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    • 2. 发明专利
    • Diagnostic imaging for age-related macular degeneration (amd) using second harmonic generation (shg) techniques
    • 使用第二次谐波生成(SHG)技术的年龄相关性变差(AMD)的诊断成像
    • JP2013085950A
    • 2013-05-13
    • JP2012173675
    • 2012-08-06
    • Heidelberg Engineering Gmbhハイデルベルク エンジニアリング ゲゼルシャフト ミット ベシュレンクテル ハフツング
    • BILLE JOSEF
    • A61F9/008A61F9/007
    • A61N5/062A61B3/12A61F9/008A61F2009/00848A61F2009/00863
    • PROBLEM TO BE SOLVED: To provide a system for treating age-related macular degeneration (AMD).SOLUTION: The system for treating age-related macular degeneration includes an agent with non-centro symmetric molecules for marking a region of diseased tissue. An optical assembly focuses the laser beam to a plurality of focal points in the region of diseased tissue, each focal point having a volumetric measurement of about 2 μm×2 μm×20 μm. Due to an increased concentration of photons in the relatively small volume of each focal point, two photons interact with a single molecule of the marking agent, within a very short interval of time (e.g. 10-13 sec). The resultant excited electron state (e.g. 3 eV) is sufficient to induce the marking agent to convert oxygen in a manner that causes the oxygen to kill the diseased tissue. Also, an interaction between photons and a non-centro symmetric molecule in the marking agent will cause a second harmonic generation (SHG) response that can be used for imaging purposes.
    • 要解决的问题:提供一种治疗年龄相关性黄斑变性(AMD)的系统。 解决方案:用于治疗年龄相关性黄斑变性的系统包括用于标记患病组织区域的具有非中心对称分子的药剂。 光学组件将激光束聚焦到患病组织区域中的多个焦点,每个焦点具有约2μm×2μm×20μm的体积测量。 由于在每个焦点的相对较小的体积中光子的浓度增加,两个光子在非常短的时间间隔(例如10-13秒)内与标记剂的单分子相互作用。 所产生的激发的电子态(例如3eV)足以诱导标记剂以使氧气杀死患病组织的方式转化氧。 此外,光子和标记剂中的非中心对称分子之间的相互作用将导致可用于成像目的的二次谐波产生(SHG)响应。 版权所有(C)2013,JPO&INPIT
    • 5. 发明专利
    • System and method for imaging retinal tissue with tissue generated light
    • 用组织生成的光成像后组织的系统和方法
    • JP2010057896A
    • 2010-03-18
    • JP2009148479
    • 2009-06-23
    • Heidelberg Engineering Gmbhハイデルベルク エンジニアリング ゲゼルシャフト ミット ベシュレンクテル ハフツング
    • BILLE JOSEF F
    • A61B3/14A61B3/10
    • A61B3/1225A61B5/0059
    • PROBLEM TO BE SOLVED: To provide a system and a method for imaging retinal tissues in an eye.
      SOLUTION: The system and method generates an input light beam having ultra-short pulses and an input wavelength (λι) to stimulate the tissue. Depending on the particular type tissue being imaged, the retinal tissue responds to the input beam by generating a return beam of light having the first component and second component of different wavelengths (λτ1 and λτ2 ). An imaging unit then receives the return light and images the tissue according to the return wavelength (λτ1 vis-a-vis λτ2 ). Further, a sensor unit is used to evaluate light returning from the retina to measure optical and phase aberrations introduced by the eye, and to program a compensator, an active mirror for instance, that compensates the input beam by removing the aberrations.
      COPYRIGHT: (C)2010,JPO&INPIT
    • 要解决的问题:提供用于对眼睛中的视网膜组织进行成像的系统和方法。 解决方案:该系统和方法产生具有超短脉冲和输入波长(λι)的输入光束以刺激组织。 根据被成像的特定类型的组织,视网膜组织通过产生具有不同波长的第一分量和第二分量(λτ1和λτ2)的返回光束来响应输入光束。 然后,成像单元接收返回光并根据返回波长(λτ1相对于λτ2)对组织进行成像。 此外,传感器单元用于评估从视网膜返回的光,以测量由眼睛引入的光学和相位像差,以及编程补偿器,例如主动反射镜,其通过去除像差来补偿输入光束。 版权所有(C)2010,JPO&INPIT
    • 6. 发明专利
    • Laser control with phase plate feedback
    • 激光控制与相位反馈
    • JP2010104769A
    • 2010-05-13
    • JP2009174412
    • 2009-07-27
    • Heidelberg Engineering Gmbhハイデルベルク エンジニアリング ゲゼルシャフト ミット ベシュレンクテル ハフツング
    • BILLE JOSEF F
    • A61B3/10A61B3/12G02B5/30
    • A61B3/1225A61B3/1015
    • PROBLEM TO BE SOLVED: To provide an ophthalmic imaging system and method for optimizing a diffraction limited point spread function (DL-PSF) of an imaging light beam.
