related genes and uses thereof 有权
标题翻译：生育酚生物合成相关基因及其用途
公开(公告)号：US07230165B2
公开(公告)日：2007-06-12
申请号：US10634548
申请日：2003-08-05
申请人： Susan R. Norris , Kim Lincoln , Mark S. Abad , Robert J. Eilers , Karen Kindle Hartsuyker , Joseph Hirschberg , Balasulojini Karunanandaa , Farhad Moshiri , Joshua C. Stein , Henry E. Valentin , Tyamagondlu V. Venkatesh
发明人： Susan R. Norris , Kim Lincoln , Mark S. Abad , Robert J. Eilers , Karen Kindle Hartsuyker , Joseph Hirschberg , Balasulojini Karunanandaa , Farhad Moshiri , Joshua C. Stein , Henry E. Valentin , Tyamagondlu V. Venkatesh
IPC分类号： A01H1/00 , C07K14/415 , C12N5/14 , C12N9/00
CPC分类号： C12N9/12 , C12N15/8243
摘要： The present invention relates to genes associated with the tocopherol biosynthesis pathway. More particularly, the present invention provides and includes nucleic acid molecules and proteins associated with genes that encode polypeptides associated with the tocopherol biosynthesis pathway. The present invention also provides methods for utilizing such agents, for example in gene isolation, gene analysis, and the production of transgenic plants. Moreover, the present invention includes transgenic plants modified to express the aforementioned polypeptides. In addition, the present invention includes methods for the production of products from the tocopherol biosynthesis pathway as well as in production of plants that are drought resistant.
摘要翻译：本发明涉及与生育酚生物合成途径相关的基因。更具体地，本发明提供并包括与编码与生育酚生物合成途径相关的多肽的基因相关的核酸分子和蛋白质。本发明还提供了利用这些试剂的方法，例如在基因分离，基因分析和转基因植物的生产中。此外，本发明包括被修饰以表达上述多肽的转基因植物。此外，本发明包括从生育酚生物合成途径生产产品的方法以及耐干旱植物的生产方法。

6. 发明授权

US06835820B2 Polyhydroxyalkanoate biosynthesis associated proteins and coding region in bacillus megaterium 失效
标题翻译：聚羟基链烷酸酯生物合成相关蛋白和巨大芽孢杆菌的编码区
公开(公告)号：US06835820B2
公开(公告)日：2004-12-28
申请号：US09479040
申请日：2000-01-07
申请人： Maura Cannon , Francis C. Cannon , Gabriel J. McCool , Henry E. Valentin , Kenneth J. Gruys
发明人： Maura Cannon , Francis C. Cannon , Gabriel J. McCool , Henry E. Valentin , Kenneth J. Gruys
IPC分类号： C07H2104
CPC分类号： C12N15/52 , C12P7/625
摘要： A 7,916 base pair nucleic acid fragment from Bacillus megaterium is disclosed. The fragment encodes five proteins, PhaP, PhaQ, PhaR, PhaB, 09 and PhaC, shown or inferred to be involved in the biosynthesis of polyhydroxyalkanoate materials.
摘要翻译：公开了来自巨大芽孢杆菌的7,916个碱基对核酸片段。该片段编码五种蛋白质PhaP，PhaQ，PhaR，PhaB，09和PhaC，显示或推断参与聚羟基链烷酸酯材料的生物合成。

7. 发明授权

US6117658A Methods of making polyhydroxyalkanoates comprising 4-hydroxybutyrate monomer units 失效
标题翻译：制备包含4-羟基丁酸酯单体单元的聚羟基链烷酸酯的方法
公开(公告)号：US6117658A
公开(公告)日：2000-09-12
申请号：US23029
申请日：1998-02-12
申请人： Douglas E. Dennis , Henry E. Valentin
发明人： Douglas E. Dennis , Henry E. Valentin
IPC分类号： C12N9/04 , C12N9/10 , C12N15/52 , C12N15/82 , C12P7/62 , C12P1/04 , C12P7/42 , C12P7/52
CPC分类号： C12N9/0006 , C12N15/52 , C12N15/8243 , C12N9/13 , C12P7/625
摘要： The PHA biosynthetic pathway is combined with a succinic semialdehyde metabolic pathway that metabolizes succinic semialdehyde via a 4-hydroxybutyryl-CoA intermediate in order to produce high levels of PHA comprising 4HB monomer units. This combination is particularly useful, in part, because the PHA biosynthetic pathway is well known and has been expressed to produce P(3HB) to levels as high as 70-80% of the cell dry weight, while the succinic semialdehyde metabolic pathway is also well known, and the combination of the two pathways means that production of PHAs comprising 4HB monomer units does not depend on immediate precursors of 4-hydroxybutyrate. Rather, the production of the PHAs comprising 4HB monomer units can occur simply from the extraction of succinate or succinyl-CoA from the citric acid cycle when the host cell is grown on an inexpensive carbon source such as glucose.
摘要翻译：将PHA生物合成途径与琥珀酸半醛代谢途径结合，其通过4-羟基丁酰-CoA中间体代谢琥珀酸半醛，以产生包含4HB单体单元的高水平PHA。这种组合在某种程度上是特别有用的，因为PHA生物合成途径是众所周知的并已表达以产生P（3HB）至高达细胞干重的70-80％的水平，而琥珀酸半醛代谢途径也是众所周知，并且两个途径的组合意味着包含4HB单体单元的PHA的生产不依赖于4-羟基丁酸酯的即时前体。相反，当宿主细胞在廉价的碳源如葡萄糖上生长时，包含4HB单体单元的PHA的生产可以简单地从柠檬酸循环中提取琥珀酸盐或琥珀酰-CoA。

