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    • 3. 发明授权
    • Increased drug-loading and reduced stress drug delivery device
    • 增加药物负荷和减少应激药物输送装置
    • US06758859B1
    • 2004-07-06
    • US09699786
    • 2000-10-30
    • Kenny L. DangNazanine MatinHenjen Ho
    • Kenny L. DangNazanine MatinHenjen Ho
    • A61F206
    • A61F2/91A61F2/88A61F2/915A61F2002/91533A61F2002/91575A61F2250/0068
    • An implantable prosthesis, for example a stent, is provided having one or more elements that form the body structure of the prosthesis. The elements have a width that is variable from a nominal or conventional width to an increased width. Depots are formed in the elements and are generally located at the increased width portions of the elements. The diameter of the depots is based on a percentage of the width of the element. As such, the depots have increased drug-loading capabilities. Substances such as therapeutic substances, polymeric materials, polymeric materials containing therapeutic substances, radioactive isotopes, and radiopaque materials can be deposited into the depots. Further, the variable width of the elements ensures that sufficient material surrounds each depot so as not to compromise the structural integrity of the prosthesis.
    • 提供了可植入的假体,例如支架,其具有形成假体的身体结构的一个或多个元件。 这些元件具有从标称或常规宽度到增加的宽度可变的宽度。 部件形成在元件中,并且通常位于元件的增宽部分。 仓库的直径基于元件宽度的百分比。 因此,仓库增加了药物装载能力。 诸如治疗物质,聚合材料,含有治疗物质的聚合材料,放射性同位素和不透射线材料等物质可以沉积到贮库中。 此外,元件的可变宽度确保了足够的材料围绕每个仓库,以便不损害假体的结构完整性。