      SOLUTION: This ophthalmic imaging system includes: a light source; focusing optics; compensating optics; and a computer that coordinates both of the optics. In detail, the compensating optics include a customized phase plate that provides substantially complete compensation for static aberrations introduced by an eye into the imaging light beam. Further, the computer measures an operational error signal that results from dynamic aberrations. The computer then uses the error signal to control the compensating optics and thereby optimize the DL-PSF by compensating for both static and dynamic aberrations. For an alternate embodiment, an active mirror can be included in the compensating optics to provide additional compensation for the dynamic aberrations.
      COPYRIGHT: (C)2010,JPO&INPIT
    • 要解决的问题:提供一种用于优化成像光束的衍射限制点扩散函数(DL-PSF)的眼科成像系统和方法。 解决方案:该眼科成像系统包括:光源; 聚焦光学; 补偿光学; 以及一个协调两个光学元件的计算机。 详细地,补偿光学器件包括定制的相位板,其为由眼睛引入成像光束的静态像差提供基本上完全的补偿。 此外,计算机测量由动态像差产生的操作误差信号。 然后,计算机使用误差信号来控制补偿光学元件,从而通过补偿静态和动态像差来优化DL-PSF。 对于替代实施例,可以在补偿光学器件中包括有源反射镜以为动态像差提供额外的补偿。 版权所有(C)2010,JPO&INPIT
    • 8. 发明专利
    • System and method for imaging fine part of cell in retina with high resolution
    • 用高分辨率成像细胞细胞部分的系统和方法
    • JP2009254830A
    • 2009-11-05
    • JP2009099462
    • 2009-04-16
    • Heidelberg Engineering Gmbhハイデルベルク エンジニアリング ゲゼルシャフト ミット ベシュレンクテル ハフツング
    • BILLE JOSEF F
    • A61B3/10G01J9/00G01N21/17
    • G02B9/02A61B3/1015A61B3/102A61B3/1225A61B3/13G02B26/06
    • PROBLEM TO BE SOLVED: To provide a system and method for imaging the tissue cell in a predetermined depth of the retina of an eye. SOLUTION: This system and method includes a component for compensating a refraction error. Specifically, this system is fundamentally equipped with three subassemblies operated together with each other. A first subassembly is present in order to guide a first laser beam for measuring a forward optical aberration into the eye and the second subassembly is present in order to guide a second laser beam up to a predetermined depth where tissue cells are positioned through the tissue of the retina. The phase aberration introduced by the tissue of the retina is measured using the second laser beam. Further, the third subassembly is present in order to guide a third laser beam to the tissue cells in order to form an image of the tissue cells. The forward optical aberration and phase aberration in the third laser beam are substantially removed and a sharper image of the tissue cells is provided. COPYRIGHT: (C)2010,JPO&INPIT
    • 要解决的问题:提供用于在眼睛的视网膜的预定深度中成像组织细胞的系统和方法。 解决方案:该系统和方法包括用于补偿折射误差的组件。 具体来说,该系统基本上配备有彼此一起操作的三个子组件。 存在第一子组件以便引导用于测量向眼中的正向光学像差的第一激光束,并且存在第二子组件以便将第二激光束引导到预定深度,其中组织细胞定位穿过组织的组织 视网膜 使用第二激光束测量由视网膜的组织引入的相位差。 此外,存在第三子组件以便将第三激光束引导到组织细胞,以形成组织细胞的图像。 基本上去除了第三激光束中的正向光学像差和相位差,并且提供了组织细胞的更清晰的图像。 版权所有(C)2010,JPO&INPIT