8. 发明授权

US07262339B2 Tocopherol methyltransferase tMT2 and uses thereof 有权
标题翻译：生育酚甲基转移酶tMT2及其用途
公开(公告)号：US07262339B2
公开(公告)日：2007-08-28
申请号：US10279029
申请日：2002-10-24
申请人： Susan R. Norris , Kim Lincoln , Joshua C. Stein , Henry E. Valentin , Alison Van Eenennaam
发明人： Susan R. Norris , Kim Lincoln , Joshua C. Stein , Henry E. Valentin , Alison Van Eenennaam
IPC分类号： C12N15/82 , C12N15/29 , A01H5/00 , A01H5/10
CPC分类号： C12N15/8243 , C12N9/1007
摘要： The present invention relates to genes associated with the tocopherol biosynthesis pathway. More particularly, the present invention provides and includes nucleic acid molecules, proteins, and antibodies associated with genes that encode polypeptides that have tocopherol methyltransferase (tMT2) activity. The present invention also provides methods for utilizing such agents, for example in gene isolation, gene analysis and the production of transgenic plants. Moreover, the present invention includes transgenic plants modified to express the aforementioned polypeptides. in addition, the present invention includes methods for the production of products from the tocopherol biosynthesis pathway.
摘要翻译：本发明涉及与生育酚生物合成途径相关的基因。更具体地，本发明提供并包括与编码具有生育酚甲基转移酶（tMT2）活性的多肽的基因相关的核酸分子，蛋白质和抗体。本发明还提供了利用这些试剂的方法，例如在基因分离，基因分析和转基因植物的生产中。此外，本发明包括被修饰以表达上述多肽的转基因植物。此外，本发明包括从生育酚生物合成途径生产产物的方法。

9. 发明授权

US07112717B2 Homogentisate prenyl transferase gene (HPT2) from arabidopsis and uses thereof 有权
标题翻译：拟南芥的同源异戊烯转移酶基因（HPT2）及其用途
公开(公告)号：US07112717B2
公开(公告)日：2006-09-26
申请号：US10391363
申请日：2003-03-18
申请人： Henry E. Valentin , Tyamagondlu V. Venkatesh , Karunanandaa Balasulojini
发明人： Henry E. Valentin , Tyamagondlu V. Venkatesh , Karunanandaa Balasulojini
IPC分类号： C12N15/82 , C12N15/29 , C12N5/14
CPC分类号： C12N15/8243
摘要： The present invention is in the field of plant genetics and biochemistry. More specifically, the present invention relates to genes and polypeptides associated with the tocopherol biosynthesis pathway, namely those encoding homogentisate prenyl transferase activity, and uses thereof. In particular, the sequence of the HPT2 gene from Arabidopsis thaliana is disclosed for expression in any plant species to increase the levels of tocopherol.
摘要翻译：本发明在植物遗传学和生物化学领域。更具体地说，本发明涉及与生育酚生物合成途径相关的基因和多肽，即编码重要蛋白异戊烯转移酶活性的基因和多肽及其用途。特别地，公开了来自拟南芥的HPT2基因的序列用于在任何植物物种中表达以增加生育酚的水平。

10. 发明申请

US20090325264A1 Engineered Delta-15-Fatty Acid Desaturases 审中-公开
标题翻译：工程化的Delta-15-脂肪酸去饱和酶
公开(公告)号：US20090325264A1
公开(公告)日：2009-12-31
申请号：US12428820
申请日：2009-04-23
申请人： MICHAEL J. STOREK , HENRY E. VALENTIN , STEVEN E. SCREEN , VIRGINIA URSIN , BYRON FROMAN , KEVIN JARRELL , SARA A. SALVADOR , ROBERT MCCARROLL , PRASHANTH VISHWANATH
发明人： MICHAEL J. STOREK , HENRY E. VALENTIN , STEVEN E. SCREEN , VIRGINIA URSIN , BYRON FROMAN , KEVIN JARRELL , SARA A. SALVADOR , ROBERT MCCARROLL , PRASHANTH VISHWANATH
IPC分类号： C12N9/02 , C07H21/00 , C12N5/04 , C12N5/10
CPC分类号： C12N15/8247 , A23D9/00 , C12N9/0083
摘要： The present invention provides engineered fatty acid desaturase molecules preferring Gamma Linolenic Acid (GLA) over Linoleic Acid (LA) as a substrate. The invention further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds comprising the desaturase molecule, and methods for preparing and using the same. In particular, the disclosed engineered desaturase molecules are capable of altering the omega-3 fatty acid profiles in plants and plant parts.
摘要翻译：本发明提供优选亚麻酸（GLA）以亚油酸（LA）为底物的工程化脂肪酸去饱和酶分子。本发明还公开了组合物，多核苷酸构建体，转化的宿主细胞，转基因植物和包含去饱和酶分子的种子，以及其制备和使用该方法。特别地，所公开的工程化去饱和酶分子能够改变植物和植物部分中的ω-3脂肪酸谱。

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