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    • 8. 发明申请
    • High throughput isolation of biological compounds
    • 生物化合物的高通量分离
    • US20050086822A1
    • 2005-04-28
    • US10493842
    • 2002-10-29
    • Henrik FrisnerLars Lehmann Christensen
    • Henrik FrisnerLars Lehmann Christensen
    • C07K1/20C12N9/00F26B19/00
    • C07K1/20C12N9/00
    • A method for high throughput micro-purification of a library of tag-free biological compounds is claimed wherein a population of discrete liquid samples comprising the library of tag-free biological compounds is contacted with a solid chromatographic material comprising a functional group selected from ion exchange materials, hydrophobic materials, affinity materials and hydrophobic charge induction materials so as to retain the tag-free biological compounds of the library, isolating the chromatographic material retaining the biological compounds, releasing the biological compounds of the library from the solid chromatographic material and collecting the released biological compounds of the library to produce a population of samples comprising the isolated biological compound.
    • 要求一种用于无标记生物化合物文库的高通量微量纯化的方法,其中包含无标记生物化学文库的离散液体样品群与包含选自离子交换的官能团的固体色谱材料接触 材料,疏水材料,亲和材料和疏水电荷诱导材料,以便保留文库的无标签生物化合物,分离保留生物化合物的色谱材料,从固相层析材料中释放文库的生物化合物并收集 释放文库的生物化合物以产生包含分离的生物化合物的样品群体。